diff --git a/.github/workflows/core_contrib_test_0.yml b/.github/workflows/core_contrib_test_0.yml
index a8336e093f..cbe61bbf5e 100644
--- a/.github/workflows/core_contrib_test_0.yml
+++ b/.github/workflows/core_contrib_test_0.yml
@@ -19,8 +19,8 @@ env:
 
 jobs:
 
-  py38-test-instrumentation-openai-v2-0:
-    name: instrumentation-openai-v2-0 
+  py38-test-instrumentation-openai-v2-oldest:
+    name: instrumentation-openai-v2-oldest 
     runs-on: ubuntu-latest
     steps:
       - name: Checkout contrib repo @ SHA - ${{ env.CONTRIB_REPO_SHA }}
@@ -39,10 +39,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py38-test-instrumentation-openai-v2-oldest -- -ra
 
-  py38-test-instrumentation-openai-v2-1:
-    name: instrumentation-openai-v2-1 
+  py38-test-instrumentation-openai-v2-latest:
+    name: instrumentation-openai-v2-latest 
     runs-on: ubuntu-latest
     steps:
       - name: Checkout contrib repo @ SHA - ${{ env.CONTRIB_REPO_SHA }}
@@ -61,10 +61,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py38-test-instrumentation-openai-v2-latest -- -ra
 
-  py38-test-instrumentation-vertexai-0:
-    name: instrumentation-vertexai-0 
+  py38-test-instrumentation-vertexai-oldest:
+    name: instrumentation-vertexai-oldest 
     runs-on: ubuntu-latest
     steps:
       - name: Checkout contrib repo @ SHA - ${{ env.CONTRIB_REPO_SHA }}
@@ -83,10 +83,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py38-test-instrumentation-vertexai-oldest -- -ra
 
-  py38-test-instrumentation-vertexai-1:
-    name: instrumentation-vertexai-1 
+  py38-test-instrumentation-vertexai-latest:
+    name: instrumentation-vertexai-latest 
     runs-on: ubuntu-latest
     steps:
       - name: Checkout contrib repo @ SHA - ${{ env.CONTRIB_REPO_SHA }}
@@ -105,7 +105,7 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py38-test-instrumentation-vertexai-latest -- -ra
 
   py38-test-resource-detector-container:
     name: resource-detector-container 
diff --git a/.github/workflows/test_0.yml b/.github/workflows/test_0.yml
index b43a46b94f..9ef80687bc 100644
--- a/.github/workflows/test_0.yml
+++ b/.github/workflows/test_0.yml
@@ -16,8 +16,8 @@ env:
 
 jobs:
 
-  py38-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.8 Ubuntu
+  py38-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -32,10 +32,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py38-test-instrumentation-openai-v2-oldest -- -ra
 
-  py38-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.8 Ubuntu
+  py38-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -50,10 +50,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py38-test-instrumentation-openai-v2-latest -- -ra
 
-  py39-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.9 Ubuntu
+  py39-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.9 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -68,10 +68,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py39-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py39-test-instrumentation-openai-v2-oldest -- -ra
 
-  py39-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.9 Ubuntu
+  py39-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.9 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -86,10 +86,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py39-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py39-test-instrumentation-openai-v2-latest -- -ra
 
-  py310-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.10 Ubuntu
+  py310-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.10 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -104,10 +104,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py310-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py310-test-instrumentation-openai-v2-oldest -- -ra
 
-  py310-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.10 Ubuntu
+  py310-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.10 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -122,10 +122,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py310-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py310-test-instrumentation-openai-v2-latest -- -ra
 
-  py311-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.11 Ubuntu
+  py311-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.11 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -140,10 +140,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py311-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py311-test-instrumentation-openai-v2-oldest -- -ra
 
-  py311-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.11 Ubuntu
+  py311-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.11 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -158,10 +158,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py311-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py311-test-instrumentation-openai-v2-latest -- -ra
 
-  py312-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.12 Ubuntu
+  py312-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.12 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -176,10 +176,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py312-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py312-test-instrumentation-openai-v2-oldest -- -ra
 
