diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index 4b01b6ac8ca2..253a0ca648b0 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -60,7 +60,7 @@ python 3.6 and to install each tool:
 
 ```
 # Install the dependencies
-pip install -U black flake8 isort
+pip install -U black flake8 flake8-comprehensions isort
 
 # Run the linter script
 ./scripts-dev/lint.sh
diff --git a/changelog.d/6957.misc b/changelog.d/6957.misc
new file mode 100644
index 000000000000..4f98030110cf
--- /dev/null
+++ b/changelog.d/6957.misc
@@ -0,0 +1 @@
+Use flake8-comprehensions to enforce good hygiene of list/set/dict comprehensions.
diff --git a/docs/code_style.md b/docs/code_style.md
index 71aecd41f7dd..6ef6f802908d 100644
--- a/docs/code_style.md
+++ b/docs/code_style.md
@@ -30,7 +30,7 @@ The necessary tools are detailed below.
 
     Install `flake8` with:
 
-        pip install --upgrade flake8
+        pip install --upgrade flake8 flake8-comprehensions
 
     Check all application and test code with:
 
diff --git a/scripts-dev/convert_server_keys.py b/scripts-dev/convert_server_keys.py
index 179be61c30d9..06b4c1e2ff13 100644
--- a/scripts-dev/convert_server_keys.py
+++ b/scripts-dev/convert_server_keys.py
@@ -103,7 +103,7 @@ def main():
 
     yaml.safe_dump(result, sys.stdout, default_flow_style=False)
 
-    rows = list(row for server, json in result.items() for row in rows_v2(server, json))
+    rows = [row for server, json in result.items() for row in rows_v2(server, json)]
 
     cursor = connection.cursor()
     cursor.executemany(
diff --git a/synapse/app/_base.py b/synapse/app/_base.py
index 109b1e2fb5ed..9ffd23c6df37 100644
--- a/synapse/app/_base.py
+++ b/synapse/app/_base.py
@@ -141,7 +141,7 @@ def run():
 
 def quit_with_error(error_string):
     message_lines = error_string.split("\n")
-    line_length = max([len(l) for l in message_lines if len(l) < 80]) + 2
+    line_length = max(len(l) for l in message_lines if len(l) < 80) + 2
     sys.stderr.write("*" * line_length + "\n")
     for line in message_lines:
         sys.stderr.write(" %s\n" % (line.rstrip(),))
diff --git a/synapse/app/federation_sender.py b/synapse/app/federation_sender.py
index 63a91f1177f5..b7fcf80ddc85 100644
--- a/synapse/app/federation_sender.py
+++ b/synapse/app/federation_sender.py
@@ -262,7 +262,7 @@ def process_replication_rows(self, stream_name, token, rows):
 
         # ... as well as device updates and messages
         elif stream_name == DeviceListsStream.NAME:
-            hosts = set(row.destination for row in rows)
+            hosts = {row.destination for row in rows}
             for host in hosts:
                 self.federation_sender.send_device_messages(host)
 
@@ -270,7 +270,7 @@ def process_replication_rows(self, stream_name, token, rows):
             # The to_device stream includes stuff to be pushed to both local
             # clients and remote servers, so we ignore entities that start with
             # '@' (since they'll be local users rather than destinations).
-            hosts = set(row.entity for row in rows if not row.entity.startswith("@"))
+            hosts = {row.entity for row in rows if not row.entity.startswith("@")}
             for host in hosts:
                 self.federation_sender.send_device_messages(host)
 
diff --git a/synapse/app/pusher.py b/synapse/app/pusher.py
index e46b6ac598c6..84e9f8d5e201 100644
--- a/synapse/app/pusher.py
+++ b/synapse/app/pusher.py
@@ -158,7 +158,7 @@ def poke_pushers(self, stream_name, token, rows):
                 yield self.pusher_pool.on_new_notifications(token, token)
             elif stream_name == "receipts":
                 yield self.pusher_pool.on_new_receipts(
-                    token, token, set(row.room_id for row in rows)
+                    token, token, {row.room_id for row in rows}
                 )
         except Exception:
             logger.exception("Error poking pushers")
diff --git a/synapse/config/server.py b/synapse/config/server.py
index 0ec1b0fadd78..7525765fee00 100644
--- a/synapse/config/server.py
+++ b/synapse/config/server.py
@@ -1066,12 +1066,12 @@ def _warn_if_webclient_configured(listeners):
 
 
 def _check_resource_config(listeners):
-    resource_names = set(
+    resource_names = {
         res_name
         for listener in listeners
         for res in listener.get("resources", [])
         for res_name in res.get("names", [])
-    )
+    }
 
     for resource in resource_names:
         if resource not in KNOWN_RESOURCES:
diff --git a/synapse/config/tls.py b/synapse/config/tls.py
index 97a12d51f65b..a65538562beb 100644
--- a/synapse/config/tls.py
+++ b/synapse/config/tls.py
@@ -260,7 +260,7 @@ def read_certificate_from_disk(self, require_cert_and_key):
                 crypto.FILETYPE_ASN1, self.tls_certificate
             )
             sha256_fingerprint = encode_base64(sha256(x509_certificate_bytes).digest())
-            sha256_fingerprints = set(f["sha256"] for f in self.tls_fingerprints)
+            sha256_fingerprints = {f["sha256"] for f in self.tls_fingerprints}
             if sha256_fingerprint not in sha256_fingerprints:
                 self.tls_fingerprints.append({"sha256": sha256_fingerprint})
 
diff --git a/synapse/crypto/keyring.py b/synapse/crypto/keyring.py
index 6fe5a6a26ad9..983f0ead8cce 100644
--- a/synapse/crypto/keyring.py
+++ b/synapse/crypto/keyring.py
@@ -326,9 +326,7 @@ def _get_server_verify_keys(self, verify_requests):
             verify_requests (list[VerifyJsonRequest]): list of verify requests
         """
 
-        remaining_requests = set(
-            (rq for rq in verify_requests if not rq.key_ready.called)
-        )
+        remaining_requests = {rq for rq in verify_requests if not rq.key_ready.called}
 
         @defer.inlineCallbacks
         def do_iterations():
@@ -396,7 +394,7 @@ def _attempt_key_fetches_with_fetcher(self, fetcher, remaining_requests):
 
         results = yield fetcher.get_keys(missing_keys)
 
-        completed = list()
+        completed = []
         for verify_request in remaining_requests:
             server_name = verify_request.server_name
 
diff --git a/synapse/federation/send_queue.py b/synapse/federation/send_queue.py
index 001bb304ae62..876fb0e24570 100644
--- a/synapse/federation/send_queue.py
+++ b/synapse/federation/send_queue.py
@@ -129,9 +129,9 @@ def _clear_queue_before_pos(self, position_to_delete):
             for key in keys[:i]:
                 del self.presence_changed[key]
 
-            user_ids = set(
+            user_ids = {
                 user_id for uids in self.presence_changed.values() for user_id in uids
-            )
+            }
 
             keys = self.presence_destinations.keys()
             i = self.presence_destinations.bisect_left(position_to_delete)
diff --git a/synapse/groups/groups_server.py b/synapse/groups/groups_server.py
index c106abae2136..4f0dc0a20980 100644
--- a/synapse/groups/groups_server.py
+++ b/synapse/groups/groups_server.py
@@ -608,7 +608,7 @@ def invite_to_group(self, group_id, user_id, requester_user_id, content):
         user_results = yield self.store.get_users_in_group(
             group_id, include_private=True
         )
-        if user_id in [user_result["user_id"] for user_result in user_results]:
+        if user_id in (user_result["user_id"] for user_result in user_results):
             raise SynapseError(400, "User already in group")
 
         content = {
diff --git a/synapse/handlers/device.py b/synapse/handlers/device.py
index 50cea3f37885..a514c3071445 100644
--- a/synapse/handlers/device.py
+++ b/synapse/handlers/device.py
@@ -742,6 +742,6 @@ def user_device_resync(self, user_id):
 
         # We clobber the seen updates since we've re-synced from a given
         # point.
-        self._seen_updates[user_id] = set([stream_id])
+        self._seen_updates[user_id] = {stream_id}
 
         defer.returnValue(result)
diff --git a/synapse/handlers/directory.py b/synapse/handlers/directory.py
index 921d887b2419..0b23ca919ade 100644
--- a/synapse/handlers/directory.py
+++ b/synapse/handlers/directory.py
@@ -72,7 +72,7 @@ def _create_association(self, room_alias, room_id, servers=None, creator=None):
         # TODO(erikj): Check if there is a current association.
         if not servers:
             users = yield self.state.get_current_users_in_room(room_id)
-            servers = set(get_domain_from_id(u) for u in users)
+            servers = {get_domain_from_id(u) for u in users}
 
         if not servers:
             raise SynapseError(400, "Failed to get server list")
@@ -255,7 +255,7 @@ def get_association(self, room_alias):
             )
 
         users = yield self.state.get_current_users_in_room(room_id)
-        extra_servers = set(get_domain_from_id(u) for u in users)
+        extra_servers = {get_domain_from_id(u) for u in users}
         servers = set(extra_servers) | set(servers)
 
         # If this server is in the list of servers, return it first.
diff --git a/synapse/handlers/federation.py b/synapse/handlers/federation.py
index eb20ef4aece9..a689065f8912 100644
--- a/synapse/handlers/federation.py
+++ b/synapse/handlers/federation.py
@@ -659,11 +659,11 @@ async def _get_events_from_store_or_dest(
         # this can happen if a remote server claims that the state or
         # auth_events at an event in room A are actually events in room B
 
-        bad_events = list(
+        bad_events = [
             (event_id, event.room_id)
             for event_id, event in fetched_events.items()
             if event.room_id != room_id
-        )
+        ]
 
         for bad_event_id, bad_room_id in bad_events:
             # This is a bogus situation, but since we may only discover it a long time
@@ -856,7 +856,7 @@ async def backfill(self, dest, room_id, limit, extremities):
 
         # Don't bother processing events we already have.
         seen_events = await self.store.have_events_in_timeline(
-            set(e.event_id for e in events)
+            {e.event_id for e in events}
         )
 
         events = [e for e in events if e.event_id not in seen_events]
@@ -866,7 +866,7 @@ async def backfill(self, dest, room_id, limit, extremities):
 
         event_map = {e.event_id: e for e in events}
 
-        event_ids = set(e.event_id for e in events)
+        event_ids = {e.event_id for e in events}
 
