diff --git a/pato-base.json b/pato-base.json index 0eae36b..1002a64 100644 --- a/pato-base.json +++ b/pato-base.json @@ -25,9 +25,9 @@ "val" : "1.2" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-09-04" + "val" : "2024-11-11" } ], - "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-09-04/pato-base.json" + "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-11-11/pato-base.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000020", diff --git a/pato-base.obo b/pato-base.obo index 6e4c94a..22abc6b 100644 --- a/pato-base.obo +++ b/pato-base.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: pato/releases/2024-09-04/pato-base.owl +data-version: pato/releases/2024-11-11/pato-base.owl subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" @@ -19,7 +19,7 @@ property_value: dc:description "An ontology of phenotypic qualities (properties, property_value: dc:title "PATO - the Phenotype And Trait Ontology" xsd:string property_value: dc:type IAO:8000001 property_value: IAO:0000700 PATO:0000001 -property_value: owl:versionInfo "2024-09-04" xsd:string +property_value: owl:versionInfo "2024-11-11" xsd:string property_value: terms:license https://creativecommons.org/licenses/by/3.0/ [Term] diff --git a/pato-base.owl b/pato-base.owl index 3bd5d0c..812a94c 100644 --- a/pato-base.owl +++ b/pato-base.owl @@ -12,7 +12,7 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + An ontology of phenotypic qualities (properties, attributes or characteristics). PATO - the Phenotype And Trait Ontology @@ -20,7 +20,7 @@ quality 1.2 - 2024-09-04 + 2024-11-11 diff --git a/pato-full.json b/pato-full.json index 132b275..53140be 100644 --- a/pato-full.json +++ b/pato-full.json @@ -22,9 +22,9 @@ "val" : "1.2" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-09-04" + "val" : "2024-11-11" } ], - "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-09-04/pato-full.json" + "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-11-11/pato-full.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", @@ -1147,92 +1147,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "lbl" : "deoxyribonucleic acid", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." - }, - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "Deoxyribonucleic acid", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)m", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)n", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)n+m", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "IUPAC" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "UniProt" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNAn", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNAn+1", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNS", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "Desoxyribonukleinsaeure", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "deoxyribonucleic acids", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "desoxyribose nucleic acid", - "xrefs" : [ "ChemIDplus" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "thymus nucleic acid", - "xrefs" : [ "ChEBI" ] - } ], - "xrefs" : [ { - "val" : "KEGG:C00039" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:13302" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:21123" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:33698" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:4291" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_17087", "lbl" : "ketone", @@ -5626,42 +5540,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_33793", - "lbl" : "canonical deoxyribonucleoside residue", - "type" : "CLASS", - "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasRelatedSynonym", - "val" : "canonical deoxyribonucleoside residues", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "common 2'-deoxyribonucleoside residue", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "common 2'-deoxyribonucleoside residues", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "dN", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "dNuc", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "standard deoxyribonucleoside residues", - "xrefs" : [ "ChEBI" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_33822", "lbl" : "organic hydroxy compound", @@ -7972,22 +7850,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_50298", - "lbl" : "canonical deoxyribonucleotide residue", - "type" : "CLASS", - "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasRelatedSynonym", - "val" : "canonical deoxyribonucleotide residues", - "xrefs" : [ "ChEBI" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_50299", "lbl" : "canonical ribonucleotide residue", @@ -11122,6 +10984,10 @@ "lbl" : "squamous epithelial cell", "type" : "CLASS", "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of some squamous epithelium.", + "xrefs" : [ "FBC:Autogenerated" ] + }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], "xrefs" : [ { "val" : "CALOHA:TS-1249" @@ -11133,9 +10999,10 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.", - "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + "val" : "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "PMID:26106328" ] }, + "comments" : [ "Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", @@ -11406,6 +11273,8 @@ "val" : "CALOHA:TS-0415" }, { "val" : "FMA:54536" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000125" } ] } }, { @@ -11698,6 +11567,8 @@ "val" : "FMA:62930" }, { "val" : "MESH:D019858" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000164" } ] } }, { @@ -11916,7 +11787,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A cell specialized to detect and transduce light.", + "val" : "A cell specialized in detecting light stimuli that are involved in visual perception.", "xrefs" : [ "MESH:D010786" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -12116,22 +11987,16 @@ "meta" : { "definition" : { "val" : "A cell with more than one nucleus.", - "xrefs" : [ "FB:ma" ] + "xrefs" : [ "FB:ma", "Wikipedia:Multinucleate" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", - "val" : "syncitium" + "val" : "multinucleated cells", + "xrefs" : [ "Wikipedia:Multinucleate" ] }, { "pred" : "hasExactSynonym", - "val" : "syncytial cell" - }, { - "pred" : "hasExactSynonym", - "val" : "syncytium" - } ], - "xrefs" : [ { - "val" : "AEO:0000203" - }, { - "val" : "WBbt:0008074" + "val" : "polynuclear cells", + "xrefs" : [ "Wikipedia:Multinucleate" ] } ] } }, { @@ -12165,7 +12030,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Eukaryota.", + "val" : "Any cell that in taxon some Eukaryota.", "xrefs" : [ "FBC:Autogenerated" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -12179,7 +12044,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Eumycetozoa.", + "val" : "Any cell that in taxon some Eumycetozoa.", "xrefs" : [ "FBC:Autogenerated" ] } } @@ -12362,7 +12227,7 @@ "meta" : { "definition" : { "val" : "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.", - "xrefs" : [ "GOC:tfm", "MESH:D014327", "PMID:37630754" ] + "xrefs" : [ "GOC:tfm", "MESH:D014327", "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", @@ -12695,7 +12560,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Fungi.", + "val" : "Any cell that in taxon some Fungi.", "xrefs" : [ "FBC:Autogenerated" ] } } @@ -13254,6 +13119,9 @@ "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "window cell" + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000666" } ] } }, { @@ -13361,6 +13229,8 @@ "val" : "FMA:62938" }, { "val" : "FMA:83409" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000696" } ] } }, { @@ -13927,6 +13797,8 @@ }, "xrefs" : [ { "val" : "FMA:62939" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002067" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -14753,15 +14625,17 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.", + "val" : "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development.", "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", - "val" : "myotubule" + "val" : "myofiber", + "xrefs" : [ "FBbt:00005812" ] }, { "pred" : "hasExactSynonym", - "val" : "single cell sarcomere" + "val" : "myofibril", + "xrefs" : [ "FBbt:00005812" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -14777,9 +14651,10 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19.", - "xrefs" : [ "GOC:tfm" ] + "val" : "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage.", + "xrefs" : [ "GOC:tfm", "PMID:15580626", "PMID:30971890", "PMID:35815410" ] }, + "comments" : [ "Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], "synonyms" : [ { "pred" : "hasExactSynonym", @@ -14864,7 +14739,6 @@ "val" : "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.", "xrefs" : [ "GOC:tfm", "PMID:10704434", "PMID:11756508", "PMID:20142420", "PMID:2182078", "PMID:24133281", "PMID:9826671" ] }, - "comments" : [ "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", @@ -15021,6 +14895,8 @@ "val" : "FMA:62104" }, { "val" : "KUPO:0001099" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002543" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -15030,24 +14906,6 @@ "val" : "2011-02-28T03:48:11Z" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0002546", - "lbl" : "embryonic blood vessel endothelial progenitor cell", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "An endothelial progenitor cell that participates in angiogenesis during development.", - "xrefs" : [ "GOC:tfm" ] - }, - "comments" : [ "See CL:0002619." ], - "basicPropertyValues" : [ { - "pred" : "http://purl.org/dc/terms/contributor", - "val" : "https://orcid.org/0000-0003-1980-3228" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2011-02-28T04:20:39Z" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002547", "lbl" : "fibroblast of the aortic adventitia", @@ -15159,6 +15017,9 @@ "pred" : "hasExactSynonym", "val" : "mesenchymal stem cell of adipose" } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002570" + } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" @@ -15189,6 +15050,8 @@ "val" : "CALOHA:TS-0898" }, { "val" : "MESH:D012583" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002573" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -15208,6 +15071,9 @@ "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002585" + } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" @@ -15627,6 +15493,31 @@ }, "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0005012", + "lbl" : "multi-ciliated epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.", + "xrefs" : [ "CL:CVS", "PMID:28400610", "PMID:30422572", "PMID:38032388" ] + }, + "comments" : [ "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility" ], + "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], + "synonyms" : [ { + "pred" : "hasBroadSynonym", + "val" : "multi-ciliated cell" + }, { + "pred" : "hasBroadSynonym", + "val" : "multiciliated cell" + }, { + "pred" : "hasExactSynonym", + "val" : "multiciliated epithelial cell" + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0005012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005024", "lbl" : "somatomotor neuron", @@ -16130,7 +16021,10 @@ "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ] + "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0011012" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011019", @@ -16412,6 +16306,9 @@ "pred" : "hasExactSynonym", "val" : "pulmonary neuroendocrine cell", "xrefs" : [ "PMID:33355253" ] + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000223" } ] } }, { @@ -16420,8 +16317,8 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any ciliated cell that is part of some lung.", - "xrefs" : [ "FBC:Autogenerated" ] + "val" : "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.", + "xrefs" : [ "PMID:27864314" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ] } @@ -16713,6 +16610,8 @@ "val" : "FMA:67761" }, { "val" : "KUPO:0001095" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000413" } ] } }, { @@ -16885,6 +16784,8 @@ } ], "xrefs" : [ { "val" : "FMA:86737" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000491" } ] } }, { @@ -16912,6 +16813,8 @@ "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "FMA:86739" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000493" } ] } }, { @@ -17012,7 +16915,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Endothelial cells forming the walls of the capillaries within the cerebral cortex.", + "val" : "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.", "xrefs" : [ "NPX:PDR" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -18006,6 +17909,28 @@ "val" : "2024-07-19T09:14:23Z" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4052002", + "lbl" : "syncytial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm.", + "xrefs" : [ "PMID:20851884", "Wikipedia:Syncytium" ] + }, + "synonyms" : [ { + "pred" : "hasExactSynonym", + "val" : "syncytium", + "xrefs" : [ "WBbt:0008074" ] + } ], + "basicPropertyValues" : [ { + "pred" : "http://purl.org/dc/terms/contributor", + "val" : "https://orcid.org/0009-0000-8480-9277" + }, { + "pred" : "http://purl.org/dc/terms/date", + "val" : "2024-08-15T10:38:46Z" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000011", "lbl" : "vacuole inheritance", @@ -24661,31 +24586,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0006259", - "lbl" : "DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.", - "xrefs" : [ "ISBN:0198506732" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA metabolism" - }, { - "pred" : "hasExactSynonym", - "val" : "cellular DNA metabolism" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "GO:0055132" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006325", "lbl" : "chromatin organization", @@ -25873,7 +25773,6 @@ "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:mah" ] }, - "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", @@ -28012,27 +27911,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0008272", - "lbl" : "sulfate transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:krc" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "sulphate transport" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "GO:0006870" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008283", "lbl" : "cell population proliferation", @@ -29215,9 +29093,6 @@ "pred" : "hasExactSynonym", "val" : "alkaloid synthesis" } ], - "xrefs" : [ { - "val" : "UM-BBD_enzymeID:e0711" - } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" @@ -29844,26 +29719,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0010243", - "lbl" : "response to organonitrogen compound", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", - "xrefs" : [ "PMID:9869419" ] - }, - "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "response to organic nitrogen" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010256", "lbl" : "endomembrane system organization", @@ -33114,25 +32969,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0015869", - "lbl" : "protein-DNA complex transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex transport", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015870", "lbl" : "acetylcholine transport", @@ -41083,25 +40919,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0032986", - "lbl" : "protein-DNA complex disassembly", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The disaggregation of a protein-DNA complex into its constituent components.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex disassembly", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032988", "lbl" : "protein-RNA complex disassembly", @@ -41184,27 +41001,6 @@ "val" : "cellular_component" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0032993", - "lbl" : "protein-DNA complex", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "A macromolecular complex containing both protein and DNA molecules.", - "xrefs" : [ "GOC:mah" ] - }, - "comments" : [ "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here." ], - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "cellular_component" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033002", "lbl" : "muscle cell proliferation", @@ -45923,6 +45719,7 @@ "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", "xrefs" : [ "GOC:go_curators" ] }, + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "membrane-enclosed organelle" @@ -45944,7 +45741,7 @@ "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.", "xrefs" : [ "GOC:go_curators" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_mouse" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_mouse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "non-membrane-enclosed organelle" @@ -45969,7 +45766,7 @@ "val" : "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", "xrefs" : [ "GOC:go_curators" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" @@ -47040,7 +46837,7 @@ "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.", "xrefs" : [ "GOC:jl", "GOC:mah" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular component biogenesis at cellular level" @@ -56542,20 +56339,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051027", - "lbl" : "DNA transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:ai" ] - }, - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051046", "lbl" : "regulation of secretion", @@ -56699,88 +56482,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051052", - "lbl" : "regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA metabolism" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051053", - "lbl" : "negative regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "down regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "down-regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "downregulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA metabolism" - }, { - "pred" : "hasNarrowSynonym", - "val" : "inhibition of DNA metabolic process" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051054", - "lbl" : "positive regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA metabolism" - }, { - "pred" : "hasExactSynonym", - "val" : "up regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "up-regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "upregulation of DNA metabolic process" - }, { - "pred" : "hasNarrowSynonym", - "val" : "activation of DNA metabolic process" - }, { - "pred" : "hasNarrowSynonym", - "val" : "stimulation of DNA metabolic process" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051055", "lbl" : "negative regulation of lipid biosynthetic process", @@ -66449,25 +66150,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0065004", - "lbl" : "protein-DNA complex assembly", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.", - "xrefs" : [ "GOC:jl" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex assembly", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065007", "lbl" : "biological regulation", @@ -67725,7 +67407,7 @@ "val" : "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", "xrefs" : [ "GOC:mah" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" @@ -67866,38 +67548,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0071824", - "lbl" : "protein-DNA complex organization", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex subunit organization", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "protein-DNA complex subunit organisation", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "protein-DNA complex subunit organization" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "mah" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-09-08T10:03:26Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071826", "lbl" : "protein-RNA complex organization", @@ -68076,43 +67726,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0071897", - "lbl" : "DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The biosynthetic process resulting in the formation of DNA.