-  py312-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.12 Ubuntu
+  py312-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.12 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -194,10 +194,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py312-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py312-test-instrumentation-openai-v2-latest -- -ra
 
-  py313-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 3.13 Ubuntu
+  py313-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest 3.13 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -212,10 +212,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py313-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e py313-test-instrumentation-openai-v2-oldest -- -ra
 
-  py313-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 3.13 Ubuntu
+  py313-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest 3.13 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -230,10 +230,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py313-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e py313-test-instrumentation-openai-v2-latest -- -ra
 
-  pypy3-test-instrumentation-openai-v2-0_ubuntu-latest:
-    name: instrumentation-openai-v2-0 pypy-3.8 Ubuntu
+  pypy3-test-instrumentation-openai-v2-oldest_ubuntu-latest:
+    name: instrumentation-openai-v2-oldest pypy-3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -248,10 +248,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e pypy3-test-instrumentation-openai-v2-0 -- -ra
+        run: tox -e pypy3-test-instrumentation-openai-v2-oldest -- -ra
 
-  pypy3-test-instrumentation-openai-v2-1_ubuntu-latest:
-    name: instrumentation-openai-v2-1 pypy-3.8 Ubuntu
+  pypy3-test-instrumentation-openai-v2-latest_ubuntu-latest:
+    name: instrumentation-openai-v2-latest pypy-3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -266,10 +266,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e pypy3-test-instrumentation-openai-v2-1 -- -ra
+        run: tox -e pypy3-test-instrumentation-openai-v2-latest -- -ra
 
-  py38-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.8 Ubuntu
+  py38-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -284,10 +284,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py38-test-instrumentation-vertexai-oldest -- -ra
 
-  py38-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.8 Ubuntu
+  py38-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.8 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -302,10 +302,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py38-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py38-test-instrumentation-vertexai-latest -- -ra
 
-  py39-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.9 Ubuntu
+  py39-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.9 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -320,10 +320,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py39-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py39-test-instrumentation-vertexai-oldest -- -ra
 
-  py39-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.9 Ubuntu
+  py39-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.9 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -338,10 +338,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py39-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py39-test-instrumentation-vertexai-latest -- -ra
 
-  py310-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.10 Ubuntu
+  py310-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.10 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -356,10 +356,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py310-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py310-test-instrumentation-vertexai-oldest -- -ra
 
-  py310-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.10 Ubuntu
+  py310-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.10 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -374,10 +374,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py310-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py310-test-instrumentation-vertexai-latest -- -ra
 
-  py311-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.11 Ubuntu
+  py311-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.11 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -392,10 +392,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py311-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py311-test-instrumentation-vertexai-oldest -- -ra
 
-  py311-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.11 Ubuntu
+  py311-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.11 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -410,10 +410,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py311-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py311-test-instrumentation-vertexai-latest -- -ra
 
-  py312-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.12 Ubuntu
+  py312-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.12 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -428,10 +428,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py312-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py312-test-instrumentation-vertexai-oldest -- -ra
 
-  py312-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.12 Ubuntu
+  py312-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.12 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -446,10 +446,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py312-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py312-test-instrumentation-vertexai-latest -- -ra
 
-  py313-test-instrumentation-vertexai-0_ubuntu-latest:
-    name: instrumentation-vertexai-0 3.13 Ubuntu
+  py313-test-instrumentation-vertexai-oldest_ubuntu-latest:
+    name: instrumentation-vertexai-oldest 3.13 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -464,10 +464,10 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py313-test-instrumentation-vertexai-0 -- -ra
+        run: tox -e py313-test-instrumentation-vertexai-oldest -- -ra
 
-  py313-test-instrumentation-vertexai-1_ubuntu-latest:
-    name: instrumentation-vertexai-1 3.13 Ubuntu
+  py313-test-instrumentation-vertexai-latest_ubuntu-latest:
+    name: instrumentation-vertexai-latest 3.13 Ubuntu
     runs-on: ubuntu-latest
     steps:
       - name: Checkout repo @ SHA - ${{ github.sha }}
@@ -482,7 +482,7 @@ jobs:
         run: pip install tox-uv
 
