diff --git a/test/sequential/sequential.status b/test/sequential/sequential.status
index f73b428de5f390..fce8bd959f0326 100644
--- a/test/sequential/sequential.status
+++ b/test/sequential/sequential.status
@@ -17,8 +17,6 @@ test-worker-prof: PASS, FLAKY
 [$system==linux]
 
 [$system==macos]
-# https://github.com/nodejs/node/issues/21781
-test-timers-blocking-callback: PASS, FLAKY
 
 [$system==solaris] # Also applies to SmartOS
 
diff --git a/test/sequential/test-timers-blocking-callback.js b/test/sequential/test-timers-blocking-callback.js
deleted file mode 100644
index a5e0f596a34b93..00000000000000
--- a/test/sequential/test-timers-blocking-callback.js
+++ /dev/null
@@ -1,114 +0,0 @@
-// Flags: --expose-internals
-'use strict';
-
-/*
- * This is a regression test for
- * https://github.com/nodejs/node-v0.x-archive/issues/15447 and
- * https://github.com/nodejs/node-v0.x-archive/issues/9333.
- *
- * When a timer is added in another timer's callback, its underlying timer
- * handle was started with a timeout that was actually incorrect.
- *
- * The reason was that the value that represents the current time was not
- * updated between the time the original callback was called and the time
- * the added timer was processed by timers.listOnTimeout. That led the
- * logic in timers.listOnTimeout to do an incorrect computation that made
- * the added timer fire with a timeout of scheduledTimeout +
- * timeSpentInCallback.
- *
- * This test makes sure that a timer added by another timer's callback
- * fires with the expected timeout.
- *
- * It makes sure that it works when the timers list for a given timeout is
- * empty (see testAddingTimerToEmptyTimersList) and when the timers list
- * is not empty (see testAddingTimerToNonEmptyTimersList).
- */
-
-const common = require('../common');
-const assert = require('assert');
-const { sleep } = require('internal/util');
-
-const TIMEOUT = 100;
-
-let nbBlockingCallbackCalls;
-let latestDelay;
-let timeCallbackScheduled;
-
-// These tests are timing dependent so they may fail even when the bug is
-// not present (if the host is sufficiently busy that the timers are delayed
-// significantly). However, they fail 100% of the time when the bug *is*
-// present, so to increase reliability, allow for a small number of retries.
-let retries = 2;
-
-function initTest() {
-  nbBlockingCallbackCalls = 0;
-  latestDelay = 0;
-  timeCallbackScheduled = 0;
-}
-
-function blockingCallback(retry, callback) {
-  ++nbBlockingCallbackCalls;
-
-  if (nbBlockingCallbackCalls > 1) {
-    latestDelay = Date.now() - timeCallbackScheduled;
-    // Even if timers can fire later than when they've been scheduled
-    // to fire, they shouldn't generally be more than 100% late in this case.
-    // But they are guaranteed to be at least 100ms late given the bug in
-    // https://github.com/nodejs/node-v0.x-archive/issues/15447 and
-    // https://github.com/nodejs/node-v0.x-archive/issues/9333.
-    if (latestDelay >= TIMEOUT * 2) {
-      if (retries > 0) {
-        retries--;
-        return retry(callback);
-      }
-      assert.fail(`timeout delayed by more than 100% (${latestDelay}ms)`);
-    }
-    if (callback)
-      return callback();
-  } else {
-    // Block by busy-looping to trigger the issue
-    sleep(TIMEOUT);
-
-    timeCallbackScheduled = Date.now();
-    setTimeout(blockingCallback.bind(null, retry, callback), TIMEOUT);
-  }
-}
-
-function testAddingTimerToEmptyTimersList(callback) {
-  initTest();
-  // Call setTimeout just once to make sure the timers list is
-  // empty when blockingCallback is called.
-  setTimeout(
-    blockingCallback.bind(null, testAddingTimerToEmptyTimersList, callback),
-    TIMEOUT
-  );
-}
-
-function testAddingTimerToNonEmptyTimersList() {
-  // If both timers fail and attempt a retry, only actually do anything for one
-  // of them.
-  let retryOK = true;
-  const retry = () => {
-    if (retryOK)
-      testAddingTimerToNonEmptyTimersList();
-    retryOK = false;
-  };
-
-  initTest();
-  // Call setTimeout twice with the same timeout to make
-  // sure the timers list is not empty when blockingCallback is called.
-  setTimeout(
-    blockingCallback.bind(null, retry),
-    TIMEOUT
-  );
-  setTimeout(
-    blockingCallback.bind(null, retry),
-    TIMEOUT
-  );
-}
-
-// Run the test for the empty timers list case, and then for the non-empty
-// timers list one.
-testAddingTimerToEmptyTimersList(
-  common.mustCall(testAddingTimerToNonEmptyTimersList)
-);