diff --git a/lib/config/build-instrumentation-config.js b/lib/config/build-instrumentation-config.js
index c4fdebfb55..8582cbeef0 100644
--- a/lib/config/build-instrumentation-config.js
+++ b/lib/config/build-instrumentation-config.js
@@ -7,6 +7,13 @@
 const { boolean } = require('./formatters')
 const instrumentedLibraries = require('../instrumentations')()
 const pkgNames = Object.keys(instrumentedLibraries)
+const coreLibraries = require('../core-instrumentation')
+const corePkgs = Object.keys(coreLibraries)
+// Manually adding undici as it is registered separately in shimmer
+corePkgs.push('undici')
+// Manually adding domain as it is registered separately in shimmer
+corePkgs.push('domain')
+pkgNames.push(...corePkgs)
 
 /**
  * Builds the stanza for config.instrumentation.*
diff --git a/lib/config/default.js b/lib/config/default.js
index ac2d1481c3..68d28c2f21 100644
--- a/lib/config/default.js
+++ b/lib/config/default.js
@@ -1592,9 +1592,9 @@ defaultConfig.definition = () => ({
     }
   },
   /**
-   * Stanza that contains all keys to disable 3rd party package instrumentation(i.e. mongodb, pg, redis, etc)
-   * Note: Disabling a given 3rd party library may affect the instrumentation of 3rd party libraries used after
-   * the disabled library.
+   * Stanza that contains all keys to disable core & 3rd party package instrumentation(i.e. dns, http, mongodb, pg, redis, etc)
+   * **Note**: Disabling a given library may affect the instrumentation of libraries used after
+   * the disabled library. Use at your own risk.
    */
   instrumentation: pkgInstrumentation
 })
diff --git a/lib/core-instrumentation.js b/lib/core-instrumentation.js
new file mode 100644
index 0000000000..f0c64ca68d
--- /dev/null
+++ b/lib/core-instrumentation.js
@@ -0,0 +1,51 @@
+/*
+ * Copyright 2025 New Relic Corporation. All rights reserved.
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+'use strict'
+
+const InstrumentationDescriptor = require('./instrumentation-descriptor')
+
+module.exports = {
+  child_process: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'child_process.js'
+  },
+  crypto: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'crypto.js'
+  },
+  dns: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'dns.js'
+  },
+  fs: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'fs.js'
+  },
+  http: {
+    type: InstrumentationDescriptor.TYPE_TRANSACTION,
+    file: 'http.js'
+  },
+  https: {
+    type: InstrumentationDescriptor.TYPE_TRANSACTION,
+    file: 'http.js'
+  },
+  inspector: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'inspector.js'
+  },
+  net: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'net.js'
+  },
+  timers: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'timers.js'
+  },
+  zlib: {
+    type: InstrumentationDescriptor.TYPE_GENERIC,
+    file: 'zlib.js'
+  }
+}
diff --git a/lib/shimmer.js b/lib/shimmer.js
index ec2ee4cc2f..938d99ec0e 100644
--- a/lib/shimmer.js
+++ b/lib/shimmer.js
@@ -10,6 +10,7 @@ const semver = require('semver')
 const fs = require('./util/unwrapped-core').fs
 const logger = require('./logger').child({ component: 'shimmer' })
 const INSTRUMENTATIONS = require('./instrumentations')()
+const CORE_INSTRUMENTATION = require('./core-instrumentation')
 const shims = require('./shim')
 const { Hook } = require('require-in-the-middle')
 const IitmHook = require('import-in-the-middle')
@@ -24,53 +25,6 @@ const symbols = require('./symbols')
 const { unsubscribe } = require('./instrumentation/undici')
 const setupOtel = require('./otel/setup')
 
-const CORE_INSTRUMENTATION = {
-  child_process: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'child_process.js'
-  },
-  crypto: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'crypto.js'
-  },
-  // domain: {                     // XXX Do not include domains in this list! The
-  //   type: InstrumentationDescriptor.TYPE_GENERIC,  // core instrumentations are run at startup by
-  //   file: 'domain.js'           // requiring each of their modules. Loading
-  // },                            // `domain` has side effects that we try to avoid.
-  dns: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'dns.js'
-  },
-  fs: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'fs.js'
-  },
-  http: {
-    type: InstrumentationDescriptor.TYPE_TRANSACTION,
-    file: 'http.js'
-  },
-  https: {
-    type: InstrumentationDescriptor.TYPE_TRANSACTION,
-    file: 'http.js'
-  },
-  inspector: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'inspector.js'
-  },
-  net: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'net.js'
-  },
-  timers: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'timers.js'
-  },
-  zlib: {
-    type: InstrumentationDescriptor.TYPE_GENERIC,
-    file: 'zlib.js'
-  }
-}
-
 /**
  * Unwrapping is only likely to be used by test code, and is a fairly drastic
  * maneuver, but it should be pretty safe if there's a desire to reboot the
@@ -314,12 +268,7 @@ const shimmer = (module.exports = {
     // Even though domain is a core module we add it as a registered
     // instrumentation to be lazy-loaded because we do not want to cause domain
     // usage.
-    const domainPath = path.join(__dirname, 'instrumentation/core/domain.js')
-    shimmer.registerInstrumentation({
-      moduleName: 'domain',
-      type: null,
-      onRequire: _firstPartyInstrumentation.bind(null, agent, domainPath)
-    })
+    instrumentDomain(agent)
   },
 
