diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index ce0291367b510..d1d09f32dd8cd 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -39772,6 +39772,8 @@ export function createTypeChecker(host: TypeCheckerHost): TypeChecker {
                     case SyntaxKind.AmpersandAmpersandToken:
                     case SyntaxKind.AmpersandAmpersandEqualsToken:
                         return PredicateSemantics.Sometimes;
+                    case SyntaxKind.CommaToken:
+                        return getSyntacticNullishnessSemantics((node as BinaryExpression).right);
                 }
                 return PredicateSemantics.Never;
             case SyntaxKind.ConditionalExpression:
diff --git a/tests/baselines/reference/predicateSemantics.errors.txt b/tests/baselines/reference/predicateSemantics.errors.txt
index 14251121358c4..1c9de704f1628 100644
--- a/tests/baselines/reference/predicateSemantics.errors.txt
+++ b/tests/baselines/reference/predicateSemantics.errors.txt
@@ -9,9 +9,12 @@ predicateSemantics.ts(33,8): error TS2872: This kind of expression is always tru
 predicateSemantics.ts(34,11): error TS2872: This kind of expression is always truthy.
 predicateSemantics.ts(35,8): error TS2872: This kind of expression is always truthy.
 predicateSemantics.ts(36,8): error TS2872: This kind of expression is always truthy.
+predicateSemantics.ts(51,14): error TS2869: Right operand of ?? is unreachable because the left operand is never nullish.
+predicateSemantics.ts(52,14): error TS2695: Left side of comma operator is unused and has no side effects.
+predicateSemantics.ts(52,14): error TS2869: Right operand of ?? is unreachable because the left operand is never nullish.
 
 
-==== predicateSemantics.ts (11 errors) ====
+==== predicateSemantics.ts (14 errors) ====
     declare let cond: any;
     
     // OK: One or other operand is possibly nullish
@@ -77,4 +80,20 @@ predicateSemantics.ts(36,8): error TS2872: This kind of expression is always tru
     function foo(this: Object | undefined) {
         // Should be OK
         return this ?? 0;
-    }
\ No newline at end of file
+    }
+    
+    // https://github.com/microsoft/TypeScript/issues/60401
+    {
+      const maybe = null as true | null;
+      let i = 0;
+      const d = (i++, maybe) ?? true; // ok
+      const e = (i++, i++) ?? true; // error
+                 ~~~~~~~~
+!!! error TS2869: Right operand of ?? is unreachable because the left operand is never nullish.
+      const f = (maybe, i++) ?? true; // error
+                 ~~~~~
+!!! error TS2695: Left side of comma operator is unused and has no side effects.
+                 ~~~~~~~~~~
+!!! error TS2869: Right operand of ?? is unreachable because the left operand is never nullish.
+    }
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/predicateSemantics.js b/tests/baselines/reference/predicateSemantics.js
index eb0b66516b62c..3641305b71805 100644
--- a/tests/baselines/reference/predicateSemantics.js
+++ b/tests/baselines/reference/predicateSemantics.js
@@ -44,10 +44,20 @@ console.log((cond || undefined) && 1 / cond);
 function foo(this: Object | undefined) {
     // Should be OK
     return this ?? 0;
-}
+}
+
+// https://github.com/microsoft/TypeScript/issues/60401
+{
+  const maybe = null as true | null;
+  let i = 0;
+  const d = (i++, maybe) ?? true; // ok
+  const e = (i++, i++) ?? true; // error
+  const f = (maybe, i++) ?? true; // error
+}
+
 
 //// [predicateSemantics.js]
-var _a, _b, _c, _d, _e, _f;
+var _a, _b, _c, _d, _e, _f, _g, _h, _j;
 // OK: One or other operand is possibly nullish
 var test1 = (_a = (cond ? undefined : 32)) !== null && _a !== void 0 ? _a : "possibly reached";
 // Not OK: Both operands nullish
@@ -88,3 +98,11 @@ function foo() {
     // Should be OK
     return this !== null && this !== void 0 ? this : 0;
 }
+// https://github.com/microsoft/TypeScript/issues/60401
+{
+    var maybe = null;
+    var i = 0;
+    var d = (_g = (i++, maybe)) !== null && _g !== void 0 ? _g : true; // ok
+    var e = (_h = (i++, i++)) !== null && _h !== void 0 ? _h : true; // error
+    var f = (_j = (maybe, i++)) !== null && _j !== void 0 ? _j : true; // error
+}
diff --git a/tests/baselines/reference/predicateSemantics.symbols b/tests/baselines/reference/predicateSemantics.symbols
index 790e965f988cc..c91201e3fcda2 100644
--- a/tests/baselines/reference/predicateSemantics.symbols
+++ b/tests/baselines/reference/predicateSemantics.symbols
@@ -79,3 +79,28 @@ function foo(this: Object | undefined) {
     return this ?? 0;
 >this : Symbol(this, Decl(predicateSemantics.ts, 40, 13))
 }
+
+// https://github.com/microsoft/TypeScript/issues/60401
+{
+  const maybe = null as true | null;
+>maybe : Symbol(maybe, Decl(predicateSemantics.ts, 47, 7))
+
+  let i = 0;
+>i : Symbol(i, Decl(predicateSemantics.ts, 48, 5))
+
+  const d = (i++, maybe) ?? true; // ok
+>d : Symbol(d, Decl(predicateSemantics.ts, 49, 7))
+>i : Symbol(i, Decl(predicateSemantics.ts, 48, 5))
+>maybe : Symbol(maybe, Decl(predicateSemantics.ts, 47, 7))
+
+  const e = (i++, i++) ?? true; // error
+>e : Symbol(e, Decl(predicateSemantics.ts, 50, 7))
+>i : Symbol(i, Decl(predicateSemantics.ts, 48, 5))
+>i : Symbol(i, Decl(predicateSemantics.ts, 48, 5))
+
+  const f = (maybe, i++) ?? true; // error
+>f : Symbol(f, Decl(predicateSemantics.ts, 51, 7))
+>maybe : Symbol(maybe, Decl(predicateSemantics.ts, 47, 7))
+>i : Symbol(i, Decl(predicateSemantics.ts, 48, 5))
+}
+
diff --git a/tests/baselines/reference/predicateSemantics.types b/tests/baselines/reference/predicateSemantics.types
index 3d3eba6683e25..ee88a95cd16ea 100644
--- a/tests/baselines/reference/predicateSemantics.types
+++ b/tests/baselines/reference/predicateSemantics.types
@@ -234,3 +234,77 @@ function foo(this: Object | undefined) {
 >0 : 0
 >  : ^
 }
+
+// https://github.com/microsoft/TypeScript/issues/60401
+{
+  const maybe = null as true | null;
+>maybe : true
+>      : ^^^^
+>null as true | null : true
+>                    : ^^^^
+>true : true
+>     : ^^^^
+
+  let i = 0;
+>i : number
+>  : ^^^^^^
+>0 : 0
+>  : ^
+
+  const d = (i++, maybe) ?? true; // ok
+>d : true
+>  : ^^^^
+>(i++, maybe) ?? true : true
+>                     : ^^^^
+>(i++, maybe) : true
+>             : ^^^^
+>i++, maybe : true
+>           : ^^^^
+>i++ : number
+>    : ^^^^^^
+>i : number
+>  : ^^^^^^
+>maybe : true
+>      : ^^^^
+>true : true
+>     : ^^^^
+
+  const e = (i++, i++) ?? true; // error
+>e : number | true
+>  : ^^^^^^^^^^^^^
+>(i++, i++) ?? true : number | true
+>                   : ^^^^^^^^^^^^^
+>(i++, i++) : number
+>           : ^^^^^^
+>i++, i++ : number
+>         : ^^^^^^
+>i++ : number
+>    : ^^^^^^
+>i : number
+>  : ^^^^^^
+>i++ : number
+>    : ^^^^^^
+>i : number
+>  : ^^^^^^
+>true : true
+>     : ^^^^
+
+  const f = (maybe, i++) ?? true; // error
+>f : number | true
+>  : ^^^^^^^^^^^^^
+>(maybe, i++) ?? true : number | true
+>                     : ^^^^^^^^^^^^^
+>(maybe, i++) : number
+>             : ^^^^^^
+>maybe, i++ : number
+>           : ^^^^^^
+>maybe : true
+>      : ^^^^
+>i++ : number
+>    : ^^^^^^
+>i : number
+>  : ^^^^^^
+>true : true
+>     : ^^^^
+}
+
diff --git a/tests/cases/compiler/predicateSemantics.ts b/tests/cases/compiler/predicateSemantics.ts
index d6e12b297b25b..88374b9a2ff6b 100644
--- a/tests/cases/compiler/predicateSemantics.ts
+++ b/tests/cases/compiler/predicateSemantics.ts
@@ -41,4 +41,13 @@ console.log((cond || undefined) && 1 / cond);
 function foo(this: Object | undefined) {
     // Should be OK
     return this ?? 0;
-}
\ No newline at end of file
+}
+
+// https://github.com/microsoft/TypeScript/issues/60401
+{
+  const maybe = null as true | null;
+  let i = 0;
+  const d = (i++, maybe) ?? true; // ok
+  const e = (i++, i++) ?? true; // error
+  const f = (maybe, i++) ?? true; // error
+}