diff --git a/.chloggen/3090-enable-multiinstrumentation-by-default.yaml b/.chloggen/3090-enable-multiinstrumentation-by-default.yaml
new file mode 100755
index 0000000000..e70319c5a5
--- /dev/null
+++ b/.chloggen/3090-enable-multiinstrumentation-by-default.yaml
@@ -0,0 +1,16 @@
+# One of 'breaking', 'deprecation', 'new_component', 'enhancement', 'bug_fix'
+change_type: 'breaking'
+
+# The name of the component, or a single word describing the area of concern, (e.g. collector, target allocator, auto-instrumentation, opamp, github action)
+component: auto-instrumentation
+
+# A brief description of the change. Surround your text with quotes ("") if it needs to start with a backtick (`).
+note: Enable multi instrumentation by default.
+
+# One or more tracking issues related to the change
+issues: [3090]
+
+# (Optional) One or more lines of additional information to render under the primary note.
+# These lines will be padded with 2 spaces and then inserted directly into the document.
+# Use pipe (|) for multiline entries.
+subtext:
diff --git a/main.go b/main.go
index a348db6496..55c754f2fb 100644
--- a/main.go
+++ b/main.go
@@ -151,7 +151,7 @@ func main() {
 			"Enabling this will ensure there is only one active controller manager.")
 	pflag.BoolVar(&createRBACPermissions, "create-rbac-permissions", false, "Automatically create RBAC permissions needed by the processors (deprecated)")
 	pflag.BoolVar(&createOpenShiftDashboard, "openshift-create-dashboard", false, "Create an OpenShift dashboard for monitoring the OpenTelemetryCollector instances")
-	pflag.BoolVar(&enableMultiInstrumentation, "enable-multi-instrumentation", false, "Controls whether the operator supports multi instrumentation")
+	pflag.BoolVar(&enableMultiInstrumentation, "enable-multi-instrumentation", true, "Controls whether the operator supports multi instrumentation")
 	pflag.BoolVar(&enableApacheHttpdInstrumentation, constants.FlagApacheHttpd, true, "Controls whether the operator supports Apache HTTPD auto-instrumentation")
 	pflag.BoolVar(&enableDotNetInstrumentation, constants.FlagDotNet, true, "Controls whether the operator supports dotnet auto-instrumentation")
 	pflag.BoolVar(&enableGoInstrumentation, constants.FlagGo, false, "Controls whether the operator supports Go auto-instrumentation")