diff --git a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.20__periodics.yaml b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.20__periodics.yaml
index 7940796f4568b..425cc9f8823c0 100644
--- a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.20__periodics.yaml
+++ b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.20__periodics.yaml
@@ -212,12 +212,12 @@ tests:
       REDHAT_OPERATORS_INDEX_TAG: v4.18
     workflow: hypershift-kubevirt-baremetalds-conformance-cilium
 - as: e2e-aws-conformance-calico
-  minimum_interval: 168h
+  minimum_interval: 336h
   steps:
     cluster_profile: hypershift-aws
     workflow: hypershift-aws-conformance-calico
 - as: e2e-aws-conformance-calico-private
-  minimum_interval: 168h
+  minimum_interval: 336h
   steps:
     cluster_profile: aws-qe
     env:
diff --git a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics-mce.yaml b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics-mce.yaml
index 2269be1e44b6d..304998250dcba 100644
--- a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics-mce.yaml
+++ b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics-mce.yaml
@@ -328,6 +328,21 @@ tests:
     - chain: hypershift-mce-power-test
     - ref: hypershift-mce-agent-info
     workflow: hypershift-mce-power-conformance
+- as: e2e-agent-connected-calico-ipv4-metal-conformance
+  capabilities:
+  - intranet
+  minimum_interval: 168h
+  steps:
+    cluster_profile: equinix-ocp-hcp
+    env:
+      KONFLUX_DEPLOY_CATALOG_SOURCE: "true"
+      KONFLUX_DEPLOY_OPERATORS: "true"
+      KONFLUX_DEPLOY_SUBSCRIPTION: "false"
+      LVM_OPERATOR_SUB_CHANNEL: stable-4.21
+      LVM_OPERATOR_SUB_SOURCE: lvm-catalogsource
+      MCE_VERSION: "2.11"
+      METALLB_OPERATOR_SUB_SOURCE: metallb-konflux
+    workflow: hypershift-mce-agent-metal3-conformance-calico
 - as: e2e-aws-critical
   cron: 0 0 29 2 *
   steps:
diff --git a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics.yaml b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics.yaml
index 85c65a2f2b506..1cd4ec35fa3be 100644
--- a/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics.yaml
+++ b/ci-operator/config/openshift/hypershift/openshift-hypershift-release-4.21__periodics.yaml
@@ -274,6 +274,52 @@ tests:
       CI_TESTS_RUN: TestExternalOIDC
       ENABLE_HYPERSHIFT_CERT_ROTATION_SCALE: "true"
     workflow: hypershift-azure-aks-external-oidc
+- as: e2e-aws-conformance-calico
+  minimum_interval: 168h
+  steps:
+    cluster_profile: hypershift
+    workflow: hypershift-aws-conformance-calico
+- as: e2e-aws-conformance-calico-private
+  minimum_interval: 168h
+  steps:
+    cluster_profile: aws-qe
+    env:
+      BASE_DOMAIN: qe.devcluster.openshift.com
+      HYPERSHIFT_GUEST_INFRA_OCP_ACCOUNT: "true"
+      TEST_ARGS: --disable-monitor=apiserver-incluster-availability,service-type-load-balancer-availability
+      TEST_SKIPS: The default cluster RBAC policy should have correct RBAC rules\|
+        Cluster scoped load balancer healthcheck port and path should be 10256/healthz\|
+        Prometheus \[apigroup:image.openshift.io\] when installed on the cluster should
+        provide named network metrics\| Unidling \[apigroup:apps.openshift.io\]\[apigroup:route.openshift.io\]
+        should work with UDP\| Unidling with Deployments \[apigroup:route.openshift.io\]
+        should work with TCP (when fully idled)\| Unidling \[apigroup:apps.openshift.io\]\[apigroup:route.openshift.io\]
+        should work with TCP (when fully idled)\| Unidling with Deployments \[apigroup:route.openshift.io\]
+        should work with UDP\|pod should not start for sysctls not on whitelist \[apigroup:k8s.cni.cncf.io\]
+        net.ipv4.conf.IFNAME.arp_filter\| pod should not start for sysctls not on
+        whitelist \[apigroup:k8s.cni.cncf.io\] net.ipv4.conf.all.send_redirects\|
+        sysctl allowlist update should start a pod with custom sysctl only when the
+        sysctl is added to whitelist\|Ensure HTTPRoute object is created
+    test:
+    - chain: hypershift-conformance
+    workflow: cucushift-installer-rehearse-aws-ipi-ovn-hypershift-private-guest-calico
+- as: e2e-kubevirt-metal-conformance-calico
+  capabilities:
+  - intranet
+  minimum_interval: 168h
+  steps:
+    cluster_profile: equinix-ocp-hcp
+    env:
+      KONFLUX_DEPLOY_CATALOG_SOURCE: "true"
+      KONFLUX_DEPLOY_OPERATORS: "true"
+      KONFLUX_DEPLOY_SUBSCRIPTION: "false"
+      LOCAL_STORAGE_OPERATOR_SUB_SOURCE: local-storage-konflux
+      LVM_OPERATOR_SUB_CHANNEL: stable-4.21
+      LVM_OPERATOR_SUB_SOURCE: lvm-catalogsource
+      METALLB_OPERATOR_SUB_SOURCE: metallb-konflux
+      ODF_OPERATOR_SUB_CHANNEL: stable-4.19
+      ODF_OPERATOR_SUB_SOURCE: redhat-operators-v4-19
+      REDHAT_OPERATORS_INDEX_TAG: v4.19
+    workflow: hypershift-kubevirt-baremetalds-conformance-calico
 - as: e2e-azure-aks-external-oidc-techpreview
   cron: 0 20 9,18,25 * *
   steps:
diff --git a/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.20-periodics.yaml b/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.20-periodics.yaml
index c9f7bd1b76124..675b5fd459db5 100644
--- a/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.20-periodics.yaml
+++ b/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.20-periodics.yaml
@@ -165,7 +165,7 @@ periodics:
     ci.openshift.io/generator: prowgen
     job-release: "4.20"
     pj-rehearse.openshift.io/can-be-rehearsed: "true"
-  minimum_interval: 168h
+  minimum_interval: 336h
   name: periodic-ci-openshift-hypershift-release-4.20-periodics-e2e-aws-conformance-calico
   spec:
     containers:
@@ -240,7 +240,7 @@ periodics:
     ci.openshift.io/generator: prowgen
     job-release: "4.20"
     pj-rehearse.openshift.io/can-be-rehearsed: "true"
-  minimum_interval: 168h
+  minimum_interval: 336h
   name: periodic-ci-openshift-hypershift-release-4.20-periodics-e2e-aws-conformance-calico-private
   spec:
     containers:
diff --git a/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.21-periodics.yaml b/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.21-periodics.yaml
index 2381934df860f..79a1be139d202 100644
--- a/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.21-periodics.yaml
+++ b/ci-operator/jobs/openshift/hypershift/openshift-hypershift-release-4.21-periodics.yaml
@@ -149,6 +149,156 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build01
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: release-4.21
+    org: openshift
+    repo: hypershift
+  labels:
+    ci-operator.openshift.io/cloud: hypershift
+    ci-operator.openshift.io/cloud-cluster-profile: hypershift
+    ci-operator.openshift.io/variant: periodics
+    ci.openshift.io/generator: prowgen
+    job-release: "4.21"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  minimum_interval: 168h
+  name: periodic-ci-openshift-hypershift-release-4.21-periodics-e2e-aws-conformance-calico
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-aws-conformance-calico
+      - --variant=periodics
+      command:
+      - ci-operator
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
+- agent: kubernetes
+  cluster: build11
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: release-4.21
+    org: openshift
+    repo: hypershift
+  labels:
+    ci-operator.openshift.io/cloud: aws
+    ci-operator.openshift.io/cloud-cluster-profile: aws-qe
+    ci-operator.openshift.io/variant: periodics
+    ci.openshift.io/generator: prowgen
+    job-release: "4.21"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  minimum_interval: 168h
+  name: periodic-ci-openshift-hypershift-release-4.21-periodics-e2e-aws-conformance-calico-private
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-aws-conformance-calico-private
+      - --variant=periodics
+      command:
+      - ci-operator
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build01
   decorate: true
@@ -1401,6 +1551,82 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build05
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: release-4.21
+    org: openshift
+    repo: hypershift
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-hcp
+    ci-operator.openshift.io/variant: periodics
+    ci.openshift.io/generator: prowgen
+    job-release: "4.21"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  minimum_interval: 168h
+  name: periodic-ci-openshift-hypershift-release-4.21-periodics-e2e-kubevirt-metal-conformance-calico
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-kubevirt-metal-conformance-calico
+      - --variant=periodics