         # build a list of events whose prev_events weren't in the batch.
         # (XXX: this will include events whose prev_events we already have; that doesn't
@@ -892,13 +892,13 @@ async def backfill(self, dest, room_id, limit, extremities):
             state_events.update({s.event_id: s for s in state})
             events_to_state[e_id] = state
 
-        required_auth = set(
+        required_auth = {
             a_id
             for event in events
             + list(state_events.values())
             + list(auth_events.values())
             for a_id in event.auth_event_ids()
-        )
+        }
         auth_events.update(
             {e_id: event_map[e_id] for e_id in required_auth if e_id in event_map}
         )
@@ -1247,7 +1247,7 @@ async def send_invite(self, target_host, event):
     async def on_event_auth(self, event_id: str) -> List[EventBase]:
         event = await self.store.get_event(event_id)
         auth = await self.store.get_auth_chain(
-            [auth_id for auth_id in event.auth_event_ids()], include_given=True
+            list(event.auth_event_ids()), include_given=True
         )
         return list(auth)
 
@@ -2152,7 +2152,7 @@ async def on_query_auth(
 
         # Now get the current auth_chain for the event.
         local_auth_chain = await self.store.get_auth_chain(
-            [auth_id for auth_id in event.auth_event_ids()], include_given=True
+            list(event.auth_event_ids()), include_given=True
         )
 
         # TODO: Check if we would now reject event_id. If so we need to tell
@@ -2654,7 +2654,7 @@ def exchange_third_party_invite(
             member_handler = self.hs.get_room_member_handler()
             yield member_handler.send_membership_event(None, event, context)
         else:
-            destinations = set(x.split(":", 1)[-1] for x in (sender_user_id, room_id))
+            destinations = {x.split(":", 1)[-1] for x in (sender_user_id, room_id)}
             yield self.federation_client.forward_third_party_invite(
                 destinations, room_id, event_dict
             )
diff --git a/synapse/handlers/presence.py b/synapse/handlers/presence.py
index 202aa9294fd9..0d6cf2b00834 100644
--- a/synapse/handlers/presence.py
+++ b/synapse/handlers/presence.py
@@ -313,7 +313,7 @@ def _update_states(self, new_states):
                 notified_presence_counter.inc(len(to_notify))
                 yield self._persist_and_notify(list(to_notify.values()))
 
-            self.unpersisted_users_changes |= set(s.user_id for s in new_states)
+            self.unpersisted_users_changes |= {s.user_id for s in new_states}
             self.unpersisted_users_changes -= set(to_notify.keys())
 
             to_federation_ping = {
@@ -698,7 +698,7 @@ def get_states(self, target_user_ids, as_event=False):
         updates = yield self.current_state_for_users(target_user_ids)
         updates = list(updates.values())
 
-        for user_id in set(target_user_ids) - set(u.user_id for u in updates):
+        for user_id in set(target_user_ids) - {u.user_id for u in updates}:
             updates.append(UserPresenceState.default(user_id))
 
         now = self.clock.time_msec()
@@ -886,7 +886,7 @@ def _on_user_joined_room(self, room_id, user_id):
             hosts = yield self.state.get_current_hosts_in_room(room_id)
 
             # Filter out ourselves.
-            hosts = set(host for host in hosts if host != self.server_name)
+            hosts = {host for host in hosts if host != self.server_name}
 
             self.federation.send_presence_to_destinations(
                 states=[state], destinations=hosts
diff --git a/synapse/handlers/receipts.py b/synapse/handlers/receipts.py
index 9283c039e3dd..8bc100db42b8 100644
--- a/synapse/handlers/receipts.py
+++ b/synapse/handlers/receipts.py
@@ -94,7 +94,7 @@ async def _handle_new_receipts(self, receipts):
             # no new receipts
             return False
 
-        affected_room_ids = list(set([r.room_id for r in receipts]))
+        affected_room_ids = list({r.room_id for r in receipts})
 
         self.notifier.on_new_event("receipt_key", max_batch_id, rooms=affected_room_ids)
         # Note that the min here shouldn't be relied upon to be accurate.
diff --git a/synapse/handlers/room.py b/synapse/handlers/room.py
index 76e8f61b74a8..8ee870f0bbae 100644
--- a/synapse/handlers/room.py
+++ b/synapse/handlers/room.py
@@ -355,7 +355,7 @@ def clone_existing_room(
             # If so, mark the new room as non-federatable as well
             creation_content["m.federate"] = False
 
-        initial_state = dict()
+        initial_state = {}
 
         # Replicate relevant room events
         types_to_copy = (
diff --git a/synapse/handlers/search.py b/synapse/handlers/search.py
index 110097eab90a..ec1542d416ae 100644
--- a/synapse/handlers/search.py
+++ b/synapse/handlers/search.py
@@ -184,7 +184,7 @@ def search(self, user, content, batch=None):
             membership_list=[Membership.JOIN],
             # membership_list=[Membership.JOIN, Membership.LEAVE, Membership.Ban],
         )
-        room_ids = set(r.room_id for r in rooms)
+        room_ids = {r.room_id for r in rooms}
 
         # If doing a subset of all rooms seearch, check if any of the rooms
         # are from an upgraded room, and search their contents as well
@@ -374,12 +374,12 @@ def search(self, user, content, batch=None):
                 ).to_string()
 
                 if include_profile:
-                    senders = set(
+                    senders = {
                         ev.sender
                         for ev in itertools.chain(
                             res["events_before"], [event], res["events_after"]
                         )
-                    )
+                    }
 
                     if res["events_after"]:
                         last_event_id = res["events_after"][-1].event_id
@@ -421,7 +421,7 @@ def search(self, user, content, batch=None):
 
         state_results = {}
         if include_state:
-            rooms = set(e.room_id for e in allowed_events)
+            rooms = {e.room_id for e in allowed_events}
             for room_id in rooms:
                 state = yield self.state_handler.get_current_state(room_id)
                 state_results[room_id] = list(state.values())
diff --git a/synapse/handlers/sync.py b/synapse/handlers/sync.py
index 4324bc702e25..669dbc8a487c 100644
--- a/synapse/handlers/sync.py
+++ b/synapse/handlers/sync.py
@@ -682,11 +682,9 @@ async def compute_summary(
 
         # FIXME: order by stream ordering rather than as returned by SQL
         if joined_user_ids or invited_user_ids:
-            summary["m.heroes"] = sorted(
-                [user_id for user_id in (joined_user_ids + invited_user_ids)]
-            )[0:5]
+            summary["m.heroes"] = sorted(joined_user_ids + invited_user_ids)[0:5]
         else:
-            summary["m.heroes"] = sorted([user_id for user_id in gone_user_ids])[0:5]
+            summary["m.heroes"] = sorted(gone_user_ids)[0:5]
 
         if not sync_config.filter_collection.lazy_load_members():
             return summary
@@ -697,9 +695,9 @@ async def compute_summary(
 
         # track which members the client should already know about via LL:
         # Ones which are already in state...
-        existing_members = set(
+        existing_members = {
             user_id for (typ, user_id) in state.keys() if typ == EventTypes.Member
-        )
+        }
 
         # ...or ones which are in the timeline...
         for ev in batch.events:
@@ -773,10 +771,10 @@ async def compute_state_delta(
                 # We only request state for the members needed to display the
                 # timeline:
 
-                members_to_fetch = set(
+                members_to_fetch = {
                     event.sender  # FIXME: we also care about invite targets etc.
