diff --git a/Lib/enum.py b/Lib/enum.py
index 1efddfa1a0acc6..7ad599bb1e62e3 100644
--- a/Lib/enum.py
+++ b/Lib/enum.py
@@ -430,7 +430,9 @@ def __setitem__(self, key, value):
             if isinstance(value, auto):
                 single = True
                 value = (value, )
-            if isinstance(value, tuple):
+            if type(value) is tuple and any(isinstance(v, auto) for v in value):
+                # insist on an actual tuple, no subclasses, in keeping with only supporting
+                # top-level auto() usage (not contained in any other data structure)
                 auto_valued = []
                 for v in value:
                     if isinstance(v, auto):
diff --git a/Lib/test/test_enum.py b/Lib/test/test_enum.py
index a9b80ad0d3dbc3..0e2da1d64c1950 100644
--- a/Lib/test/test_enum.py
+++ b/Lib/test/test_enum.py
@@ -2727,6 +2727,19 @@ class MyIntFlag(IntFlag):
         self.assertEqual(deep, flags)
         self.assertEqual(copied.value, 1 | 2 | 8)
 
+    def test_namedtuple_as_value(self):
+        from collections import namedtuple
+        TTuple = namedtuple('TTuple', 'id a blist')
+        class NTEnum(Enum):
+            NONE = TTuple(0, 0, [])
+            A = TTuple(1, 2, [4])
+            B = TTuple(2, 4, [0, 1, 2])
+        self.assertEqual(repr(NTEnum.NONE), "<NTEnum.NONE: TTuple(id=0, a=0, blist=[])>")
+        self.assertEqual(NTEnum.NONE.value, TTuple(id=0, a=0, blist=[]))
+        self.assertEqual(
+                [x.value for x in NTEnum],
+                [TTuple(id=0, a=0, blist=[]), TTuple(id=1, a=2, blist=[4]), TTuple(id=2, a=4, blist=[0, 1, 2])],
+                )
 
 class TestOrder(unittest.TestCase):
     "test usage of the `_order_` attribute"
diff --git a/Misc/NEWS.d/next/Library/2022-12-08-06-18-06.gh-issue-100098.uBvPlp.rst b/Misc/NEWS.d/next/Library/2022-12-08-06-18-06.gh-issue-100098.uBvPlp.rst
new file mode 100644
index 00000000000000..256f2bcd39f81d
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-12-08-06-18-06.gh-issue-100098.uBvPlp.rst
@@ -0,0 +1 @@
+Fix ``tuple`` subclasses being cast to ``tuple`` when used as enum values.