diff --git a/kubetest2-gke/deployer/deployer.go b/kubetest2-gke/deployer/deployer.go
index c12eb4b6..1efb42d4 100644
--- a/kubetest2-gke/deployer/deployer.go
+++ b/kubetest2-gke/deployer/deployer.go
@@ -38,9 +38,8 @@ import (
 const Name = "gke"
 
 const (
-	e2eAllow      = "tcp:22,tcp:80,tcp:8080,tcp:30000-32767,udp:30000-32767"
-	defaultCreate = "container clusters create --quiet"
-	image         = "cos"
+	e2eAllow     = "tcp:22,tcp:80,tcp:8080,tcp:30000-32767,udp:30000-32767"
+	defaultImage = "cos"
 )
 
 type privateClusterAccessLevel string
@@ -52,12 +51,14 @@ const (
 )
 
 var (
-	// poolRe matches instance group URLs of the form `https://www.googleapis.com/compute/v1/projects/some-project/zones/a-zone/instanceGroupManagers/gke-some-cluster-some-pool-90fcb815-grp`. Match meaning:
+	// poolRe matches instance group URLs of the form `https://www.googleapis.com/compute/v1/projects/some-project/zones/a-zone/instanceGroupManagers/gke-some-cluster-some-pool-90fcb815-grp`
+	// or `https://www.googleapis.com/compute/v1/projects/some-project/zones/a-zone/instanceGroupManagers/gk3-some-cluster-some-pool-90fcb815-grp` for GKE in Autopilot mode.
+	// Match meaning:
 	// m[0]: path starting with zones/
 	// m[1]: zone
 	// m[2]: pool name (passed to e2es)
 	// m[3]: unique hash (used as nonce for firewall rules)
-	poolRe = regexp.MustCompile(`zones/([^/]+)/instanceGroupManagers/(gke-.*-([0-9a-f]{8})-grp)$`)
+	poolRe = regexp.MustCompile(`zones/([^/]+)/instanceGroupManagers/(gk[e|3]-.*-([0-9a-f]{8})-grp)$`)
 
 	urlRe           = regexp.MustCompile(`https://.*/`)
 	defaultNodePool = gkeNodePool{
@@ -106,12 +107,17 @@ type deployer struct {
 	projectClustersLayout map[string][]cluster
 	nodes                 int
 	machineType           string
+	imageType             string
 	network               string
 	subnetworkRanges      []string
 	environment           string
-	createCommandFlag     string
 	gcpServiceAccount     string
 
+	gcloudCommandGroup string
+	autopilot          bool
+	gcloudExtraFlags   string
+	createCommandFlag  string
+
 	kubecfgPath  string
 	testPrepared bool
 	// project -> cluster -> instance groups
@@ -209,9 +215,14 @@ func bindFlags(d *deployer) *pflag.FlagSet {
 		klog.Fatalf("unable to generate flags from deployer")
 		return nil
 	}
+
+	flags.StringVar(&d.gcloudCommandGroup, "gcloud-command-group", "", "gcloud command group, can be one of empty, alpha, beta")
+	flags.BoolVar(&d.autopilot, "autopilot", false, "Whether to create GKE Autopilot clusters or not")
+	flags.StringVar(&d.gcloudExtraFlags, "gcloud-extra-flags", "", "Extra gcloud flags to pass when creating the clusters")
+	flags.StringVar(&d.createCommandFlag, "create-command", "", "gcloud subcommand and additional flags used to create a cluster, such as `container clusters create --quiet`."+
+		"If it's specified, --gcloud-command-group, --autopilot, --gcloud-extra-flags will be ignored.")
 	flags.StringSliceVar(&d.clusters, "cluster-name", []string{}, "Cluster names separated by comma. Must be set. "+
 		"For multi-project profile, it should be in the format of clusterA:0,clusterB:1,clusterC:2, where the index means the index of the project.")
-	flags.StringVar(&d.createCommandFlag, "create-command", defaultCreate, "gcloud subcommand used to create a cluster. Modify if you need to pass arbitrary arguments to create.")
 	flags.StringVar(&d.gcpServiceAccount, "gcp-service-account", "", "Service account to activate before using gcloud")
 	flags.StringVar(&d.network, "network", "default", "Cluster network. Defaults to the default network if not provided. For multi-project use cases, this will be the Shared VPC network name.")
 	flags.StringSliceVar(&d.subnetworkRanges, "subnetwork-ranges", []string{}, "Subnetwork ranges as required for shared VPC setup as described in https://cloud.google.com/kubernetes-engine/docs/how-to/cluster-shared-vpc#creating_a_network_and_two_subnets."+
@@ -223,6 +234,7 @@ func bindFlags(d *deployer) *pflag.FlagSet {
 	flags.StringVar(&d.zone, "zone", "", "For use with gcloud commands to specify the cluster zone.")
 	flags.IntVar(&d.nodes, "num-nodes", defaultNodePool.Nodes, "For use with gcloud commands to specify the number of nodes for the cluster.")
 	flags.StringVar(&d.machineType, "machine-type", defaultNodePool.MachineType, "For use with gcloud commands to specify the machine type for the cluster.")
+	flags.StringVar(&d.imageType, "image-type", defaultImage, "The image type to use for the cluster.")
 	flags.BoolVar(&d.gcpSSHKeyIgnored, "ignore-gcp-ssh-key", true, "Whether the GCP SSH key should be ignored or not for bringing up the cluster.")
 	flags.BoolVar(&d.workloadIdentityEnabled, "enable-workload-identity", false, "Whether enable workload identity for the cluster or not.")
 	flags.StringVar(&d.privateClusterAccessLevel, "private-cluster-access-level", "", "Private cluster access level, if not empty, must be one of 'no', 'limited' or 'unrestricted'")
diff --git a/kubetest2-gke/deployer/network.go b/kubetest2-gke/deployer/network.go
index b6ea48f3..84bb76a1 100644
--- a/kubetest2-gke/deployer/network.go
+++ b/kubetest2-gke/deployer/network.go
@@ -169,7 +169,7 @@ func transformNetworkName(projects []string, network string) string {
 