                     for event in batch.events
-                )
+                }
 
                 if full_state:
                     # always make sure we LL ourselves so we know we're in the room
@@ -1993,10 +1991,10 @@ def _calculate_state(
         )
     }
 
-    c_ids = set(e for e in itervalues(current))
-    ts_ids = set(e for e in itervalues(timeline_start))
-    p_ids = set(e for e in itervalues(previous))
-    tc_ids = set(e for e in itervalues(timeline_contains))
+    c_ids = set(itervalues(current))
+    ts_ids = set(itervalues(timeline_start))
+    p_ids = set(itervalues(previous))
+    tc_ids = set(itervalues(timeline_contains))
 
     # If we are lazyloading room members, we explicitly add the membership events
     # for the senders in the timeline into the state block returned by /sync,
diff --git a/synapse/handlers/typing.py b/synapse/handlers/typing.py
index 540661843178..391bceb0c483 100644
--- a/synapse/handlers/typing.py
+++ b/synapse/handlers/typing.py
@@ -198,7 +198,7 @@ def _push_remote(self, member, typing):
                 now=now, obj=member, then=now + FEDERATION_PING_INTERVAL
             )
 
-            for domain in set(get_domain_from_id(u) for u in users):
+            for domain in {get_domain_from_id(u) for u in users}:
                 if domain != self.server_name:
                     logger.debug("sending typing update to %s", domain)
                     self.federation.build_and_send_edu(
@@ -231,7 +231,7 @@ def _recv_edu(self, origin, content):
             return
 
         users = yield self.state.get_current_users_in_room(room_id)
-        domains = set(get_domain_from_id(u) for u in users)
+        domains = {get_domain_from_id(u) for u in users}
 
         if self.server_name in domains:
             logger.info("Got typing update from %s: %r", user_id, content)
diff --git a/synapse/logging/utils.py b/synapse/logging/utils.py
index 6073fc27255a..0c2527bd8686 100644
--- a/synapse/logging/utils.py
+++ b/synapse/logging/utils.py
@@ -148,7 +148,7 @@ def wrapped(*args, **kwargs):
             pathname=pathname,
             lineno=lineno,
             msg=msg,
-            args=tuple(),
+            args=(),
             exc_info=None,
         )
 
diff --git a/synapse/metrics/__init__.py b/synapse/metrics/__init__.py
index 0b45e1f52a85..0dba997a2357 100644
--- a/synapse/metrics/__init__.py
+++ b/synapse/metrics/__init__.py
@@ -240,7 +240,7 @@ def collect(self):
         res.append(["+Inf", sum(data.values())])
 
         metric = HistogramMetricFamily(
-            self.name, "", buckets=res, sum_value=sum([x * y for x, y in data.items()])
+            self.name, "", buckets=res, sum_value=sum(x * y for x, y in data.items())
         )
         yield metric
 
diff --git a/synapse/metrics/background_process_metrics.py b/synapse/metrics/background_process_metrics.py
index c53d2a0d401c..b65bcd880651 100644
--- a/synapse/metrics/background_process_metrics.py
+++ b/synapse/metrics/background_process_metrics.py
@@ -80,13 +80,13 @@
 # map from description to a counter, so that we can name our logcontexts
 # incrementally. (It actually duplicates _background_process_start_count, but
 # it's much simpler to do so than to try to combine them.)
-_background_process_counts = dict()  # type: dict[str, int]
+_background_process_counts = {}  # type: dict[str, int]
 
 # map from description to the currently running background processes.
 #
 # it's kept as a dict of sets rather than a big set so that we can keep track
 # of process descriptions that no longer have any active processes.
-_background_processes = dict()  # type: dict[str, set[_BackgroundProcess]]
+_background_processes = {}  # type: dict[str, set[_BackgroundProcess]]
 
 # A lock that covers the above dicts
 _bg_metrics_lock = threading.Lock()
diff --git a/synapse/push/bulk_push_rule_evaluator.py b/synapse/push/bulk_push_rule_evaluator.py
index 7d9f5a38d984..433ca2f416fa 100644
--- a/synapse/push/bulk_push_rule_evaluator.py
+++ b/synapse/push/bulk_push_rule_evaluator.py
@@ -400,11 +400,11 @@ def _update_rules_with_member_event_ids(
         if logger.isEnabledFor(logging.DEBUG):
             logger.debug("Found members %r: %r", self.room_id, members.values())
 
-        interested_in_user_ids = set(
+        interested_in_user_ids = {
             user_id
             for user_id, membership in itervalues(members)
             if membership == Membership.JOIN
-        )
+        }
 
         logger.debug("Joined: %r", interested_in_user_ids)
 
@@ -412,9 +412,9 @@ def _update_rules_with_member_event_ids(
             interested_in_user_ids, on_invalidate=self.invalidate_all_cb
         )
 
-        user_ids = set(
+        user_ids = {
             uid for uid, have_pusher in iteritems(if_users_with_pushers) if have_pusher
-        )
+        }
 
         logger.debug("With pushers: %r", user_ids)
 
diff --git a/synapse/push/emailpusher.py b/synapse/push/emailpusher.py
index 8c818a86bfc1..ba4551d61964 100644
--- a/synapse/push/emailpusher.py
+++ b/synapse/push/emailpusher.py
@@ -204,7 +204,7 @@ def _unsafe_process(self):
                 yield self.send_notification(unprocessed, reason)
 
                 yield self.save_last_stream_ordering_and_success(
-                    max([ea["stream_ordering"] for ea in unprocessed])
+                    max(ea["stream_ordering"] for ea in unprocessed)
                 )
 
                 # we update the throttle on all the possible unprocessed push actions
diff --git a/synapse/push/mailer.py b/synapse/push/mailer.py
index b13b646bfd3d..4ccaf178cedd 100644
--- a/synapse/push/mailer.py
+++ b/synapse/push/mailer.py
@@ -526,12 +526,10 @@ def make_summary_text(
                     # If the room doesn't have a name, say who the messages
                     # are from explicitly to avoid, "messages in the Bob room"
                     sender_ids = list(
-                        set(
-                            [
-                                notif_events[n["event_id"]].sender
-                                for n in notifs_by_room[room_id]
-                            ]
-                        )
+                        {
+                            notif_events[n["event_id"]].sender
+                            for n in notifs_by_room[room_id]
+                        }
                     )
 
                     member_events = yield self.store.get_events(
@@ -558,12 +556,10 @@ def make_summary_text(
                 # If the reason room doesn't have a name, say who the messages
                 # are from explicitly to avoid, "messages in the Bob room"
                 sender_ids = list(
-                    set(
-                        [
-                            notif_events[n["event_id"]].sender
-                            for n in notifs_by_room[reason["room_id"]]
-                        ]
-                    )
+                    {
+                        notif_events[n["event_id"]].sender
+                        for n in notifs_by_room[reason["room_id"]]
+                    }
                 )
 
                 member_events = yield self.store.get_events(
diff --git a/synapse/push/pusherpool.py b/synapse/push/pusherpool.py
index b9dca5bc6373..01789a9fb43a 100644
--- a/synapse/push/pusherpool.py
+++ b/synapse/push/pusherpool.py
@@ -191,7 +191,7 @@ def on_new_receipts(self, min_stream_id, max_stream_id, affected_room_ids):
                 min_stream_id - 1, max_stream_id
             )
             # This returns a tuple, user_id is at index 3
-            users_affected = set([r[3] for r in updated_receipts])
+            users_affected = {r[3] for r in updated_receipts}
 
             for u in users_affected:
                 if u in self.pushers:
diff --git a/synapse/rest/admin/_base.py b/synapse/rest/admin/_base.py
index 459482eb6d53..a96f75ce2694 100644
--- a/synapse/rest/admin/_base.py
+++ b/synapse/rest/admin/_base.py
@@ -29,7 +29,7 @@ def historical_admin_path_patterns(path_regex):
     Note that this should only be used for existing endpoints: new ones should just
     register for the /_synapse/admin path.
     """
-    return list(
+    return [
         re.compile(prefix + path_regex)
         for prefix in (
             "^/_synapse/admin/v1",
@@ -37,7 +37,7 @@ def historical_admin_path_patterns(path_regex):
             "^/_matrix/client/unstable/admin",
             "^/_matrix/client/r0/admin",
         )
-    )
+    ]
 
 
 def admin_patterns(path_regex: str):
diff --git a/synapse/rest/client/v1/push_rule.py b/synapse/rest/client/v1/push_rule.py
index 4f746002393c..9fd490813693 100644
--- a/synapse/rest/client/v1/push_rule.py
+++ b/synapse/rest/client/v1/push_rule.py
@@ -49,7 +49,7 @@ async def on_PUT(self, request, path):
         if self._is_worker:
             raise Exception("Cannot handle PUT /push_rules on worker")
 
-        spec = _rule_spec_from_path([x for x in path.split("/")])
+        spec = _rule_spec_from_path(path.split("/"))
         try:
             priority_class = _priority_class_from_spec(spec)
         except InvalidRuleException as e:
@@ -110,7 +110,7 @@ async def on_DELETE(self, request, path):
         if self._is_worker:
             raise Exception("Cannot handle DELETE /push_rules on worker")
 
-        spec = _rule_spec_from_path([x for x in path.split("/")])
+        spec = _rule_spec_from_path(path.split("/"))
 
         requester = await self.auth.get_user_by_req(request)
         user_id = requester.user.to_string()
@@ -138,7 +138,7 @@ async def on_GET(self, request, path):
 
         rules = format_push_rules_for_user(requester.user, rules)
 
-        path = [x for x in path.split("/")][1:]
+        path = path.split("/")[1:]
 
         if path == []:
             # we're a reference impl: pedantry is our job.
diff --git a/synapse/rest/client/v1/pusher.py b/synapse/rest/client/v1/pusher.py
index 6f6b7aed6ee1..550a2f1b448b 100644
--- a/synapse/rest/client/v1/pusher.py
+++ b/synapse/rest/client/v1/pusher.py
@@ -54,9 +54,9 @@ async def on_GET(self, request):
 
         pushers = await self.hs.get_datastore().get_pushers_by_user_id(user.to_string())
 
-        filtered_pushers = list(
+        filtered_pushers = [
             {k: v for k, v in p.items() if k in ALLOWED_KEYS} for p in pushers
-        )
+        ]
 
         return 200, {"pushers": filtered_pushers}
 
diff --git a/synapse/rest/client/v2_alpha/sync.py b/synapse/rest/client/v2_alpha/sync.py
index d8292ce29fc6..8fa68dd37f4d 100644
--- a/synapse/rest/client/v2_alpha/sync.py
+++ b/synapse/rest/client/v2_alpha/sync.py
@@ -72,7 +72,7 @@ class SyncRestServlet(RestServlet):
     """
 
     PATTERNS = client_patterns("/sync$")
-    ALLOWED_PRESENCE = set(["online", "offline", "unavailable"])
+    ALLOWED_PRESENCE = {"online", "offline", "unavailable"}
 
     def __init__(self, hs):
         super(SyncRestServlet, self).__init__()
diff --git a/synapse/rest/key/v2/remote_key_resource.py b/synapse/rest/key/v2/remote_key_resource.py
index 9d6813a04720..4b6d030a573e 100644
--- a/synapse/rest/key/v2/remote_key_resource.py
+++ b/synapse/rest/key/v2/remote_key_resource.py
@@ -149,7 +149,7 @@ def query_keys(self, request, query, query_remote_on_cache_miss=False):
 
         time_now_ms = self.clock.time_msec()
 
-        cache_misses = dict()  # type: Dict[str, Set[str]]
+        cache_misses = {}  # type: Dict[str, Set[str]]
         for (server_name, key_id, from_server), results in cached.items():
             results = [(result["ts_added_ms"], result) for result in results]
 
diff --git a/synapse/rest/media/v1/_base.py b/synapse/rest/media/v1/_base.py
index 65bbf0007317..ba28dd089d83 100644
--- a/synapse/rest/media/v1/_base.py
+++ b/synapse/rest/media/v1/_base.py
@@ -135,27 +135,25 @@ def _quote(x):
 
