diff --git a/changelog.d/16241.misc b/changelog.d/16241.misc
new file mode 100644
index 000000000000..0fc5f34c5ce1
--- /dev/null
+++ b/changelog.d/16241.misc
@@ -0,0 +1 @@
+Cache device resync requests over replication.
diff --git a/synapse/replication/http/devices.py b/synapse/replication/http/devices.py
index 73f3de364205..209833d28753 100644
--- a/synapse/replication/http/devices.py
+++ b/synapse/replication/http/devices.py
@@ -62,7 +62,7 @@ class ReplicationMultiUserDevicesResyncRestServlet(ReplicationEndpoint):
 
     NAME = "multi_user_device_resync"
     PATH_ARGS = ()
-    CACHE = False
+    CACHE = True
 
     def __init__(self, hs: "HomeServer"):
         super().__init__(hs)