diff --git a/docs/pages/api-docs/card-header.json b/docs/pages/api-docs/card-header.json
index ec2825b28cf9eb..38d9e3e97f3c8a 100644
--- a/docs/pages/api-docs/card-header.json
+++ b/docs/pages/api-docs/card-header.json
@@ -7,6 +7,7 @@
     "disableTypography": { "type": { "name": "bool" } },
     "subheader": { "type": { "name": "node" } },
     "subheaderTypographyProps": { "type": { "name": "object" } },
+    "sx": { "type": { "name": "object" } },
     "title": { "type": { "name": "node" } },
     "titleTypographyProps": { "type": { "name": "object" } }
   },
@@ -21,6 +22,6 @@
   "filename": "/packages/material-ui/src/CardHeader/CardHeader.js",
   "inheritance": null,
   "demos": "<ul><li><a href=\"/components/cards/\">Cards</a></li></ul>",
-  "styledComponent": false,
+  "styledComponent": true,
   "cssComponent": false
 }
diff --git a/docs/translations/api-docs/card-header/card-header.json b/docs/translations/api-docs/card-header/card-header.json
index 3c285917a4523d..d18739b747626c 100644
--- a/docs/translations/api-docs/card-header/card-header.json
+++ b/docs/translations/api-docs/card-header/card-header.json
@@ -8,6 +8,7 @@
     "disableTypography": "If <code>true</code>, <code>subheader</code> and <code>title</code> won&#39;t be wrapped by a Typography component. This can be useful to render an alternative Typography variant by wrapping the <code>title</code> text, and optional <code>subheader</code> text with the Typography component.",
     "subheader": "The content of the component.",
     "subheaderTypographyProps": "These props will be forwarded to the subheader (as long as disableTypography is not <code>true</code>).",
+    "sx": "The system prop that allows defining system overrides as well as additional CSS styles. See the <a href=\"/system/basics/#the-sx-prop\">`sx` page</a> for more details.",
     "title": "The content of the component.",
     "titleTypographyProps": "These props will be forwarded to the title (as long as disableTypography is not <code>true</code>)."
   },
diff --git a/packages/material-ui/src/CardHeader/CardHeader.d.ts b/packages/material-ui/src/CardHeader/CardHeader.d.ts
index 490cae40d0888f..68404b6fdf9653 100644
--- a/packages/material-ui/src/CardHeader/CardHeader.d.ts
+++ b/packages/material-ui/src/CardHeader/CardHeader.d.ts
@@ -1,6 +1,8 @@
 import * as React from 'react';
+import { SxProps } from '@material-ui/system';
 import { TypographyProps } from '../Typography';
 import { OverridableComponent, OverrideProps } from '../OverridableComponent';
+import { Theme } from '..';
 
 export interface CardHeaderTypeMap<
   Props = {},
@@ -54,6 +56,10 @@ export interface CardHeaderTypeMap<
       SubheaderTypographyComponent,
       { component?: SubheaderTypographyComponent }
     >;
+    /**
+     * The system prop that allows defining system overrides as well as additional CSS styles.
+     */
+    sx?: SxProps<Theme>;
     /**
      * The content of the component.
      */
diff --git a/packages/material-ui/src/CardHeader/CardHeader.js b/packages/material-ui/src/CardHeader/CardHeader.js
index f052113ba8e9d9..0f798a0e1a1f17 100644
--- a/packages/material-ui/src/CardHeader/CardHeader.js
+++ b/packages/material-ui/src/CardHeader/CardHeader.js
@@ -1,47 +1,102 @@
 import * as React from 'react';
 import PropTypes from 'prop-types';
 import clsx from 'clsx';
-import withStyles from '../styles/withStyles';
+import { deepmerge } from '@material-ui/utils';
+import { unstable_composeClasses as composeClasses } from '@material-ui/unstyled';
 import Typography from '../Typography';
+import useThemeProps from '../styles/useThemeProps';
+import experimentalStyled from '../styles/experimentalStyled';
+import cardHeaderClasses, { getCardHeaderUtilityClass } from './cardHeaderClasses';
 
-export const styles = {
+const overridesResolver = (props, styles) => {
+  return deepmerge(styles.root || {}, {
+    [`& .${cardHeaderClasses.avatar}`]: styles.avatar,
+    [`& .${cardHeaderClasses.action}`]: styles.action,
+    [`& .${cardHeaderClasses.content}`]: styles.content,
+    [`& .${cardHeaderClasses.title}`]: styles.title,
+    [`& .${cardHeaderClasses.subheader}`]: styles.subheader,
+  });
+};
+
+const useUtilityClasses = (styleProps) => {
+  const { classes } = styleProps;
+
+  const slots = {
+    root: ['root'],
+    avatar: ['avatar'],
+    action: ['action'],
+    content: ['content'],
+    title: ['title'],
+    subheader: ['subheader'],
+  };
+
+  return composeClasses(slots, getCardHeaderUtilityClass, classes);
+};
+
+const CardHeaderRoot = experimentalStyled(
+  'div',
+  {},
+  {
+    name: 'MuiCardHeader',
+    slot: 'Root',
+    overridesResolver,
+  },
+)({
   /* Styles applied to the root element. */
-  root: {
-    display: 'flex',
-    alignItems: 'center',
-    padding: 16,
+  display: 'flex',
+  alignItems: 'center',
+  padding: 16,
+});
+
+const CardHeaderAvatar = experimentalStyled(
+  'div',
+  {},
+  {
+    name: 'MuiCardHeader',
+    slot: 'Avatar',
   },
+)({
   /* Styles applied to the avatar element. */
-  avatar: {
-    display: 'flex',
-    flex: '0 0 auto',
-    marginRight: 16,
+  display: 'flex',
+  flex: '0 0 auto',
+  marginRight: 16,
+});
+
+const CardHeaderAction = experimentalStyled(
+  'div',
+  {},
+  {
+    name: 'MuiCardHeader',
+    slot: 'Action',
   },
+)({
   /* Styles applied to the action element. */
-  action: {
-    flex: '0 0 auto',
-    alignSelf: 'flex-start',
-    marginTop: -4,
-    marginRight: -8,
-    marginBottom: -4,
+  flex: '0 0 auto',
+  alignSelf: 'flex-start',
+  marginTop: -4,
+  marginRight: -8,
+  marginBottom: -4,
+});
+
+const CardHeaderContent = experimentalStyled(
+  'div',
+  {},
+  {
+    name: 'MuiCardHeader',
+    slot: 'Content',
   },
+)({
   /* Styles applied to the content wrapper element. */
-  content: {
-    flex: '1 1 auto',
-  },
-  /* Styles applied to the title Typography element. */
-  title: {},
-  /* Styles applied to the subheader Typography element. */
-  subheader: {},
-};
+  flex: '1 1 auto',
+});
 
-const CardHeader = React.forwardRef(function CardHeader(props, ref) {
+const CardHeader = React.forwardRef(function CardHeader(inProps, ref) {
+  const props = useThemeProps({ props: inProps, name: 'MuiCardHeader' });
   const {
     action,
     avatar,
-    classes,
     className,
-    component: Component = 'div',
+    component = 'div',
     disableTypography = false,
     subheader: subheaderProp,
     subheaderTypographyProps,
@@ -50,6 +105,14 @@ const CardHeader = React.forwardRef(function CardHeader(props, ref) {
     ...other
   } = props;
 
+  const styleProps = {
+    ...props,
+    component,
+    disableTypography,
+  };
+
+  const classes = useUtilityClasses(styleProps);
+
   let title = titleProp;
   if (title != null && title.type !== Typography && !disableTypography) {
     title = (
@@ -82,14 +145,29 @@ const CardHeader = React.forwardRef(function CardHeader(props, ref) {
   }
 
   return (
-    <Component className={clsx(classes.root, className)} ref={ref} {...other}>
-      {avatar && <div className={classes.avatar}>{avatar}</div>}
-      <div className={classes.content}>
+    <CardHeaderRoot
+      className={clsx(classes.root, className)}
+      as={component}
+      ref={ref}
+      styleProps={styleProps}
+      {...other}
+    >
+      {avatar && (
+        <CardHeaderAvatar className={classes.avatar} styleProps={styleProps}>
+          {avatar}
+        </CardHeaderAvatar>
+      )}
+
+      <CardHeaderContent className={classes.content} styleProps={styleProps}>
         {title}
         {subheader}
-      </div>
-      {action && <div className={classes.action}>{action}</div>}
-    </Component>
+      </CardHeaderContent>
+      {action && (
+        <CardHeaderAction className={classes.action} styleProps={styleProps}>
+          {action}
+        </CardHeaderAction>
+      )}
+    </CardHeaderRoot>
   );
 });
 
@@ -140,6 +218,10 @@ CardHeader.propTypes = {
    * (as long as disableTypography is not `true`).
    */
   subheaderTypographyProps: PropTypes.object,
+  /**
+   * The system prop that allows defining system overrides as well as additional CSS styles.
+   */
+  sx: PropTypes.object,
   /**
    * The content of the component.
    */
@@ -151,4 +233,4 @@ CardHeader.propTypes = {
   titleTypographyProps: PropTypes.object,
 };
 
-export default withStyles(styles, { name: 'MuiCardHeader' })(CardHeader);
+export default CardHeader;
diff --git a/packages/material-ui/src/CardHeader/CardHeader.test.js b/packages/material-ui/src/CardHeader/CardHeader.test.js
index 8ed3b31bdbdb31..0a097c73787710 100644
--- a/packages/material-ui/src/CardHeader/CardHeader.test.js
+++ b/packages/material-ui/src/CardHeader/CardHeader.test.js
@@ -1,24 +1,24 @@
 import * as React from 'react';
 import { expect } from 'chai';
-import { getClasses, createMount, createClientRender, describeConformance } from 'test/utils';
+import { createMount, createClientRender, describeConformanceV5 } from 'test/utils';
 import CardHeader from './CardHeader';
 import { typographyClasses } from '../Typography';
+import classes from './cardHeaderClasses';
 
 describe('<CardHeader />', () => {
   const mount = createMount();
-  let classes;
   const render = createClientRender();
 
-  before(() => {
-    classes = getClasses(<CardHeader />);
-  });
-
-  describeConformance(<CardHeader />, () => ({
+  describeConformanceV5(<CardHeader />, () => ({
     classes,
     inheritComponent: 'div',
     mount,
+    muiName: 'MuiCardHeader',
     refInstanceof: window.HTMLDivElement,
+    testDeepOverrides: { slotName: 'content', slotClassName: classes.content },
     testComponentPropWith: 'span',
+    testVariantProps: { variant: 'foo' },
+    skip: ['componentsProp'],
   }));
 
   describe('without an avatar', () => {
diff --git a/packages/material-ui/src/CardHeader/cardHeaderClasses.d.ts b/packages/material-ui/src/CardHeader/cardHeaderClasses.d.ts
new file mode 100644
index 00000000000000..0961c645ed6e54
--- /dev/null
+++ b/packages/material-ui/src/CardHeader/cardHeaderClasses.d.ts
@@ -0,0 +1,14 @@
+export interface CardHeaderClasses {
+  root: string;
+  avatar: string;
+  action: string;
+  content: string;
+  title: string;
+  subheader: string;
+}
+
+declare const cardHeaderClasses: CardHeaderClasses;
+
+export function getCardHeaderUtilityClass(slot: string): string;
+
+export default cardHeaderClasses;
diff --git a/packages/material-ui/src/CardHeader/cardHeaderClasses.js b/packages/material-ui/src/CardHeader/cardHeaderClasses.js
new file mode 100644
index 00000000000000..3396d8dac56083
--- /dev/null
+++ b/packages/material-ui/src/CardHeader/cardHeaderClasses.js
@@ -0,0 +1,16 @@
+import { generateUtilityClass, generateUtilityClasses } from '@material-ui/unstyled';
+
+export function getCardHeaderUtilityClass(slot) {
+  return generateUtilityClass('MuiCardHeader', slot);
+}
+
+const cardHeaderClasses = generateUtilityClasses('MuiCardHeader', [
+  'root',
+  'avatar',
+  'action',
+  'content',
+  'title',
+  'subheader',
+]);
+
+export default cardHeaderClasses;
diff --git a/packages/material-ui/src/CardHeader/index.d.ts b/packages/material-ui/src/CardHeader/index.d.ts
index d989494e94ab60..c599bc0c40ab71 100644
--- a/packages/material-ui/src/CardHeader/index.d.ts
+++ b/packages/material-ui/src/CardHeader/index.d.ts
@@ -1,2 +1,5 @@
 export { default } from './CardHeader';
 export * from './CardHeader';
+
+export { default as cardHeaderClasses } from './cardHeaderClasses';
+export * from './cardHeaderClasses';
diff --git a/packages/material-ui/src/CardHeader/index.js b/packages/material-ui/src/CardHeader/index.js
index 9879cb20030b62..7f66c751b27942 100644
--- a/packages/material-ui/src/CardHeader/index.js
+++ b/packages/material-ui/src/CardHeader/index.js
@@ -1 +1,4 @@
 export { default } from './CardHeader';
+
+export { default as cardHeaderClasses } from './cardHeaderClasses';
+export * from './cardHeaderClasses';