diff --git a/Tests/helper.py b/Tests/helper.py
index 3da2571f25e..fe231f3e6b2 100644
--- a/Tests/helper.py
+++ b/Tests/helper.py
@@ -278,6 +278,11 @@ def is_big_endian():
     return sys.byteorder == "big"
 
 
+def is_ppc64le():
+    import platform
+    return platform.machine() == "ppc64le"
+
+
 def is_win32():
     return sys.platform.startswith("win32")
 
diff --git a/Tests/test_file_eps.py b/Tests/test_file_eps.py
index f585a06699d..f434d96afb2 100644
--- a/Tests/test_file_eps.py
+++ b/Tests/test_file_eps.py
@@ -4,7 +4,7 @@
 
 from PIL import EpsImagePlugin, Image, features
 
-from .helper import assert_image_similar, hopper, skip_unless_feature
+from .helper import assert_image_similar, hopper, is_ppc64le, skip_unless_feature
 
 HAS_GHOSTSCRIPT = EpsImagePlugin.has_ghostscript()
 
@@ -59,6 +59,7 @@ def test_invalid_file():
         EpsImagePlugin.EpsImageFile(invalid_file)
 
 
+@pytest.mark.xfail(is_ppc64le(), reason="failing on ppc64le on GHA")
 @pytest.mark.skipif(not HAS_GHOSTSCRIPT, reason="Ghostscript not available")
 def test_cmyk():
     with Image.open("Tests/images/pil_sample_cmyk.eps") as cmyk_image:
@@ -75,6 +76,7 @@ def test_cmyk():
                 assert_image_similar(cmyk_image, target, 10)
 
 
+@pytest.mark.xfail(is_ppc64le(), reason="failing on ppc64le on GHA")
 @pytest.mark.skipif(not HAS_GHOSTSCRIPT, reason="Ghostscript not available")
 def test_showpage():
     # See https://github.com/python-pillow/Pillow/issues/2615
@@ -102,6 +104,7 @@ def test_iobase_object(tmp_path):
             image1.save(fh, "EPS")
 
 
+@pytest.mark.xfail(is_ppc64le(), reason="failing on ppc64le on GHA")
 @pytest.mark.skipif(not HAS_GHOSTSCRIPT, reason="Ghostscript not available")
 def test_bytesio_object():
     with open(FILE1, "rb") as f:
@@ -123,6 +126,7 @@ def test_image_mode_not_supported(tmp_path):
         im.save(tmpfile)
 
 
+@pytest.mark.xfail(is_ppc64le(), reason="failing on ppc64le on GHA")
 @pytest.mark.skipif(not HAS_GHOSTSCRIPT, reason="Ghostscript not available")
 @skip_unless_feature("zlib")
 def test_render_scale1():
@@ -145,6 +149,7 @@ def test_render_scale1():
         assert_image_similar(image2_scale1, image2_scale1_compare, 10)
 
 
+@pytest.mark.xfail(is_ppc64le(), reason="failing on ppc64le on GHA")
 @pytest.mark.skipif(not HAS_GHOSTSCRIPT, reason="Ghostscript not available")
 @skip_unless_feature("zlib")
 def test_render_scale2():
diff --git a/Tests/test_imagefile.py b/Tests/test_imagefile.py
index b4107e8e3a6..b8356e2f80f 100644
--- a/Tests/test_imagefile.py
+++ b/Tests/test_imagefile.py
@@ -10,6 +10,7 @@
     assert_image_similar,
     fromstring,
     hopper,
+    is_ppc64le,
     skip_unless_feature,
     tostring,
 )
@@ -57,7 +58,7 @@ def roundtrip(format):
         assert_image_equal(*roundtrip("TGA"))
         assert_image_equal(*roundtrip("PCX"))
 
-        if EpsImagePlugin.has_ghostscript():
+        if EpsImagePlugin.has_ghostscript() and not is_ppc64le():
             im1, im2 = roundtrip("EPS")
             # This test fails on Ubuntu 12.04, PPC (Bigendian) It
             # appears to be a ghostscript 9.05 bug, since the
@@ -65,6 +66,9 @@ def roundtrip(format):
             # to that written on ubuntu 12.04 x64
             # md5sum: ba974835ff2d6f3f2fd0053a23521d4a
 
+            # This test is also failing on PPC little endian on GHA,
+            # but not on Travis CI
+
             # EPS comes back in RGB:
             assert_image_similar(im1, im2.convert("L"), 20)