diff --git a/lib/_http_outgoing.js b/lib/_http_outgoing.js
index 23b850d1522c97..5816a34efa4ace 100644
--- a/lib/_http_outgoing.js
+++ b/lib/_http_outgoing.js
@@ -1218,6 +1218,8 @@ OutgoingMessage.prototype._flushOutput = function _flushOutput(socket) {
   // Refs: https://github.com/nodejs/node/pull/30958
   for (let i = 0; i < outputLength; i++) {
     const { data, encoding, callback } = outputData[i];
+    // Avoid any potential ref to Buffer in new generation from old generation
+    outputData[i].data = null;
     ret = socket.write(data, encoding, callback);
   }
   socket.uncork();