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA anabolism", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA biosynthesis", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA formation", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA synthesis", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "mah" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-09-15T02:14:33Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071944", "lbl" : "cell periphery", @@ -72461,7 +72074,7 @@ "val" : "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.", "xrefs" : [ "GOC:dos" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_synapse" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate", "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" @@ -78186,70 +77799,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1901564", - "lbl" : "organonitrogen compound metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The chemical reactions and pathways involving organonitrogen compound.", - "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound metabolism", - "xrefs" : [ "GOC:TermGenie" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "pr" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2012-11-04T15:17:52Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1901566", - "lbl" : "organonitrogen compound biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The chemical reactions and pathways resulting in the formation of organonitrogen compound.", - "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound anabolism", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound biosynthesis", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound formation", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound synthesis", - "xrefs" : [ "GOC:TermGenie" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "pr" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2012-11-04T15:18:00Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901588", "lbl" : "dendritic microtubule", @@ -81249,6 +80798,10 @@ "val" : "The directed movement of sulfate across a membrane.", "xrefs" : [ "GOC:TermGenie", "GOC:dph", "PMID:9055073" ] }, + "synonyms" : [ { + "pred" : "hasExactSynonym", + "val" : "sulphate transport" + } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" @@ -84693,6 +84246,30 @@ "val" : "biological_process" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903251", + "lbl" : "multi-ciliated epithelial cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:sp", "GO_REF:0000086", "PMID:22231168", "PMID:24934224" ] + }, + "synonyms" : [ { + "pred" : "hasBroadSynonym", + "val" : "multiciliate cell differentiation" + } ], + "basicPropertyValues" : [ { + "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", + "val" : "tb" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", + "val" : "2014-08-05T19:21:21Z" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", + "val" : "biological_process" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903292", "lbl" : "protein localization to Golgi membrane", @@ -101159,80 +100736,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000278", - "lbl" : "regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that modulates the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-12-08T04:48:15Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000279", - "lbl" : "negative regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-12-08T04:48:20Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000282", "lbl" : "regulation of cellular amino acid biosynthetic process", @@ -102010,43 +101513,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000573", - "lbl" : "positive regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2011-04-04T10:01:20Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000647", "lbl" : "negative regulation of stem cell proliferation", @@ -154411,6 +153877,9 @@ "val" : "protein" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/PR_000050567", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PR_000064867", "lbl" : "protein-containing molecular entity", @@ -162854,7 +162323,7 @@ "val" : "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].", "xrefs" : [ "BIRNLEX:844", "ISBN:0-14-051288-8", "ISBN:3110148986", "NLM:nervous+system", "WB:rynl", "Wikipedia:Nervous_system", "ZFIN:curator" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#cumbo", "http://purl.obolibrary.org/obo/uberon/core#efo_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas", "http://purl.obolibrary.org/obo/uberon/core#pheno_slim", "http://purl.obolibrary.org/obo/uberon/core#uberon_slim", "http://purl.obolibrary.org/obo/uberon/core#vertebrate_core" ], + "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#cumbo", "http://purl.obolibrary.org/obo/uberon/core#efo_slim", "http://purl.obolibrary.org/obo/uberon/core#pheno_slim", "http://purl.obolibrary.org/obo/uberon/core#uberon_slim", "http://purl.obolibrary.org/obo/uberon/core#vertebrate_core" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neurological system", @@ -218774,6 +218243,10 @@ "id" : "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" }, { "id" : "http://purl.obolibrary.org/obo/go#goslim_agr", "type" : "PROPERTY", @@ -219488,30 +218961,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765", "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of", "obj" : "http://purl.obolibrary.org/obo/CHEBI_57887" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000004" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33696" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33793" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_50298" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/RO_0000087", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/RO_0000087", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_17087", "pred" : "is_a", @@ -220696,10 +220145,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_33792", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33791" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_33793", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33791" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_33822", "pred" : "is_a", @@ -221312,10 +220757,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_50297", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CHEBI_50319" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_50298", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_50297" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_50299", "pred" : "is_a", @@ -221878,7 +221319,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000000", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000005", @@ -221916,6 +221357,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000014", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000039" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000021", "pred" : "is_a", @@ -221940,17 +221385,13 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000023", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000021" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000023", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000023", "pred" : "http://purl.obolibrary.org/obo/RO_0000056", "obj" : "http://purl.obolibrary.org/obo/GO_0007143" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000023", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000024", @@ -222012,6 +221453,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000030", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000055" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000030", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000030", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -222026,8 +221471,12 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000031", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000034", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000034", "pred" : "is_a", @@ -222227,7 +221676,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000064", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000064", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -222235,7 +221688,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000066", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000066", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222264,10 +221717,6 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000071", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004638" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000071", - "pred" : "http://purl.obolibrary.org/obo/RO_0002202", - "obj" : "http://purl.obolibrary.org/obo/CL_0002546" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000075", "pred" : "is_a", @@ -222276,6 +221725,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000076", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006914" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000077", "pred" : "is_a", @@ -222288,10 +221741,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000077", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002078" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001136" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000080", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000080", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222392,6 +221849,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000115", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000213" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000115", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000115", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -222430,11 +221891,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000095" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000123", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000255" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000123", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000123", @@ -222544,6 +222001,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000152", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000152", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222572,6 +222033,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000163", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000163", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222640,6 +222105,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000187", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000183" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000187", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000187", "pred" : "is_a", @@ -222651,7 +222120,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000188", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000188", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222671,7 +222140,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000197", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000197", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222707,11 +222176,15 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000210", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000006" + "obj" : "http://purl.obolibrary.org/obo/CL_0000101" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000210", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008028" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000210", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", - "obj" : "http://purl.obolibrary.org/obo/GO_0050962" + "obj" : "http://purl.obolibrary.org/obo/GO_0050908" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000211", "pred" : "is_a", @@ -222764,6 +222237,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000219", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0048870" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000221", "pred" : "is_a", @@ -222772,6 +222249,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000221", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000222", "pred" : "is_a", @@ -222780,6 +222261,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000222", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000223", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000223", "pred" : "is_a", @@ -222796,6 +222281,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000225", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001405" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000226", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000226", "pred" : "is_a", @@ -222812,6 +222301,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000227", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001406" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000228", "pred" : "is_a", @@ -222854,7 +222347,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000000" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000255", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000257", @@ -222862,8 +222355,12 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000257", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_142796" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000287", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000287", "pred" : "is_a", @@ -222948,6 +222445,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000347", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000347", "pred" : "is_a", @@ -222964,6 +222465,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000348", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000348", "pred" : "is_a", @@ -222979,7 +222484,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000349", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000349", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -223046,7 +222551,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0010017" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000365", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000393", @@ -223182,16 +222687,16 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000521", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + "obj" : "http://purl.obolibrary.org/obo/CL_0000351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000351" + "obj" : "http://purl.obolibrary.org/obo/CL_4052002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -223248,6 +222753,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000547", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002242" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000547", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000547", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223316,6 +222825,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000549", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000765" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000549", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000549", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223332,6 +222845,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000550", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000765" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000550", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000550", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223448,6 +222965,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000558", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000764" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000558", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000558", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -223524,6 +223045,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000566", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0011026" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000566", "pred" : "http://purl.obolibrary.org/obo/RO_0002104", @@ -223660,6 +223185,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000680", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000055" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000680", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -223758,7 +223287,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002405" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000738", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000738", @@ -223800,6 +223329,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000763", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000763", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000763", "pred" : "is_a", @@ -223892,10 +223425,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000837", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000837", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -224011,7 +223552,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001035", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001035", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224096,6 +223637,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0001066", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000038" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0001066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001066", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -224152,6 +223697,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002031", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002031", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002031", "pred" : "is_a", @@ -224168,6 +223717,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002032", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002032", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002032", "pred" : "is_a", @@ -224415,7 +223968,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002319", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002319", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224423,7 +223976,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002320", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002320", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224475,11 +224028,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + "obj" : "http://purl.obolibrary.org/obo/CL_0000737" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000737" + "obj" : "http://purl.obolibrary.org/obo/CL_4052002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", @@ -224487,15 +224040,19 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000030" + "obj" : "http://purl.obolibrary.org/obo/CL_0011026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0011026" + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001402" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000333" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002375", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/CL_0002573" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002377", "pred" : "is_a", @@ -224535,7 +224092,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002494", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002494", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224584,10 +224141,6 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002543", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0002546", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000222" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002547", "pred" : "is_a", @@ -224848,6 +224401,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0005000", "pred" : "http://purl.obolibrary.org/obo/RO_0002100", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0031514" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0010007" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0005024", "pred" : "is_a", @@ -224940,6 +224509,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0008019", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000219" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008019", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0008019", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -225192,6 +224765,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0011026", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011026", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0011026", "pred" : "is_a", @@ -225351,15 +224928,23 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000271", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_4030034" + "obj" : "http://purl.obolibrary.org/obo/CL_0000067" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000271", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", - "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000082" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4030034" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000272", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000272", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -225763,7 +225348,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000020", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000020", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -226200,6 +225785,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4047005", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002354" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0000768" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000011", "pred" : "is_a", @@ -226339,11 +225936,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000785", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000004" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0000785", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" + "obj" : "http://purl.obolibrary.org/obo/GO_0110165" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000785", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -229464,10 +229057,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006022", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901135" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006022", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006022", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -229484,10 +229073,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006023", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901137" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006023", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006023", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -229548,18 +229133,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006139", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006259", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0090304" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006259", - "pred" : "http://purl.obolibrary.org/obo/RO_0004007", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" + "obj" : "http://purl.obolibrary.org/obo/GO_0016043" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", @@ -229592,10 +229169,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006412", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0019538" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006412", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006412", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -230992,6 +230565,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008088", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0043005" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008089", "pred" : "is_a", @@ -231048,18 +230625,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008219", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0009987" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0015698" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0072348" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008283", "pred" : "is_a", @@ -231276,10 +230841,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901137" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009101", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231288,10 +230849,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009112", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0055086" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009112", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009112", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231311,7 +230868,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009308", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009308", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009308", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231319,11 +230880,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009308" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0009308" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231523,7 +231084,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009820", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009820", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231536,10 +231101,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009821", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044550" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009821", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009821", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231824,14 +231385,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010171", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0010243", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901698" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0010243", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010256", "pred" : "is_a", @@ -233415,7 +232968,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014075", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014075", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", @@ -233900,22 +233453,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015851", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18282" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0006886" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0015931" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0031503" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015870", "pred" : "is_a", @@ -234288,10 +233825,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044238" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0019538", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -238064,18 +237597,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032984", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032984" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "http://purl.obolibrary.org/obo/RO_0002590", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032988", "pred" : "is_a", @@ -238100,14 +237621,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032991", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/PR_000000001" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032993", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032993", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033002", "pred" : "is_a", @@ -239851,7 +239364,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042430", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -239859,11 +239376,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0042430" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0042430" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -240427,7 +239944,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043279", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043279", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", @@ -240499,7 +240016,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "is_a", @@ -242307,11 +241824,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009112" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0009112" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -242607,11 +242124,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_0017085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0017085" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", @@ -245308,10 +244825,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050907", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0007606" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0050908", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009584" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050908", "pred" : "is_a", @@ -245416,14 +244929,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050975", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050954" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051027", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0050657" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051027", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051046", "pred" : "is_a", @@ -245488,50 +244993,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051051", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0006810" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0019219" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0060255" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "http://purl.obolibrary.org/obo/RO_0002211", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010605" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0045934" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "http://purl.obolibrary.org/obo/RO_0002212", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010604" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0045935" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "http://purl.obolibrary.org/obo/RO_0002213", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051055", "pred" : "is_a", @@ -250500,18 +249961,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0065003", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0065004", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0065003" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0065004", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" - 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}, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0141187" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "http://purl.obolibrary.org/obo/RO_0004008", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0071944", "pred" : "is_a", @@ -254923,7 +254352,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901160", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -254931,11 +254364,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901160" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_1901160" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -255340,30 +254773,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901552", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0001885" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0008152" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "http://purl.obolibrary.org/obo/RO_0004007", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009058" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "http://purl.obolibrary.org/obo/RO_0004008", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901588", "pred" : "is_a", @@ -256103,11 +255512,15 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902358", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0008272" + "obj" : "http://purl.obolibrary.org/obo/GO_0072348" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902358", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0098661" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902358", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902414", "pred" : "is_a", @@ -256788,6 +256201,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903226", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002065" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0005012" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903292", "pred" : "is_a", @@ -258059,7 +257480,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904587", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904587", "pred" : "is_a", @@ -260728,34 +260149,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000271", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0044346" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010556" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "http://purl.obolibrary.org/obo/RO_0002211", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010558" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051053" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_2000278" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "http://purl.obolibrary.org/obo/RO_0002212", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000282", "pred" : "is_a", @@ -261088,22 +260481,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000543", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007369" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010557" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051054" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_2000278" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "http://purl.obolibrary.org/obo/RO_0002213", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000647", "pred" : "is_a", @@ -271686,7 +271063,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", @@ -271770,7 +271147,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0015165" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6656" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", @@ -271838,7 +271215,7 @@ "obj" : "http://purl.obolibrary.org/obo/PATO_0002236" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000023", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000023", @@ -271862,7 +271239,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000026", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000030", @@ -271898,7 +271275,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007811" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000033", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000042", @@ -271934,7 +271311,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000327" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000043", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000043", @@ -272142,7 +271519,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000075", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000075", @@ -272414,7 +271791,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0007369" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000109", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000110", @@ -272438,7 +271815,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0001841" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000110", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000111", @@ -272458,7 +271835,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0048513" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000111", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000114", @@ -272554,7 +271931,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011215" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000125", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000125", @@ -272578,7 +271955,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000153", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000154", @@ -272586,7 +271963,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000154", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000158", @@ -272614,7 +271991,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", @@ -272722,7 +272099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000179", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000203", @@ -272814,7 +272191,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000344", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", @@ -272822,7 +272199,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", @@ -272858,7 +272235,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000088" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000358", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32525" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000358", @@ -272954,7 +272331,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000383", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000383", @@ -273174,7 +272551,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005769" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000483", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000483", @@ -273246,7 +272623,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002417" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000916", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000922", @@ -273266,7 +272643,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010316" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000923", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000924", @@ -273318,7 +272695,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035804" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000930", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", @@ -273334,7 +272711,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", @@ -273390,7 +272767,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004151" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000948", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000948", @@ -273410,7 +272787,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0015204" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000949", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000949", @@ -273690,7 +273067,7 @@ "obj" : "http://purl.obolibrary.org/obo/PATO_0001748" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000977", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32524" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000977", @@ -273726,7 +273103,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000988", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000988", @@ -273786,7 +273163,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003134" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000992", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000992", @@ -273818,7 +273195,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001004", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001004", @@ -273866,7 +273243,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", @@ -273918,7 +273295,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000540" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001016", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001016", @@ -273950,7 +273327,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001017", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001017", @@ -274006,7 +273383,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001033", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001033", @@ -274058,7 +273435,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001042", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001042", @@ -274302,7 +273679,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001884" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", @@ -274378,7 +273755,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001137", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", @@ -274646,7 +274023,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004765" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001474", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001474", @@ -274894,7 +274271,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001555", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001555", @@ -275238,7 +274615,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001572" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001650", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001650", @@ -275342,7 +274719,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_117570" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", @@ -275446,7 +274823,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", @@ -276414,7 +275791,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000956" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001950", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001950", @@ -276606,7 +275983,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0012275" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", @@ -276674,7 +276051,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002019", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002019", @@ -276698,7 +276075,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", @@ -276774,7 +276151,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000170" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002048", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002048", @@ -277086,7 +276463,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000026" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002091", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002091", @@ -277354,7 +276731,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002193", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002199", @@ -277382,7 +276759,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002199", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002200", @@ -277482,7 +276859,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000982" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002217", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002217", @@ -277714,7 +277091,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002328", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002328", @@ -277746,7 +277123,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007503" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002329", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002329", @@ -277758,7 +277135,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002330", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002330", @@ -277802,7 +277179,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002342", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002342", @@ -278202,7 +277579,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000479" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002384", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", @@ -278218,7 +277595,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001015" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", @@ -278242,7 +277619,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", @@ -278426,7 +277803,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000010" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", @@ -278478,7 +277855,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000138" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002418", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002418", @@ -278590,7 +277967,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002481", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002506", @@ -278694,7 +278071,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002530", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002530", @@ -278722,7 +278099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002536", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6656" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", @@ -278746,7 +278123,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0008816" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", @@ -278762,7 +278139,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002546", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002553", @@ -278810,7 +278187,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005844" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002726", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002726", @@ -279090,7 +278467,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003068", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003068", @@ -279198,7 +278575,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0016879" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003075", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003075", @@ -279302,7 +278679,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003081", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003081", @@ -279378,7 +278755,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007530" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", @@ -279426,7 +278803,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000479" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", @@ -279446,7 +278823,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010364" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003113", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003114", @@ -279542,7 +278919,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003278" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003129", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003133", @@ -280822,7 +280199,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003716", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003716", @@ -281134,7 +280511,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", @@ -281414,7 +280791,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0014950" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004040", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004040", @@ -281570,7 +280947,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004117", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004117", @@ -281754,7 +281131,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002350" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004146", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004148", @@ -282786,7 +282163,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004708", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004708", @@ -282978,7 +282355,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002418" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", @@ -283038,7 +282415,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004770", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004770", @@ -283358,7 +282735,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003068" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004880", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004883", @@ -283462,7 +282839,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000060" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004923", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004924", @@ -283638,7 +283015,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000187" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005090", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005092", @@ -284122,7 +283499,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005434", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005456", @@ -284642,7 +284019,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0005587" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005769", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005769", @@ -285038,7 +284415,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0043209" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006135", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006136", @@ -285246,7 +284623,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005423" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", @@ -285266,7 +284643,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011997" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", @@ -285390,7 +284767,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006562", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006563", @@ -285442,7 +284819,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", @@ -285474,7 +284851,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006601", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006601", @@ -285490,7 +284867,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", @@ -285562,7 +284939,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001676" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006682", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006682", @@ -285662,7 +285039,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", @@ -286226,7 +285603,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004710" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007272", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007272", @@ -286418,7 +285795,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", @@ -286470,7 +285847,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007272" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007390", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007414", @@ -286706,7 +286083,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007779", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007779", @@ -286774,7 +286151,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010707" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", @@ -286894,7 +286271,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007823" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", @@ -287002,7 +286379,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0009145" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008814", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008816", @@ -287818,7 +287195,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004140" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009889", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009891", @@ -288178,7 +287555,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004571" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010191", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010192", @@ -288598,7 +287975,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011137" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010323", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010329", @@ -288794,7 +288171,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010362", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010362", @@ -288810,7 +288187,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010364", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010371", @@ -288958,7 +288335,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", @@ -289362,7 +288739,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", @@ -289754,7 +289131,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011997", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012054", @@ -289834,7 +289211,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012314", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012320", @@ -289882,7 +289259,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004923" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", @@ -290174,7 +289551,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013701", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013702", @@ -290586,7 +289963,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000100" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014892", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014892", @@ -290722,7 +290099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015212", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015228", @@ -291450,7 +290827,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034713", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034713", @@ -293755,6 +293132,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000076", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006914" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000080", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -293920,7 +293304,7 @@ "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ], "restrictions" : [ { "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0050962" + "fillerId" : "http://purl.obolibrary.org/obo/GO_0050908" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000219", @@ -293980,14 +293364,14 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000255", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000257", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_142796" } ] }, { @@ -294060,7 +293444,7 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000365", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0010017" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" } ] }, { @@ -294150,7 +293534,7 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000521", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" } ] }, { @@ -295193,6 +294577,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002240" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005012", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031514" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010007" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005024", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000100" ], @@ -295504,10 +294898,10 @@ } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000271", - "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000064" ], + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000067" ], "restrictions" : [ { "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", - "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000115" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000272", @@ -296123,6 +295517,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002354" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4052002", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001908" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0000768" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000011", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048308" ], @@ -297870,13 +297274,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006259", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006325", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -298592,13 +297989,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008272", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16189" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008284", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -298945,13 +298335,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000468" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010243", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010256", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -300183,13 +299566,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18282" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015869", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015870", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -302437,13 +301813,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032986", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032988", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], @@ -306440,13 +305809,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051027", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051046", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -306489,27 +305851,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006810" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051052", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051053", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051054", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051055", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -309372,13 +308713,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065004", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065010", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043227" ], @@ -309753,13 +309087,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071824", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -309795,13 +309122,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000738" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071897", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071971", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -312630,20 +311950,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0001885" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901564", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901566", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901588", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005874" ], @@ -313538,6 +312844,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0005012" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903292", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -315893,20 +315206,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044346" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000278", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000279", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000282", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -316117,13 +315416,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007369" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000573", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000647", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -326885,6 +326177,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007610", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", diff --git a/pato-full.obo b/pato-full.obo index d74fff2..ef027b9 100644 --- a/pato-full.obo +++ b/pato-full.