diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index e9c5e3eeda..66903dc756 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -6,7 +6,7 @@ on:
     - 'release/*'
   pull_request:
 env:
-  CORE_REPO_SHA: cad261e5dae1fe986c87e6965664b45cc9ab73c3
+  CORE_REPO_SHA: 6bd163f6d670319eba6693b8465a068a1828f484
 
 jobs:
   build:
@@ -98,6 +98,6 @@ jobs:
         uses: actions/cache@v2
         with:
           path: .tox
-          key: tox-cache-${{ matrix.tox-environment }}-${{ hashFiles('tox.ini', 'dev-requirements.txt', 'docs-requirements.txt') }}
+          key: v2-tox-cache-${{ matrix.tox-environment }}-${{ hashFiles('tox.ini', 'dev-requirements.txt', 'docs-requirements.txt') }}
       - name: run tox
         run: tox -e ${{ matrix.tox-environment }}
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5457ac5f94..9d92afba25 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -34,7 +34,18 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#415](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/415))
 - `opentelemetry-instrumentation-tornado` Add request/response hooks.
   ([#426](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/426))
-- `opentelemetry-exporter-datadog` Add parsing exception events for error tags([#459](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/459))
+- `opentelemetry-exporter-datadog` Add parsing exception events for error tags.
+  ([#459](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/459))
+- `opentelemetry-instrumenation-django` now supports trace response headers.
+  ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
+- `opentelemetry-instrumenation-tornado` now supports trace response headers.
+  ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
+- `opentelemetry-instrumenation-pyramid` now supports trace response headers.
+  ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
+- `opentelemetry-instrumenation-falcon` now supports trace response headers.
+  ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
+- `opentelemetry-instrumenation-flask` now supports trace response headers.
+  ([#436](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/436))
 
 ### Removed
 - Remove `http.status_text` from span attributes
diff --git a/docs-requirements.txt b/docs-requirements.txt
index 4f0f3c3303..d378198d43 100644
--- a/docs-requirements.txt
+++ b/docs-requirements.txt
@@ -6,14 +6,13 @@ sphinx-autodoc-typehints
 # doesn't work for pkg_resources.
 -e "git+https://github.com/open-telemetry/opentelemetry-python.git#egg=opentelemetry-api&subdirectory=opentelemetry-api"
 -e "git+https://github.com/open-telemetry/opentelemetry-python.git#egg=opentelemetry-sdk&subdirectory=opentelemetry-sdk"
+-e "git+https://github.com/open-telemetry/opentelemetry-python.git#egg=opentelemetry-instrumentation&subdirectory=opentelemetry-instrumentation"
 
 # Required by opentelemetry-instrumentation
 fastapi~=0.58.1
 psutil~=5.7.0
 pymemcache~=1.3
 
--e "git+https://github.com/open-telemetry/opentelemetry-python.git#egg=opentelemetry-instrumentation&subdirectory=opentelemetry-instrumentation"
-
 # Required by conf
 django>=2.2
 
diff --git a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
index aeeb42bcb9..9b526c521f 100644
--- a/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-django/src/opentelemetry/instrumentation/django/middleware.py
@@ -20,6 +20,9 @@
 
 from opentelemetry.context import attach, detach
 from opentelemetry.instrumentation.django.version import __version__
+from opentelemetry.instrumentation.propagators import (
+    get_global_response_propagator,
+)
 from opentelemetry.instrumentation.utils import extract_attributes_from_object
 from opentelemetry.instrumentation.wsgi import (
     add_response_attributes,
@@ -179,6 +182,11 @@ def process_response(self, request, response):
                 response,
             )
 
+            propagator = get_global_response_propagator()
+            if propagator:
+                propagator.inject(response)
+
+            # record any exceptions raised while processing the request
             exception = request.META.pop(self._environ_exception_key, None)
             if _DjangoMiddleware._otel_response_hook:
                 _DjangoMiddleware._otel_response_hook(  # pylint: disable=not-callable
diff --git a/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py b/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
index fb12dd24f4..b6174e3000 100644
--- a/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
+++ b/instrumentation/opentelemetry-instrumentation-django/tests/test_middleware.py
@@ -26,10 +26,19 @@
     DjangoInstrumentor,
     _DjangoMiddleware,
 )
+from opentelemetry.instrumentation.propagators import (
+    TraceResponsePropagator,
+    set_global_response_propagator,
+)
 from opentelemetry.sdk.trace import Span
 from opentelemetry.test.test_base import TestBase
 from opentelemetry.test.wsgitestutil import WsgiTestBase
-from opentelemetry.trace import SpanKind, StatusCode
+from opentelemetry.trace import (
+    SpanKind,
+    StatusCode,
+    format_span_id,
+    format_trace_id,
+)
 from opentelemetry.util.http import get_excluded_urls, get_traced_request_attrs
 