       - name: Run tests
-        run: tox -e py313-test-instrumentation-vertexai-1 -- -ra
+        run: tox -e py313-test-instrumentation-vertexai-latest -- -ra
 
   py38-test-resource-detector-container_ubuntu-latest:
     name: resource-detector-container 3.8 Ubuntu
diff --git a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-0.txt b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-0.txt
deleted file mode 100644
index 4e88239d1c..0000000000
--- a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-0.txt
+++ /dev/null
@@ -1,16 +0,0 @@
-openai==1.26.0
-pydantic==2.8.2
-httpx==0.27.2
-Deprecated==1.2.14
-importlib-metadata==6.11.0
-packaging==24.0
-pytest==7.4.4
-pytest-vcr==1.0.2
-pytest-asyncio==0.21.0
-wrapt==1.16.0
-opentelemetry-exporter-otlp-proto-http~=1.30
-opentelemetry-api==1.30  # when updating, also update in pyproject.toml
-opentelemetry-sdk==1.30  # when updating, also update in pyproject.toml
-opentelemetry-semantic-conventions==0.51b0  # when updating, also update in pyproject.toml
-
--e instrumentation-genai/opentelemetry-instrumentation-openai-v2
diff --git a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-1.txt b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-1.txt
deleted file mode 100644
index 6725ed7b66..0000000000
--- a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-1.txt
+++ /dev/null
@@ -1,14 +0,0 @@
-openai==1.26.0
-pydantic==2.8.2
-httpx==0.27.2
-Deprecated==1.2.14
-importlib-metadata==6.11.0
-packaging==24.0
-pytest==7.4.4
-pytest-vcr==1.0.2
-pytest-asyncio==0.21.0
-wrapt==1.16.0
-# test with the latest version of opentelemetry-api, sdk, and semantic conventions
-
--e opentelemetry-instrumentation
--e instrumentation-genai/opentelemetry-instrumentation-openai-v2
diff --git a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.latest.txt b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.latest.txt
new file mode 100644
index 0000000000..abed97360f
--- /dev/null
+++ b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.latest.txt
@@ -0,0 +1,52 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+
+# ********************************
+# WARNING: NOT HERMETIC !!!!!!!!!!
+# ********************************
+#
+# This "requirements.txt" is installed in conjunction
+# with multiple other dependencies in the top-level "tox.ini"
+# file. In particular, please see:
+#
+#   openai-latest: {[testenv]test_deps}
+#   openai-latest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.latest.txt
+#
+# This provides additional dependencies, namely:
+#
+#   opentelemetry-api
+#   opentelemetry-sdk
+#   opentelemetry-semantic-conventions
+#
+# ... with a "dev" version based on the latest distribution.
+
+
+# This variant of the requirements aims to test the system using
+# the newest supported version of external dependencies.
+
+openai==1.26.0
+pydantic==2.8.2
+httpx==0.27.2
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+packaging==24.0
+pytest==7.4.4
+pytest-vcr==1.0.2
+pytest-asyncio==0.21.0
+wrapt==1.16.0
+# test with the latest version of opentelemetry-api, sdk, and semantic conventions
+
+-e opentelemetry-instrumentation
+-e instrumentation-genai/opentelemetry-instrumentation-openai-v2
diff --git a/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.oldest.txt b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.oldest.txt
new file mode 100644
index 0000000000..6b46a6eaa4
--- /dev/null
+++ b/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.oldest.txt
@@ -0,0 +1,33 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+# This variant of the requirements aims to test the system using
+# the oldest supported version of external dependencies.
+
+openai==1.26.0
+pydantic==2.8.2
+httpx==0.27.2
+Deprecated==1.2.14
+importlib-metadata==6.11.0
+packaging==24.0
+pytest==7.4.4
+pytest-vcr==1.0.2
+pytest-asyncio==0.21.0
+wrapt==1.16.0
+opentelemetry-exporter-otlp-proto-http~=1.30
+opentelemetry-api==1.30  # when updating, also update in pyproject.toml
+opentelemetry-sdk==1.30  # when updating, also update in pyproject.toml
+opentelemetry-semantic-conventions==0.51b0  # when updating, also update in pyproject.toml
+
+-e instrumentation-genai/opentelemetry-instrumentation-openai-v2
diff --git a/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-1.txt b/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-1.txt
deleted file mode 100644
index 96ee7fd47e..0000000000
--- a/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-1.txt
+++ /dev/null
@@ -1,54 +0,0 @@
