-
Notifications
You must be signed in to change notification settings - Fork 0
/
run145.mod
73 lines (62 loc) · 1.71 KB
/
run145.mod
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
;; 1. Based on: run144
;; 2. Description: FINAL IG, Three dose, CL, BIO, Constant Km
;; x1. Author: RZ
$PROBLEM METABOLISM OF ARCTIGENIN IN RATS AFTER IV - ADVAN6
$DATA Arctigenin_IG_for_nonmem.csv IGNORE=@
$INPUT ID TIME DV DOSE=AMT MDV CMT DL
$SUBROUTINE ADVAN6 TOL=6
$MODEL
COMP=(LUMEN DEFDOSE) ; 1. intestine lumen
COMP=(AG_CENTR) ; 2. AG in central
COMP=(AA_CENTR) ; 3. AA in Central
COMP=(INTESTIN) ; 4. Intestine compartment
;COMP=(AG_INTES) ; 5. AG in intestine
;COMP=(AG_PER) ; 5. AG in perp
;COMP=(AA_PER) ; 6. AA in perp
$PK
Ka = THETA(1)*EXP(ETA(1)) ; absorption rate of AR
K2e= THETA(2)*EXP(ETA(2)) ; elimination rate of AG from Central
K3e= THETA(3)*EXP(ETA(3)) ; elimination rate of AA from central comp
V2= THETA(4) ; volume of central
S2= V2
S3= V2
CLI= THETA(5)*EXP(ETA(4)) ; Clearance of intestine
CLB= THETA(6)*EXP(ETA(5)) ; Clearance of Blood
F1= THETA(7)*EXP(ETA(6)) ; Bioavailability
Ki=CLI
Kb=CLB
K20=K2e/1000
K30=K3e/1000
tKi=Ki
$DES
;IF(DL==1) tKi=Ki*1.314277
;IF(DL==2) tKi=Ki
;IF(DL==3) tKi=Ki*0.610052
DADT(1)=-Ka*A(1)
DADT(2)= tKi*A(4)-K20*A(2)
DADT(3)= Kb*A(4)-K30*A(3)
DADT(4)= Ka*A(1)-tKi*A(4)-Kb*A(4)
$ERROR
Y = F+ERR(1)
$THETA
(0, 0.3) ; Ka(1/min)
(0, 1) ; K2e(1/min)
(0, 10) ; K3e(1/min)
(0, 0.289 FIX) ; V2(L)
(0, 0.7) ; Ki (1/min)
(0, 0.8) ; Kb (1/min)
(0,0.01,1) ; BIO
$OMEGA
0 FIX ; IIV Ka
0 FIX ; IIV K20
0 FIX ; IIV K30
0 FIX ; IIV Ki
0 FIX ; IIV Kb
0 FIX ; IIV BIO
$SIGMA
0.000432 ; Residual error
$EST METHOD=0 MAXEVAL=999 NOABORT SIG=5 PRINT=1
$COV
; Xpose
$TABLE ID TIME DV MDV CMT DL ONEHEADER NOPRINT FILE=sdtab145.tab
$TABLE ID Ka K20 K30 V2 ONEHEADER NOPRINT FILE=patab145.tab