diff --git a/change/@react-native-windows-cli-3aac23ad-e95a-4369-b241-c4fea1afcb7a.json b/change/@react-native-windows-cli-3aac23ad-e95a-4369-b241-c4fea1afcb7a.json
new file mode 100644
index 00000000000..1bf94d669a7
--- /dev/null
+++ b/change/@react-native-windows-cli-3aac23ad-e95a-4369-b241-c4fea1afcb7a.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "[0.66] fix(cli): fix cache not being used when there are no dependencies",
+  "packageName": "@react-native-windows/cli",
+  "email": "jthysell@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/packages/@react-native-windows/cli/src/runWindows/utils/autolink.ts b/packages/@react-native-windows/cli/src/runWindows/utils/autolink.ts
index 824063127e3..d8fee676199 100644
--- a/packages/@react-native-windows/cli/src/runWindows/utils/autolink.ts
+++ b/packages/@react-native-windows/cli/src/runWindows/utils/autolink.ts
@@ -394,13 +394,13 @@ export class AutolinkWindows {
   }
 
   /** Cache of dependencies */
-  private readonly windowsDependencies: Record<
-    string,
-    WindowsDependencyConfig
-  > = {};
+  private windowsDependencies:
+    | Record<string, WindowsDependencyConfig>
+    | undefined;
 
   private getWindowsDependencies() {
-    if (Object.keys(this.windowsDependencies).length === 0) {
+    if (!this.windowsDependencies) {
+      this.windowsDependencies = {};
       for (const dependencyName of Object.keys(this.dependenciesConfig)) {
         const windowsDependency: WindowsDependencyConfig | undefined = this
           .dependenciesConfig[dependencyName].platforms.windows;