diff --git a/nipype/interfaces/ants/registration.py b/nipype/interfaces/ants/registration.py
index 7ab6b30c30..478b26dc36 100644
--- a/nipype/interfaces/ants/registration.py
+++ b/nipype/interfaces/ants/registration.py
@@ -585,7 +585,11 @@ class RegistrationInputSpec(ANTSCommandInputSpec):
         usedefault=True,
         desc="The Lower quantile to clip image ranges",
     )
-
+    random_seed = traits.Int(
+        argstr="--random-seed %d",
+        desc="Fixed seed for random number generation",
+        min_ver="2.3.0",
+    )
     verbose = traits.Bool(
         argstr="-v", default_value=False, usedefault=True, nohash=True
     )
@@ -1708,6 +1712,11 @@ class RegistrationSynQuickInputSpec(ANTSCommandInputSpec):
         desc="precision type (default = double)",
         usedefault=True,
     )
+    random_seed = traits.Int(
+        argstr="-e %d",
+        desc="fixed random seed",
+        min_ver="2.3.0",
+    )
 
 
 class RegistrationSynQuickOutputSpec(TraitedSpec):
diff --git a/nipype/interfaces/ants/tests/test_auto_Registration.py b/nipype/interfaces/ants/tests/test_auto_Registration.py
index 507e0effe2..814948835c 100644
--- a/nipype/interfaces/ants/tests/test_auto_Registration.py
+++ b/nipype/interfaces/ants/tests/test_auto_Registration.py
@@ -115,6 +115,10 @@ def test_Registration_inputs():
             requires=["metric_weight"],
             usedefault=True,
         ),
+        random_seed=dict(
+            argstr="--random-seed %d",
+            min_ver="2.3.0",
+        ),
         restore_state=dict(
             argstr="--restore-state %s",
             extensions=None,
diff --git a/nipype/interfaces/ants/tests/test_auto_RegistrationSynQuick.py b/nipype/interfaces/ants/tests/test_auto_RegistrationSynQuick.py
index c09f08d17a..c799f47299 100644
--- a/nipype/interfaces/ants/tests/test_auto_RegistrationSynQuick.py
+++ b/nipype/interfaces/ants/tests/test_auto_RegistrationSynQuick.py
@@ -39,6 +39,10 @@ def test_RegistrationSynQuick_inputs():
             argstr="-p %s",
             usedefault=True,
         ),
+        random_seed=dict(
+            argstr="-e %d",
+            min_ver="2.3.0",
+        ),
         spline_distance=dict(
             argstr="-s %d",
             usedefault=True,