 # separators as defined in RFC2616. SP and HT are handled separately.
 # see _can_encode_filename_as_token.
-_FILENAME_SEPARATOR_CHARS = set(
-    (
-        "(",
-        ")",
-        "<",
-        ">",
-        "@",
-        ",",
-        ";",
-        ":",
-        "\\",
-        '"',
-        "/",
-        "[",
-        "]",
-        "?",
-        "=",
-        "{",
-        "}",
-    )
-)
+_FILENAME_SEPARATOR_CHARS = {
+    "(",
+    ")",
+    "<",
+    ">",
+    "@",
+    ",",
+    ";",
+    ":",
+    "\\",
+    '"',
+    "/",
+    "[",
+    "]",
+    "?",
+    "=",
+    "{",
+    "}",
+}
 
 
 def _can_encode_filename_as_token(x):
diff --git a/synapse/state/v1.py b/synapse/state/v1.py
index 24b7c0faef54..9bf98d06f264 100644
--- a/synapse/state/v1.py
+++ b/synapse/state/v1.py
@@ -69,9 +69,9 @@ def resolve_events_with_store(
 
     unconflicted_state, conflicted_state = _seperate(state_sets)
 
-    needed_events = set(
+    needed_events = {
         event_id for event_ids in itervalues(conflicted_state) for event_id in event_ids
-    )
+    }
     needed_event_count = len(needed_events)
     if event_map is not None:
         needed_events -= set(iterkeys(event_map))
@@ -261,11 +261,11 @@ def _resolve_state_events(conflicted_state, auth_events):
 
 
 def _resolve_auth_events(events, auth_events):
-    reverse = [i for i in reversed(_ordered_events(events))]
+    reverse = list(reversed(_ordered_events(events)))
 
-    auth_keys = set(
+    auth_keys = {
         key for event in events for key in event_auth.auth_types_for_event(event)
-    )
+    }
 
     new_auth_events = {}
     for key in auth_keys:
diff --git a/synapse/state/v2.py b/synapse/state/v2.py
index 75fe58305a46..0ffe6d8c1428 100644
--- a/synapse/state/v2.py
+++ b/synapse/state/v2.py
@@ -105,7 +105,7 @@ def resolve_events_with_store(
                 % (room_id, event.event_id, event.room_id,)
             )
 
-    full_conflicted_set = set(eid for eid in full_conflicted_set if eid in event_map)
+    full_conflicted_set = {eid for eid in full_conflicted_set if eid in event_map}
 
     logger.debug("%d full_conflicted_set entries", len(full_conflicted_set))
 
@@ -233,7 +233,7 @@ def _get_auth_chain_difference(state_sets, event_map, state_res_store):
 
     auth_sets = []
     for state_set in state_sets:
-        auth_ids = set(
+        auth_ids = {
             eid
             for key, eid in iteritems(state_set)
             if (
@@ -246,7 +246,7 @@ def _get_auth_chain_difference(state_sets, event_map, state_res_store):
                 )
             )
             and eid not in common
-        )
+        }
 
         auth_chain = yield state_res_store.get_auth_chain(auth_ids, common)
         auth_ids.update(auth_chain)
@@ -275,7 +275,7 @@ def _seperate(state_sets):
     conflicted_state = {}
 
     for key in set(itertools.chain.from_iterable(state_sets)):
-        event_ids = set(state_set.get(key) for state_set in state_sets)
+        event_ids = {state_set.get(key) for state_set in state_sets}
         if len(event_ids) == 1:
             unconflicted_state[key] = event_ids.pop()
         else:
diff --git a/synapse/storage/_base.py b/synapse/storage/_base.py
index da3b99f93dc9..13de5f1f62b1 100644
--- a/synapse/storage/_base.py
+++ b/synapse/storage/_base.py
@@ -56,7 +56,7 @@ def _invalidate_state_caches(self, room_id, members_changed):
             members_changed (iterable[str]): The user_ids of members that have
                 changed
         """
-        for host in set(get_domain_from_id(u) for u in members_changed):
+        for host in {get_domain_from_id(u) for u in members_changed}:
             self._attempt_to_invalidate_cache("is_host_joined", (room_id, host))
             self._attempt_to_invalidate_cache("was_host_joined", (room_id, host))
 
diff --git a/synapse/storage/background_updates.py b/synapse/storage/background_updates.py
index bd547f35cf1f..eb1a7e50027b 100644
--- a/synapse/storage/background_updates.py
+++ b/synapse/storage/background_updates.py
@@ -189,7 +189,7 @@ async def do_next_background_update(
                 keyvalues=None,
                 retcols=("update_name", "depends_on"),
             )
-            in_flight = set(update["update_name"] for update in updates)
+            in_flight = {update["update_name"] for update in updates}
             for update in updates:
                 if update["depends_on"] not in in_flight:
                     self._background_update_queue.append(update["update_name"])
diff --git a/synapse/storage/data_stores/main/appservice.py b/synapse/storage/data_stores/main/appservice.py
index b2f39649fdbe..efbc06c79694 100644
--- a/synapse/storage/data_stores/main/appservice.py
+++ b/synapse/storage/data_stores/main/appservice.py
@@ -135,7 +135,7 @@ def get_appservices_by_state(self, state):
             may be empty.
         """
         results = yield self.db.simple_select_list(
-            "application_services_state", dict(state=state), ["as_id"]
+            "application_services_state", {"state": state}, ["as_id"]
         )
         # NB: This assumes this class is linked with ApplicationServiceStore
         as_list = self.get_app_services()
@@ -158,7 +158,7 @@ def get_appservice_state(self, service):
         """
         result = yield self.db.simple_select_one(
             "application_services_state",
-            dict(as_id=service.id),
+            {"as_id": service.id},
             ["state"],
             allow_none=True,
             desc="get_appservice_state",
@@ -177,7 +177,7 @@ def set_appservice_state(self, service, state):
             A Deferred which resolves when the state was set successfully.
