diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 52857fed5b95f..c695c04052f9d 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -10936,10 +10936,8 @@ def quantile(
                 if needs_i8_conversion(cdtype):
                     dtype = cdtype
 
-            if is_list_like(q):
-                res = self._constructor([], index=q, columns=cols, dtype=dtype)
-                return res.__finalize__(self, method="quantile")
-            return self._constructor_sliced([], index=cols, name=q, dtype=dtype)
+            res = self._constructor([], index=q, columns=cols, dtype=dtype)
+            return res.__finalize__(self, method="quantile")
 
         res = data._mgr.quantile(qs=q, axis=1, interpolation=interpolation)
 
diff --git a/pandas/tests/generic/test_finalize.py b/pandas/tests/generic/test_finalize.py
index 540a30e691d3c..6901d415a5ae7 100644
--- a/pandas/tests/generic/test_finalize.py
+++ b/pandas/tests/generic/test_finalize.py
@@ -262,6 +262,13 @@
             operator.methodcaller("quantile", numeric_only=False),
         ),
     ),
+    pytest.param(
+        (
+            pd.DataFrame,
+            ({"A": [np.datetime64("2022-01-01"), np.datetime64("2022-01-02")]},),
+            operator.methodcaller("quantile", numeric_only=True),
+        ),
+    ),
     (
         pd.DataFrame,
         ({"A": [1]}, [pd.Period("2000", "D")]),