diff --git a/lib/internal/bootstrap/cache.js b/lib/internal/bootstrap/cache.js
index 6181228b033228..41159d650bc375 100644
--- a/lib/internal/bootstrap/cache.js
+++ b/lib/internal/bootstrap/cache.js
@@ -52,6 +52,27 @@ if (process.config.variables.v8_enable_inspector !== 1) {
 if (!hasTracing) {
   cannotUseCache.push('trace_events');
 }
+if (!process.versions.openssl) {
+  cannotUseCache.push('crypto');
+  cannotUseCache.push('https');
+  cannotUseCache.push('http2');
+  cannotUseCache.push('tls');
+  cannotUseCache.push('_tls_common');
+  cannotUseCache.push('_tls_wrap');
+  cannotUseCache.push('internal/crypto/certificate');
+  cannotUseCache.push('internal/crypto/cipher');
+  cannotUseCache.push('internal/crypto/diffiehellman');
+  cannotUseCache.push('internal/crypto/hash');
+  cannotUseCache.push('internal/crypto/keygen');
+  cannotUseCache.push('internal/crypto/pbkdf2');
+  cannotUseCache.push('internal/crypto/random');
+  cannotUseCache.push('internal/crypto/scrypt');
+  cannotUseCache.push('internal/crypto/sig');
+  cannotUseCache.push('internal/crypto/util');
+  cannotUseCache.push('internal/http2/core');
+  cannotUseCache.push('internal/http2/compat');
+  cannotUseCache.push('internal/streams/lazy_transform');
+}
 
 module.exports = {
   cachableBuiltins: Object.keys(NativeModule._source).filter(