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vv.effects()
INFO:varcode.effects.effect_prediction:Mutation in variant Variant(contig='16', start=30128112, ref='CTGGGGTGGTAGAGACAGCAAGGCTCAGGCCTGGCATGGGGGATGCCTACGTGCCCCCCTGCTCCCCTGCCCCCAGCCCCACTGCTGCTGGGGACTG', alt='', reference_name='GRCh37') starts before exon Exon(exon_id='ENSE00001520895', gene_id='ENSG00000102882', gene_name='MAPK3', contig='16', start=30128158, end=30128324, strand='-')
Traceback (most recent call last):
File "", line 1, in
File "/usr/local/lib/python2.7/dist-packages/varcode/variant.py", line 452, in effects
variant=self, raise_on_error=raise_on_error)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_prediction.py", line 96, in predict_variant_effects
transcript=transcript)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_prediction.py", line 215, in predict_variant_effect_on_transcript
variant, exon, exon_number, transcript)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_prediction.py", line 392, in exonic_transcript_effect
transcript_offset=transcript_offset)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_prediction_coding.py", line 122, in predict_variant_coding_effect_on_transcript
sequence_from_start_codon=sequence_from_start_codon)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_prediction_coding_in_frame.py", line 239, in predict_in_frame_coding_effect
aa_alt=aa_alt)
File "/usr/local/lib/python2.7/dist-packages/varcode/effects/effect_classes.py", line 670, in init
"If no amino acids added by StopLoss then it should be Silent")
ValueError: If no amino acids added by StopLoss then it should be Silent
Seems to instantiate a StopLoss object and it raises error from there.
The text was updated successfully, but these errors were encountered:
Dear all,
we are experiencing this error on a non-frameshift deletion, ending with a stopgain (quite rare):
protein change: p.V340_*358del
varcode definition:
vv = Variant(contig=16, start=30128111, ref='CTGGGGTGGTAGAGACAGCAAGGCTCAGGCCTGGCATGGGGGATGCCTACGTGCCCCCCTGCTCCCCTGCCCCCAGCCCCACTGCTGCTGGGGACTGGCCCAC', alt='', ensembl='GRCh37')
Seems to instantiate a StopLoss object and it raises error from there.
The text was updated successfully, but these errors were encountered: