Scripps_16_brand-name_heterocyclic_pharmaceuticals.smi

O=C(O)C[C@H](O)C[C@H](O)CCn2c(c(c(c2c1ccc(F)cc1)c3ccccc3)C(=O)Nc4ccccc4)C(C)C  Lipitor  Pfizer  $6.58B  high LDL, cholesterol  Atorvastatin
COc1ccc2nc([nH]c2c1)S(=O)Cc1ncc(C)c(OC)c1C  Nexium  Astra-Zeneca  $4.06B  heartburn / esophagitis  Esomeprazole
FC(F)(F)COc1ccnc(c1C)CS(=O)c2[nH]c3ccccc3n2  Prevacid  TAP  $3.31B  gastric reflux  Lansoprazole
O=C(O)CC1(CC1)CS[C@@H](c2cccc(c2)\C=C\c3nc4cc(Cl)ccc4cc3)CCc5ccccc5C(O)(C)C  Singulair  Merck  $2.48B  asthma  Montelukast
O=C(O[C@@H]1[C@H]3C(=C/[C@H](C)C1)\C=C/[C@@H]([C@@H]3CC[C@H]2OC(=O)C[C@H](O)C2)C)C(C)(C)CC  Zocor  Merck  $2.17B  high LDL, cholesterol  Simvastatin
COC(=O)[C@H](c1ccccc1Cl)N2CCc3c(ccs3)C2  Plavix  BMS  $2.23B  stroke / heart attack  Clopidogrel
Clc1ccccc1C2/C(C(=O)OC)=C(/C)N/C(COCCN)=C2/C(=O)OCC  Norvasc  Pfizer  $2.15B  hypertension / angina  Amlodipine
Fc1ccc(cc1)[C@@]3(OCc2cc(C#N)ccc23)CCCN(C)C  Lexapro  Forest  $2.10B  depression and axiety  Escitalopram
N\1=C(\c3c(Sc2c/1cccc2)cccc3)N4CCN(CCOCCO)CC4  Seroquel  Astra-Zeneca  $2.07B  schizophrenia / bipolar mania  Quetiapine
FC(F)Oc1ccc2[nH]c(nc2c1)S(=O)Cc3nccc(OC)c3OC  Protonix  Wyeth  $2.02B  esophagitis  Pantoprazole
CN(C)C(=O)Cc1c(nc2ccc(C)cn12)c3ccc(C)cc3  Ambien  Sanofi-Aventis  $1.94B  insomia  Zolpidem
O=C1NC(=O)SC1Cc3ccc(OCCc2ncc(cc2)CC)cc3  Actos  Eli Lilly  $1.93B  type 2 diabetes  Pioglitazone
O=C1NC(=O)SC1Cc3ccc(OCCN(c2ncccc2)C)cc3  Avandia  GSK  $1.66B  type 2 diabetes  Rosiglitazone
Cc1c(c(=O)n2c(n1)CCCC2)CCN3CCC(CC3)c4c5ccc(cc5on4)F  Risperdal  J & J  $1.66B  schizophrenia / bipolar mania  Risperidone
CN1CCN(CC1)C/2=N/c4ccccc4Nc3sc(C)cc\23  Zyprexa  Eli Lilly  $1.54B  schizophrenia / bipolar mania  Olanzapine
O=S(=O)(OC[C@@]21OC(O[C@H]1[C@@H]3OC(O[C@@H]3CO2)(C)C)(C)C)N  Topamax  J & J  $1.52B  seizures and migranes  Topiramate
Nc3nc2[nH]cc(CCc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)c2c(=O)[nH]3  Alimta  Eli Lilly   $-.--  cancer  Pemetrexed