         """
         return self.db.simple_upsert(
-            "application_services_state", dict(as_id=service.id), dict(state=state)
+            "application_services_state", {"as_id": service.id}, {"state": state}
         )
 
     def create_appservice_txn(self, service, events):
@@ -253,13 +253,15 @@ def _complete_appservice_txn(txn):
             self.db.simple_upsert_txn(
                 txn,
                 "application_services_state",
-                dict(as_id=service.id),
-                dict(last_txn=txn_id),
+                {"as_id": service.id},
+                {"last_txn": txn_id},
             )
 
             # Delete txn
             self.db.simple_delete_txn(
-                txn, "application_services_txns", dict(txn_id=txn_id, as_id=service.id)
+                txn,
+                "application_services_txns",
+                {"txn_id": txn_id, "as_id": service.id},
             )
 
         return self.db.runInteraction(
diff --git a/synapse/storage/data_stores/main/client_ips.py b/synapse/storage/data_stores/main/client_ips.py
index 13f4c9c72e9a..e1ccb2714237 100644
--- a/synapse/storage/data_stores/main/client_ips.py
+++ b/synapse/storage/data_stores/main/client_ips.py
@@ -530,7 +530,7 @@ def get_user_ip_and_agents(self, user):
             ((row["access_token"], row["ip"]), (row["user_agent"], row["last_seen"]))
             for row in rows
         )
-        return list(
+        return [
             {
                 "access_token": access_token,
                 "ip": ip,
@@ -538,7 +538,7 @@ def get_user_ip_and_agents(self, user):
                 "last_seen": last_seen,
             }
             for (access_token, ip), (user_agent, last_seen) in iteritems(results)
-        )
+        ]
 
     @wrap_as_background_process("prune_old_user_ips")
     async def _prune_old_user_ips(self):
diff --git a/synapse/storage/data_stores/main/devices.py b/synapse/storage/data_stores/main/devices.py
index b7617efb80a8..d55733a4cd9f 100644
--- a/synapse/storage/data_stores/main/devices.py
+++ b/synapse/storage/data_stores/main/devices.py
@@ -137,7 +137,7 @@ def get_device_updates_by_remote(self, destination, from_stream_id, limit):
 
         # get the cross-signing keys of the users in the list, so that we can
         # determine which of the device changes were cross-signing keys
-        users = set(r[0] for r in updates)
+        users = {r[0] for r in updates}
         master_key_by_user = {}
         self_signing_key_by_user = {}
         for user in users:
@@ -446,7 +446,7 @@ def get_user_devices_from_cache(self, query_list):
             a set of user_ids and results_map is a mapping of
             user_id -> device_id -> device_info
         """
-        user_ids = set(user_id for user_id, _ in query_list)
+        user_ids = {user_id for user_id, _ in query_list}
         user_map = yield self.get_device_list_last_stream_id_for_remotes(list(user_ids))
 
         # We go and check if any of the users need to have their device lists
@@ -454,10 +454,9 @@ def get_user_devices_from_cache(self, query_list):
         users_needing_resync = yield self.get_user_ids_requiring_device_list_resync(
             user_ids
         )
-        user_ids_in_cache = (
-            set(user_id for user_id, stream_id in user_map.items() if stream_id)
-            - users_needing_resync
-        )
+        user_ids_in_cache = {
+            user_id for user_id, stream_id in user_map.items() if stream_id
+        } - users_needing_resync
         user_ids_not_in_cache = user_ids - user_ids_in_cache
 
         results = {}
@@ -604,7 +603,7 @@ def get_users_whose_signatures_changed(self, user_id, from_key):
             rows = yield self.db.execute(
                 "get_users_whose_signatures_changed", None, sql, user_id, from_key
             )
-            return set(user for row in rows for user in json.loads(row[0]))
+            return {user for row in rows for user in json.loads(row[0])}
         else:
             return set()
 
diff --git a/synapse/storage/data_stores/main/event_federation.py b/synapse/storage/data_stores/main/event_federation.py
index 750ec1b70d11..49a7b8b4338d 100644
--- a/synapse/storage/data_stores/main/event_federation.py
+++ b/synapse/storage/data_stores/main/event_federation.py
@@ -426,7 +426,7 @@ def _get_missing_events(self, txn, room_id, earliest_events, latest_events, limi
                     query, (room_id, event_id, False, limit - len(event_results))
                 )
 
-                new_results = set(t[0] for t in txn) - seen_events
+                new_results = {t[0] for t in txn} - seen_events
 
                 new_front |= new_results
                 seen_events |= new_results
diff --git a/synapse/storage/data_stores/main/events.py b/synapse/storage/data_stores/main/events.py
index c9d0d68c3a86..8ae23df00a74 100644
--- a/synapse/storage/data_stores/main/events.py
+++ b/synapse/storage/data_stores/main/events.py
@@ -145,7 +145,7 @@ def fetch(txn):
             return txn.fetchall()
 
         res = yield self.db.runInteraction("read_forward_extremities", fetch)
-        self._current_forward_extremities_amount = c_counter(list(x[0] for x in res))
+        self._current_forward_extremities_amount = c_counter([x[0] for x in res])
 
     @_retry_on_integrity_error
     @defer.inlineCallbacks
@@ -598,11 +598,11 @@ def _update_current_state_txn(
             # We find out which membership events we may have deleted
             # and which we have added, then we invlidate the caches for all
             # those users.
-            members_changed = set(
+            members_changed = {
                 state_key
                 for ev_type, state_key in itertools.chain(to_delete, to_insert)
                 if ev_type == EventTypes.Member
-            )
+            }
 
             for member in members_changed:
                 txn.call_after(
@@ -1615,7 +1615,7 @@ def _purge_history_txn(self, txn, room_id, token_str, delete_local_events):
         """
         )
 
-        referenced_state_groups = set(sg for sg, in txn)
+        referenced_state_groups = {sg for sg, in txn}
         logger.info(
             "[purge] found %i referenced state groups", len(referenced_state_groups)
         )
diff --git a/synapse/storage/data_stores/main/events_bg_updates.py b/synapse/storage/data_stores/main/events_bg_updates.py
index 5177b7101600..f54c8b1ee0a9 100644
--- a/synapse/storage/data_stores/main/events_bg_updates.py
+++ b/synapse/storage/data_stores/main/events_bg_updates.py
@@ -402,7 +402,7 @@ def _cleanup_extremities_bg_update_txn(txn):
                     keyvalues={},
                     retcols=("room_id",),
                 )
-                room_ids = set(row["room_id"] for row in rows)
+                room_ids = {row["room_id"] for row in rows}
                 for room_id in room_ids:
                     txn.call_after(
                         self.get_latest_event_ids_in_room.invalidate, (room_id,)
diff --git a/synapse/storage/data_stores/main/events_worker.py b/synapse/storage/data_stores/main/events_worker.py
index 7251e819f5a3..47a3a26072fb 100644
--- a/synapse/storage/data_stores/main/events_worker.py
+++ b/synapse/storage/data_stores/main/events_worker.py
@@ -494,9 +494,9 @@ def _fetch_event_list(self, conn, event_list):
         """
         with Measure(self._clock, "_fetch_event_list"):
             try:
-                events_to_fetch = set(
+                events_to_fetch = {
                     event_id for events, _ in event_list for event_id in events
-                )
+                }
 
                 row_dict = self.db.new_transaction(
                     conn, "do_fetch", [], [], self._fetch_event_rows, events_to_fetch
@@ -804,7 +804,7 @@ def have_events_in_timeline(self, event_ids):
             desc="have_events_in_timeline",
         )
 
-        return set(r["event_id"] for r in rows)
+        return {r["event_id"] for r in rows}
 
     @defer.inlineCallbacks
     def have_seen_events(self, event_ids):
diff --git a/synapse/storage/data_stores/main/push_rule.py b/synapse/storage/data_stores/main/push_rule.py
index e2673ae07371..62ac88d9f285 100644
--- a/synapse/storage/data_stores/main/push_rule.py
+++ b/synapse/storage/data_stores/main/push_rule.py
@@ -276,21 +276,21 @@ def _bulk_get_push_rules_for_room(
         # We ignore app service users for now. This is so that we don't fill
         # up the `get_if_users_have_pushers` cache with AS entries that we
         # know don't have pushers, nor even read receipts.
-        local_users_in_room = set(
+        local_users_in_room = {
             u
             for u in users_in_room
             if self.hs.is_mine_id(u)
             and not self.get_if_app_services_interested_in_user(u)
-        )
+        }
 
         # users in the room who have pushers need to get push rules run because
         # that's how their pushers work
         if_users_with_pushers = yield self.get_if_users_have_pushers(
             local_users_in_room, on_invalidate=cache_context.invalidate
         )
-        user_ids = set(
+        user_ids = {
             uid for uid, have_pusher in if_users_with_pushers.items() if have_pusher
-        )
+        }
 
         users_with_receipts = yield self.get_users_with_read_receipts_in_room(
             room_id, on_invalidate=cache_context.invalidate
diff --git a/synapse/storage/data_stores/main/receipts.py b/synapse/storage/data_stores/main/receipts.py
index 96e54d145ebf..0d932a06728d 100644
--- a/synapse/storage/data_stores/main/receipts.py
+++ b/synapse/storage/data_stores/main/receipts.py
@@ -58,7 +58,7 @@ def get_max_receipt_stream_id(self):
     @cachedInlineCallbacks()
     def get_users_with_read_receipts_in_room(self, room_id):
         receipts = yield self.get_receipts_for_room(room_id, "m.read")
-        return set(r["user_id"] for r in receipts)
+        return {r["user_id"] for r in receipts}
 
     @cached(num_args=2)
     def get_receipts_for_room(self, room_id, receipt_type):
@@ -283,7 +283,7 @@ def get_all_updated_receipts_txn(txn):
                 args.append(limit)
             txn.execute(sql, args)
 
-            return list(r[0:5] + (json.loads(r[5]),) for r in txn)
+            return [r[0:5] + (json.loads(r[5]),) for r in txn]
 
         return self.db.runInteraction(
             "get_all_updated_receipts", get_all_updated_receipts_txn
diff --git a/synapse/storage/data_stores/main/roommember.py b/synapse/storage/data_stores/main/roommember.py
index d5ced05701b8..d5bd0cb5cf26 100644
--- a/synapse/storage/data_stores/main/roommember.py
+++ b/synapse/storage/data_stores/main/roommember.py
@@ -465,7 +465,7 @@ def _get_users_server_still_shares_room_with_txn(txn):
 
             txn.execute(sql % (clause,), args)
 
-            return set(row[0] for row in txn)
+            return {row[0] for row in txn}
 
         return await self.db.runInteraction(
             "get_users_server_still_shares_room_with",
@@ -826,7 +826,7 @@ def _get_forgotten_rooms_for_user_txn(txn):
                 GROUP BY room_id, user_id;
             """
             txn.execute(sql, (user_id,))
-            return set(row[0] for row in txn if row[1] == 0)
+            return {row[0] for row in txn if row[1] == 0}
 
         return self.db.runInteraction(
             "get_forgotten_rooms_for_user", _get_forgotten_rooms_for_user_txn
diff --git a/synapse/storage/data_stores/main/state.py b/synapse/storage/data_stores/main/state.py
index 3d34103e6776..3a3b9a8e7274 100644
--- a/synapse/storage/data_stores/main/state.py
+++ b/synapse/storage/data_stores/main/state.py
@@ -321,7 +321,7 @@ def get_referenced_state_groups(self, state_groups):
             desc="get_referenced_state_groups",
         )
 
-        return set(row["state_group"] for row in rows)
+        return {row["state_group"] for row in rows}
 
 
 class MainStateBackgroundUpdateStore(RoomMemberWorkerStore):
@@ -367,7 +367,7 @@ def _background_remove_left_rooms_txn(txn):
             """
 
             txn.execute(sql, (last_room_id, batch_size))
-            room_ids = list(row[0] for row in txn)
+            room_ids = [row[0] for row in txn]
             if not room_ids:
                 return True, set()
 
@@ -384,7 +384,7 @@ def _background_remove_left_rooms_txn(txn):
 
             txn.execute(sql, (last_room_id, room_ids[-1], "%:" + self.server_name))
 
-            joined_room_ids = set(row[0] for row in txn)
+            joined_room_ids = {row[0] for row in txn}
 
             left_rooms = set(room_ids) - joined_room_ids
 
@@ -404,7 +404,7 @@ def _background_remove_left_rooms_txn(txn):
                 retcols=("state_key",),
             )
 
-            potentially_left_users = set(row["state_key"] for row in rows)
+            potentially_left_users = {row["state_key"] for row in rows}
 
             # Now lets actually delete the rooms from the DB.
             self.db.simple_delete_many_txn(
diff --git a/synapse/storage/data_stores/main/stream.py b/synapse/storage/data_stores/main/stream.py
index 056b25b13a3f..ada5cce6c2c3 100644
--- a/synapse/storage/data_stores/main/stream.py
+++ b/synapse/storage/data_stores/main/stream.py
@@ -346,11 +346,11 @@ def get_rooms_that_changed(self, room_ids, from_key):
             from_key (str): The room_key portion of a StreamToken
         """
         from_key = RoomStreamToken.parse_stream_token(from_key).stream
-        return set(
+        return {
             room_id
             for room_id in room_ids
             if self._events_stream_cache.has_entity_changed(room_id, from_key)
-        )
+        }
 
     @defer.inlineCallbacks
     def get_room_events_stream_for_room(
@@ -679,11 +679,11 @@ def get_events_around(
         )
 
         events_before = yield self.get_events_as_list(
-            [e for e in results["before"]["event_ids"]], get_prev_content=True
+            list(results["before"]["event_ids"]), get_prev_content=True
         )
 
         events_after = yield self.get_events_as_list(
-            [e for e in results["after"]["event_ids"]], get_prev_content=True
+            list(results["after"]["event_ids"]), get_prev_content=True
         )
 
         return {
diff --git a/synapse/storage/data_stores/main/user_erasure_store.py b/synapse/storage/data_stores/main/user_erasure_store.py
index af8025bc17a0..ec6b8a4ffd10 100644
--- a/synapse/storage/data_stores/main/user_erasure_store.py
+++ b/synapse/storage/data_stores/main/user_erasure_store.py
@@ -63,9 +63,9 @@ def are_users_erased(self, user_ids):
             retcols=("user_id",),
             desc="are_users_erased",
         )
-        erased_users = set(row["user_id"] for row in rows)
+        erased_users = {row["user_id"] for row in rows}
 
-        res = dict((u, u in erased_users) for u in user_ids)
+        res = {u: u in erased_users for u in user_ids}
         return res
 
 
diff --git a/synapse/storage/data_stores/state/store.py b/synapse/storage/data_stores/state/store.py
index c4ee9b7ccb36..57a526766346 100644
--- a/synapse/storage/data_stores/state/store.py
+++ b/synapse/storage/data_stores/state/store.py
@@ -520,11 +520,11 @@ def _purge_unreferenced_state_groups(self, txn, room_id, state_groups_to_delete)
             retcols=("state_group",),
         )
 
-        remaining_state_groups = set(
+        remaining_state_groups = {
             row["state_group"]
             for row in rows
             if row["state_group"] not in state_groups_to_delete
-        )
+        }
 
         logger.info(
             "[purge] de-delta-ing %i remaining state groups",
diff --git a/synapse/storage/database.py b/synapse/storage/database.py
index 6dcb5c04dacf..1953614401c9 100644
--- a/synapse/storage/database.py
+++ b/synapse/storage/database.py
@@ -554,8 +554,8 @@ def cursor_to_dict(cursor):
         Returns:
             A list of dicts where the key is the column header.
         """
-        col_headers = list(intern(str(column[0])) for column in cursor.description)
-        results = list(dict(zip(col_headers, row)) for row in cursor)
+        col_headers = [intern(str(column[0])) for column in cursor.description]
+        results = [dict(zip(col_headers, row)) for row in cursor]
         return results
 
     def execute(self, desc, decoder, query, *args):
diff --git a/synapse/storage/persist_events.py b/synapse/storage/persist_events.py
index b950550f23cc..0f9ac1cf0973 100644
--- a/synapse/storage/persist_events.py
+++ b/synapse/storage/persist_events.py
@@ -602,14 +602,14 @@ async def _get_new_state_after_events(
             event_id_to_state_group.update(event_to_groups)
 
         # State groups of old_latest_event_ids
-        old_state_groups = set(
+        old_state_groups = {
             event_id_to_state_group[evid] for evid in old_latest_event_ids
-        )
+        }
 
         # State groups of new_latest_event_ids
-        new_state_groups = set(
+        new_state_groups = {
             event_id_to_state_group[evid] for evid in new_latest_event_ids
-        )
+        }
 
         # If they old and new groups are the same then we don't need to do
         # anything.
diff --git a/synapse/storage/prepare_database.py b/synapse/storage/prepare_database.py
index c285ef52a0ba..fc69c32a0a6d 100644
--- a/synapse/storage/prepare_database.py
+++ b/synapse/storage/prepare_database.py
@@ -345,9 +345,9 @@ def _upgrade_existing_database(
                     "Could not open delta dir for version %d: %s" % (v, directory)
                 )
 
-        duplicates = set(
+        duplicates = {
             file_name for file_name, count in file_name_counter.items() if count > 1
-        )
+        }
         if duplicates:
             # We don't support using the same file name in the same delta version.
             raise PrepareDatabaseException(
@@ -454,7 +454,7 @@ def _apply_module_schema_files(cur, database_engine, modname, names_and_streams)
         ),
         (modname,),
     )
-    applied_deltas = set(d for d, in cur)
+    applied_deltas = {d for d, in cur}
     for (name, stream) in names_and_streams:
         if name in applied_deltas:
             continue
diff --git a/synapse/util/frozenutils.py b/synapse/util/frozenutils.py
index 635b897d6c1a..f2ccd5e7c6bd 100644
--- a/synapse/util/frozenutils.py
+++ b/synapse/util/frozenutils.py
@@ -30,7 +30,7 @@ def freeze(o):
         return o
 
     try:
-        return tuple([freeze(i) for i in o])
+        return tuple(freeze(i) for i in o)
     except TypeError:
         pass
 
diff --git a/synapse/visibility.py b/synapse/visibility.py
index d0abd8f04ffc..e60d9756b78f 100644
--- a/synapse/visibility.py
+++ b/synapse/visibility.py
@@ -75,7 +75,7 @@ def filter_events_for_client(
     """
     # Filter out events that have been soft failed so that we don't relay them
     # to clients.
-    events = list(e for e in events if not e.internal_metadata.is_soft_failed())
+    events = [e for e in events if not e.internal_metadata.is_soft_failed()]
 
     types = ((EventTypes.RoomHistoryVisibility, ""), (EventTypes.Member, user_id))
     event_id_to_state = yield storage.state.get_state_for_events(
@@ -97,7 +97,7 @@ def filter_events_for_client(
     erased_senders = yield storage.main.are_users_erased((e.sender for e in events))
 
     if apply_retention_policies:
-        room_ids = set(e.room_id for e in events)
+        room_ids = {e.room_id for e in events}
         retention_policies = {}
 
         for room_id in room_ids:
diff --git a/tests/config/test_generate.py b/tests/config/test_generate.py
index 2684e662de32..463855ecc8db 100644
--- a/tests/config/test_generate.py
+++ b/tests/config/test_generate.py
@@ -48,7 +48,7 @@ def test_generate_config_generates_files(self):
             )
 
         self.assertSetEqual(
-            set(["homeserver.yaml", "lemurs.win.log.config", "lemurs.win.signing.key"]),
+            {"homeserver.yaml", "lemurs.win.log.config", "lemurs.win.signing.key"},
             set(os.listdir(self.dir)),
         )
 
diff --git a/tests/federation/test_federation_server.py b/tests/federation/test_federation_server.py
index e7d869904029..296dc887bef6 100644
--- a/tests/federation/test_federation_server.py
+++ b/tests/federation/test_federation_server.py
@@ -83,7 +83,7 @@ def test_without_event_id(self):
             )
         )
 
-        self.assertEqual(members, set(["@user:other.example.com", u1]))
+        self.assertEqual(members, {"@user:other.example.com", u1})
         self.assertEqual(len(channel.json_body["pdus"]), 6)
 
     def test_needs_to_be_in_room(self):
diff --git a/tests/handlers/test_presence.py b/tests/handlers/test_presence.py
index c171038df8e2..64915bafcd06 100644
--- a/tests/handlers/test_presence.py
+++ b/tests/handlers/test_presence.py
@@ -338,7 +338,7 @@ def test_sync_online(self):
         )
 
         new_state = handle_timeout(
-            state, is_mine=True, syncing_user_ids=set([user_id]), now=now
+            state, is_mine=True, syncing_user_ids={user_id}, now=now
         )
 
         self.assertIsNotNone(new_state)
@@ -579,7 +579,7 @@ def test_remote_gets_presence_when_local_user_joins(self):
         )
         self.assertEqual(expected_state.state, PresenceState.ONLINE)
         self.federation_sender.send_presence_to_destinations.assert_called_once_with(
-            destinations=set(("server2", "server3")), states=[expected_state]
+            destinations={"server2", "server3"}, states=[expected_state]
         )
 
     def _add_new_user(self, room_id, user_id):
diff --git a/tests/handlers/test_typing.py b/tests/handlers/test_typing.py
index 140cc0a3c24a..07b204666e53 100644
--- a/tests/handlers/test_typing.py
+++ b/tests/handlers/test_typing.py
@@ -129,12 +129,12 @@ def check_user_in_room(room_id, user_id):
         hs.get_auth().check_user_in_room = check_user_in_room
 
         def get_joined_hosts_for_room(room_id):
-            return set(member.domain for member in self.room_members)
+            return {member.domain for member in self.room_members}
 
         self.datastore.get_joined_hosts_for_room = get_joined_hosts_for_room
 
         def get_current_users_in_room(room_id):
-            return set(str(u) for u in self.room_members)
+            return {str(u) for u in self.room_members}
 
         hs.get_state_handler().get_current_users_in_room = get_current_users_in_room
 
@@ -257,7 +257,7 @@ def test_stopped_typing(self):
 
         member = RoomMember(ROOM_ID, U_APPLE.to_string())
         self.handler._member_typing_until[member] = 1002000
-        self.handler._room_typing[ROOM_ID] = set([U_APPLE.to_string()])
+        self.handler._room_typing[ROOM_ID] = {U_APPLE.to_string()}
 
         self.assertEquals(self.event_source.get_current_key(), 0)
 
diff --git a/tests/handlers/test_user_directory.py b/tests/handlers/test_user_directory.py
index 0a4765fff4d8..7b92bdbc4767 100644
--- a/tests/handlers/test_user_directory.py
+++ b/tests/handlers/test_user_directory.py
@@ -114,7 +114,7 @@ def test_private_room(self):
         public_users = self.get_users_in_public_rooms()
 
         self.assertEqual(
-            self._compress_shared(shares_private), set([(u1, u2, room), (u2, u1, room)])
+            self._compress_shared(shares_private), {(u1, u2, room), (u2, u1, room)}
         )
         self.assertEqual(public_users, [])
 
@@ -169,7 +169,7 @@ def test_spam_checker(self):
         public_users = self.get_users_in_public_rooms()
 
         self.assertEqual(
-            self._compress_shared(shares_private), set([(u1, u2, room), (u2, u1, room)])
+            self._compress_shared(shares_private), {(u1, u2, room), (u2, u1, room)}
         )
         self.assertEqual(public_users, [])
 
@@ -226,7 +226,7 @@ def test_legacy_spam_checker(self):
         public_users = self.get_users_in_public_rooms()
 
         self.assertEqual(
-            self._compress_shared(shares_private), set([(u1, u2, room), (u2, u1, room)])
+            self._compress_shared(shares_private), {(u1, u2, room), (u2, u1, room)}
         )
         self.assertEqual(public_users, [])
 
@@ -358,12 +358,12 @@ def test_initial(self):
         public_users = self.get_users_in_public_rooms()
 
         # User 1 and User 2 are in the same public room
-        self.assertEqual(set(public_users), set([(u1, room), (u2, room)]))
+        self.assertEqual(set(public_users), {(u1, room), (u2, room)})
 
         # User 1 and User 3 share private rooms
         self.assertEqual(
             self._compress_shared(shares_private),
-            set([(u1, u3, private_room), (u3, u1, private_room)]),
+            {(u1, u3, private_room), (u3, u1, private_room)},
         )
 
     def test_initial_share_all_users(self):
@@ -398,7 +398,7 @@ def test_initial_share_all_users(self):
 
         # No users share rooms
         self.assertEqual(public_users, [])
-        self.assertEqual(self._compress_shared(shares_private), set([]))
+        self.assertEqual(self._compress_shared(shares_private), set())
 
         # Despite not sharing a room, search_all_users means we get a search
         # result.
diff --git a/tests/push/test_email.py b/tests/push/test_email.py
index 80187406bc3f..83032cc9eab6 100644
--- a/tests/push/test_email.py
+++ b/tests/push/test_email.py
@@ -163,7 +163,7 @@ def _check_for_mail(self):
 
         # Get the stream ordering before it gets sent
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=self.user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": self.user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
@@ -174,7 +174,7 @@ def _check_for_mail(self):
 
         # It hasn't succeeded yet, so the stream ordering shouldn't have moved
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=self.user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": self.user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
@@ -192,7 +192,7 @@ def _check_for_mail(self):
 
         # The stream ordering has increased
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=self.user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": self.user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
diff --git a/tests/push/test_http.py b/tests/push/test_http.py
index fe3441f08196..baf9c785f48c 100644
--- a/tests/push/test_http.py
+++ b/tests/push/test_http.py
@@ -102,7 +102,7 @@ def test_sends_http(self):
 
         # Get the stream ordering before it gets sent
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
@@ -113,7 +113,7 @@ def test_sends_http(self):
 
         # It hasn't succeeded yet, so the stream ordering shouldn't have moved
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
@@ -132,7 +132,7 @@ def test_sends_http(self):
 
         # The stream ordering has increased
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
@@ -152,7 +152,7 @@ def test_sends_http(self):
 
         # The stream ordering has increased, again
         pushers = self.get_success(
-            self.hs.get_datastore().get_pushers_by(dict(user_name=user_id))
+            self.hs.get_datastore().get_pushers_by({"user_name": user_id})
         )
         pushers = list(pushers)
         self.assertEqual(len(pushers), 1)
diff --git a/tests/rest/client/v2_alpha/test_sync.py b/tests/rest/client/v2_alpha/test_sync.py
index 9c13a137867a..fa3a3ec1bddd 100644
--- a/tests/rest/client/v2_alpha/test_sync.py
+++ b/tests/rest/client/v2_alpha/test_sync.py
@@ -40,16 +40,14 @@ def test_sync_argless(self):
 
         self.assertEqual(channel.code, 200)
         self.assertTrue(
-            set(
-                [
-                    "next_batch",
-                    "rooms",
-                    "presence",
-                    "account_data",
-                    "to_device",
-                    "device_lists",
-                ]
-            ).issubset(set(channel.json_body.keys()))
+            {
+                "next_batch",
+                "rooms",
+                "presence",
+                "account_data",
+                "to_device",
+                "device_lists",
+            }.issubset(set(channel.json_body.keys()))
         )
 
     def test_sync_presence_disabled(self):
@@ -63,9 +61,13 @@ def test_sync_presence_disabled(self):
 
         self.assertEqual(channel.code, 200)
         self.assertTrue(
-            set(
-                ["next_batch", "rooms", "account_data", "to_device", "device_lists"]
-            ).issubset(set(channel.json_body.keys()))
+            {
+                "next_batch",
+                "rooms",
+                "account_data",
+                "to_device",
+                "device_lists",
+            }.issubset(set(channel.json_body.keys()))
         )
 
 
diff --git a/tests/storage/test__base.py b/tests/storage/test__base.py
index d491ea29242b..e37260a820c6 100644
--- a/tests/storage/test__base.py
+++ b/tests/storage/test__base.py
@@ -373,7 +373,7 @@ def test_upsert_many(self):
         )
         self.assertEqual(
             set(self._dump_to_tuple(res)),
-            set([(1, "user1", "hello"), (2, "user2", "there")]),
+            {(1, "user1", "hello"), (2, "user2", "there")},
         )
 
         # Update only user2
@@ -400,5 +400,5 @@ def test_upsert_many(self):
         )
         self.assertEqual(
             set(self._dump_to_tuple(res)),
-            set([(1, "user1", "hello"), (2, "user2", "bleb")]),
+            {(1, "user1", "hello"), (2, "user2", "bleb")},
         )
diff --git a/tests/storage/test_appservice.py b/tests/storage/test_appservice.py
index fd5251269645..31710949a820 100644
--- a/tests/storage/test_appservice.py
+++ b/tests/storage/test_appservice.py
@@ -69,14 +69,14 @@ def tearDown(self):
                 pass
 
     def _add_appservice(self, as_token, id, url, hs_token, sender):
-        as_yaml = dict(
-            url=url,
-            as_token=as_token,
-            hs_token=hs_token,
-            id=id,
-            sender_localpart=sender,
-            namespaces={},
-        )
+        as_yaml = {
+            "url": url,
+            "as_token": as_token,
+            "hs_token": hs_token,
+            "id": id,
+            "sender_localpart": sender,
+            "namespaces": {},
+        }
         # use the token as the filename
         with open(as_token, "w") as outfile:
             outfile.write(yaml.dump(as_yaml))
@@ -135,14 +135,14 @@ def setUp(self):
         )
 
     def _add_service(self, url, as_token, id):
-        as_yaml = dict(
-            url=url,
-            as_token=as_token,
-            hs_token="something",
-            id=id,
-            sender_localpart="a_sender",
-            namespaces={},
-        )
+        as_yaml = {
+            "url": url,
+            "as_token": as_token,
+            "hs_token": "something",
+            "id": id,
+            "sender_localpart": "a_sender",
+            "namespaces": {},
+        }
         # use the token as the filename
         with open(as_token, "w") as outfile:
             outfile.write(yaml.dump(as_yaml))
@@ -384,8 +384,8 @@ def test_get_appservices_by_state_multiple(self):
         )
         self.assertEquals(2, len(services))
         self.assertEquals(
-            set([self.as_list[2]["id"], self.as_list[0]["id"]]),
-            set([services[0].id, services[1].id]),
+            {self.as_list[2]["id"], self.as_list[0]["id"]},
+            {services[0].id, services[1].id},
         )
 
 
diff --git a/tests/storage/test_cleanup_extrems.py b/tests/storage/test_cleanup_extrems.py
index 029ac264542d..0e04b2cf9274 100644
--- a/tests/storage/test_cleanup_extrems.py
+++ b/tests/storage/test_cleanup_extrems.py
@@ -134,7 +134,7 @@ def test_basic_cleanup(self):
         latest_event_ids = self.get_success(
             self.store.get_latest_event_ids_in_room(self.room_id)
         )
-        self.assertEqual(set(latest_event_ids), set((event_id_a, event_id_b)))