-annotated-types==0.7.0
-asgiref==3.8.1
-cachetools==5.5.0
-certifi==2024.8.30
-charset-normalizer==3.4.0
-Deprecated==1.2.15
-docstring_parser==0.16
-exceptiongroup==1.2.2
-google-api-core==2.23.0
-google-auth==2.36.0
-google-cloud-aiplatform==1.79.0
-google-cloud-bigquery==3.27.0
-google-cloud-core==2.4.1
-google-cloud-resource-manager==1.13.1
-google-cloud-storage==2.19.0
-google-crc32c==1.5.0
-google-resumable-media==2.7.2
-googleapis-common-protos==1.66.0
-grpc-google-iam-v1==0.13.1
-grpcio==1.68.1
-grpcio-status==1.68.1
-idna==3.10
-importlib_metadata==8.5.0
-iniconfig==2.0.0
-multidict==6.1.0
-packaging==24.2
-pluggy==1.5.0
-propcache==0.2.0
-proto-plus==1.25.0
-protobuf==5.29.1
-pyasn1==0.6.1
-pyasn1_modules==0.4.1
-pydantic==2.10.3
-pydantic_core==2.27.1
-pytest==7.4.4
-pytest-asyncio==0.21.0
-pytest-vcr==1.0.2
-python-dateutil==2.9.0.post0
-PyYAML==6.0.2
-requests==2.32.3
-rsa==4.9
-shapely==2.0.6
-six==1.17.0
-tomli==2.2.1
-typing_extensions==4.12.2
-urllib3==1.26.20
-vcrpy==6.0.2
-wrapt==1.17.0
-yarl==1.15.2
-zipp==3.20.2
-# test with the latest version of opentelemetry-api, sdk, and semantic conventions
-
--e opentelemetry-instrumentation
--e instrumentation-genai/opentelemetry-instrumentation-vertexai[instruments]
diff --git a/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.latest.txt b/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.latest.txt
new file mode 100644
index 0000000000..76f3c77070
--- /dev/null
+++ b/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.latest.txt
@@ -0,0 +1,92 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+
+# ********************************
+# WARNING: NOT HERMETIC !!!!!!!!!!
+# ********************************
+#
+# This "requirements.txt" is installed in conjunction
+# with multiple other dependencies in the top-level "tox.ini"
+# file. In particular, please see:
+#
+#   vertexai-latest: {[testenv]test_deps}
+#   vertexai-latest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.latest.txt
+#
+# This provides additional dependencies, namely:
+#
+#   opentelemetry-api
+#   opentelemetry-sdk
+#   opentelemetry-semantic-conventions
+#
+# ... with a "dev" version based on the latest distribution.
+
+
+# This variant of the requirements aims to test the system using
+# the newest supported version of external dependencies.
+
+annotated-types==0.7.0
+asgiref==3.8.1
+cachetools==5.5.0
+certifi==2024.8.30
+charset-normalizer==3.4.0
+Deprecated==1.2.15
+docstring_parser==0.16
+exceptiongroup==1.2.2
+google-api-core==2.23.0
+google-auth==2.36.0
+google-cloud-aiplatform==1.79.0
+google-cloud-bigquery==3.27.0
+google-cloud-core==2.4.1
+google-cloud-resource-manager==1.13.1
+google-cloud-storage==2.19.0
+google-crc32c==1.5.0
+google-resumable-media==2.7.2
+googleapis-common-protos==1.66.0
+grpc-google-iam-v1==0.13.1
+grpcio==1.68.1
+grpcio-status==1.68.1
+idna==3.10
+importlib_metadata==8.5.0
+iniconfig==2.0.0
+multidict==6.1.0
+packaging==24.2
+pluggy==1.5.0
+propcache==0.2.0
+proto-plus==1.25.0
+protobuf==5.29.1
+pyasn1==0.6.1
+pyasn1_modules==0.4.1
+pydantic==2.10.3
+pydantic_core==2.27.1
+pytest==7.4.4
+pytest-asyncio==0.21.0
+pytest-vcr==1.0.2
+python-dateutil==2.9.0.post0
+PyYAML==6.0.2
+requests==2.32.3
+rsa==4.9
+shapely==2.0.6
+six==1.17.0
+tomli==2.2.1
+typing_extensions==4.12.2
+urllib3==1.26.20
+vcrpy==6.0.2
+wrapt==1.17.0
+yarl==1.15.2
+zipp==3.20.2
+# test with the latest version of opentelemetry-api, sdk, and semantic conventions
+
+-e opentelemetry-instrumentation
+-e instrumentation-genai/opentelemetry-instrumentation-vertexai[instruments]
diff --git a/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-0.txt b/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.oldest.txt
similarity index 63%
rename from instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-0.txt
rename to instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.oldest.txt
index 340ad3ac5f..ab633081d9 100644
--- a/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-0.txt
+++ b/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.oldest.txt
@@ -1,3 +1,20 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+# This variant of the requirements aims to test the system using
+# the oldest supported version of external dependencies.
+
 annotated-types==0.7.0
 cachetools==5.5.0
 certifi==2024.8.30
diff --git a/tox.ini b/tox.ini
index c12cf0a681..25f8b81b39 100644
--- a/tox.ini
+++ b/tox.ini
@@ -9,14 +9,14 @@ envlist =
     ; for specifying supported Python versions per package.
 
