diff --git a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/reflect/target/ReflectionSubstitutionSupport.java b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/reflect/target/ReflectionSubstitutionSupport.java
index 7fff16c01154..d9c07a5da80b 100644
--- a/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/reflect/target/ReflectionSubstitutionSupport.java
+++ b/substratevm/src/com.oracle.svm.core/src/com/oracle/svm/core/reflect/target/ReflectionSubstitutionSupport.java
@@ -24,6 +24,7 @@
  */
 package com.oracle.svm.core.reflect.target;
 
+import java.lang.reflect.Constructor;
 import java.lang.reflect.Executable;
 import java.lang.reflect.Field;
 
@@ -52,4 +53,6 @@ static ReflectionSubstitutionSupport singleton() {
      * deleted.
      */
     String getDeletionReason(Field field);
+
+    boolean isCustomSerializationConstructor(Constructor<?> reflectConstructor);
 }
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionDataBuilder.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionDataBuilder.java
index 513e0a887e9d..4417d017fe2c 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionDataBuilder.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionDataBuilder.java
@@ -40,6 +40,7 @@
 import static com.oracle.svm.core.configure.ConfigurationFiles.Options.TreatAllTypeReachableConditionsAsTypeReached;
 
 import java.lang.reflect.AnnotatedElement;
+import java.lang.reflect.Constructor;
 import java.lang.reflect.Executable;
 import java.lang.reflect.Field;
 import java.lang.reflect.GenericArrayType;
@@ -87,6 +88,7 @@
 import com.oracle.svm.core.hub.ClassForNameSupport;
 import com.oracle.svm.core.hub.DynamicHub;
 import com.oracle.svm.core.reflect.SubstrateAccessor;
+import com.oracle.svm.core.reflect.target.ReflectionSubstitutionSupport;
 import com.oracle.svm.core.util.VMError;
 import com.oracle.svm.hosted.ClassLoaderFeature;
 import com.oracle.svm.hosted.ConditionalConfigurationRegistry;
@@ -1243,6 +1245,15 @@ public void registerHeapReflectionField(Field reflectField, ScanReason reason) {
 
     @Override
     public void registerHeapReflectionExecutable(Executable reflectExecutable, ScanReason reason) {
+        if (reflectExecutable instanceof Constructor<?> reflectConstructor && ReflectionSubstitutionSupport.singleton().isCustomSerializationConstructor(reflectConstructor)) {
+            /*
+             * Constructors created by Constructor.newWithAccessor are indistinguishable from an
+             * equivalent constructor with a "correct" accessor, and as such could hide this
+             * constructor from reflection queries. We therefore exclude such constructors from the
+             * internal reflection metadata.
+             */
+            return;
+        }
         AnalysisMethod analysisMethod = metaAccess.lookupJavaMethod(reflectExecutable);
         if (heapMethods.put(analysisMethod, reflectExecutable) == null) {
             if (sealed) {
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionFeature.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionFeature.java
index 13f195ecffe1..4fb9c890dda4 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionFeature.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/reflect/ReflectionFeature.java
@@ -50,6 +50,7 @@
 
 import com.oracle.graal.pointsto.ObjectScanner;
 import com.oracle.graal.pointsto.infrastructure.UniverseMetaAccess;
+import com.oracle.graal.pointsto.meta.AnalysisMetaAccess;
 import com.oracle.graal.pointsto.meta.AnalysisMethod;
 import com.oracle.graal.pointsto.meta.AnalysisUniverse;
 import com.oracle.svm.configure.ConfigurationFile;
@@ -270,6 +271,16 @@ private MethodPointer asMethodPointer(ResolvedJavaMethod method) {
         return new MethodPointer(aMethod);
     }
 
+    @Override
+    public boolean isCustomSerializationConstructor(Constructor<?> reflectConstructor) {
+        if (ReflectionUtil.readField(Constructor.class, "constructorAccessor", reflectConstructor) instanceof SubstrateConstructorAccessor accessor) {
+            AnalysisMetaAccess analysisMetaAccess = analysisAccess.getMetaAccess();
+            AnalysisMethod analysisConstructor = analysisMetaAccess.lookupJavaMethod(reflectConstructor);
+            return !accessor.getFactoryMethod().equals(FactoryMethodSupport.singleton().lookup(analysisMetaAccess, analysisConstructor, analysisConstructor.getDeclaringClass(), false));
+        }
+        return false;
+    }
+
     @Override
     public List<Class<? extends Feature>> getRequiredFeatures() {
         return List.of(ClassForNameSupportFeature.class, DynamicProxyFeature.class);