 # pylint: disable=import-error
@@ -309,3 +318,27 @@ def response_hook(span, request, response):
         self.assertIsInstance(response_hook_args[1], HttpRequest)
         self.assertIsInstance(response_hook_args[2], HttpResponse)
         self.assertEqual(response_hook_args[2], response)
+
+    def test_trace_response_headers(self):
+        response = Client().get("/span_name/1234/")
+
+        self.assertNotIn("Server-Timing", response.headers)
+        self.memory_exporter.clear()
+
+        set_global_response_propagator(TraceResponsePropagator())
+
+        response = Client().get("/span_name/1234/")
+        span = self.memory_exporter.get_finished_spans()[0]
+
+        self.assertIn("traceresponse", response.headers)
+        self.assertEqual(
+            response.headers["Access-Control-Expose-Headers"], "traceresponse",
+        )
+        self.assertEqual(
+            response.headers["traceresponse"],
+            "00-{0}-{1}-01".format(
+                format_trace_id(span.get_span_context().trace_id),
+                format_span_id(span.get_span_context().span_id),
+            ),
+        )
+        self.memory_exporter.clear()
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
index 9aa3c14ea0..e5b6bae7d2 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/src/opentelemetry/instrumentation/falcon/__init__.py
@@ -99,6 +99,10 @@ def response_hook(span, req, resp):
 from opentelemetry import context, trace
 from opentelemetry.instrumentation.falcon.version import __version__
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.instrumentation.propagators import (
+    FuncSetter,
+    get_global_response_propagator,
+)
 from opentelemetry.instrumentation.utils import (
     extract_attributes_from_object,
     http_status_to_status_code,
@@ -119,6 +123,7 @@ def response_hook(span, req, resp):
 
 _excluded_urls = get_excluded_urls("FALCON")
 _traced_request_attrs = get_traced_request_attrs("FALCON")
+_response_propagation_setter = FuncSetter(falcon.api.Response.append_header)
 
 
 class FalconInstrumentor(BaseInstrumentor):
@@ -273,5 +278,9 @@ def process_response(
                 )
             )
 
+        propagator = get_global_response_propagator()
+        if propagator:
+            propagator.inject(resp, setter=_response_propagation_setter)
+
         if self._response_hook:
             self._response_hook(span, req, resp)
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/tests/test_falcon.py b/instrumentation/opentelemetry-instrumentation-falcon/tests/test_falcon.py
index 61c752afcd..016529a424 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/tests/test_falcon.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/tests/test_falcon.py
@@ -17,8 +17,13 @@
 from falcon import testing
 
 from opentelemetry.instrumentation.falcon import FalconInstrumentor
+from opentelemetry.instrumentation.propagators import (
+    TraceResponsePropagator,
+    get_global_response_propagator,
+    set_global_response_propagator,
+)
 from opentelemetry.test.test_base import TestBase
-from opentelemetry.trace import StatusCode
+from opentelemetry.trace import StatusCode, format_span_id, format_trace_id
 from opentelemetry.util.http import get_excluded_urls, get_traced_request_attrs
 
 from .app import make_app
@@ -197,6 +202,28 @@ def test_traced_request_attributes(self):
         self.assertEqual(span.attributes["query_string"], "q=abc")
         self.assertNotIn("not_available_attr", span.attributes)
 
+    def test_trace_response(self):
+        orig = get_global_response_propagator()
+        set_global_response_propagator(TraceResponsePropagator())
+
+        response = self.client().simulate_get(path="/hello?q=abc")
+        headers = response.headers
+        span = self.memory_exporter.get_finished_spans()[0]
+
+        self.assertIn("traceresponse", headers)
+        self.assertEqual(
+            headers["access-control-expose-headers"], "traceresponse",
+        )
+        self.assertEqual(
+            headers["traceresponse"],
+            "00-{0}-{1}-01".format(
+                format_trace_id(span.get_span_context().trace_id),
+                format_span_id(span.get_span_context().span_id),
+            ),
+        )
+
+        set_global_response_propagator(orig)
+
     def test_traced_not_recording(self):
         mock_tracer = Mock()
         mock_span = Mock()
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index f657a1f3bd..2b114f6821 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -55,6 +55,9 @@ def hello():
 from opentelemetry import context, trace
 from opentelemetry.instrumentation.flask.version import __version__
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.instrumentation.propagators import (
+    get_global_response_propagator,
+)
 from opentelemetry.propagate import extract
 from opentelemetry.util._time import _time_ns
 from opentelemetry.util.http import get_excluded_urls
@@ -91,6 +94,13 @@ def _start_response(status, response_headers, *args, **kwargs):
             if not _excluded_urls.url_disabled(flask.request.url):
                 span = flask.request.environ.get(_ENVIRON_SPAN_KEY)
 
