diff --git a/src/main/java/com/leinardi/pycharm/mypy/MypyAnnotator.java b/src/main/java/com/leinardi/pycharm/mypy/MypyAnnotator.java
index d0ace6c..2b7eb48 100644
--- a/src/main/java/com/leinardi/pycharm/mypy/MypyAnnotator.java
+++ b/src/main/java/com/leinardi/pycharm/mypy/MypyAnnotator.java
@@ -16,12 +16,16 @@
 
 package com.leinardi.pycharm.mypy;
 
+import com.intellij.codeInsight.daemon.HighlightDisplayKey;
+import com.intellij.codeInspection.InspectionProfile;
 import com.intellij.lang.annotation.AnnotationHolder;
 import com.intellij.lang.annotation.ExternalAnnotator;
 import com.intellij.openapi.diagnostic.Logger;
 import com.intellij.openapi.progress.ProcessCanceledException;
 import com.intellij.openapi.project.Project;
+import com.intellij.profile.codeInspection.InspectionProjectProfileManager;
 import com.intellij.psi.PsiFile;
+import com.jetbrains.python.inspections.PyPep8Inspection;
 import com.leinardi.pycharm.mypy.checker.Problem;
 import com.leinardi.pycharm.mypy.checker.ScanFiles;
 import com.leinardi.pycharm.mypy.checker.ScannableFile;
@@ -49,6 +53,11 @@
  * `ExternalAnnotator` cancels the previous running check (if any) before running the next one.
  * <p>
  * Modeled after `com.jetbrains.python.validation.Pep8ExternalAnnotator`
+ * <p>
+ * IDE calls methods in three phases:
+ * 1. `State collectInformation(PsiFile)`: preparation
+ * 2. `Results doAnnotate(State)`: called in the background.
+ * 3. `void apply(PsiFile, State, AnnotationHolder)`: apply the annotations to the editor.
  */
 public class MypyAnnotator extends ExternalAnnotator<MypyAnnotator.State, MypyAnnotator.Results> {
     /* Inner classes storing intermediate results */
@@ -95,6 +104,15 @@ public State collectInformation(@NotNull PsiFile file) {
                 + " modified=" + file.getModificationStamp()
                 + " thread=" + Thread.currentThread().getName()
         );
+
+        final InspectionProfile profile =
+                InspectionProjectProfileManager.getInstance(file.getProject()).getCurrentProfile();
+        final HighlightDisplayKey key = HighlightDisplayKey.find(PyPep8Inspection.INSPECTION_SHORT_NAME);
+        if (!profile.isToolEnabled(key, file)) {
+            LOG.debug("Mypy inspection disabled");
+            return null;
+        }
+
         return new State(file);
     }