+        self.assertEqual(set(latest_event_ids), {event_id_a, event_id_b})
 
         # Run the background update and check it did the right thing
         self.run_background_update()
@@ -172,7 +172,7 @@ def test_chain_of_fail_cleanup(self):
         latest_event_ids = self.get_success(
             self.store.get_latest_event_ids_in_room(self.room_id)
         )
-        self.assertEqual(set(latest_event_ids), set((event_id_a, event_id_b)))
+        self.assertEqual(set(latest_event_ids), {event_id_a, event_id_b})
 
         # Run the background update and check it did the right thing
         self.run_background_update()
@@ -227,9 +227,7 @@ def test_forked_graph_cleanup(self):
         latest_event_ids = self.get_success(
             self.store.get_latest_event_ids_in_room(self.room_id)
         )
-        self.assertEqual(
-            set(latest_event_ids), set((event_id_a, event_id_b, event_id_c))
-        )
+        self.assertEqual(set(latest_event_ids), {event_id_a, event_id_b, event_id_c})
 
         # Run the background update and check it did the right thing
         self.run_background_update()
@@ -237,7 +235,7 @@ def test_forked_graph_cleanup(self):
         latest_event_ids = self.get_success(
             self.store.get_latest_event_ids_in_room(self.room_id)
         )
-        self.assertEqual(set(latest_event_ids), set([event_id_b, event_id_c]))
+        self.assertEqual(set(latest_event_ids), {event_id_b, event_id_c})
 
 
 class CleanupExtremDummyEventsTestCase(HomeserverTestCase):
diff --git a/tests/storage/test_event_metrics.py b/tests/storage/test_event_metrics.py
index f26ff57a186c..a7b7fd36d3ca 100644
--- a/tests/storage/test_event_metrics.py
+++ b/tests/storage/test_event_metrics.py
@@ -59,24 +59,22 @@ def test_exposed_to_prometheus(self):
             )
         )
 
-        expected = set(
-            [
-                b'synapse_forward_extremities_bucket{le="1.0"} 0.0',
-                b'synapse_forward_extremities_bucket{le="2.0"} 2.0',
-                b'synapse_forward_extremities_bucket{le="3.0"} 2.0',
-                b'synapse_forward_extremities_bucket{le="5.0"} 2.0',
-                b'synapse_forward_extremities_bucket{le="7.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="10.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="15.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="20.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="50.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="100.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="200.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="500.0"} 3.0',
-                b'synapse_forward_extremities_bucket{le="+Inf"} 3.0',
-                b"synapse_forward_extremities_count 3.0",
-                b"synapse_forward_extremities_sum 10.0",
-            ]
-        )
+        expected = {
+            b'synapse_forward_extremities_bucket{le="1.0"} 0.0',
+            b'synapse_forward_extremities_bucket{le="2.0"} 2.0',
+            b'synapse_forward_extremities_bucket{le="3.0"} 2.0',
+            b'synapse_forward_extremities_bucket{le="5.0"} 2.0',
+            b'synapse_forward_extremities_bucket{le="7.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="10.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="15.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="20.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="50.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="100.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="200.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="500.0"} 3.0',
+            b'synapse_forward_extremities_bucket{le="+Inf"} 3.0',
+            b"synapse_forward_extremities_count 3.0",
+            b"synapse_forward_extremities_sum 10.0",
+        }
 
         self.assertEqual(items, expected)
diff --git a/tests/storage/test_state.py b/tests/storage/test_state.py
index 04d58fbf2479..0b88308ff4bc 100644
--- a/tests/storage/test_state.py
+++ b/tests/storage/test_state.py
@@ -394,7 +394,7 @@ def test_get_state_for_event(self):
         ) = self.state_datastore._state_group_cache.get(group)
 
         self.assertEqual(is_all, False)
-        self.assertEqual(known_absent, set([(e1.type, e1.state_key)]))
+        self.assertEqual(known_absent, {(e1.type, e1.state_key)})
         self.assertDictEqual(state_dict_ids, {(e1.type, e1.state_key): e1.event_id})
 
         ############################################
diff --git a/tests/test_state.py b/tests/test_state.py
index d1578fe581f7..66f22f681323 100644
--- a/tests/test_state.py
+++ b/tests/test_state.py
@@ -254,9 +254,7 @@ def test_branch_basic_conflict(self):
         ctx_d = context_store["D"]
 
         prev_state_ids = yield ctx_d.get_prev_state_ids()
-        self.assertSetEqual(
-            {"START", "A", "C"}, {e_id for e_id in prev_state_ids.values()}
-        )
+        self.assertSetEqual({"START", "A", "C"}, set(prev_state_ids.values()))
 
         self.assertEqual(ctx_c.state_group, ctx_d.state_group_before_event)
         self.assertEqual(ctx_d.state_group_before_event, ctx_d.state_group)
@@ -313,9 +311,7 @@ def test_branch_have_banned_conflict(self):
         ctx_e = context_store["E"]
 
         prev_state_ids = yield ctx_e.get_prev_state_ids()
-        self.assertSetEqual(
-            {"START", "A", "B", "C"}, {e for e in prev_state_ids.values()}
-        )
+        self.assertSetEqual({"START", "A", "B", "C"}, set(prev_state_ids.values()))
         self.assertEqual(ctx_c.state_group, ctx_e.state_group_before_event)
         self.assertEqual(ctx_e.state_group_before_event, ctx_e.state_group)
 
@@ -388,9 +384,7 @@ def test_branch_have_perms_conflict(self):
         ctx_d = context_store["D"]
 
         prev_state_ids = yield ctx_d.get_prev_state_ids()
-        self.assertSetEqual(
-            {"A1", "A2", "A3", "A5", "B"}, {e for e in prev_state_ids.values()}
-        )
+        self.assertSetEqual({"A1", "A2", "A3", "A5", "B"}, set(prev_state_ids.values()))
 
         self.assertEqual(ctx_b.state_group, ctx_d.state_group_before_event)
         self.assertEqual(ctx_d.state_group_before_event, ctx_d.state_group)
@@ -482,7 +476,7 @@ def test_trivial_annotate_message(self):
         current_state_ids = yield context.get_current_state_ids()
 
         self.assertEqual(
-            set([e.event_id for e in old_state]), set(current_state_ids.values())
+            {e.event_id for e in old_state}, set(current_state_ids.values())
         )
 
         self.assertEqual(group_name, context.state_group)
@@ -513,9 +507,7 @@ def test_trivial_annotate_state(self):
 
         prev_state_ids = yield context.get_prev_state_ids()
 
-        self.assertEqual(
-            set([e.event_id for e in old_state]), set(prev_state_ids.values())
-        )
+        self.assertEqual({e.event_id for e in old_state}, set(prev_state_ids.values()))
 
         self.assertIsNotNone(context.state_group)
 
diff --git a/tests/util/test_stream_change_cache.py b/tests/util/test_stream_change_cache.py
index f2be63706bba..72a9de5370ec 100644
--- a/tests/util/test_stream_change_cache.py
+++ b/tests/util/test_stream_change_cache.py
@@ -67,7 +67,7 @@ def test_has_entity_changed_pops_off_start(self):
         # If we update an existing entity, it keeps the two existing entities
         cache.entity_has_changed("bar@baz.net", 5)
         self.assertEqual(
-            set(["bar@baz.net", "user@elsewhere.org"]), set(cache._entity_to_key)
+            {"bar@baz.net", "user@elsewhere.org"}, set(cache._entity_to_key)
         )
 
     def test_get_all_entities_changed(self):
@@ -137,7 +137,7 @@ def test_get_entities_changed(self):
             cache.get_entities_changed(
                 ["user@foo.com", "bar@baz.net", "user@elsewhere.org"], stream_pos=2
             ),
-            set(["bar@baz.net", "user@elsewhere.org"]),
+            {"bar@baz.net", "user@elsewhere.org"},
         )
 
         # Query all the entries mid-way through the stream, but include one
@@ -153,7 +153,7 @@ def test_get_entities_changed(self):
                 ],
                 stream_pos=2,
             ),
-            set(["bar@baz.net", "user@elsewhere.org"]),
+            {"bar@baz.net", "user@elsewhere.org"},
         )
 
         # Query all the entries, but before the first known point. We will get
@@ -168,21 +168,13 @@ def test_get_entities_changed(self):
                 ],
                 stream_pos=0,
             ),
-            set(
-                [
-                    "user@foo.com",
-                    "bar@baz.net",
-                    "user@elsewhere.org",
-                    "not@here.website",
-                ]
-            ),
+            {"user@foo.com", "bar@baz.net", "user@elsewhere.org", "not@here.website"},
         )
 
         # Query a subset of the entries mid-way through the stream. We should
         # only get back the subset.
         self.assertEqual(
-            cache.get_entities_changed(["bar@baz.net"], stream_pos=2),
-            set(["bar@baz.net"]),
+            cache.get_entities_changed(["bar@baz.net"], stream_pos=2), {"bar@baz.net"},
         )
 
     def test_max_pos(self):
diff --git a/tox.ini b/tox.ini
index b9132a317745..b715ea0bff40 100644
--- a/tox.ini
+++ b/tox.ini
@@ -123,6 +123,7 @@ skip_install = True
 basepython = python3.6
 deps =
     flake8
+    flake8-comprehensions
     black==19.10b0  # We pin so that our tests don't start failing on new releases of black.
 commands =
     python -m black --check --diff .