diff --git a/app/code/Magento/PaypalGraphQl/Model/Plugin/Cart/PayflowPro/SetPaymentMethodOnCart.php b/app/code/Magento/PaypalGraphQl/Model/Plugin/Cart/PayflowPro/SetPaymentMethodOnCart.php
new file mode 100644
index 0000000000000..7ca4d41cfd33a
--- /dev/null
+++ b/app/code/Magento/PaypalGraphQl/Model/Plugin/Cart/PayflowPro/SetPaymentMethodOnCart.php
@@ -0,0 +1,70 @@
+<?php
+/**
+ * Copyright © Magento, Inc. All rights reserved.
+ * See COPYING.txt for license details.
+ */
+declare(strict_types=1);
+
+namespace Magento\PaypalGraphQl\Model\Plugin\Cart\PayflowPro;
+
+use Magento\Framework\GraphQl\Exception\GraphQlInputException;
+use Magento\Paypal\Model\Config;
+use Magento\Quote\Model\Quote;
+use Magento\QuoteGraphQl\Model\Cart\Payment\AdditionalDataProviderPool;
+use Magento\Sales\Model\Order\Payment\Repository as PaymentRepository;
+use Magento\PaypalGraphQl\Observer\PayflowProSetCcData;
+
+/**
+ * Set additionalInformation on payment for PayflowPro method
+ */
+class SetPaymentMethodOnCart
+{
+    /**
+     * @var PaymentRepository
+     */
+    private $paymentRepository;
+
+    /**
+     * @var AdditionalDataProviderPool
+     */
+    private $additionalDataProviderPool;
+
+    /**
+     * @param PaymentRepository $paymentRepository
+     * @param AdditionalDataProviderPool $additionalDataProviderPool
+     */
+    public function __construct(
+        PaymentRepository $paymentRepository,
+        AdditionalDataProviderPool $additionalDataProviderPool
+    ) {
+        $this->paymentRepository = $paymentRepository;
+        $this->additionalDataProviderPool = $additionalDataProviderPool;
+    }
+
+    /**
+     * Set redirect URL paths on payment additionalInformation
+     *
+     * @param \Magento\QuoteGraphQl\Model\Cart\SetPaymentMethodOnCart $subject
+     * @param mixed $result
+     * @param Quote $cart
+     * @param array $paymentData
+     * @return void
+     * @throws GraphQlInputException
+     * @SuppressWarnings(PHPMD.UnusedFormalParameter)
+     */
+    public function afterExecute(
+        \Magento\QuoteGraphQl\Model\Cart\SetPaymentMethodOnCart $subject,
+        $result,
+        Quote $cart,
+        array $paymentData
+    ): void {
+        $paymentData = $this->additionalDataProviderPool->getData(Config::METHOD_PAYFLOWPRO, $paymentData);
+        $cartCustomerId = (int)$cart->getCustomerId();
+        if ($cartCustomerId === 0 &&
+            array_key_exists(PayflowProSetCcData::IS_ACTIVE_PAYMENT_TOKEN_ENABLER, $paymentData)) {
+            $payment = $cart->getPayment();
+            $payment->unsAdditionalInformation(PayflowProSetCcData::IS_ACTIVE_PAYMENT_TOKEN_ENABLER);
+            $payment->save();
+        }
+    }
+}
diff --git a/app/code/Magento/PaypalGraphQl/Model/Resolver/PayflowProResponse.php b/app/code/Magento/PaypalGraphQl/Model/Resolver/PayflowProResponse.php
index ce44511c60f3e..b3ddced97aca6 100644
--- a/app/code/Magento/PaypalGraphQl/Model/Resolver/PayflowProResponse.php
+++ b/app/code/Magento/PaypalGraphQl/Model/Resolver/PayflowProResponse.php
@@ -126,9 +126,9 @@ public function resolve(
         $this->parameters->fromString(urldecode($paypalPayload));
         $data = $this->parameters->toArray();
         try {
-            $do = $this->dataObjectFactory->create(['data' => array_change_key_case($data, CASE_LOWER)]);
-            $this->responseValidator->validate($do, $this->transparent);
-            $this->transaction->savePaymentInQuote($do, $cart->getId());
+            $response = $this->transaction->getResponseObject($data);
+            $this->responseValidator->validate($response, $this->transparent);
+            $this->transaction->savePaymentInQuote($response, $cart->getId());
         } catch (LocalizedException $exception) {
             $parameters['error'] = true;
             $parameters['error_msg'] = $exception->getMessage();
diff --git a/app/code/Magento/PaypalGraphQl/Observer/PayflowProSetCcData.php b/app/code/Magento/PaypalGraphQl/Observer/PayflowProSetCcData.php
new file mode 100644
index 0000000000000..801ec91d063c5
--- /dev/null
+++ b/app/code/Magento/PaypalGraphQl/Observer/PayflowProSetCcData.php
@@ -0,0 +1,88 @@
+<?php
+/**
+ * Copyright © Magento, Inc. All rights reserved.
