diff --git a/lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp b/lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
index dadcde612614b..a1ad3f569ec71 100644
--- a/lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
+++ b/lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
@@ -97,24 +97,28 @@ struct InitializePythonRAII {
   InitializePythonRAII() {
     InitializePythonHome();
 
+    // The table of built-in modules can only be extended before Python is
+    // initialized.
+    if (!Py_IsInitialized()) {
 #ifdef LLDB_USE_LIBEDIT_READLINE_COMPAT_MODULE
-    // Python's readline is incompatible with libedit being linked into lldb.
-    // Provide a patched version local to the embedded interpreter.
-    bool ReadlinePatched = false;
-    for (auto *p = PyImport_Inittab; p->name != nullptr; p++) {
-      if (strcmp(p->name, "readline") == 0) {
-        p->initfunc = initlldb_readline;
-        break;
+      // Python's readline is incompatible with libedit being linked into lldb.
+      // Provide a patched version local to the embedded interpreter.
+      bool ReadlinePatched = false;
+      for (auto *p = PyImport_Inittab; p->name != nullptr; p++) {
+        if (strcmp(p->name, "readline") == 0) {
+          p->initfunc = initlldb_readline;
+          break;
+        }
+      }
+      if (!ReadlinePatched) {
+        PyImport_AppendInittab("readline", initlldb_readline);
+        ReadlinePatched = true;
       }
-    }
-    if (!ReadlinePatched) {
-      PyImport_AppendInittab("readline", initlldb_readline);
-      ReadlinePatched = true;
-    }
 #endif
 
-    // Register _lldb as a built-in module.
-    PyImport_AppendInittab("_lldb", LLDBSwigPyInit);
+      // Register _lldb as a built-in module.
+      PyImport_AppendInittab("_lldb", LLDBSwigPyInit);
+    }
 
 // Python < 3.2 and Python >= 3.2 reversed the ordering requirements for
 // calling `Py_Initialize` and `PyEval_InitThreads`.  < 3.2 requires that you