[NTR]Age-associated B cell

[emquardokus]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
age-associated B cell

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during autoimmune disease, including those with systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. doi: 10.1007/s00018-022-04433-9

Kira Rubtsova, Anatoly V. Rubtsov, Michael P. Cancro, Philippa Marrack; Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity. J Immunol 1 September 2015; 195 (5): 1933–1937. https://doi.org/10.4049/jimmunol.1501209

Mouat IC, Goldberg E, Horwitz MS. Age-associated B cells in autoimmune diseases. Cell Mol Life Sci. 2022 Jul 7;79(8):402. doi: 10.1007/s00018-022-04433-9. PMID: 35798993; PMCID: PMC9263041. (review article)
Excerpt from review: "ABCs, identified by expression of T-bet, CD11c, CD11b, and lack of CD21, were initially shown to increase during both aging and autoimmunity [10, 11]. It was then shown that ABCs also expand in a number of intracellular infections [12–14] and during transplant rejection [15]. ABCs are a class-switched, antigen-specific memory population that display a distinct transcriptional program from other B cell subsets [16, 17]. Single-cell RNA sequencing demonstrates that ABCs differentially express an array of genes compared to other B cell subsets, including those encoding transcription factors, cytokines, signaling molecules, and proteins related to motility and metabolism [18]."

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
Memory B cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID
Ellen M. Quardokus 0000-0001-7655-4833

Additional notes or concerns
NOTE: Category of B memory found in CellTypist annotation tool