diff --git a/lib/internal/blob.js b/lib/internal/blob.js
index 4188d999f7fde7..9c6be6981f5b88 100644
--- a/lib/internal/blob.js
+++ b/lib/internal/blob.js
@@ -69,6 +69,8 @@ const {
   CountQueuingStrategy,
 } = require('internal/webstreams/queuingstrategies');
 
+const { queueMicrotask } = require('internal/process/task_queues');
+
 const kHandle = Symbol('kHandle');
 const kType = Symbol('kType');
 const kLength = Symbol('kLength');
@@ -284,7 +286,7 @@ class Blob {
         }
         if (buffer !== undefined)
           buffers.push(buffer);
-        readNext();
+        queueMicrotask(() => readNext());
       });
     };
     readNext();
diff --git a/test/parallel/test-blob.js b/test/parallel/test-blob.js
index 68fd2d547a0e80..6b6ce70687660e 100644
--- a/test/parallel/test-blob.js
+++ b/test/parallel/test-blob.js
@@ -315,3 +315,16 @@ assert.throws(() => new Blob({}), {
 
   delete Object.prototype.type;
 }
+
+(async () => {
+  // Refs: https://github.com/nodejs/node/issues/47301
+
+  const random = Buffer.alloc(256).fill('0');
+  const chunks = [];
+
+  for (let i = 0; i < random.length; i += 2) {
+    chunks.push(random.subarray(i, i + 2));
+  }
+
+  await new Blob(chunks).arrayBuffer();
+})().then(common.mustCall());