   /**
@@ -328,42 +277,34 @@ const shimmer = (module.exports = {
    * @param {object} agent NR agent
    */
   registerCoreInstrumentation(agent) {
-    // Instrument global.
-    const globalShim = new shims.Shim(agent, 'globals', '.')
-    applyDebugState(globalShim, global, false)
-    const globalsFilepath = path.join(__dirname, 'instrumentation', 'core', 'globals.js')
-    _firstPartyInstrumentation(agent, globalsFilepath, globalShim, global, 'globals')
-
-    // Since this just registers subscriptions to diagnostics_channel events from undici
-    // We register this as core and it'll work for both fetch and undici
-    const undiciPath = path.join(__dirname, 'instrumentation', 'undici.js')
-    const undiciShim = shims.createShimFromType({
-      type: InstrumentationDescriptor.TYPE_TRANSACTION,
-      agent,
-      moduleName: 'undici',
-      resolvedName: '.'
-    })
-    _firstPartyInstrumentation(agent, undiciPath, undiciShim)
+    instrumentProcessMethods(agent)
+    instrumentUndiciFetch(agent)
 
     // Instrument each of the core modules.
     for (const [mojule, core] of Object.entries(CORE_INSTRUMENTATION)) {
-      const filePath = path.join(__dirname, 'instrumentation', 'core', core.file)
-      let uninstrumented = null
+      if (agent.config.instrumentation?.[mojule].enabled === false) {
+        logger.warn(
+            `Instrumentation for ${mojule} has been disabled via 'config.instrumentation.${mojule}.enabled. Not instrumenting package`
+        )
+      } else if (core.file) {
+        const filePath = path.join(__dirname, 'instrumentation', 'core', core.file)
+        let uninstrumented = null
 
-      try {
-        uninstrumented = require(mojule)
-      } catch (err) {
-        logger.trace('Could not load core module %s got error %s', mojule, err)
-      }
+        try {
+          uninstrumented = require(mojule)
+        } catch (err) {
+          logger.trace('Could not load core module %s got error %s', mojule, err)
+        }
 
-      const shim = shims.createShimFromType({
-        type: core.type,
-        agent,
-        moduleName: mojule,
-        resolvedName: mojule
-      })
-      applyDebugState(shim, core, false)
-      _firstPartyInstrumentation(agent, filePath, shim, uninstrumented, mojule)
+        const shim = shims.createShimFromType({
+          type: core.type,
+          agent,
+          moduleName: mojule,
+          resolvedName: mojule
+        })
+        applyDebugState(shim, core, false)
+        _firstPartyInstrumentation(agent, filePath, shim, uninstrumented, mojule)
+      }
     }
   },
 
