diff --git a/CHANGELOG.md b/CHANGELOG.md
index b834f2fe..01f4cca1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -31,6 +31,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Make target bed file optional for WGS mode (Issue [#375](https://github.com/nf-core/raredisease/issues/375)) [#395](https://github.com/nf-core/raredisease/pull/395)
 - Added constraints to block the pipeline from running CollectWgsMetrics on WES samples [#396](https://github.com/nf-core/raredisease/pull/396)
 - Updated modules from nf-core [#412](https://github.com/nf-core/raredisease/pull/412)
+- If present, remove duplicate entries in probands and upd_children in the meta. [#420](https://github.com/nf-core/raredisease/pull/420)
 
 ### `Updated`
 
diff --git a/workflows/raredisease.nf b/workflows/raredisease.nf
index 1d1d8ddd..a3e1050d 100644
--- a/workflows/raredisease.nf
+++ b/workflows/raredisease.nf
@@ -650,8 +650,8 @@ def create_case_channel(List rows) {
 
     case_info.father       = father
     case_info.mother       = mother
-    case_info.probands     = probands
-    case_info.upd_children = upd_children
+    case_info.probands     = probands.unique()
+    case_info.upd_children = upd_children.unique()
     case_info.id           = rows[0].case_id
 
     return case_info