diff --git a/bundles/org.openhab.ui/web/src/pages/developer/widgets/widget-edit.vue b/bundles/org.openhab.ui/web/src/pages/developer/widgets/widget-edit.vue
index dc7dd38d0d..e767aeef5f 100644
--- a/bundles/org.openhab.ui/web/src/pages/developer/widgets/widget-edit.vue
+++ b/bundles/org.openhab.ui/web/src/pages/developer/widgets/widget-edit.vue
@@ -171,7 +171,7 @@ export default {
       }
     },
     keyDown (ev) {
-      if (ev.ctrlKey || ev.metaKey) {
+      if ((ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         switch (ev.keyCode) {
           case 80:
             this.widgetPropsOpened = true
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/items/item-edit.vue b/bundles/org.openhab.ui/web/src/pages/settings/items/item-edit.vue
index 5ccd091d09..b6db0ba5b8 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/items/item-edit.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/items/item-edit.vue
@@ -127,7 +127,7 @@ export default {
       }
     },
     keyDown (ev) {
-      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey)) {
+      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         this.save()
         ev.stopPropagation()
         ev.preventDefault()
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/pages/pagedesigner-mixin.js b/bundles/org.openhab.ui/web/src/pages/settings/pages/pagedesigner-mixin.js
index d6fa05f034..e935277f08 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/pages/pagedesigner-mixin.js
+++ b/bundles/org.openhab.ui/web/src/pages/settings/pages/pagedesigner-mixin.js
@@ -83,7 +83,7 @@ export default {
       this.$store.dispatch('stopTrackingStates')
     },
     keyDown (ev) {
-      if (ev.ctrlKey || ev.metaKey) {
+      if ((ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         switch (ev.keyCode) {
           case 82:
             this.togglePreviewMode()
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/pages/sitemap/sitemap-edit.vue b/bundles/org.openhab.ui/web/src/pages/settings/pages/sitemap/sitemap-edit.vue
index 375227f29d..8a15391092 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/pages/sitemap/sitemap-edit.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/pages/sitemap/sitemap-edit.vue
@@ -261,7 +261,7 @@ export default {
       this.detailsOpened = false
     },
     keyDown (ev) {
-      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey)) {
+      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         this.save(!this.createMode)
         ev.stopPropagation()
         ev.preventDefault()
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/rules/rule-edit.vue b/bundles/org.openhab.ui/web/src/pages/settings/rules/rule-edit.vue
index c2ff359d97..5641c2f562 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/rules/rule-edit.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/rules/rule-edit.vue
@@ -406,7 +406,7 @@ export default {
       this.eventSource = null
     },
     keyDown (ev) {
-      if (ev.ctrlKey || ev.metaKey) {
+      if ((ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         if (this.currentModule) return
         switch (ev.keyCode) {
           case 68:
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/rules/script/script-edit.vue b/bundles/org.openhab.ui/web/src/pages/settings/rules/script/script-edit.vue
index 855f70174f..7e658f0fbc 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/rules/script/script-edit.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/rules/script/script-edit.vue
@@ -393,7 +393,7 @@ export default {
       this.eventSource = null
     },
     keyDown (ev) {
-      if (ev.ctrlKey || ev.metaKey) {
+      if ((ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         switch (ev.keyCode) {
           case 66:
             if (this.isBlockly) {
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/services/service-settings.vue b/bundles/org.openhab.ui/web/src/pages/settings/services/service-settings.vue
index c55835ebda..f5eb39c37f 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/services/service-settings.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/services/service-settings.vue
@@ -81,7 +81,7 @@ export default {
       }
     },
     keyDown (ev) {
-      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey)) {
+      if (ev.keyCode === 83 && (ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         this.save()
         ev.stopPropagation()
         ev.preventDefault()
diff --git a/bundles/org.openhab.ui/web/src/pages/settings/things/thing-details.vue b/bundles/org.openhab.ui/web/src/pages/settings/things/thing-details.vue
index 6a6133e3ad..a536206afc 100644
--- a/bundles/org.openhab.ui/web/src/pages/settings/things/thing-details.vue
+++ b/bundles/org.openhab.ui/web/src/pages/settings/things/thing-details.vue
@@ -505,7 +505,7 @@ export default {
       })
     },
     keyDown (ev) {
-      if (ev.ctrlKey || ev.metaKey) {
+      if ((ev.ctrlKey || ev.metaKey) && !(ev.altKey || ev.shiftKey)) {
         switch (ev.keyCode) {
           case 68:
             this.toggleDisabled()