diff --git a/deps/uv/config-unix.mk b/deps/uv/config-unix.mk
index 8fe7254cfdd..ca1b1453e37 100644
--- a/deps/uv/config-unix.mk
+++ b/deps/uv/config-unix.mk
@@ -50,7 +50,7 @@ endif
 ifeq (Darwin,$(uname_S))
 EV_CONFIG=config_darwin.h
 EIO_CONFIG=config_darwin.h
-CPPFLAGS += -Isrc/ares/config_darwin
+CPPFLAGS += -D_DARWIN_USE_64_BIT_INODE=1 -Isrc/ares/config_darwin
 LINKFLAGS+=-framework CoreServices
 OBJS += src/unix/darwin.o
 OBJS += src/unix/kqueue.o
diff --git a/wscript b/wscript
index 2b04358559a..a63db7d3aeb 100644
--- a/wscript
+++ b/wscript
@@ -469,6 +469,9 @@ def configure(conf):
   conf.env.append_value('CPPFLAGS',  '-D_LARGEFILE_SOURCE')
   conf.env.append_value('CPPFLAGS',  '-D_FILE_OFFSET_BITS=64')
 
+  if sys.platform.startswith('darwin'):
+    conf.env.append_value('CPPFLAGS', '-D_DARWIN_USE_64_BIT_INODE=1')
+
   # Makes select on windows support more than 64 FDs
   if sys.platform.startswith("win32"):
     conf.env.append_value('CPPFLAGS', '-DFD_SETSIZE=1024');