diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
index 097a75fd74..824db2983e 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/setup.py b/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
index fa8f48952c..35b33958ef 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/setup.py b/instrumentation/opentelemetry-instrumentation-asgi/setup.py
index cd0c883524..f89c65f0a2 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-asgi/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
index 8ef61369cf..785d822287 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-boto/setup.py b/instrumentation/opentelemetry-instrumentation-boto/setup.py
index 6facaa7344..0d99cc8926 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-boto/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/setup.py b/instrumentation/opentelemetry-instrumentation-botocore/setup.py
index fd9d7a6b0b..5317443224 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-botocore/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-celery/setup.py b/instrumentation/opentelemetry-instrumentation-celery/setup.py
index dab3395e73..c4a01d212a 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-celery/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/setup.py b/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
index 3bc6a5c0a9..2c1d28b951 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-django/setup.py b/instrumentation/opentelemetry-instrumentation-django/setup.py
index 7d1d1c64b0..5a425c0e5a 100644
--- a/instrumentation/opentelemetry-instrumentation-django/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-django/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
index 93972b63a9..41914e50a8 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/setup.py b/instrumentation/opentelemetry-instrumentation-falcon/setup.py
index 31a6510979..ca770e9260 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-falcon/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/setup.py b/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
index 2e82525512..a56f7434a0 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-flask/setup.py b/instrumentation/opentelemetry-instrumentation-flask/setup.py
index eb49ed319c..251d905739 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/setup.py b/instrumentation/opentelemetry-instrumentation-grpc/setup.py
index 564b2bc741..aaac587baa 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-grpc/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/setup.py b/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
index f7fec88457..f89c545429 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-logging/setup.py b/instrumentation/opentelemetry-instrumentation-logging/setup.py
index 51e00e8268..38f3826d33 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-logging/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/setup.py b/instrumentation/opentelemetry-instrumentation-mysql/setup.py
index 50326baefa..ba396f9ffb 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-mysql/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
index e59caef689..077f70345b 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
index 9173c05b9b..2964e4c7a6 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/setup.py b/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
index 49c97a0f45..23ea29503b 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/setup.py b/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
index fed1e1e99c..2da219349a 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/setup.py b/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
index 6e4176250b..20790df8c1 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-redis/setup.py b/instrumentation/opentelemetry-instrumentation-redis/setup.py
index 4a17a8c815..bc90b25aa8 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-redis/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-requests/setup.py b/instrumentation/opentelemetry-instrumentation-requests/setup.py
index bf5c455688..c8e36d3b1f 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-requests/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-sklearn/setup.py b/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
index 003d9736a6..8aec671b8d 100644
--- a/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sklearn/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
index e79859c22a..90170b54a7 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
index 4e3218495a..1ea62e9c0a 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/setup.py b/instrumentation/opentelemetry-instrumentation-starlette/setup.py
index a256b63c45..f7c28941c1 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-starlette/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/setup.py b/instrumentation/opentelemetry-instrumentation-tornado/setup.py
index cd4bb7484c..018b4773b3 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-tornado/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/setup.py b/instrumentation/opentelemetry-instrumentation-urllib/setup.py
index dcd501aa41..bebd64a09f 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/setup.py b/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
index fca33a5982..99c2c04396 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/setup.py b/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
index 3caa6fccd1..2ee7cfbfcf 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/setup.py
@@ -17,8 +17,6 @@
 # RUN `python scripts/generate_setup.py` TO REGENERATE.
 
 
-import distutils.cmd
-import json
 import os
 import distutils.cmd
 import json
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/package.py b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/package.py
index 7a66a17a93..fe3d56c0e3 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/package.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/src/opentelemetry/instrumentation/wsgi/package.py
@@ -13,4 +13,4 @@
 # limitations under the License.
 
 
-_instruments = tuple()
+_instruments = ("wsgiref ~= 0.1.2",)
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
index e691f0c360..20d1cc4361 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
@@ -105,6 +105,17 @@ def _is_installed(req):
         return False
     return True
 
+    try:
+        pkg_resources.get_distribution(req)
+    except pkg_resources.DistributionNotFound:
+        return False
+    except pkg_resources.VersionConflict as exc:
+        logger.warning(
+            "instrumentation for package %s is available but version %s is installed. Skipping."
+            % (exc.req, exc.dist.as_requirement())
+        )
+        return False
+    return True
 
 def _find_installed_libraries():
     libs = default_instrumentations[:]
diff --git a/templates/instrumentation_setup.py.txt b/templates/instrumentation_setup.py.txt
index 69fa7a1e4a..7d8ef523f5 100644
--- a/templates/instrumentation_setup.py.txt
+++ b/templates/instrumentation_setup.py.txt
@@ -81,7 +81,7 @@ class JSONMetadataCommand(distutils.cmd.Command):
 
 
 setuptools.setup(
-    cmdclass={'meta':  JSONMetadataCommand},
+    cmdclass={'meta': JSONMetadataCommand},
     version=PACKAGE_INFO["__version__"],
     extras_require=extras_require
 )
\ No newline at end of file