+ * See COPYING.txt for license details.
+ */
+
+declare(strict_types=1);
+
+namespace Magento\PaypalGraphQl\Observer;
+
+use Magento\Framework\App\Config\ScopeConfigInterface;
+use Magento\Framework\Event\Observer;
+use Magento\Framework\GraphQl\Exception\GraphQlInputException;
+use Magento\Payment\Observer\AbstractDataAssignObserver;
+use Magento\Quote\Api\Data\PaymentInterface;
+
+/**
+ * Class PayflowProSetCcData set CcData to quote payment
+ * @SuppressWarnings(PHPMD.CookieAndSessionMisuse)
+ */
+class PayflowProSetCcData extends AbstractDataAssignObserver
+{
+    const XML_PATH_PAYMENT_PAYFLOWPRO_CC_VAULT_ACTIVE = "payment/payflowpro_cc_vault/active";
+    const IS_ACTIVE_PAYMENT_TOKEN_ENABLER = "is_active_payment_token_enabler";
+
+    /**
+     * Core store config
+     *
+     * @var ScopeConfigInterface
+     */
+    private $scopeConfig;
+
+    /**
+     * @param ScopeConfigInterface $scopeConfig
+     */
+    public function __construct(
+        ScopeConfigInterface $scopeConfig
+    ) {
+        $this->scopeConfig = $scopeConfig;
+    }
+
+    /**
+     * Set CcData
+     *
+     * @param Observer $observer
+     *
+     * @throws GraphQlInputException
+     */
+    public function execute(Observer $observer)
+    {
+        $dataObject = $this->readDataArgument($observer);
+        $additionalData = $dataObject->getData(PaymentInterface::KEY_ADDITIONAL_DATA);
+        $paymentModel = $this->readPaymentModelArgument($observer);
+
+        if (!isset($additionalData['cc_details'])) {
+            return;
+        }
+
+        if ($this->isPayflowProVaultEnable()) {
+            if (!isset($additionalData[self::IS_ACTIVE_PAYMENT_TOKEN_ENABLER])) {
+                $paymentModel->setData(self::IS_ACTIVE_PAYMENT_TOKEN_ENABLER, false);
+            }
+
+            $paymentModel->setData(
+                self::IS_ACTIVE_PAYMENT_TOKEN_ENABLER,
+                $additionalData[self::IS_ACTIVE_PAYMENT_TOKEN_ENABLER]
+            );
+        } else {
+            $paymentModel->setData(self::IS_ACTIVE_PAYMENT_TOKEN_ENABLER, false);
+        }
+
+        $ccData = $additionalData['cc_details'];
+        $paymentModel->setCcType($ccData['cc_type']);
+        $paymentModel->setCcExpYear($ccData['cc_exp_year']);
+        $paymentModel->setCcExpMonth($ccData['cc_exp_month']);
+        $paymentModel->setCcLast4($ccData['cc_last_4']);
+    }
+
+    /**
+     * Check if payflowpro vault is enable
+     *
+     * @return bool
+     */
+    private function isPayflowProVaultEnable()
+    {
+        return (bool)$this->scopeConfig->getValue(self::XML_PATH_PAYMENT_PAYFLOWPRO_CC_VAULT_ACTIVE);
+    }
+}
diff --git a/app/code/Magento/PaypalGraphQl/composer.json b/app/code/Magento/PaypalGraphQl/composer.json
index 8d012be3492dd..13864e54fa1f5 100644
--- a/app/code/Magento/PaypalGraphQl/composer.json
+++ b/app/code/Magento/PaypalGraphQl/composer.json
@@ -16,7 +16,8 @@
         "magento/module-store": "*"
     },
     "suggest": {
-        "magento/module-graph-ql": "*"
+        "magento/module-graph-ql": "*",
+        "magento/module-store-graph-ql": "*"
     },
     "type": "magento2-module",
     "license": [
diff --git a/app/code/Magento/PaypalGraphQl/etc/graphql/di.xml b/app/code/Magento/PaypalGraphQl/etc/graphql/di.xml
index cd5d6e2062bb9..f1b99295f5627 100644
--- a/app/code/Magento/PaypalGraphQl/etc/graphql/di.xml
+++ b/app/code/Magento/PaypalGraphQl/etc/graphql/di.xml
@@ -11,6 +11,7 @@
     </type>
     <type name="Magento\QuoteGraphQl\Model\Cart\SetPaymentMethodOnCart">
         <plugin name="hosted_pro_payment_method" type="Magento\PaypalGraphQl\Model\Plugin\Cart\HostedPro\SetPaymentMethodOnCart"/>
+        <plugin name="payflowpro_payment_method" type="Magento\PaypalGraphQl\Model\Plugin\Cart\PayflowPro\SetPaymentMethodOnCart"/>
     </type>
     <type name="Magento\Paypal\Model\Payflowlink">
         <plugin name="payflow_link_update_redirect_urls" type="Magento\PaypalGraphQl\Model\Plugin\Payflowlink"/>
@@ -53,4 +54,12 @@
             </argument>
         </arguments>
     </type>
+
+    <type name="Magento\StoreGraphQl\Model\Resolver\Store\StoreConfigDataProvider">
+        <arguments>
+            <argument name="extendedConfigData" xsi:type="array">
+                <item name="payment_payflowpro_cc_vault_active" xsi:type="string">payment/payflowpro_cc_vault/active</item>
+            </argument>
+        </arguments>
+    </type>
 </config>
diff --git a/app/code/Magento/PaypalGraphQl/etc/graphql/events.xml b/app/code/Magento/PaypalGraphQl/etc/graphql/events.xml
index 41154e5ae06e6..0d2be95d77c92 100644
--- a/app/code/Magento/PaypalGraphQl/etc/graphql/events.xml
+++ b/app/code/Magento/PaypalGraphQl/etc/graphql/events.xml
@@ -12,4 +12,7 @@
     <event name="payment_method_assign_data_payflow_advanced">
         <observer name="payflow_advanced_data_assigner" instance="Magento\PaypalGraphQl\Observer\PayflowLinkSetAdditionalData"/>
     </event>
+    <event name="payment_method_assign_data_payflowpro">
+        <observer name="payflowpro_cc_data_assigner" instance="Magento\PaypalGraphQl\Observer\PayflowProSetCcData" />
+    </event>
 </config>
diff --git a/app/code/Magento/PaypalGraphQl/etc/schema.graphqls b/app/code/Magento/PaypalGraphQl/etc/schema.graphqls
index b8f14eec70d18..52b0a6ec97518 100644
--- a/app/code/Magento/PaypalGraphQl/etc/schema.graphqls
+++ b/app/code/Magento/PaypalGraphQl/etc/schema.graphqls
@@ -102,6 +102,7 @@ input PayflowProTokenInput @doc(description:"Input required to fetch payment tok
 
 input PayflowProInput @doc(description:"Required input for Payflow Pro and Payments Pro payment methods.") {
     cc_details: CreditCardDetailsInput! @doc(description: "Required input for credit card related information")
+    is_active_payment_token_enabler: Boolean @doc(description:"States whether details about the customer's credit/debit card should be tokenized for later usage. Required only if Vault is enabled for PayPal Payflow Pro payment integration.")