@@ -824,3 +765,55 @@ function tryGetVersion(shim) {
 
   return shim.pkgVersion
 }
+
+/**
+ * Loads the instrumentation with `./lib/instrumentation/core/globals.js`
+ * This instrumentation cannot be disabled by config at the moment as it just
+ * handles logging errors for `uncaughtException` and `unhandledRejections`
+ *
+ * @param {Agent} agent the agent instance
+ */
+function instrumentProcessMethods(agent) {
+  const globalShim = new shims.Shim(agent, 'globals', '.')
+  applyDebugState(globalShim, global, false)
+  const globalsFilepath = path.join(__dirname, 'instrumentation', 'core', 'globals.js')
+  _firstPartyInstrumentation(agent, globalsFilepath, globalShim, global, 'globals')
+}
+
+/**
+ * Checks if undici/fetch instrumentation is enabled.
+ * If so, it loads the diagnostics_channel hooks to instrument outbound
+ * undici/fetch calls.
+ * Since this just registers subscriptions to diagnostics_channel events from undici,
+ * we register this as core and it'll work for both fetch and undici
+ *
+ * @param {Agent} agent the agent instance
+ */
+function instrumentUndiciFetch(agent) {
+  if (agent.config.instrumentation?.undici.enabled === false) {
+    logger.warn('Instrumentation for undici/fetch has been disabled via `config.instrumentation.undici.enabled`. Not instrumenting package')
+    return
+  }
+
+  const undiciPath = path.join(__dirname, 'instrumentation', 'undici.js')
+  const undiciShim = shims.createShimFromType({
+    type: InstrumentationDescriptor.TYPE_TRANSACTION,
+    agent,
+    moduleName: 'undici',
+    resolvedName: '.'
+  })
+  _firstPartyInstrumentation(agent, undiciPath, undiciShim)
+}
+
+function instrumentDomain(agent) {
+  if (agent.config.instrumentation?.domain.enabled === false) {
+    logger.warn('Instrumentation for domain has been disabled via `config.instrumentation.domain.enabled`. Not instrumenting package')
+    return
+  }
+  const domainPath = path.join(__dirname, 'instrumentation/core/domain.js')
+  shimmer.registerInstrumentation({
+    moduleName: 'domain',
+    type: null,
+    onRequire: _firstPartyInstrumentation.bind(null, agent, domainPath)
+  })
+}
diff --git a/test/unit/config/build-instrumentation-config.test.js b/test/unit/config/build-instrumentation-config.test.js
index 70f0fbebf5..30a7cf899a 100644
--- a/test/unit/config/build-instrumentation-config.test.js
+++ b/test/unit/config/build-instrumentation-config.test.js
@@ -17,4 +17,11 @@ test('should default the instrumentation stanza', () => {
   pkgNames.forEach((pkg) => {
     assert.deepEqual(pkgs[pkg], { enabled: { formatter: boolean, default: true } })
   })
+
+  assert.deepEqual(pkgs.undici, { enabled: { formatter: boolean, default: true } })
+  const coreLibraries = require('../../../lib/core-instrumentation')
+  const corePkgs = Object.keys(coreLibraries)
+  corePkgs.forEach((pkg) => {
+    assert.deepEqual(pkgs[pkg], { enabled: { formatter: boolean, default: true } })
+  })
 })
diff --git a/test/unit/config/config-defaults.test.js b/test/unit/config/config-defaults.test.js
index b67975fb2a..0907b4b986 100644
--- a/test/unit/config/config-defaults.test.js
+++ b/test/unit/config/config-defaults.test.js
@@ -315,6 +315,9 @@ test('with default properties', async (t) => {
     assert.equal(configuration.instrumentation.express.enabled, true)
     assert.equal(configuration.instrumentation['@prisma/client'].enabled, true)
     assert.equal(configuration.instrumentation.npmlog.enabled, true)
+    assert.equal(configuration.instrumentation.http.enabled, true)
+    assert.equal(configuration.instrumentation.undici.enabled, true)
+    assert.equal(configuration.instrumentation.domain.enabled, true)
   })
 })
 
diff --git a/test/unit/config/config-env.test.js b/test/unit/config/config-env.test.js
index 35501d9365..6fda03ef1c 100644
--- a/test/unit/config/config-env.test.js
+++ b/test/unit/config/config-env.test.js
@@ -874,12 +874,18 @@ test('when overriding configuration values via environment variables', async (t)
       const env = {
         NEW_RELIC_INSTRUMENTATION_IOREDIS_ENABLED: 'false',
         'NEW_RELIC_INSTRUMENTATION_@GRPC/GRPC-JS_ENABLED': 'false',
-        NEW_RELIC_INSTRUMENTATION_KNEX_ENABLED: 'false'
+        NEW_RELIC_INSTRUMENTATION_KNEX_ENABLED: 'false',
+        NEW_RELIC_INSTRUMENTATION_HTTP_ENABLED: 'false',
+        NEW_RELIC_INSTRUMENTATION_UNDICI_ENABLED: 'false',
+        NEW_RELIC_INSTRUMENTATION_DOMAIN_ENABLED: 'false',
       }
       idempotentEnv(env, (config) => {
         assert.equal(config.instrumentation.ioredis.enabled, false)
         assert.equal(config.instrumentation['@grpc/grpc-js'].enabled, false)
         assert.equal(config.instrumentation.knex.enabled, false)
+        assert.equal(config.instrumentation.http.enabled, false)
+        assert.equal(config.instrumentation.undici.enabled, false)
+        assert.equal(config.instrumentation.domain.enabled, false)
         end()
       })
     })