+                propagator = get_global_response_propagator()
+                if propagator:
+                    propagator.inject(
+                        response_headers,
+                        setter=otel_wsgi.default_response_propagation_setter,
+                    )
+
                 if span:
                     otel_wsgi.add_response_attributes(
                         span, status, response_headers
diff --git a/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py b/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
index 3c62dd751d..aead569de8 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/tests/test_programmatic.py
@@ -18,6 +18,11 @@
 
 from opentelemetry import trace
 from opentelemetry.instrumentation.flask import FlaskInstrumentor
+from opentelemetry.instrumentation.propagators import (
+    TraceResponsePropagator,
+    get_global_response_propagator,
+    set_global_response_propagator,
+)
 from opentelemetry.test.test_base import TestBase
 from opentelemetry.test.wsgitestutil import WsgiTestBase
 from opentelemetry.util.http import get_excluded_urls
@@ -119,6 +124,31 @@ def test_simple(self):
         self.assertEqual(span_list[0].kind, trace.SpanKind.SERVER)
         self.assertEqual(span_list[0].attributes, expected_attrs)
 
+    def test_trace_response(self):
+        orig = get_global_response_propagator()
+
+        set_global_response_propagator(TraceResponsePropagator())
+        response = self.client.get("/hello/123")
+        headers = response.headers
+
+        span_list = self.memory_exporter.get_finished_spans()
+        self.assertEqual(len(span_list), 1)
+        span = span_list[0]
+
+        self.assertIn("traceresponse", headers)
+        self.assertEqual(
+            headers["access-control-expose-headers"], "traceresponse",
+        )
+        self.assertEqual(
+            headers["traceresponse"],
+            "00-{0}-{1}-01".format(
+                trace.format_trace_id(span.get_span_context().trace_id),
+                trace.format_span_id(span.get_span_context().span_id),
+            ),
+        )
+
+        set_global_response_propagator(orig)
+
     def test_not_recording(self):
         mock_tracer = Mock()
         mock_span = Mock()
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
index 45f65793ad..9e777623eb 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/src/opentelemetry/instrumentation/pyramid/callbacks.py
@@ -21,6 +21,9 @@
 
 import opentelemetry.instrumentation.wsgi as otel_wsgi
 from opentelemetry import context, trace
+from opentelemetry.instrumentation.propagators import (
+    get_global_response_propagator,
+)
 from opentelemetry.instrumentation.pyramid.version import __version__
 from opentelemetry.propagate import extract
 from opentelemetry.util._time import _time_ns
@@ -157,6 +160,10 @@ def trace_tween(request):
                     response_or_exception.headers,
                 )
 
+                propagator = get_global_response_propagator()
+                if propagator:
+                    propagator.inject(response.headers)
+
                 activation = request.environ.get(_ENVIRON_ACTIVATION_KEY)
 
                 if isinstance(response_or_exception, HTTPException):
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/tests/test_programmatic.py b/instrumentation/opentelemetry-instrumentation-pyramid/tests/test_programmatic.py
index ea3fd266a1..ce4151ad95 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/tests/test_programmatic.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/tests/test_programmatic.py
@@ -17,6 +17,11 @@
 from pyramid.config import Configurator
 
 from opentelemetry import trace
+from opentelemetry.instrumentation.propagators import (
+    TraceResponsePropagator,
+    get_global_response_propagator,
+    set_global_response_propagator,
+)
 from opentelemetry.instrumentation.pyramid import PyramidInstrumentor
 from opentelemetry.test.test_base import TestBase
 from opentelemetry.test.wsgitestutil import WsgiTestBase
@@ -98,6 +103,28 @@ def test_simple(self):
         self.assertEqual(span_list[0].kind, trace.SpanKind.SERVER)
         self.assertEqual(span_list[0].attributes, expected_attrs)
 