 }
 
 input CreditCardDetailsInput @doc(description:"Required fields for Payflow Pro and Payments Pro credit card payments") {
@@ -141,3 +142,7 @@ input PayflowProResponseInput @doc(description:"Input required to complete payme
 type PayflowProResponseOutput {
     cart: Cart!
 }
+
+type StoreConfig {
+    payment_payflowpro_cc_vault_active: String @doc(description: "Payflow Pro vault status.")
+}
diff --git a/dev/tests/integration/testsuite/Magento/PaypalGraphQl/Model/Resolver/Customer/SaveCartDataWithPayflowProTest.php b/dev/tests/integration/testsuite/Magento/PaypalGraphQl/Model/Resolver/Customer/SaveCartDataWithPayflowProTest.php
new file mode 100644
index 0000000000000..11bd306211b9a
--- /dev/null
+++ b/dev/tests/integration/testsuite/Magento/PaypalGraphQl/Model/Resolver/Customer/SaveCartDataWithPayflowProTest.php
@@ -0,0 +1,258 @@
+<?php
+/**
+ * Copyright © Magento, Inc. All rights reserved.
+ * See COPYING.txt for license details.
+ */
+declare(strict_types=1);
+
+namespace Magento\PaypalGraphQl\Model\Resolver\Customer;
+
+use Magento\Integration\Model\Oauth\Token;
+use Magento\PaypalGraphQl\PaypalPayflowProAbstractTest;
+use Magento\Framework\Serialize\SerializerInterface;
+use Magento\Quote\Model\QuoteIdToMaskedQuoteId;
+use Magento\Framework\DataObject;
+use Magento\Vault\Api\Data\PaymentTokenInterface;
+use Magento\Vault\Model\PaymentTokenManagement;
+use Magento\Vault\Model\PaymentTokenRepository;
+
+/**
+ * End to end place order test using payflowpro via graphql endpoint for customer
+ *
+ * @magentoAppArea graphql
+ */
+class SaveCartDataWithPayflowProTest extends PaypalPayflowProAbstractTest
+{
+    /**
+     * @var SerializerInterface
+     */
+    private $json;
+
+    /**
+     * @var QuoteIdToMaskedQuoteId
+     */
+    private $quoteIdToMaskedId;
+
+    protected function setUp(): void
+    {
+        parent::setUp();
+
+        $this->json = $this->objectManager->get(SerializerInterface::class);
+        $this->quoteIdToMaskedId = $this->objectManager->get(QuoteIdToMaskedQuoteId::class);
+    }
+
+    /**
+     * Place order use payflowpro method and save cart data to future
+     *
+     * @magentoDataFixture Magento/Sales/_files/default_rollback.php
+     * @magentoDataFixture Magento/Sales/_files/default_rollback.php
+     * @magentoDataFixture Magento/Customer/_files/customer.php
+     * @magentoDataFixture Magento/GraphQl/Catalog/_files/simple_product.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/customer/create_empty_cart.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/add_simple_product.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_new_shipping_address.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_new_billing_address.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_flatrate_shipping_method.php
+     *
+     * @return void
+     *
+     * @SuppressWarnings(PHPMD.ExcessiveMethodLength)
+     */
+    public function testPlaceOrderAndSaveDataForFuturePayflowPro(): void
+    {
+        $responseData = $this->placeOrderPayflowPro('is_active_payment_token_enabler: true');
+        $this->assertArrayHasKey('data', $responseData);
+        $this->assertArrayHasKey('createPayflowProToken', $responseData['data']);
+        $this->assertNotEmpty($this->getVaultCartData()->getPublicHash());
+        $this->assertNotEmpty($this->getVaultCartData()->getTokenDetails());
+        $this->assertNotEmpty($this->getVaultCartData()->getGatewayToken());
+        $this->assertTrue($this->getVaultCartData()->getIsActive());
+        $this->assertTrue($this->getVaultCartData()->getIsVisible());
