diff --git a/tox.ini b/tox.ini
index d8461a1b81..be821e9adf 100644
--- a/tox.ini
+++ b/tox.ini
@@ -93,7 +93,7 @@ envlist =
 
     ; opentelemetry-instrumentation-urllib3
     py3{7,8,9,10,11}-test-instrumentation-urllib3
-    pypy3-test-instrumentation-urllib3
+    ;pypy3-test-instrumentation-urllib3
 
     ; opentelemetry-instrumentation-requests
     py3{7,8,9,10,11}-test-instrumentation-requests