diff --git a/src/node.cc b/src/node.cc
index fe2fc2a6a4eda6..41aeb1934aee74 100644
--- a/src/node.cc
+++ b/src/node.cc
@@ -2925,7 +2925,7 @@ static Local<Object> GetFeatures(Environment* env) {
   // TODO(bnoordhuis) ping libuv
   obj->Set(FIXED_ONE_BYTE_STRING(env->isolate(), "ipv6"), True(env->isolate()));
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   Local<Boolean> tls_npn = True(env->isolate());
 #else
   Local<Boolean> tls_npn = False(env->isolate());
diff --git a/src/node_constants.cc b/src/node_constants.cc
index 2e6be8df37c345..750df9c669bad3 100644
--- a/src/node_constants.cc
+++ b/src/node_constants.cc
@@ -940,7 +940,7 @@ void DefineOpenSSLConstants(Local<Object> target) {
     NODE_DEFINE_CONSTANT(target, DH_NOT_SUITABLE_GENERATOR);
 #endif
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
 #define NPN_ENABLED 1
     NODE_DEFINE_CONSTANT(target, NPN_ENABLED);
 #endif
diff --git a/src/node_crypto.cc b/src/node_crypto.cc
index eb23d787c238e2..28057e774f3802 100644
--- a/src/node_crypto.cc
+++ b/src/node_crypto.cc
@@ -147,7 +147,7 @@ template void SSLWrap<TLSWrap>::OnClientHello(
     void* arg,
     const ClientHelloParser::ClientHello& hello);
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
 template int SSLWrap<TLSWrap>::AdvertiseNextProtoCallback(
     SSL* s,
     const unsigned char** data,
@@ -1309,11 +1309,11 @@ void SSLWrap<Base>::AddMethods(Environment* env, Local<FunctionTemplate> t) {
   env->SetProtoMethod(t, "setMaxSendFragment", SetMaxSendFragment);
 #endif  // SSL_set_max_send_fragment
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   env->SetProtoMethod(t, "getNegotiatedProtocol", GetNegotiatedProto);
-#endif  // OPENSSL_NPN_NEGOTIATED
+#endif  // OPENSSL_NO_NEXTPROTONEG
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   env->SetProtoMethod(t, "setNPNProtocols", SetNPNProtocols);
 #endif
 
@@ -1333,7 +1333,7 @@ void SSLWrap<Base>::AddMethods(Environment* env, Local<FunctionTemplate> t) {
 
 template <class Base>
 void SSLWrap<Base>::InitNPN(SecureContext* sc) {
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   // Server should advertise NPN protocols
   SSL_CTX_set_next_protos_advertised_cb(sc->ctx_,
                                         AdvertiseNextProtoCallback,
@@ -1341,7 +1341,7 @@ void SSLWrap<Base>::InitNPN(SecureContext* sc) {
   // Client should select protocol from list of advertised
   // If server supports NPN
   SSL_CTX_set_next_proto_select_cb(sc->ctx_, SelectNextProtoCallback, nullptr);
-#endif  // OPENSSL_NPN_NEGOTIATED
+#endif  // OPENSSL_NO_NEXTPROTONEG
 
 #ifdef NODE__HAVE_TLSEXT_STATUS_CB
   // OCSP stapling
@@ -2098,7 +2098,7 @@ void SSLWrap<Base>::GetProtocol(const FunctionCallbackInfo<Value>& args) {
 }
 
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
 template <class Base>
 int SSLWrap<Base>::AdvertiseNextProtoCallback(SSL* s,
                                               const unsigned char** data,
@@ -2238,7 +2238,7 @@ void SSLWrap<Base>::SetNPNProtocols(const FunctionCallbackInfo<Value>& args) {
           env->npn_buffer_private_symbol(),
           args[0]).FromJust());
 }
-#endif  // OPENSSL_NPN_NEGOTIATED
+#endif  // OPENSSL_NO_NEXTPROTONEG
 
 #ifdef TLSEXT_TYPE_application_layer_protocol_negotiation
 template <class Base>
diff --git a/src/node_crypto.h b/src/node_crypto.h
index 175206c40df586..38f49ba5a05063 100644
--- a/src/node_crypto.h
+++ b/src/node_crypto.h
@@ -249,7 +249,7 @@ class SSLWrap {
       const v8::FunctionCallbackInfo<v8::Value>& args);
 #endif  // SSL_set_max_send_fragment
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   static void GetNegotiatedProto(
       const v8::FunctionCallbackInfo<v8::Value>& args);
   static void SetNPNProtocols(const v8::FunctionCallbackInfo<v8::Value>& args);
@@ -263,7 +263,7 @@ class SSLWrap {
                                      const unsigned char* in,
                                      unsigned int inlen,
                                      void* arg);
-#endif  // OPENSSL_NPN_NEGOTIATED
+#endif  // OPENSSL_NO_NEXTPROTONEG
 
   static void GetALPNNegotiatedProto(
       const v8::FunctionCallbackInfo<v8::Value>& args);
@@ -328,7 +328,7 @@ class Connection : public AsyncWrap, public SSLWrap<Connection> {
   static void Initialize(Environment* env, v8::Local<v8::Object> target);
   void NewSessionDoneCb();
 
-#ifdef OPENSSL_NPN_NEGOTIATED
+#ifndef OPENSSL_NO_NEXTPROTONEG
   v8::Persistent<v8::Object> npnProtos_;
   v8::Persistent<v8::Value> selectedNPNProto_;
 #endif