     ; instrumentation-openai
-    py3{8,9,10,11,12,13}-test-instrumentation-openai-v2-{0,1}
-    pypy3-test-instrumentation-openai-v2-{0,1}
+    py3{8,9,10,11,12,13}-test-instrumentation-openai-v2-{oldest,latest}
+    pypy3-test-instrumentation-openai-v2-{oldest,latest}
     lint-instrumentation-openai-v2
 
     ; instrumentation-vertexai
-    py3{8,9,10,11,12,13}-test-instrumentation-vertexai-{0,1}
+    py3{8,9,10,11,12,13}-test-instrumentation-vertexai-{oldest,latest}
     # Disabling pypy3 as shapely does not have wheels and fails to compile
-    # pypy3-test-instrumentation-vertexai-{0,1}
+    # pypy3-test-instrumentation-vertexai-{oldest,latest}
     lint-instrumentation-vertexai
 
     ; opentelemetry-resource-detector-container
@@ -435,16 +435,16 @@ deps =
 
   # packages that are released individually should provide a test-requirements.txt with the lowest version of OTel API
   # and SDK supported to test we are honoring it
-  openai-0: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-0.txt
+  openai-oldest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.oldest.txt
   # and the latest version of OTel API and SDK
-  openai-1: {[testenv]test_deps}
-  openai-1: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-1.txt
-  lint-instrumentation-openai-v2: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/test-requirements-0.txt
-
-  vertexai-0: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-0.txt
-  vertexai-1: {[testenv]test_deps}
-  vertexai-1: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-1.txt
-  lint-instrumentation-vertexai: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/test-requirements-0.txt
+  openai-latest: {[testenv]test_deps}
+  openai-latest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.latest.txt
+  lint-instrumentation-openai-v2: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-openai-v2/tests/requirements.oldest.txt
+
+  vertexai-oldest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.oldest.txt
+  vertexai-latest: {[testenv]test_deps}
+  vertexai-latest: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.latest.txt
+  lint-instrumentation-vertexai: -r {toxinidir}/instrumentation-genai/opentelemetry-instrumentation-vertexai/tests/requirements.oldest.txt
 
   asgi: {[testenv]test_deps}
   asgi: -r {toxinidir}/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt