diff --git a/pandas/tests/groupby/aggregate/test_aggregate.py b/pandas/tests/groupby/aggregate/test_aggregate.py
index dca0281d610ad..9a529f1cccb3c 100644
--- a/pandas/tests/groupby/aggregate/test_aggregate.py
+++ b/pandas/tests/groupby/aggregate/test_aggregate.py
@@ -1577,3 +1577,12 @@ def test_agg_groupings_selection():
     )
     expected = DataFrame({"b": [6, 4], "c": [11, 7]}, index=index)
     tm.assert_frame_equal(result, expected)
+
+
+def test_agg_multiple_with_as_index_false_subset_to_a_single_column():
+    # GH#50724
+    df = DataFrame({"a": [1, 1, 2], "b": [3, 4, 5]})
+    gb = df.groupby("a", as_index=False)["b"]
+    result = gb.agg(["sum", "mean"])
+    expected = DataFrame({"a": [1, 2], "sum": [7, 5], "mean": [3.5, 5.0]})
+    tm.assert_frame_equal(result, expected)