+    def test_response_headers(self):
+        orig = get_global_response_propagator()
+        set_global_response_propagator(TraceResponsePropagator())
+
+        response = self.client.get("/hello/500")
+        headers = response.headers
+        span = self.memory_exporter.get_finished_spans()[0]
+
+        self.assertIn("traceresponse", headers)
+        self.assertEqual(
+            headers["access-control-expose-headers"], "traceresponse",
+        )
+        self.assertEqual(
+            headers["traceresponse"],
+            "00-{0}-{1}-01".format(
+                trace.format_trace_id(span.get_span_context().trace_id),
+                trace.format_span_id(span.get_span_context().span_id),
+            ),
+        )
+
+        set_global_response_propagator(orig)
+
     def test_not_recording(self):
         mock_tracer = Mock()
         mock_span = Mock()
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
index 2fd6c7ffae..d7cf74b93f 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/src/opentelemetry/instrumentation/tornado/__init__.py
@@ -83,6 +83,10 @@ def client_resposne_hook(span, future):
 
 from opentelemetry import context, trace
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.instrumentation.propagators import (
+    FuncSetter,
+    get_global_response_propagator,
+)
 from opentelemetry.instrumentation.tornado.version import __version__
 from opentelemetry.instrumentation.utils import (
     extract_attributes_from_object,
@@ -105,6 +109,8 @@ def client_resposne_hook(span, future):
 _excluded_urls = get_excluded_urls("TORNADO")
 _traced_request_attrs = get_traced_request_attrs("TORNADO")
 
+response_propagation_setter = FuncSetter(tornado.web.RequestHandler.add_header)
+
 
 class TornadoInstrumentor(BaseInstrumentor):
     patched_handlers = []
@@ -256,6 +262,14 @@ def _start_span(tracer, handler, start_time) -> _TraceContext:
     activation.__enter__()  # pylint: disable=E1101
     ctx = _TraceContext(activation, span, token)
     setattr(handler, _HANDLER_CONTEXT_KEY, ctx)
+
+    # finish handler is called after the response is sent back to
+    # the client so it is too late to inject trace response headers
+    # there.
+    propagator = get_global_response_propagator()
+    if propagator:
+        propagator.inject(handler, setter=response_propagation_setter)
+
     return ctx
 
 
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py b/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
index d16e69e933..003f544008 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/tests/test_instrumentation.py
@@ -18,6 +18,11 @@
 from tornado.testing import AsyncHTTPTestCase
 
 from opentelemetry import trace
+from opentelemetry.instrumentation.propagators import (
+    TraceResponsePropagator,
+    get_global_response_propagator,
+    set_global_response_propagator,
+)
 from opentelemetry.instrumentation.tornado import (
     TornadoInstrumentor,
     patch_handler_class,
@@ -370,6 +375,32 @@ def test_traced_attrs(self):
         )
         self.memory_exporter.clear()
 
+    def test_response_headers(self):
+        orig = get_global_response_propagator()
+        set_global_response_propagator(TraceResponsePropagator())
+
+        response = self.fetch("/")
+        headers = response.headers
+
+        spans = self.sorted_spans(self.memory_exporter.get_finished_spans())
+        self.assertEqual(len(spans), 3)
+        server_span = spans[1]
+
+        self.assertIn("traceresponse", headers)
+        self.assertEqual(
+            headers["access-control-expose-headers"], "traceresponse",
+        )
+        self.assertEqual(
+            headers["traceresponse"],
+            "00-{0}-{1}-01".format(
+                trace.format_trace_id(server_span.get_span_context().trace_id),
+                trace.format_span_id(server_span.get_span_context().span_id),
+            ),
+        )
+
+        self.memory_exporter.clear()
+        set_global_response_propagator(orig)
+
 
 class TornadoHookTest(TornadoTest):
     _client_request_hook = None
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
index 2dffe0c5a1..bb5226ab67 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/__init__.py
@@ -75,14 +75,14 @@ def get(
         self, carrier: dict, key: str
     ) -> typing.Optional[typing.List[str]]:
         """Getter implementation to retrieve a HTTP header value from the
-            PEP3333-conforming WSGI environ
-
-       Args:
-            carrier: WSGI environ object
-            key: header name in environ object
-        Returns:
-            A list with a single string with the header value if it exists,
-            else None.
+             PEP3333-conforming WSGI environ
+
+        Args:
+             carrier: WSGI environ object
+             key: header name in environ object
+         Returns:
+             A list with a single string with the header value if it exists,
+             else None.
         """
         environ_key = "HTTP_" + key.upper().replace("-", "_")
         value = carrier.get(environ_key)
@@ -264,3 +264,14 @@ def _end_span_after_iterating(iterable, span, tracer, token):
             close()
         span.end()
         context.detach(token)
+
+
+# TODO: inherit from opentelemetry.instrumentation.propagators.Setter
+
+
+class ResponsePropagationSetter:
+    def set(self, carrier, key, value):  # pylint: disable=no-self-use
+        carrier.append((key, value))
+
+
+default_response_propagation_setter = ResponsePropagationSetter()