diff --git a/configure.py b/configure.py
index ace3d4e4dbeab3..04a7db46856016 100755
--- a/configure.py
+++ b/configure.py
@@ -55,7 +55,7 @@
 valid_mips_float_abi = ('soft', 'hard')
 valid_intl_modes = ('none', 'small-icu', 'full-icu', 'system-icu')
 icu_versions = json.loads((tools_path / 'icu' / 'icu_versions.json').read_text(encoding='utf-8'))
-maglev_enabled_architectures = ('x64', 'arm', 'arm64')
+maglev_enabled_architectures = ('x64', 'arm', 'arm64', 's390x')
 
 # builtins may be removed later if they have been disabled by options
 shareable_builtins = {'cjs_module_lexer/lexer': 'deps/cjs-module-lexer/lexer.js',
@@ -1830,6 +1830,7 @@ def configure_v8(o, configs):
   o['variables']['v8_promise_internal_field_count'] = 1 # Add internal field to promises for async hooks.
   o['variables']['v8_use_siphash'] = 0 if options.without_siphash else 1
   o['variables']['v8_enable_maglev'] = B(not options.v8_disable_maglev and
+                                         flavor != 'zos' and
                                          o['variables']['target_arch'] in maglev_enabled_architectures)
   o['variables']['v8_enable_pointer_compression'] = 1 if options.enable_pointer_compression else 0
   # Using the sandbox requires always allocating array buffer backing stores in the sandbox.