+    }
+
+    /**
+     * Place order use payflowpro method and not save cart data to future
+     *
+     * @magentoDataFixture Magento/Sales/_files/default_rollback.php
+     * @magentoDataFixture Magento/Sales/_files/default_rollback.php
+     * @magentoDataFixture Magento/Customer/_files/customer.php
+     * @magentoDataFixture Magento/GraphQl/Catalog/_files/simple_product.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/customer/create_empty_cart.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/add_simple_product.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_new_shipping_address.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_new_billing_address.php
+     * @magentoDataFixture Magento/GraphQl/Quote/_files/set_flatrate_shipping_method.php
+     *
+     * @return void
+     */
+    public function testPlaceOrderAndNotSaveDataForFuturePayflowPro(): void
+    {
+        $responseData = $this->placeOrderPayflowPro('is_active_payment_token_enabler: false');
+        $this->assertArrayHasKey('data', $responseData);
+        $this->assertArrayHasKey('createPayflowProToken', $responseData['data']);
+        $this->assertNotEmpty($this->getVaultCartData()->getPublicHash());
+        $this->assertNotEmpty($this->getVaultCartData()->getTokenDetails());
+        $this->assertNotEmpty($this->getVaultCartData()->getGatewayToken());
+        $this->assertTrue($this->getVaultCartData()->getIsActive());
+        $this->assertFalse($this->getVaultCartData()->getIsVisible());
+    }
+
+    /**
+     * @param $isActivePaymentTokenEnabler
+     *
+     * @return array
+     * @SuppressWarnings(PHPMD.ExcessiveMethodLength)
+     */
+    private function placeOrderPayflowPro($isActivePaymentTokenEnabler)
+    {
+        $paymentMethod = 'payflowpro';
+        $this->enablePaymentMethod($paymentMethod);
+        $this->enablePaymentMethod('payflowpro_cc_vault');
+        $reservedQuoteId = 'test_quote';
+
+        $payload = 'BILLTOCITY=CityM&AMT=0.00&BILLTOSTREET=Green+str,+67&VISACARDLEVEL=12&SHIPTOCITY=CityM'
+            . '&NAMETOSHIP=John+Smith&ZIP=75477&BILLTOLASTNAME=Smith&BILLTOFIRSTNAME=John'
+            . '&RESPMSG=Verified&PROCCVV2=M&STATETOSHIP=AL&NAME=John+Smith&BILLTOZIP=75477&CVV2MATCH=Y'
+            . '&PNREF=B70CCC236815&ZIPTOSHIP=75477&SHIPTOCOUNTRY=US&SHIPTOSTREET=Green+str,+67&CITY=CityM'
+            . '&HOSTCODE=A&LASTNAME=Smith&STATE=AL&SECURETOKEN=MYSECURETOKEN&CITYTOSHIP=CityM&COUNTRYTOSHIP=US'
+            . '&AVSDATA=YNY&ACCT=1111&AUTHCODE=111PNI&FIRSTNAME=John&RESULT=0&IAVS=N&POSTFPSMSG=No+Rules+Triggered&'
+            . 'BILLTOSTATE=AL&BILLTOCOUNTRY=US&EXPDATE=0222&CARDTYPE=0&PREFPSMSG=No+Rules+Triggered&SHIPTOZIP=75477&'
+            . 'PROCAVS=A&COUNTRY=US&AVSZIP=N&ADDRESS=Green+str,+67&BILLTONAME=John+Smith&'
+            . 'ADDRESSTOSHIP=Green+str,+67&'
+            . 'AVSADDR=Y&SECURETOKENID=MYSECURETOKENID&SHIPTOSTATE=AL&TRANSTIME=2019-06-24+07%3A53%3A10';
+
+        $cart = $this->getQuoteByReservedOrderId($reservedQuoteId);
+        $cartId = $this->quoteIdToMaskedId->execute((int)$cart->getId());
+
+        $query = <<<QUERY
+mutation {
+    setPaymentMethodOnCart(input: {
+        payment_method: {
+          code: "{$paymentMethod}",
+            payflowpro: {
+              {$isActivePaymentTokenEnabler}
+              cc_details: {
+                 cc_exp_month: 12,
+                 cc_exp_year: 2030,
+                 cc_last_4: 1111,
+                 cc_type: "IV",
+              }
+          }
+        },
+        cart_id: "{$cartId}"})
+      {
+        cart {
+          selected_payment_method {
+            code
+          }
+        }
+      }
+      createPayflowProToken(
+        input: {
+          cart_id:"{$cartId}",
+          urls: {
+            cancel_url: "paypal/transparent/cancel/"
+            error_url: "paypal/transparent/error/"
+            return_url: "paypal/transparent/response/"
+          }
+        }
+      ) {
+          response_message
+          result
+          result_code
+          secure_token
+          secure_token_id
+        }
+      handlePayflowProResponse(input: {
+          paypal_payload: "$payload",
+          cart_id: "{$cartId}"
+        })
+      {
+        cart {
+          selected_payment_method {
+            code
+          }
+        }
+      }
+      placeOrder(input: {cart_id: "{$cartId}"}) {
+        order {
+          order_number
+        }
+      }
+}
+QUERY;
+
+        /** @var Token $tokenModel */
+        $tokenModel = $this->objectManager->create(Token::class);
+        $customerToken = $tokenModel->createCustomerToken(1)->getToken();
+
+        $requestHeaders = [
+            'Content-Type' => 'application/json',
+            'Accept' => 'application/json',
+            'Authorization' => 'Bearer ' . $customerToken
+        ];
+        $paypalResponse = new DataObject(
+            [
+                'result' => '0',
+                'securetoken' => 'mysecuretoken',
+                'securetokenid' => 'mysecuretokenid',
+                'respmsg' => 'Approved',
+                'result_code' => '0',
+            ]
+        );
+
+        $this->gatewayMock
+            ->method('postRequest')
+            ->willReturn($paypalResponse);
+
+        $this->gatewayMock
+            ->method('postRequest')
+            ->willReturn(
+                new DataObject(
+                    [
+                        'result' => '0',
+                        'pnref' => 'A70AAC2378BA',
+                        'respmsg' => 'Approved',
+                        'authcode' => '647PNI',
+                        'avsaddr' => 'Y',
+                        'avszip' => 'N',
+                        'hostcode' => 'A',
+                        'procavs' => 'A',
+                        'visacardlevel' => '12',
+                        'transtime' => '2019-06-24 10:12:03',
+                        'firstname' => 'Cristian',
+                        'lastname' => 'Partica',
+                        'amt' => '14.99',
+                        'acct' => '1111',
+                        'expdate' => '0221',
+                        'cardtype' => '0',
+                        'iavs' => 'N',
+                        'result_code' => '0',
+                    ]
+                )
+            );
+
+        $response = $this->graphQlRequest->send($query, [], '', $requestHeaders);
+
+        return $this->json->unserialize($response->getContent());
+    }
+
+    /**
+     * Get saved cart data
+     *
+     * @return PaymentTokenInterface
+     */
+    private function getVaultCartData()
+    {
+        /** @var PaymentTokenManagement $tokenManagement */
+        $tokenManagement = $this->objectManager->get(PaymentTokenManagement::class);
+        $token = $tokenManagement->getByGatewayToken(
+            'B70CCC236815',
+            'payflowpro',
+            1
+        );
+        /** @var PaymentTokenRepository $tokenRepository */
+        $tokenRepository = $this->objectManager->get(PaymentTokenRepository::class);
+        return $tokenRepository->getById($token->getEntityId());
+    }
+}