 // Returns the sub network args needed for the cluster creation command.
 // Reference: https://cloud.google.com/kubernetes-engine/docs/how-to/cluster-shared-vpc#creating_a_cluster_in_your_first_service_project
-func subNetworkArgs(projects []string, region, network string, projectIndex int) []string {
+func subNetworkArgs(autopilot bool, projects []string, region, network string, projectIndex int) []string {
 	// No sub network args need to be added for creating clusters in the host project.
 	if projectIndex == 0 {
 		return []string{}
@@ -179,12 +179,16 @@ func subNetworkArgs(projects []string, region, network string, projectIndex int)
 	hostProject := projects[0]
 	curtProject := projects[projectIndex]
 	subnetName := network + "-" + curtProject
-	return []string{
-		"--enable-ip-alias",
+	args := []string{
 		fmt.Sprintf("--subnetwork=projects/%s/regions/%s/subnetworks/%s", hostProject, region, subnetName),
 		fmt.Sprintf("--cluster-secondary-range-name=%s-pods", subnetName),
 		fmt.Sprintf("--services-secondary-range-name=%s-services", subnetName),
 	}
+	// GKE in Autopilot mode does not support --enable-ip-alias flag - https://cloud.google.com/sdk/gcloud/reference/container/clusters/create-auto
+	if !autopilot {
+		args = append(args, "--enable-ip-alias")
+	}
+	return args
 }
 
 func (d *deployer) setupNetwork() error {
diff --git a/kubetest2-gke/deployer/up.go b/kubetest2-gke/deployer/up.go
index 61d97894..2e90cf8d 100644
--- a/kubetest2-gke/deployer/up.go
+++ b/kubetest2-gke/deployer/up.go
@@ -67,22 +67,26 @@ func (d *deployer) Up() error {
 	loc := location(d.region, d.zone)
 	for i := range d.projects {
 		project := d.projects[i]
-		subNetworkArgs := subNetworkArgs(d.projects, d.region, d.network, i)
+		subNetworkArgs := subNetworkArgs(d.autopilot, d.projects, d.region, d.network, i)
 		for j := range d.projectClustersLayout[project] {
 			cluster := d.projectClustersLayout[project][j]
 			privateClusterArgs := privateClusterArgs(d.projects, d.network, d.privateClusterAccessLevel, d.privateClusterMasterIPRanges, cluster)
 			eg.Go(func() error {
 				// Create the cluster
-				args := make([]string, len(d.createCommand()))
-				copy(args, d.createCommand())
+				args := d.createCommand()
 				args = append(args,
 					"--project="+project,
 					loc,
-					"--machine-type="+d.machineType,
-					"--image-type="+image,
-					"--num-nodes="+strconv.Itoa(d.nodes),
 					"--network="+transformNetworkName(d.projects, d.network),
 				)
+				// A few args are not supported in GKE Autopilot cluster creation, so they should be left unset.
+				// https://cloud.google.com/sdk/gcloud/reference/container/clusters/create-auto
+				if !d.autopilot {
+					args = append(args, "--machine-type="+d.machineType)
+					args = append(args, "--num-nodes="+strconv.Itoa(d.nodes))
+					args = append(args, "--image-type="+d.imageType)
+				}
+
 				if d.workloadIdentityEnabled {
 					args = append(args, fmt.Sprintf("--workload-pool=%s.svc.id.goog", project))
 				}
@@ -127,7 +131,24 @@ func (d *deployer) Up() error {
 }
 
 func (d *deployer) createCommand() []string {
-	return strings.Fields(d.createCommandFlag)
+	// Use the --create-command flag if it's explicitly specified.
+	if d.createCommandFlag != "" {
+		return strings.Fields(d.createCommandFlag)
+	}
+
+	fs := make([]string, 0)
+	if d.gcloudCommandGroup != "" {
+		fs = append(fs, d.gcloudCommandGroup)
+	}
+	fs = append(fs, "container", "clusters")
+	if d.autopilot {
+		fs = append(fs, "create-auto")
+	} else {
+		fs = append(fs, "create")
+	}
+	fs = append(fs, "--quiet")
+	fs = append(fs, strings.Fields(d.gcloudExtraFlags)...)
+	return fs
 }
 
 func (d *deployer) IsUp() (up bool, err error) {