+      command:
+      - ci-operator
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build05
   cron: 0 4 * * *
@@ -2078,6 +2304,82 @@ periodics:
     - name: result-aggregator
       secret:
         secretName: result-aggregator
+- agent: kubernetes
+  cluster: build05
+  decorate: true
+  decoration_config:
+    skip_cloning: true
+  extra_refs:
+  - base_ref: release-4.21
+    org: openshift
+    repo: hypershift
+  labels:
+    capability/intranet: intranet
+    ci-operator.openshift.io/cloud: equinix-ocp-metal
+    ci-operator.openshift.io/cloud-cluster-profile: equinix-ocp-hcp
+    ci-operator.openshift.io/variant: periodics-mce
+    ci.openshift.io/generator: prowgen
+    job-release: "4.21"
+    pj-rehearse.openshift.io/can-be-rehearsed: "true"
+  minimum_interval: 168h
+  name: periodic-ci-openshift-hypershift-release-4.21-periodics-mce-e2e-agent-connected-calico-ipv4-metal-conformance
+  spec:
+    containers:
+    - args:
+      - --gcs-upload-secret=/secrets/gcs/service-account.json
+      - --image-import-pull-secret=/etc/pull-secret/.dockerconfigjson
+      - --lease-server-credentials-file=/etc/boskos/credentials
+      - --report-credentials-file=/etc/report/credentials
+      - --secret-dir=/secrets/ci-pull-credentials
+      - --target=e2e-agent-connected-calico-ipv4-metal-conformance
+      - --variant=periodics-mce
+      command:
+      - ci-operator
+      image: quay-proxy.ci.openshift.org/openshift/ci:ci_ci-operator_latest
+      imagePullPolicy: Always
+      name: ""
+      resources:
+        requests:
+          cpu: 10m
+      volumeMounts:
+      - mountPath: /etc/boskos
+        name: boskos
+        readOnly: true
+      - mountPath: /secrets/ci-pull-credentials
+        name: ci-pull-credentials
+        readOnly: true
+      - mountPath: /secrets/gcs
+        name: gcs-credentials
+        readOnly: true
+      - mountPath: /secrets/manifest-tool
+        name: manifest-tool-local-pusher
+        readOnly: true
+      - mountPath: /etc/pull-secret
+        name: pull-secret
+        readOnly: true
+      - mountPath: /etc/report
+        name: result-aggregator
+        readOnly: true
+    serviceAccountName: ci-operator
+    volumes:
+    - name: boskos
+      secret:
+        items:
+        - key: credentials
+          path: credentials
+        secretName: boskos-credentials
+    - name: ci-pull-credentials
+      secret:
+        secretName: ci-pull-credentials
+    - name: manifest-tool-local-pusher
+      secret:
+        secretName: manifest-tool-local-pusher
+    - name: pull-secret
+      secret:
+        secretName: registry-pull-credentials
+    - name: result-aggregator
+      secret:
+        secretName: result-aggregator
 - agent: kubernetes
   cluster: build05
   cron: 0 6 * * 0
diff --git a/ci-operator/step-registry/hypershift/mce/agent/metal3/conformance/calico/hypershift-mce-agent-metal3-conformance-calico-workflow.yaml b/ci-operator/step-registry/hypershift/mce/agent/metal3/conformance/calico/hypershift-mce-agent-metal3-conformance-calico-workflow.yaml
index 9fba8497bb184..6d9ceedef2a4a 100644
--- a/ci-operator/step-registry/hypershift/mce/agent/metal3/conformance/calico/hypershift-mce-agent-metal3-conformance-calico-workflow.yaml
+++ b/ci-operator/step-registry/hypershift/mce/agent/metal3/conformance/calico/hypershift-mce-agent-metal3-conformance-calico-workflow.yaml
@@ -15,11 +15,13 @@ workflow:
     test:
     - chain: hypershift-conformance
     pre:
-    - ref: baremetalds-packet-setup
-    - ref: calico-conf
+    - ref: ofcir-acquire
+    - ref: cilium-conf
     - ref: ipi-install-rbac
+    - ref: baremetalds-devscripts-ibm
     - ref: baremetalds-devscripts-proxy
     - ref: ipi-install-hosted-loki
+    - ref: rhcos-conf-osstream
     - ref: baremetalds-devscripts-setup
     - ref: enable-qe-catalogsource
     - ref: deploy-konflux-operator
@@ -47,10 +49,11 @@ workflow:
       LVM_OPERATOR_SUB_SOURCE: lvm-catalogsource
       METALLB_OPERATOR_SUB_SOURCE: qe-app-registry
       IP_STACK: v4
-      PACKET_METRO: dc
       DEVSCRIPTS_CONFIG: |
         IP_STACK=v4
+        NUM_WORKERS=4
         NETWORK_TYPE=Calico
+        WORKER_MEMORY=24576
         VM_EXTRADISKS=true
         VM_EXTRADISKS_LIST=vda
         VM_EXTRADISKS_SIZE=500G