diff --git a/src/interceptors/fetch/index.ts b/src/interceptors/fetch/index.ts
index 90c9fd5e..38e6eb90 100644
--- a/src/interceptors/fetch/index.ts
+++ b/src/interceptors/fetch/index.ts
@@ -7,6 +7,7 @@ import { uuidv4 } from '../../utils/uuid'
 import { toInteractiveRequest } from '../../utils/toInteractiveRequest'
 import { emitAsync } from '../../utils/emitAsync'
 import { isPropertyAccessible } from '../../utils/isPropertyAccessible'
+import { canParseUrl } from '../../utils/canParseUrl'
 
 export class FetchInterceptor extends Interceptor<HttpRequestEventMap> {
   static symbol = Symbol('fetch')
@@ -32,7 +33,21 @@ export class FetchInterceptor extends Interceptor<HttpRequestEventMap> {
 
     globalThis.fetch = async (input, init) => {
       const requestId = uuidv4()
-      const request = new Request(input, init)
+
+      /**
+       * @note Resolve potentially relative request URL
+       * against the present `location`. This is mainly
+       * for native `fetch` in JSDOM.
+       * @see https://github.com/mswjs/msw/issues/1625
+       */
+      const resolvedInput =
+        typeof input === 'string' &&
+        typeof location !== 'undefined' &&
+        !canParseUrl(input)
+          ? new URL(input, location.origin)
+          : input
+
+      const request = new Request(resolvedInput, init)
 
       this.logger.info('[%s] %s', request.method, request.url)
 
diff --git a/src/utils/canParseUrl.ts b/src/utils/canParseUrl.ts
new file mode 100644
index 00000000..7f814cd5
--- /dev/null
+++ b/src/utils/canParseUrl.ts
@@ -0,0 +1,13 @@
+/**
+ * Returns a boolean indicating whether the given URL string
+ * can be parsed into a `URL` instance.
+ * A substitute for `URL.canParse()` for Node.js 18.
+ */
+export function canParseUrl(url: string): boolean {
+  try {
+    new URL(url)
+    return true
+  } catch (_error) {
+    return false
+  }
+}
diff --git a/test/modules/fetch/intercept/fetch-relative-url.test.ts b/test/modules/fetch/intercept/fetch-relative-url.test.ts
new file mode 100644
index 00000000..2c7c7a7c
--- /dev/null
+++ b/test/modules/fetch/intercept/fetch-relative-url.test.ts
@@ -0,0 +1,27 @@
+/**
+ * @vitest-environment jsdom
+ */
+import { it, expect, afterAll, beforeAll } from 'vitest'
+import { FetchInterceptor } from '../../../../src/interceptors/fetch'
+
+const interceptor = new FetchInterceptor()
+interceptor.once('request', ({ request }) => {
+  if (request.url.endsWith('/numbers')) {
+    return request.respondWith(Response.json([1, 2, 3]))
+  }
+})
+
+beforeAll(() => {
+  interceptor.apply()
+})
+
+afterAll(() => {
+  interceptor.dispose()
+})
+
+it('intercepts a fetch request to a relative URL', async () => {
+  const response = await fetch('/numbers')
+
+  expect(response.status).toBe(200)
+  expect(await response.json()).toEqual([1, 2, 3])
+})