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: pato/releases/2024-09-04/pato-full.owl +data-version: pato/releases/2024-11-11/pato-full.owl subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" @@ -22,6 +22,7 @@ subsetdef: eye_upper_slim "" subsetdef: functional_classification "" subsetdef: general_cell_types_upper_slim "" subsetdef: gocheck_do_not_annotate "" +subsetdef: gocheck_obsoletion_candidate "" subsetdef: goslim_agr "" subsetdef: goslim_candida "" subsetdef: goslim_chembl "" @@ -73,7 +74,7 @@ ontology: pato/pato-full property_value: dc:description "An ontology of phenotypic qualities (properties, attributes or characteristics)." xsd:string property_value: dc:title "PATO - the Phenotype And Trait Ontology" xsd:string property_value: has_ontology_root_term PATO:0000001 -property_value: owl:versionInfo "2024-09-04" xsd:string +property_value: owl:versionInfo "2024-11-11" xsd:string property_value: terms:license https://creativecommons.org/licenses/by/3.0/ [Term] @@ -533,38 +534,6 @@ relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite relationship: RO:0000087 CHEBI:77746 ! has role human metabolite -[Term] -id: CHEBI:16991 -name: deoxyribonucleic acid -namespace: chebi_ontology -alt_id: CHEBI:13302 -alt_id: CHEBI:21123 -alt_id: CHEBI:33698 -alt_id: CHEBI:4291 -def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." [] -subset: 3_STAR -synonym: "(Deoxyribonucleotide)m" RELATED [KEGG_COMPOUND] -synonym: "(Deoxyribonucleotide)n" RELATED [KEGG_COMPOUND] -synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG_COMPOUND] -synonym: "Deoxyribonucleic acid" EXACT [KEGG_COMPOUND] -synonym: "deoxyribonucleic acids" RELATED [ChEBI] -synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI] -synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus] -synonym: "DNA" RELATED [IUPAC] -synonym: "DNA" RELATED [UniProt] -synonym: "DNA" RELATED [KEGG_COMPOUND] -synonym: "DNAn" RELATED [KEGG_COMPOUND] -synonym: "DNAn+1" RELATED [KEGG_COMPOUND] -synonym: "DNS" RELATED [ChEBI] -synonym: "thymus nucleic acid" RELATED [ChEBI] -xref: KEGG:C00039 -is_a: BFO:0000004 -is_a: CHEBI:33696 ! nucleic acid -relationship: has_part CHEBI:33793 ! canonical deoxyribonucleoside residue -relationship: has_part CHEBI:50298 ! canonical deoxyribonucleotide residue -relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite -relationship: RO:0000087 CHEBI:77746 ! has role human metabolite - [Term] id: CHEBI:17087 name: ketone @@ -2472,19 +2441,6 @@ synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue -[Term] -id: CHEBI:33793 -name: canonical deoxyribonucleoside residue -namespace: chebi_ontology -subset: 3_STAR -synonym: "canonical deoxyribonucleoside residues" RELATED [ChEBI] -synonym: "common 2'-deoxyribonucleoside residue" RELATED [CBN] -synonym: "common 2'-deoxyribonucleoside residues" RELATED [CBN] -synonym: "dN" RELATED [CBN] -synonym: "dNuc" RELATED [CBN] -synonym: "standard deoxyribonucleoside residues" RELATED [ChEBI] -is_a: CHEBI:33791 ! canonical nucleoside residue - [Term] id: CHEBI:33822 name: organic hydroxy compound @@ -3519,14 +3475,6 @@ subset: 3_STAR synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue -[Term] -id: CHEBI:50298 -name: canonical deoxyribonucleotide residue -namespace: chebi_ontology -subset: 3_STAR -synonym: "canonical deoxyribonucleotide residues" RELATED [ChEBI] -is_a: CHEBI:50297 ! canonical nucleotide residue - [Term] id: CHEBI:50299 name: canonical ribonucleotide residue @@ -4626,7 +4574,7 @@ disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="bearer_of"} ! nucleus relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="bearer_of"} ! nucleus -relationship: RO:0002160 NCBITaxon:131567 ! only in taxon cellular organisms +relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms [Term] id: CL:0000005 @@ -4686,6 +4634,7 @@ subset: cellxgene_subset xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: capable_of GO:0048477 ! oogenesis @@ -4713,9 +4662,8 @@ xref: MESH:D009865 xref: WBbt:0006797 is_a: BFO:0000002 is_a: CL:0000021 ! female germ cell -is_a: CL:0000255 ! eukaryotic cell relationship: participates_in GO:0007143 ! female meiotic nuclear division -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: CL:0000024 @@ -4772,6 +4720,7 @@ name: glioblast subset: cellxgene_subset is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell +is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell [Term] @@ -4784,7 +4733,7 @@ xref: BTO:0000930 xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: CL:0000034 @@ -4797,6 +4746,7 @@ subset: human_reference_atlas synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0017145 ! stem cell division @@ -5032,7 +4982,8 @@ def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] subset: cellxgene_subset xref: VHOG:0001532 xref: XAO:0000031 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell +is_a: PR:000050567 intersection_of: CL:0000000 ! cell intersection_of: has_part GO:0005929 ! cilium relationship: has_part GO:0005929 ! cilium @@ -5050,7 +5001,7 @@ xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FMA:66768 xref: WBbt:0003672 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium @@ -5085,7 +5036,6 @@ is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0004638 ! blood vessel endothelium -relationship: RO:0002202 CL:0002546 ! develops from embryonic blood vessel endothelial progenitor cell [Term] id: CL:0000075 @@ -5098,14 +5048,19 @@ is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000076 name: squamous epithelial cell +def: "Any epithelial cell that is part of some squamous epithelium." [FBC:Autogenerated] subset: cellxgene_subset xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0006914 ! squamous epithelium +relationship: part_of UBERON:0006914 ! squamous epithelium [Term] id: CL:0000077 name: mesothelial cell -def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] +def: "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." [GOC:tfm, ISBN:0721662544, PMID:26106328] +comment: Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. {xref="PMID:26106328"} subset: cellxgene_subset subset: human_reference_atlas synonym: "mesotheliocyte" EXACT [] @@ -5113,12 +5068,13 @@ xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell +relationship: part_of UBERON:0001136 ! mesothelium [Term] id: CL:0000080 name: circulating cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid @@ -5265,6 +5221,7 @@ xref: CALOHA:TS-0278 xref: FMA:66772 is_a: BFO:0000002 is_a: CL:0000213 ! lining cell +is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell [Term] @@ -5293,8 +5250,7 @@ id: CL:0000123 name: neuron associated cell (sensu Vertebrata) subset: cellxgene_subset is_a: CL:0000095 ! neuron associated cell -is_a: CL:0000255 ! eukaryotic cell -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell [Term] @@ -5310,6 +5266,7 @@ synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 +xref: https://cellxgene.cziscience.com/cellguide/CL_0000125 is_a: CL:0000095 ! neuron associated cell [Term] @@ -5442,6 +5399,7 @@ def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion vi subset: general_cell_types_upper_slim xref: FMA:16014 is_a: CL:0000151 ! secretory cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002365 ! exocrine gland relationship: part_of UBERON:0002365 ! exocrine gland @@ -5480,6 +5438,7 @@ synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000164 {gci_relation="part_of", gci_filler="UBERON:0000945"} ! enteroendocrine cell +is_a: CL:0000255 ! eukaryotic cell relationship: part_of UBERON:0000949 ! endocrine system [Term] @@ -5489,6 +5448,7 @@ def: "An endocrine cell that is located in the epithelium of the gastrointestina subset: cellxgene_subset xref: BTO:0003865 xref: FMA:62930 +xref: https://cellxgene.cziscience.com/cellguide/CL_0000164 xref: MESH:D019858 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell @@ -5569,6 +5529,7 @@ xref: FMA:67328 xref: WBbt:0003675 is_a: BFO:0000002 is_a: CL:0000183 ! contractile cell +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000393 ! electrically responsive cell relationship: RO:0002202 CL:0000056 ! develops from myoblast @@ -5583,7 +5544,7 @@ synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue @@ -5612,7 +5573,7 @@ name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] synonym: "receptor cell" EXACT [] xref: MESH:D011984 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception intersection_of: part_of UBERON:0001032 ! sensory system @@ -5645,15 +5606,16 @@ relationship: capable_of GO:0050912 ! detection of chemical stimulus involved in [Term] id: CL:0000210 name: photoreceptor cell -def: "A cell specialized to detect and transduce light." [MESH:D010786] +def: "A cell specialized in detecting light stimuli that are involved in visual perception." [MESH:D010786] subset: cellxgene_subset xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FMA:86740 -is_a: CL:0000006 ! neuronal receptor cell +is_a: CL:0000101 ! sensory neuron +is_a: CL:0008028 ! visual system neuron intersection_of: CL:0000540 ! neuron -intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception -relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception +intersection_of: capable_of GO:0050908 ! detection of light stimulus involved in visual perception +relationship: capable_of GO:0050908 ! detection of light stimulus involved in visual perception [Term] id: CL:0000211 @@ -5718,6 +5680,7 @@ name: ectodermal cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000924 ! ectoderm @@ -5729,6 +5692,7 @@ subset: cellxgene_subset synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000926 ! mesoderm @@ -5738,6 +5702,7 @@ name: endodermal cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] synonym: "endoderm cell" EXACT [] xref: FMA:72555 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000925 ! endoderm @@ -5757,6 +5722,7 @@ relationship: bearer_of PATO:0001405 ! anucleate id: CL:0000226 name: single nucleate cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: bearer_of PATO:0001407 ! mononucleate @@ -5774,12 +5740,10 @@ relationship: bearer_of PATO:0001406 ! binucleate [Term] id: CL:0000228 name: multinucleate cell -def: "A cell with more than one nucleus." [FB:ma] -synonym: "syncitium" EXACT [] -synonym: "syncytial cell" EXACT [] -synonym: "syncytium" EXACT [] -xref: AEO:0000203 -xref: WBbt:0008074 +def: "A cell with more than one nucleus." [FB:ma, Wikipedia:Multinucleate] +synonym: "multinucleated cells" EXACT [Wikipedia:Multinucleate] +synonym: "polynuclear cells" EXACT [Wikipedia:Multinucleate] +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: bearer_of PATO:0001908 ! multinucleate @@ -5814,22 +5778,22 @@ relationship: RO:0002202 CL:0000558 ! develops from reticulocyte [Term] id: CL:0000255 name: eukaryotic cell -def: "Any cell that only exists in Eukaryota." [FBC:Autogenerated] +def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated] subset: cellxgene_subset xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell -intersection_of: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota -relationship: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota +intersection_of: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota +relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota [Term] id: CL:0000257 name: Eumycetozoan cell -def: "Any cell that only exists in Eumycetozoa." [FBC:Autogenerated] +def: "Any cell that in taxon some Eumycetozoa." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell -intersection_of: RO:0002160 NCBITaxon:142796 ! only in taxon Eumycetozoa -relationship: RO:0002160 NCBITaxon:142796 ! only in taxon Eumycetozoa +intersection_of: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa +relationship: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa [Term] id: CL:0000287 @@ -5838,6 +5802,7 @@ def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas +is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000970 ! eye @@ -5934,6 +5899,7 @@ name: scleral cell def: "A cell of the sclera of the eye." [GOC:add] subset: eye_upper_slim is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera @@ -5946,6 +5912,7 @@ name: choroidal cell of the eye def: "A structural cell that is part of optic choroid." [GOC:add] subset: eye_upper_slim is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid @@ -5957,7 +5924,7 @@ id: CL:0000349 name: extraembryonic cell def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] subset: general_cell_types_upper_slim -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure @@ -5965,7 +5932,7 @@ relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell -def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [GOC:tfm, MESH:D014327, PMID:37630754] {comment="doi:10.1007/978-3-030-84725-8"} +def: "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development." [doi:10.1007/978-3-030-84725-8, GOC:tfm, MESH:D014327, PMID:37630754] synonym: "trophoblastic cell" EXACT [doi:10.1007/978-3-030-84725-8] xref: FMA:83028 is_a: BFO:0000002 @@ -6040,8 +6007,8 @@ is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote -intersection_of: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +intersection_of: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa [Term] id: CL:0000393 @@ -6204,11 +6171,11 @@ relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber [Term] id: CL:0000521 name: fungal cell -def: "Any cell that only exists in Fungi." [FBC:Autogenerated] +def: "Any cell that in taxon some Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell -intersection_of: RO:0002160 NCBITaxon:4751 ! only in taxon Fungi -relationship: RO:0002160 NCBITaxon:4751 ! only in taxon Fungi +intersection_of: RO:0002162 NCBITaxon:4751 ! in taxon Fungi +relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi [Term] id: CL:0000525 @@ -6221,8 +6188,8 @@ synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 -is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell +is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: part_of UBERON:0000371 ! syncytiotrophoblast @@ -6298,6 +6265,7 @@ synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell +is_a: PR:000050567 intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: bearer_of PATO:0002505 ! nucleated intersection_of: bearer_of PATO:0040072 ! high nuclear/cytoplasmic ratio @@ -6342,6 +6310,7 @@ synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 ! erythroblast +is_a: PR:000050567 intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017503 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin @@ -6362,6 +6331,7 @@ synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 ! erythroblast +is_a: PR:000050567 intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CL:0017504 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin @@ -6472,6 +6442,7 @@ xref: BTO:0001173 xref: CALOHA:TS-0864 xref: MESH:D012156 is_a: CL:0000764 ! erythroid lineage cell +is_a: PR:000050567 intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0071971 ! extracellular exosome assembly intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule @@ -6522,6 +6493,7 @@ synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell +is_a: PR:000050567 intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5 intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2 @@ -6650,6 +6622,7 @@ name: fenestrated endothelial cell def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] subset: cellxgene_subset synonym: "window cell" EXACT [] +xref: https://cellxgene.cziscience.com/cellguide/CL_0000666 is_a: CL:0000115 ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: bearer_of PATO:0002064 ! fenestrated @@ -6691,6 +6664,7 @@ def: "A non-terminally differentiated cell that is capable of developing into a subset: cellxgene_subset is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell @@ -6729,6 +6703,7 @@ subset: cellxgene_subset synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 +xref: https://cellxgene.cziscience.com/cellguide/CL_0000696 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell @@ -6796,7 +6771,7 @@ intersection_of: bearer_of PATO:0002505 ! nucleated intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: part_of UBERON:0002405 ! immune system -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell [Term] @@ -6852,6 +6827,7 @@ xref: BTO:0001441 xref: CALOHA:TS-0647 xref: MESH:D022423 is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor @@ -6937,7 +6913,9 @@ synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell +is_a: PR:000050567 intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001402 ! multipotent intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule @@ -7057,7 +7035,7 @@ name: bone cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] subset: general_cell_types_upper_slim subset: human_reference_atlas -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element @@ -7154,6 +7132,7 @@ synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell +is_a: PR:000050567 intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: capable_of GO:0030218 ! erythrocyte differentiation intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule @@ -7188,6 +7167,7 @@ name: hematopoietic lineage restricted progenitor cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] subset: blood_and_immune_upper_slim is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001400 ! unipotent @@ -7204,6 +7184,7 @@ def: "A hematopoietic oligopotent progenitor cell that has the ability to differ comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). subset: blood_and_immune_upper_slim is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001401 ! oligopotent @@ -7217,6 +7198,7 @@ id: CL:0002067 name: type A enteroendocrine cell def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 +xref: https://cellxgene.cziscience.com/cellguide/CL_0002067 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell @@ -7579,7 +7561,7 @@ def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] subset: cellxgene_subset xref: CALOHA:TS-2040 xref: FMA:70333 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0001016 ! nervous system relationship: part_of UBERON:0001016 ! nervous system @@ -7594,7 +7576,7 @@ subset: cellxgene_subset xref: CALOHA:TS-2096 xref: FMA:63875 xref: MESH:D003239 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue @@ -7683,11 +7665,11 @@ creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002372 name: myotube -def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] -synonym: "myotubule" EXACT [] -synonym: "single cell sarcomere" EXACT [] -is_a: CL:0000228 ! multinucleate cell +def: "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] +synonym: "myofiber" EXACT [FBbt:00005812] +synonym: "myofibril" EXACT [FBbt:00005812] is_a: CL:0000737 ! striated muscle cell +is_a: CL:4052002 ! syncytial cell intersection_of: CL:0000187 ! muscle cell intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: bearer_of PATO:0002478 ! transversely striated @@ -7699,12 +7681,14 @@ creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002375 name: Schwann cell precursor -def: "A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] +def: "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." [GOC:tfm, PMID:15580626, PMID:30971890, PMID:35815410] +comment: Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. {xref="PMID:35815410"} subset: cellxgene_subset synonym: "Schwann cell precursor cell" EXACT [] -is_a: CL:0000030 ! glioblast is_a: CL:0011026 ! progenitor cell +relationship: bearer_of PATO:0001402 ! multipotent relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell +relationship: RO:0002387 CL:0002573 ! has potential to develop into Schwann cell property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2010-09-24T02:06:10Z @@ -7750,7 +7734,6 @@ creation_date: 2010-10-15T09:24:08Z id: CL:0002453 name: oligodendrocyte precursor cell def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:10704434, PMID:11756508, PMID:20142420, PMID:2182078, PMID:24133281, PMID:9826671] -comment: This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). {xref="PMID:10704434", xref="ISBN:9780702028991", xref="PMID:2182078"} subset: cellxgene_subset subset: human_reference_atlas synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD [PMID:2253328] @@ -7771,7 +7754,7 @@ xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0007100 ! primary circulatory organ relationship: part_of UBERON:0007100 ! primary circulatory organ @@ -7840,6 +7823,7 @@ subset: human_reference_atlas synonym: "endothelial cell of vein" EXACT [] synonym: "venous endothelial cell" EXACT [] xref: FMA:62104 +xref: https://cellxgene.cziscience.com/cellguide/CL_0002543 xref: KUPO:0001099 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell @@ -7848,15 +7832,6 @@ relationship: part_of UBERON:0001638 ! vein property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-02-28T03:48:11Z -[Term] -id: CL:0002546 -name: embryonic blood vessel endothelial progenitor cell -def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] -comment: See CL:0002619. -is_a: CL:0000222 ! mesodermal cell -property_value: terms:contributor https://orcid.org/0000-0003-1980-3228 -creation_date: 2011-02-28T04:20:39Z - [Term] id: CL:0002547 name: fibroblast of the aortic adventitia @@ -7925,6 +7900,7 @@ name: mesenchymal stem cell of adipose tissue def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] subset: cellxgene_subset synonym: "mesenchymal stem cell of adipose" EXACT [] +xref: https://cellxgene.cziscience.com/cellguide/CL_0002570 is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: part_of UBERON:0001013 ! adipose tissue @@ -7942,6 +7918,7 @@ subset: human_reference_atlas synonym: "neurolemmocyte" EXACT [PMID:32119275, PMID:38638689] xref: BTO:0001220 xref: CALOHA:TS-0898 +xref: https://cellxgene.cziscience.com/cellguide/CL_0002573 xref: MESH:D012583 is_a: CL:0000125 ! glial cell relationship: part_of UBERON:0000010 ! peripheral nervous system @@ -7955,6 +7932,7 @@ def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] subset: cellxgene_subset subset: eye_upper_slim subset: human_reference_atlas +xref: https://cellxgene.cziscience.com/cellguide/CL_0002585 is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell @@ -8220,6 +8198,24 @@ intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord relationship: RO:0002100 UBERON:0002240 ! has soma location spinal cord +[Term] +id: CL:0005012 +name: multi-ciliated epithelial cell +def: "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." [CL:CVS, PMID:28400610, PMID:30422572, PMID:38032388] +comment: While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility {xref="PMID:22118931", xref="PMID:23959957", xref="PMID:26378583", xref="PMID:25729351"} +subset: cellxgene_subset +synonym: "multi-ciliated cell" BROAD [] +synonym: "multiciliated cell" BROAD [] +synonym: "multiciliated epithelial cell" EXACT [] +xref: https://cellxgene.cziscience.com/cellguide/CL_0005012 +is_a: CL:0000067 ! ciliated epithelial cell +is_a: CL:0000075 ! columnar/cuboidal epithelial cell +intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell +intersection_of: bearer_of PATO:0010007 ! multiciliated +intersection_of: has_part GO:0031514 ! motile cilium +relationship: bearer_of PATO:0010007 ! multiciliated +relationship: has_part GO:0031514 ! motile cilium + [Term] id: CL:0005024 name: somatomotor neuron @@ -8335,6 +8331,7 @@ subset: cellxgene_subset subset: human_reference_atlas synonym: "mesenchyme cell" EXACT [] is_a: CL:0000219 ! motile cell +is_a: CL:0000255 ! eukaryotic cell relationship: capable_of GO:0016477 ! cell migration relationship: part_of UBERON:0003104 ! mesenchyme @@ -8588,6 +8585,7 @@ id: CL:0011012 name: neural crest cell def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] subset: cellxgene_subset +xref: https://cellxgene.cziscience.com/cellguide/CL_0011012 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) @@ -8629,6 +8627,7 @@ name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] subset: cellxgene_subset is_a: BFO:0000002 +is_a: CL:0000255 ! eukaryotic cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: RO:0002202 CL:0000034 ! develops from stem cell @@ -8788,6 +8787,7 @@ def: "A neuroendocrine cell that is part of respiratory epithelium of the lung a subset: cellxgene_subset subset: human_reference_atlas synonym: "pulmonary neuroendocrine cell" EXACT [PMID:33355253] +xref: https://cellxgene.cziscience.com/cellguide/CL_1000223 is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell @@ -8802,13 +8802,14 @@ relationship: has_part GO:0031045 ! dense core granule [Term] id: CL:1000271 name: lung ciliated cell -def: "Any ciliated cell that is part of some lung." [FBC:Autogenerated] +def: "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." [PMID:27864314] subset: cellxgene_subset subset: human_reference_atlas +is_a: CL:0000067 ! ciliated epithelial cell +is_a: CL:0000082 ! epithelial cell of lung is_a: CL:4030034 ! respiratory ciliated cell -intersection_of: CL:0000064 ! ciliated cell -intersection_of: part_of UBERON:0002048 ! lung -relationship: part_of UBERON:0002048 ! lung +intersection_of: CL:0000067 ! ciliated epithelial cell +intersection_of: part_of UBERON:0000115 ! lung epithelium [Term] id: CL:1000272 @@ -8816,6 +8817,7 @@ name: lung secretory cell def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] subset: cellxgene_subset is_a: CL:0000151 ! secretory cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung @@ -8995,6 +8997,7 @@ subset: human_reference_atlas synonym: "arterial endothelial cell" EXACT [] xref: BTO:0004758 xref: FMA:67761 +xref: https://cellxgene.cziscience.com/cellguide/CL_1000413 xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell @@ -9119,6 +9122,7 @@ def: "A mesothelial cell that is part of the pleura." [GOC:tfm] subset: cellxgene_subset synonym: "pleural mesothelial cell" EXACT [FMA:86737] xref: FMA:86737 +xref: https://cellxgene.cziscience.com/cellguide/CL_1000491 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0000977 ! pleura @@ -9141,6 +9145,7 @@ def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] subset: cellxgene_subset subset: human_reference_atlas xref: FMA:86739 +xref: https://cellxgene.cziscience.com/cellguide/CL_1000493 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura @@ -9201,7 +9206,7 @@ relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:1001602 name: cerebral cortex endothelial cell -def: "Endothelial cells forming the walls of the capillaries within the cerebral cortex." [NPX:PDR] +def: "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." [NPX:PDR] subset: cellxgene_subset synonym: "cerebral cortex endothelial cells" RELATED [CALOHA:TS-2372] synonym: "endothelial cells of cerebral cortex" RELATED [CALOHA:TS-2372] @@ -9320,7 +9325,7 @@ creation_date: 2014-06-24T23:16:45Z id: CL:2000020 name: inner cell mass cell def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] -is_a: CL:0000000 ! cell +is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: part_of UBERON:0000087 ! inner cell mass relationship: part_of UBERON:0000087 ! inner cell mass @@ -9864,6 +9869,20 @@ relationship: RO:0000086 PATO:0002354 ! has quality active property_value: terms:contributor https://orcid.org/0009-0005-7919-4905 property_value: terms:date "2024-07-19T09:14:23Z" xsd:string +[Term] +id: CL:4052002 +name: syncytial cell +def: "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." [PMID:20851884, Wikipedia:Syncytium] +synonym: "syncytium" EXACT [WBbt:0008074] +is_a: BFO:0000002 +is_a: CL:0000228 ! multinucleate cell +intersection_of: CL:0000000 ! cell +intersection_of: bearer_of PATO:0001908 ! multinucleate +intersection_of: output_of GO:0000768 ! syncytium formation by plasma membrane fusion +relationship: output_of GO:0000768 ! syncytium formation by plasma membrane fusion +property_value: terms:contributor https://orcid.org/0009-0000-8480-9277 +property_value: terms:date "2024-08-15T10:38:46Z" xsd:dateTime + [Term] id: GO:0000011 name: vacuole inheritance @@ -10040,8 +10059,7 @@ synonym: "chromosome scaffold" RELATED [] synonym: "cytoplasmic chromatin" NARROW [] synonym: "nuclear chromatin" NARROW [] xref: NIF_Subcellular:sao1615953555 -is_a: BFO:0000004 -is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0005694 ! chromosome [Term] @@ -13894,7 +13912,6 @@ def: "The chemical reactions and pathways involving aminoglycans, any polymer co synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process -is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:22506 ! aminoglycan relationship: has_primary_input_or_output CHEBI:22506 ! aminoglycan @@ -13911,7 +13928,6 @@ synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:22506 ! aminoglycan relationship: has_primary_output CHEBI:22506 ! aminoglycan @@ -13986,28 +14002,6 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity -[Term] -id: GO:0006259 -name: DNA metabolic process -namespace: biological_process -alt_id: GO:0055132 -def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] -subset: goslim_agr -subset: goslim_candida -subset: goslim_chembl -subset: goslim_flybase_ribbon -subset: goslim_metagenomics -subset: goslim_pir -subset: goslim_plant -subset: goslim_plant_ribbon -subset: goslim_prokaryote_ribbon -synonym: "cellular DNA metabolism" EXACT [] -synonym: "DNA metabolism" EXACT [] -is_a: GO:0090304 ! nucleic acid metabolic process -intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid -relationship: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid - [Term] id: GO:0006325 name: chromatin organization @@ -14034,7 +14028,7 @@ synonym: "DNA replication-independent nuclesome assembly" NARROW [] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] synonym: "transcription-coupled nucleosome assembly" NARROW [] -is_a: GO:0071824 ! protein-DNA complex organization +is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0000785 ! chromatin relationship: results_in_organization_of GO:0000785 ! chromatin @@ -14108,7 +14102,6 @@ synonym: "protein translation" EXACT [] xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:36080 ! protein intersection_of: part_of GO:0010467 ! gene expression @@ -14764,7 +14757,6 @@ id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] -comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -15881,6 +15873,8 @@ intersection_of: GO:0046907 ! intracellular transport intersection_of: occurs_in GO:0043005 ! neuron projection intersection_of: results_in_transport_along GO:0005874 ! microtubule relationship: occurs_in GO:0043005 ! neuron projection +relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! in taxon Metazoa [Term] id: GO:0008089 @@ -16009,19 +16003,6 @@ synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process -[Term] -id: GO:0008272 -name: sulfate transport -namespace: biological_process -alt_id: GO:0006870 -def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] -synonym: "sulphate transport" EXACT [] -is_a: GO:0015698 ! inorganic anion transport -is_a: GO:0072348 ! sulfur compound transport -intersection_of: GO:0006810 ! transport -intersection_of: has_primary_input CHEBI:16189 ! sulfate -relationship: has_primary_input CHEBI:16189 ! sulfate - [Term] id: GO:0008283 name: cell population proliferation @@ -16313,7 +16294,6 @@ synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:17089 ! glycoprotein relationship: has_primary_output CHEBI:17089 ! glycoprotein @@ -16325,7 +16305,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process -is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:18282 ! nucleobase relationship: has_primary_input_or_output CHEBI:18282 ! nucleobase @@ -16356,7 +16335,8 @@ subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] synonym: "cellular amine metabolic process" EXACT [] -is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: BFO:0000003 +is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:32952 ! amine relationship: has_primary_input_or_output CHEBI:32952 ! amine @@ -16372,8 +16352,8 @@ synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process is_a: GO:0009308 ! amine metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:32952 ! amine relationship: has_primary_output CHEBI:32952 ! amine @@ -16666,7 +16646,8 @@ namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] -is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: BFO:0000003 +is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:22315 ! alkaloid relationship: has_primary_input_or_output CHEBI:22315 ! alkaloid @@ -16680,10 +16661,8 @@ synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] -xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:22315 ! alkaloid relationship: has_primary_output CHEBI:22315 ! alkaloid @@ -17031,19 +17010,6 @@ intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0000468 ! multicellular organism relationship: results_in_morphogenesis_of UBERON:0000468 ! multicellular organism -[Term] -id: GO:0010243 -name: response to organonitrogen compound -namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419] -comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. -subset: gocheck_do_not_annotate -synonym: "response to organic nitrogen" EXACT [] -is_a: GO:1901698 ! response to nitrogen compound -intersection_of: GO:0050896 ! response to stimulus -intersection_of: has_primary_input CHEBI:35352 ! organonitrogen compound -relationship: has_primary_input CHEBI:35352 ! organonitrogen compound - [Term] id: GO:0010256 name: endomembrane system organization @@ -18688,7 +18654,7 @@ name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] -is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:32952 ! amine relationship: has_primary_input CHEBI:32952 ! amine @@ -19226,19 +19192,6 @@ intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:18282 ! nucleobase relationship: has_primary_input CHEBI:18282 ! nucleobase -[Term] -id: GO:0015869 -name: protein-DNA complex transport -namespace: biological_process -def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] -synonym: "DNA-protein complex transport" EXACT [GOC:mah] -is_a: GO:0006886 ! intracellular protein transport -is_a: GO:0015931 ! nucleobase-containing compound transport -is_a: GO:0031503 ! protein-containing complex localization -intersection_of: GO:0006810 ! transport -intersection_of: has_primary_input GO:0032993 ! protein-DNA complex -relationship: has_primary_input GO:0032993 ! protein-DNA complex - [Term] id: GO:0015870 name: acetylcholine transport @@ -19780,7 +19733,6 @@ synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process -is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output PR:000000001 ! protein relationship: has_primary_input_or_output PR:000000001 ! protein @@ -24097,18 +24049,6 @@ intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0032991 ! protein-containing complex relationship: results_in_disassembly_of GO:0032991 ! protein-containing complex -[Term] -id: GO:0032986 -name: protein-DNA complex disassembly -namespace: biological_process -def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] -synonym: "DNA-protein complex disassembly" EXACT [GOC:mah] -is_a: GO:0032984 ! protein-containing complex disassembly -is_a: GO:0071824 ! protein-DNA complex organization -intersection_of: GO:0022411 ! cellular component disassembly -intersection_of: results_in_disassembly_of GO:0032993 ! protein-DNA complex -relationship: results_in_disassembly_of GO:0032993 ! protein-DNA complex - [Term] id: GO:0032988 name: protein-RNA complex disassembly @@ -24155,17 +24095,6 @@ is_a: GO:0005575 ! cellular_component disjoint_from: GO:0110165 ! cellular anatomical entity relationship: has_part PR:000000001 ! protein -[Term] -id: GO:0032993 -name: protein-DNA complex -namespace: cellular_component -def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] -comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. -subset: goslim_pir -synonym: "DNA-protein complex" EXACT [GOC:mah] -is_a: GO:0032991 ! protein-containing complex -relationship: has_part CHEBI:16991 ! deoxyribonucleic acid - [Term] id: GO:0033002 name: muscle cell proliferation @@ -26302,7 +26231,8 @@ synonym: "indole derivative metabolism" NARROW [] synonym: "indole-containing compound metabolism" EXACT [] synonym: "ketole metabolic process" EXACT [] synonym: "ketole metabolism" EXACT [] -is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: BFO:0000003 +is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:24828 ! indoles relationship: has_primary_input_or_output CHEBI:24828 ! indoles @@ -26318,8 +26248,8 @@ synonym: "indole-containing compound anabolism" EXACT [] synonym: "indole-containing compound biosynthesis" EXACT [] synonym: "indole-containing compound formation" EXACT [] synonym: "indole-containing compound synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process is_a: GO:0042430 ! indole-containing compound metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:24828 ! indoles relationship: has_primary_output CHEBI:24828 ! indoles @@ -26888,6 +26818,7 @@ id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] +subset: gocheck_do_not_annotate synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle @@ -26901,6 +26832,7 @@ id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +subset: gocheck_do_not_annotate subset: goslim_mouse synonym: "biological condensate" RELATED [] synonym: "non-membrane-enclosed organelle" EXACT [] @@ -26912,6 +26844,7 @@ id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] +subset: gocheck_do_not_annotate subset: goslim_pir is_a: GO:0043226 ! organelle intersection_of: GO:0043226 ! organelle @@ -27108,7 +27041,7 @@ id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl] -is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:22315 ! alkaloid relationship: has_primary_input CHEBI:22315 ! alkaloid @@ -27184,7 +27117,7 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] synonym: "response to polypeptide hormone stimulus" EXACT [] is_a: GO:0009725 ! response to hormone -is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:25905 ! peptide hormone @@ -27547,6 +27480,7 @@ name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] +subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis @@ -29552,8 +29486,8 @@ synonym: "nucleobase anabolism" EXACT [] synonym: "nucleobase biosynthesis" EXACT [] synonym: "nucleobase formation" EXACT [] synonym: "nucleobase synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process is_a: GO:0009112 ! nucleobase metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18282 ! nucleobase relationship: has_primary_output CHEBI:18282 ! nucleobase @@ -29890,8 +29824,8 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544] synonym: "carbamate resistance" RELATED [] synonym: "carbamate susceptibility/resistance" RELATED [] -is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0017085 ! response to insecticide +is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:13941 ! carbamate @@ -32911,7 +32845,6 @@ synonym: "sensory transduction of light stimulus during visual perception" EXACT synonym: "visual perception, detection of light stimulus" EXACT [] synonym: "visual perception, sensory transduction during perception of light" EXACT [] synonym: "visual perception, sensory transduction of light stimulus" EXACT [] -is_a: GO:0009584 ! detection of visible light is_a: GO:0050962 ! detection of light stimulus involved in sensory perception intersection_of: GO:0009583 ! detection of light stimulus intersection_of: part_of GO:0007601 ! visual perception @@ -33068,16 +33001,6 @@ synonym: "tactition" EXACT [] xref: Wikipedia:Touch is_a: GO:0050954 ! sensory perception of mechanical stimulus -[Term] -id: GO:0051027 -name: DNA transport -namespace: biological_process -def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] -is_a: GO:0050657 ! nucleic acid transport -intersection_of: GO:0006810 ! transport -intersection_of: has_primary_input CHEBI:16991 ! deoxyribonucleic acid -relationship: has_primary_input CHEBI:16991 ! deoxyribonucleic acid - [Term] id: GO:0051046 name: regulation of secretion @@ -33161,54 +33084,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006810 ! transport relationship: negatively_regulates GO:0006810 ! transport -[Term] -id: GO:0051052 -name: regulation of DNA metabolic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] -subset: goslim_yeast -synonym: "regulation of DNA metabolism" EXACT [] -is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process -is_a: GO:0060255 ! regulation of macromolecule metabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0006259 ! DNA metabolic process -relationship: regulates GO:0006259 ! DNA metabolic process - -[Term] -id: GO:0051053 -name: negative regulation of DNA metabolic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] -synonym: "down regulation of DNA metabolic process" EXACT [] -synonym: "down-regulation of DNA metabolic process" EXACT [] -synonym: "downregulation of DNA metabolic process" EXACT [] -synonym: "inhibition of DNA metabolic process" NARROW [] -synonym: "negative regulation of DNA metabolism" EXACT [] -is_a: GO:0010605 ! negative regulation of macromolecule metabolic process -is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process -is_a: GO:0051052 ! regulation of DNA metabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process -relationship: negatively_regulates GO:0006259 ! DNA metabolic process - -[Term] -id: GO:0051054 -name: positive regulation of DNA metabolic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] -synonym: "activation of DNA metabolic process" NARROW [] -synonym: "positive regulation of DNA metabolism" EXACT [] -synonym: "stimulation of DNA metabolic process" NARROW [] -synonym: "up regulation of DNA metabolic process" EXACT [] -synonym: "up-regulation of DNA metabolic process" EXACT [] -synonym: "upregulation of DNA metabolic process" EXACT [] -is_a: GO:0010604 ! positive regulation of macromolecule metabolic process -is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process -is_a: GO:0051052 ! regulation of DNA metabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0006259 ! DNA metabolic process -relationship: positively_regulates GO:0006259 ! DNA metabolic process - [Term] id: GO:0051055 name: negative regulation of lipid biosynthetic process @@ -39000,18 +38875,6 @@ intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0032991 ! protein-containing complex relationship: results_in_assembly_of GO:0032991 ! protein-containing complex -[Term] -id: GO:0065004 -name: protein-DNA complex assembly -namespace: biological_process -def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] -synonym: "DNA-protein complex assembly" EXACT [GOC:mah] -is_a: GO:0065003 ! protein-containing complex assembly -is_a: GO:0071824 ! protein-DNA complex organization -intersection_of: GO:0022607 ! cellular component assembly -intersection_of: results_in_assembly_of GO:0032993 ! protein-DNA complex -relationship: results_in_assembly_of GO:0032993 ! protein-DNA complex - [Term] id: GO:0065007 name: biological regulation @@ -39707,7 +39570,7 @@ id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] -subset: gocheck_do_not_annotate +subset: gocheck_obsoletion_candidate is_a: BFO:0000003 is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport @@ -39788,21 +39651,6 @@ intersection_of: results_in_transport_across GO:0016020 ! membrane created_by: mah creation_date: 2010-09-03T02:54:26Z -[Term] -id: GO:0071824 -name: protein-DNA complex organization -namespace: biological_process -def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] -synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah] -synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah] -synonym: "protein-DNA complex subunit organization" EXACT [] -is_a: GO:0043933 ! protein-containing complex organization -intersection_of: GO:0016043 ! cellular component organization -intersection_of: results_in_organization_of GO:0032993 ! protein-DNA complex -relationship: results_in_organization_of GO:0032993 ! protein-DNA complex -created_by: mah -creation_date: 2010-09-08T10:03:26Z - [Term] id: GO:0071826 name: protein-RNA complex organization @@ -39842,7 +39690,7 @@ name: response to monoamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] synonym: "response to monoamine stimulus" EXACT [GOC:dos] -is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:63534 ! monoamine relationship: has_primary_input CHEBI:63534 ! monoamine @@ -39895,23 +39743,6 @@ relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! in taxon Vertebrata created_by: mah creation_date: 2010-09-14T12:44:09Z -[Term] -id: GO:0071897 -name: DNA biosynthetic process -namespace: biological_process -def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah] -synonym: "DNA anabolism" EXACT [GOC:mah] -synonym: "DNA biosynthesis" EXACT [GOC:mah] -synonym: "DNA formation" EXACT [GOC:mah] -synonym: "DNA synthesis" EXACT [GOC:mah] -is_a: GO:0006259 ! DNA metabolic process -is_a: GO:0141187 ! nucleic acid biosynthetic process -intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:16991 ! deoxyribonucleic acid -relationship: has_primary_output CHEBI:16991 ! deoxyribonucleic acid -created_by: mah -creation_date: 2010-09-15T02:14:33Z - [Term] id: GO:0071944 name: cell periphery @@ -42570,7 +42401,7 @@ id: GO:0099531 name: presynaptic process involved in chemical synaptic transmission namespace: biological_process def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] -subset: gocheck_do_not_annotate +subset: gocheck_obsoletion_candidate subset: goslim_synapse is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process @@ -44921,7 +44752,8 @@ name: primary amino compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie] synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie] -is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: BFO:0000003 +is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:50994 ! primary amino compound relationship: has_primary_input_or_output CHEBI:50994 ! primary amino compound @@ -44937,8 +44769,8 @@ synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] synonym: "primary amino compound formation" EXACT [GOC:TermGenie] synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009058 ! biosynthetic process is_a: GO:1901160 ! primary amino compound metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:50994 ! primary amino compound relationship: has_primary_output CHEBI:50994 ! primary amino compound @@ -45523,39 +45355,6 @@ relationship: positively_regulates GO:0001885 ! endothelial cell development created_by: pr creation_date: 2012-10-30T12:59:58Z -[Term] -id: GO:1901564 -name: organonitrogen compound metabolic process -namespace: biological_process -def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] -subset: gocheck_do_not_annotate -synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] -is_a: BFO:0000003 -is_a: GO:0008152 ! metabolic process -intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound -relationship: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound -created_by: pr -creation_date: 2012-11-04T15:17:52Z - -[Term] -id: GO:1901566 -name: organonitrogen compound biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] -subset: gocheck_do_not_annotate -synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] -synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] -synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] -synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009058 ! biosynthetic process -is_a: GO:1901564 ! organonitrogen compound metabolic process -intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:35352 ! organonitrogen compound -relationship: has_primary_output CHEBI:35352 ! organonitrogen compound -created_by: pr -creation_date: 2012-11-04T15:18:00Z - [Term] id: GO:1901588 name: dendritic microtubule @@ -46808,10 +46607,12 @@ id: GO:1902358 name: sulfate transmembrane transport namespace: biological_process def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] -is_a: GO:0008272 ! sulfate transport +synonym: "sulphate transport" EXACT [] +is_a: GO:0072348 ! sulfur compound transport is_a: GO:0098661 ! inorganic anion transmembrane transport intersection_of: GO:0055085 ! transmembrane transport intersection_of: has_primary_input CHEBI:16189 ! sulfate +relationship: has_primary_input CHEBI:16189 ! sulfate created_by: dph creation_date: 2013-08-14T14:46:04Z @@ -48153,6 +47954,19 @@ relationship: positively_regulates GO:0035987 ! endodermal cell differentiation created_by: als creation_date: 2014-07-29T13:22:47Z +[Term] +id: GO:1903251 +name: multi-ciliated epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224] +synonym: "multiciliate cell differentiation" BROAD [] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0005012 ! multi-ciliated epithelial cell +relationship: results_in_acquisition_of_features_of CL:0005012 ! multi-ciliated epithelial cell +created_by: tb +creation_date: 2014-08-05T19:21:21Z + [Term] id: GO:1903292 name: protein localization to Golgi membrane @@ -50253,7 +50067,7 @@ name: response to glycoprotein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] synonym: "response to glycoproteins" EXACT [] -is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound intersection_of: GO:0050896 ! response to stimulus intersection_of: has_primary_input CHEBI:17089 ! glycoprotein @@ -54895,41 +54709,6 @@ relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process created_by: jl creation_date: 2010-11-23T01:07:29Z -[Term] -id: GO:2000278 -name: regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "regulation of DNA formation" EXACT [GOC:obol] -synonym: "regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0010556 ! regulation of macromolecule biosynthetic process -is_a: GO:0051052 ! regulation of DNA metabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0071897 ! DNA biosynthetic process -relationship: regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2010-12-08T04:48:15Z - -[Term] -id: GO:2000279 -name: negative regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "negative regulation of DNA formation" EXACT [GOC:obol] -synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process -is_a: GO:0051053 ! negative regulation of DNA metabolic process -is_a: GO:2000278 ! regulation of DNA biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0071897 ! DNA biosynthetic process -relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2010-12-08T04:48:20Z - [Term] id: GO:2000282 name: regulation of cellular amino acid biosynthetic process @@ -55355,24 +55134,6 @@ relationship: positively_regulates GO:0007369 ! gastrulation created_by: yaf creation_date: 2011-04-01T04:10:15Z -[Term] -id: GO:2000573 -name: positive regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "positive regulation of DNA formation" EXACT [GOC:obol] -synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process -is_a: GO:0051054 ! positive regulation of DNA metabolic process -is_a: GO:2000278 ! regulation of DNA biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process -relationship: positively_regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2011-04-04T10:01:20Z - [Term] id: GO:2000647 name: negative regulation of stem cell proliferation @@ -80467,7 +80228,7 @@ xref: SCTID:68439008 xref: Wikipedia:Submucosa is_a: UBERON:0004923 ! organ component layer relationship: BSPO:0001107 UBERON:0000344 ! mucosa -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue [Term] @@ -80664,7 +80425,7 @@ xref: Wikipedia:Compound_eye is_a: UBERON:0015165 ! multi-unit eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000971 ! composed primarily of ommatidium -relationship: RO:0002160 NCBITaxon:6656 ! only in taxon Arthropoda +relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda relationship: RO:0002473 UBERON:0000971 ! composed primarily of ommatidium [Term] @@ -80763,7 +80524,7 @@ intersection_of: UBERON:0000026 ! appendage intersection_of: RO:0000086 PATO:0002236 ! has quality aliform relationship: capable_of_part_of GO:0060361 ! flight relationship: RO:0000086 PATO:0002236 ! has quality aliform -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0000025 @@ -80806,7 +80567,7 @@ xref: VSAO:0000075 xref: Wikipedia:Appendage xref: XAO:0000218 is_a: UBERON:0000475 ! organism subdivision -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000030 @@ -80894,7 +80655,7 @@ xref: XAO:0003024 xref: ZFA:0001114 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: part_of UBERON:0007811 ! craniocervical region -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002551 UBERON:0003129 {gci_relation="part_of", gci_filler="NCBITaxon:7776"} ! has skeleton skull [Term] @@ -80949,7 +80710,7 @@ xref: ZFA:0005647 is_a: UBERON:0007846 ! dense regular connective tissue relationship: has_part CL:0000327 ! extracellular matrix secreting cell relationship: part_of UBERON:0002204 ! musculoskeletal system -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002176 UBERON:0001474 ! connects bone element relationship: RO:0002176 UBERON:0001630 ! connects muscle organ @@ -81282,7 +81043,7 @@ xref: NCIT:C34076 xref: SCTID:118966000 is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001434 ! skeletal system -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0004765 ! composed primarily of skeletal element [Term] @@ -81684,7 +81445,7 @@ is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000108 ! blastula stage relationship: RO:0002082 GO:0007369 ! simultaneous with gastrulation -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000110 @@ -81701,7 +81462,7 @@ is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000109 ! gastrula stage relationship: RO:0002082 GO:0001841 ! simultaneous with neural tube formation -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000111 @@ -81721,7 +81482,7 @@ is_a: UBERON:0000105 ! life cycle stage relationship: part_of UBERON:0000068 ! embryo stage relationship: preceded_by UBERON:0000110 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! neurula stage relationship: RO:0002082 GO:0048513 ! simultaneous with animal organ development -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000114 @@ -81840,7 +81601,7 @@ xref: NCIT:C13197 xref: NLX:28443 xref: Wikipedia:Nucleus_(neuroanatomy) is_a: UBERON:0011215 ! central nervous system cell part cluster -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002473 UBERON:0002020 ! composed primarily of gray matter [Term] @@ -81865,14 +81626,14 @@ name: anterior region of body namespace: uberon is_a: UBERON:0000475 ! organism subdivision relationship: BSPO:0000096 UBERON:0000154 ! posterior region of body -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0000154 name: posterior region of body namespace: uberon is_a: UBERON:0000475 ! organism subdivision -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0000158 @@ -81955,7 +81716,7 @@ is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BSPO:0001106 UBERON:0001555 ! digestive tract relationship: BSPO:0001106 UBERON:0001555 ! digestive tract -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002202 UBERON:0035804 ! develops from future mouth [Term] @@ -82112,7 +81873,7 @@ is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: part_of UBERON:0002193 ! hemolymphoid system relationship: part_of UBERON:0002193 ! hemolymphoid system -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa property_value: terms:contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-08T04:38:19Z @@ -82260,7 +82021,7 @@ xref: Wikipedia:Mucous_membrane is_a: UBERON:0004923 ! organ component layer relationship: has_part UBERON:0000483 ! epithelium relationship: has_part UBERON:0002384 ! connective tissue -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0000353 @@ -82285,7 +82046,7 @@ xref: Wikipedia:Parenchyma is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: capable_of GO:0032501 ! multicellular organismal process -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000355 @@ -82336,7 +82097,7 @@ is_a: UBERON:0002050 ! embryonic structure relationship: has_part UBERON:0000087 ! inner cell mass relationship: has_part UBERON:0000088 ! trophoblast relationship: part_of UBERON:0000307 ! blastula -relationship: RO:0002160 NCBITaxon:32525 ! only in taxon Theria +relationship: RO:0002162 NCBITaxon:32525 ! in taxon Theria relationship: RO:0002202 UBERON:0000085 ! develops from morula relationship: RO:0002491 UBERON:0000108 ! existence starts and ends during blastula stage @@ -82547,7 +82308,7 @@ is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: RO:0002473 UBERON:0001015 ! composed primarily of musculature relationship: capable_of GO:0003012 ! muscle system process -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 UBERON:0001015 ! composed primarily of musculature [Term] @@ -83109,7 +82870,7 @@ union_of: UBERON:0000486 ! multilaminar epithelium union_of: UBERON:0000490 ! unilaminar epithelium relationship: has_part GO:0005911 ! cell-cell junction relationship: has_part UBERON:0005769 ! basement membrane of epithelium -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002473 CL:0000066 ! composed primarily of epithelial cell [Term] @@ -83329,7 +83090,7 @@ xref: SCTID:302553009 xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk relationship: part_of UBERON:0002417 ! abdominal segment of trunk -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0000922 @@ -83402,7 +83163,7 @@ xref: Wikipedia:Germ_layer xref: XAO:0003011 xref: ZFA:0001122 is_a: UBERON:0010316 ! germ layer / neural crest -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000924 @@ -83542,7 +83303,7 @@ xref: ZFA:0001290 is_a: UBERON:0013522 ! subdivision of tube relationship: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0035804 ! future mouth -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0000945 @@ -83586,7 +83347,7 @@ is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0010039 ! food storage organ relationship: capable_of GO:0001696 ! gastric acid secretion relationship: part_of UBERON:0001041 ! foregut -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002433 UBERON:0001007 ! contributes to morphology of digestive system [Term] @@ -83672,7 +83433,7 @@ intersection_of: UBERON:0007100 ! primary circulatory organ intersection_of: has_part UBERON:0004151 ! cardiac chamber relationship: has_part UBERON:0004151 ! cardiac chamber relationship: part_of UBERON:0015410 ! heart plus pericardium -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 UBERON:0004141 ! develops from heart tube relationship: RO:0002433 UBERON:0004535 ! contributes to morphology of cardiovascular system @@ -83721,7 +83482,7 @@ disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 UBERON:0002368 ! composed primarily of endocrine gland relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage @@ -84127,7 +83888,7 @@ relationship: has_part UBERON:0002400 ! parietal pleura relationship: has_part UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0009778 ! pleural sac relationship: RO:0000086 PATO:0001748 ! has quality invaginated -relationship: RO:0002160 NCBITaxon:32524 ! only in taxon Amniota +relationship: RO:0002162 NCBITaxon:32524 ! in taxon Amniota relationship: RO:0002202 UBERON:0003081 ! develops from lateral plate mesoderm relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system @@ -84209,7 +83970,7 @@ xref: Wikipedia:Pons is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0001895 ! metencephalon relationship: part_of UBERON:0002298 ! brainstem -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0001895 ! contributes to morphology of metencephalon relationship: RO:0002433 UBERON:0002298 ! contributes to morphology of brainstem @@ -84373,7 +84134,7 @@ is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad intersection_of: part_of UBERON:0000474 ! female reproductive system disjoint_from: UBERON:0009117 ! indifferent gonad -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002202 UBERON:0009117 ! develops from indifferent gonad [Term] @@ -84469,7 +84230,7 @@ disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0003016 ! respiratory system process relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage [Term] @@ -84561,7 +84322,7 @@ disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0003013 ! circulatory system process -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage [Term] @@ -84649,7 +84410,6 @@ namespace: uberon def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator] subset: cumbo subset: efo_slim -subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -84693,7 +84453,7 @@ disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of GO:0050877 ! nervous system process relationship: has_part CL:0000540 ! neuron -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 CL:0002319 ! composed primarily of neural cell relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage relationship: RO:0002495 UBERON:0016880 ! immediate transformation of future nervous system @@ -84739,7 +84499,7 @@ xref: ZFA:0000012 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001016 ! nervous system -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002495 UBERON:0016879 ! immediate transformation of future central nervous system [Term] @@ -84900,7 +84660,7 @@ disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: capable_of_part_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage [Term] @@ -84990,7 +84750,7 @@ is_a: UBERON:0006562 ! pharynx relationship: distally_connected_to UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus relationship: part_of UBERON:0001004 ! respiratory system relationship: RO:0002150 UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! continuous with esophagus -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0009145 ! develops from pharyngeal region of foregut relationship: RO:0002551 UBERON:0008895 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! has skeleton splanchnocranium @@ -85481,7 +85241,7 @@ xref: Wikipedia:Thoracid_diaphragm is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: RO:0002005 UBERON:0001884 ! innervated_by phrenic nerve -relationship: RO:0002160 NCBITaxon:40674 ! only in taxon Mammalia +relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002495 UBERON:0010084 ! immediate transformation of future diaphragm [Term] @@ -85655,7 +85415,7 @@ xref: NCIT:C13062 xref: SCTID:123961009 xref: Wikipedia:Dorsum_(anatomy) is_a: UBERON:0000475 ! organism subdivision -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0001145 @@ -86214,7 +85974,7 @@ intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue disjoint_from: UBERON:0001630 ! muscle organ disjoint_from: UBERON:0005090 ! muscle structure -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 UBERON:0002481 ! composed primarily of bone tissue [Term] @@ -86594,7 +86354,7 @@ xref: ZFA:0000112 is_a: BFO:0000002 is_a: UBERON:0000025 ! tube relationship: part_of UBERON:0001007 ! digestive system -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002176 UBERON:0000165 ! connects mouth relationship: RO:0002495 UBERON:0007026 ! immediate transformation of presumptive gut @@ -87214,7 +86974,7 @@ intersection_of: RO:0002134 UBERON:0000378 ! innervates tongue muscle relationship: extends_fibers_into UBERON:0002871 ! hypoglossal nucleus relationship: RO:0002134 UBERON:0001571 ! innervates genioglossus muscle relationship: RO:0002134 UBERON:0001572 ! innervates hyoglossus muscle -relationship: RO:0002160 NCBITaxon:32523 ! only in taxon Tetrapoda +relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda [Term] id: UBERON:0001651 @@ -87372,7 +87132,7 @@ is_a: UBERON:0011164 ! neurocranium bone relationship: overlaps UBERON:0002241 ! chondrocranium relationship: overlaps UBERON:0003113 ! dermatocranium relationship: part_of UBERON:0005902 ! occipital region -relationship: RO:0002160 NCBITaxon:117570 ! only in taxon Teleostomi +relationship: RO:0002162 NCBITaxon:117570 ! in taxon Teleostomi relationship: RO:0002202 UBERON:0003089 ! develops from sclerotome relationship: RO:0002221 UBERON:0003687 ! surrounds foramen magnum @@ -87520,7 +87280,7 @@ relationship: capable_of NBO:0000073 relationship: overlaps UBERON:0008895 ! splanchnocranium relationship: part_of UBERON:0011156 ! facial skeleton relationship: part_of UBERON:0011595 ! jaw region -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002576 UBERON:0011595 ! skeleton of jaw region [Term] @@ -89142,7 +88902,7 @@ xref: PBA:294021746 xref: Wikipedia:Neocortex is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0000956 ! cerebral cortex -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0000956 ! contributes to morphology of cerebral cortex [Term] @@ -89510,7 +89270,7 @@ is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000115 ! composed primarily of endothelial cell -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 CL:0000115 ! composed primarily of endothelial cell [Term] @@ -89632,7 +89392,7 @@ is_a: UBERON:0035642 ! laryngeal nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0020358 ! accessory XI nerve nucleus relationship: extends_fibers_into UBERON:0020358 ! accessory XI nerve nucleus -relationship: RO:0002160 NCBITaxon:32523 ! only in taxon Tetrapoda +relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda [Term] id: UBERON:0002020 @@ -89702,7 +89462,7 @@ xref: XAO:0000015 xref: ZFA:0000029 is_a: UBERON:0002616 ! regional part of brain relationship: overlaps UBERON:0002298 ! brainstem -relationship: RO:0002160 NCBITaxon:89593 ! only in taxon Craniata +relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002433 UBERON:0000955 ! contributes to morphology of brain relationship: RO:0002495 UBERON:0007277 ! immediate transformation of presumptive hindbrain @@ -89819,7 +89579,7 @@ is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000170 ! pair of lungs relationship: part_of UBERON:0000170 ! pair of lungs -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002202 UBERON:0000118 ! develops from lung bud relationship: RO:0002433 UBERON:0001004 ! contributes to morphology of respiratory system @@ -90357,7 +90117,7 @@ xref: XAO:0003166 is_a: UBERON:0010912 ! subdivision of skeleton relationship: overlaps UBERON:0000026 ! appendage relationship: part_of UBERON:0011249 ! appendicular skeletal system -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system [Term] @@ -90920,7 +90680,7 @@ xref: EMAPA:18765 xref: FMA:74562 xref: MA:0000013 is_a: UBERON:0000467 ! anatomical system -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0002199 @@ -90954,7 +90714,7 @@ relationship: bounding_layer_of UBERON:0000468 ! multicellular organism relationship: has_part UBERON:0002072 ! hypodermis relationship: has_part UBERON:0002097 ! skin of body relationship: part_of UBERON:0002416 ! integumental system -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0002200 @@ -91144,7 +90904,7 @@ is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002219 UBERON:0001484 ! surrounded by articular capsule disjoint_from: UBERON:0011134 ! nonsynovial joint -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002219 UBERON:0001484 ! surrounded by articular capsule [Term] @@ -91588,7 +91348,7 @@ relationship: BSPO:0000102 UBERON:0001049 ! neural tube relationship: part_of UBERON:0000922 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! embryo relationship: part_of UBERON:0011137 ! axial skeletal system relationship: produces PR:000014841 ! sonic hedgehog protein -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0004880 ! develops from chordamesoderm relationship: RO:0002202 UBERON:0006267 ! develops from notochordal plate relationship: RO:0002488 UBERON:0000068 ! existence starts during embryo stage @@ -91628,7 +91388,7 @@ xref: ZFA:0000155 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 ! epithelial vesicle -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0003059 ! develops from presomitic mesoderm [Term] @@ -91653,7 +91413,7 @@ disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 UBERON:0002365 ! composed primarily of exocrine gland relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage @@ -91714,7 +91474,7 @@ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010316 ! germ layer / neural crest relationship: part_of UBERON:0002346 ! neurectoderm -relationship: RO:0002160 NCBITaxon:89593 ! only in taxon Craniata +relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata relationship: RO:0002202 UBERON:0003075 ! develops from neural plate relationship: RO:0002202 UBERON:0005062 ! develops from neural fold relationship: RO:0002473 CL:0000333 ! composed primarily of migratory neural crest cell @@ -92362,7 +92122,7 @@ xref: VSAO:0000017 xref: XAO:0001017 xref: ZFA:0001632 is_a: UBERON:0000479 ! tissue -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0002385 @@ -92392,7 +92152,7 @@ intersection_of: RO:0002473 CL:0000187 ! composed primarily of muscle cell disjoint_from: UBERON:0003714 ! neural tissue relationship: capable_of GO:0006936 ! muscle contraction relationship: part_of UBERON:0001015 ! musculature -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 CL:0000187 ! composed primarily of muscle cell [Term] @@ -92439,7 +92199,7 @@ disjoint_from: UBERON:0002416 ! integumental system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: part_of UBERON:0002193 ! hemolymphoid system -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0003061 ! develops from blood island [Term] @@ -92691,7 +92451,7 @@ xref: Wikipedia:Autonomic_nervous_system xref: ZFA:0001574 is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0000010 ! peripheral nervous system -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002433 UBERON:0001016 ! contributes to morphology of nervous system [Term] @@ -92801,7 +92561,7 @@ xref: ZFA:0005622 is_a: UBERON:0004755 ! skeletal tissue relationship: has_part CHEBI:18085 ! glycosaminoglycan relationship: has_part CL:0000138 ! chondrocyte -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002433 UBERON:0001434 ! contributes to morphology of skeletal system [Term] @@ -93032,7 +92792,7 @@ xref: ZFA:0005621 is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure relationship: part_of UBERON:0001474 ! bone element -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0002506 @@ -93196,7 +92956,7 @@ xref: WikipediaCategory:Glands is_a: UBERON:0000062 ! organ relationship: capable_of GO:0046903 ! secretion relationship: produces UBERON:0000463 ! organism substance -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0002532 @@ -93237,7 +92997,7 @@ xref: TGMA:0000540 xref: Wikipedia:Sensillum is_a: UBERON:0000020 ! sense organ relationship: part_of UBERON:0001016 ! nervous system -relationship: RO:0002160 NCBITaxon:6656 ! only in taxon Arthropoda +relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda [Term] id: UBERON:0002539 @@ -93272,7 +93032,7 @@ is_a: UBERON:0010188 ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0008814 ! pharyngeal arch system relationship: part_of UBERON:0008816 ! embryonic head -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002256 UBERON:0007690 ! developmentally induced by early pharyngeal endoderm [Term] @@ -93290,7 +93050,7 @@ xref: MIAA:0000369 xref: XAO:0000305 is_a: UBERON:0005085 ! ectodermal placode relationship: part_of UBERON:0000033 ! head -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0002553 @@ -93379,7 +93139,7 @@ is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: adjacent_to UBERON:0005434 ! cervical region relationship: adjacent_to UBERON:0005434 ! cervical region -relationship: RO:0002160 NCBITaxon:8287 ! only in taxon Sarcopterygii +relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii [Term] id: UBERON:0002812 @@ -93836,7 +93596,7 @@ xref: ZFA:0001204 is_a: BFO:0000002 is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000926 ! mesoderm -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0000926 ! develops from mesoderm [Term] @@ -93975,7 +93735,7 @@ xref: ZFA:0000132 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002256 UBERON:0002328 ! developmentally induced by notochord relationship: RO:0002495 UBERON:0007284 ! immediate transformation of presumptive neural plate @@ -94083,7 +93843,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: part_of UBERON:0000926 ! mesoderm -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002221 UBERON:0003887 ! surrounds intraembryonic coelom [Term] @@ -94184,7 +93944,7 @@ xref: XAO:0000397 xref: ZFA:0001080 is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007530 ! migrating mesenchyme population -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 UBERON:0002329 ! develops from somite [Term] @@ -94305,7 +94065,7 @@ xref: ZFA:0000393 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0008019 ! composed primarily of mesenchymal cell -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002254 UBERON:0000926 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! has developmental contribution from mesoderm relationship: RO:0002328 GO:0032502 ! functionally related to developmental process relationship: RO:0002473 CL:0008019 ! composed primarily of mesenchymal cell @@ -94334,7 +94094,7 @@ xref: XAO:0003169 xref: ZFA:0000863 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: part_of UBERON:0010364 ! dermal skeleton -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0003114 @@ -94628,7 +94388,7 @@ relationship: has_part UBERON:0003128 ! cranium relationship: has_part UBERON:0003278 ! skeleton of lower jaw relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0010323 ! cranial skeletal system -relationship: RO:0002160 NCBITaxon:89593 ! only in taxon Craniata +relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata [Term] id: UBERON:0003133 @@ -96954,7 +96714,7 @@ xref: Wikipedia:Recurrent_laryngeal_nerve is_a: BFO:0000002 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0035642 ! laryngeal nerve -relationship: RO:0002160 NCBITaxon:32523 ! only in taxon Tetrapoda +relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda relationship: RO:0002202 UBERON:0003117 ! develops from pharyngeal arch 6 relationship: RO:0002380 UBERON:0001759 ! branching part of vagus nerve @@ -97486,7 +97246,7 @@ synonym: "stromal connective tissue" RELATED [] xref: FMA:81494 xref: NCIT:C67387 is_a: UBERON:0000064 ! organ part -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002473 UBERON:0002384 ! composed primarily of connective tissue [Term] @@ -97907,7 +97667,7 @@ xref: EMAPA:17545 xref: EMAPA:32712 is_a: BFO:0000002 is_a: UBERON:0014950 ! layer of developing cerebral cortex -relationship: RO:0002160 NCBITaxon:40674 ! only in taxon Mammalia +relationship: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia relationship: RO:0002202 UBERON:0004061 ! develops from neural tube mantle layer [Term] @@ -98083,7 +97843,7 @@ is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: overlaps UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0008814 ! pharyngeal arch system -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0007690 ! develops from early pharyngeal endoderm [Term] @@ -98280,7 +98040,7 @@ synonym: "ventricular conduction system" EXACT [] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: part_of UBERON:0002350 ! conducting system of heart -relationship: RO:0002160 NCBITaxon:32523 ! only in taxon Tetrapoda +relationship: RO:0002162 NCBITaxon:32523 ! in taxon Tetrapoda [Term] id: UBERON:0004148 @@ -99906,7 +99666,7 @@ relationship: has_part UBERON:0000014 ! zone of skin relationship: has_part UBERON:0001015 ! musculature relationship: has_part UBERON:0002049 ! vasculature relationship: part_of UBERON:0010707 ! appendage girdle complex -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002170 UBERON:0007823 ! connected to appendage girdle region relationship: RO:0002202 UBERON:0004357 ! develops from paired limb/fin bud relationship: RO:0002551 UBERON:0011582 ! has skeleton paired limb/fin skeleton @@ -100133,7 +99893,7 @@ xref: XAO:0003059 is_a: BFO:0000002 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: has_part UBERON:0002418 ! cartilage tissue -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 UBERON:0009617 ! develops from head paraxial mesoderm [Term] @@ -100210,7 +99970,7 @@ is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0000982 ! has member skeletal joint relationship: part_of UBERON:0001434 ! skeletal system -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria relationship: RO:0002328 GO:0040011 ! functionally related to locomotion relationship: RO:0002351 UBERON:0000982 ! has member skeletal joint relationship: RO:0002492 UBERON:0000066 ! existence ends during fully formed stage @@ -100781,7 +100541,7 @@ xref: TAO:0000091 xref: ZFA:0000091 is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0003068 ! axial mesoderm -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0004883 @@ -100921,7 +100681,7 @@ subset: upper_level xref: FMA:82485 is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0000060 ! anatomical wall -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0004924 @@ -101160,7 +100920,7 @@ xref: FMA:30316 is_a: BFO:0000002 is_a: UBERON:0000061 ! anatomical structure relationship: has_part CL:0000187 ! muscle cell -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0005092 @@ -101959,7 +101719,7 @@ xref: FMA:24219 xref: SCTID:123958008 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: part_of UBERON:0000974 ! neck -relationship: RO:0002160 NCBITaxon:8287 ! only in taxon Sarcopterygii +relationship: RO:0002162 NCBITaxon:8287 ! in taxon Sarcopterygii [Term] id: UBERON:0005456 @@ -102733,7 +102493,7 @@ is_a: UBERON:0005764 ! acellular membrane relationship: adjacent_to CL:0000066 ! epithelial cell relationship: has_part GO:0005587 ! collagen type IV trimer relationship: part_of UBERON:0000483 ! epithelium -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: RO:0002473 GO:0005604 ! composed primarily of basement membrane [Term] @@ -103212,7 +102972,7 @@ intersection_of: UBERON:0006134 ! nerve fiber intersection_of: has_part GO:0043209 ! myelin sheath disjoint_from: UBERON:0006136 ! unmyelinated nerve fiber relationship: has_part GO:0043209 ! myelin sheath -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0006136 @@ -103476,7 +103236,7 @@ xref: NCIT:C34232 xref: VHOG:0001213 is_a: BFO:0000002 is_a: UBERON:0005423 ! developing anatomical structure -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002202 UBERON:0000924 ! develops from ectoderm [Term] @@ -103497,7 +103257,7 @@ intersection_of: UBERON:0003914 ! epithelial tube intersection_of: RO:0002176 UBERON:0001179 ! connects peritoneal cavity intersection_of: RO:0002176 UBERON:0002402 ! connects pleural cavity relationship: part_of UBERON:0011997 ! coelom -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata relationship: RO:0002176 UBERON:0001179 ! connects peritoneal cavity relationship: RO:0002176 UBERON:0002402 ! connects pleural cavity @@ -103679,7 +103439,7 @@ xref: MAT:0000049 xref: MESH:D010614 xref: MIAA:0000049 is_a: UBERON:0004921 ! subdivision of digestive tract -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0006563 @@ -103754,7 +103514,7 @@ intersection_of: UBERON:0006598 ! presumptive structure intersection_of: part_of UBERON:0000307 ! blastula intersection_of: RO:0002387 UBERON:0000925 ! has potential to develop into endoderm relationship: part_of UBERON:0000307 ! blastula -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002387 UBERON:0000925 ! has potential to develop into endoderm [Term] @@ -103805,7 +103565,7 @@ intersection_of: UBERON:0006598 ! presumptive structure intersection_of: part_of UBERON:0000307 ! blastula intersection_of: RO:0002387 UBERON:0000924 ! has potential to develop into ectoderm relationship: part_of UBERON:0000307 ! blastula -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002387 UBERON:0000924 ! has potential to develop into ectoderm [Term] @@ -103823,7 +103583,7 @@ intersection_of: UBERON:0006598 ! presumptive structure intersection_of: part_of UBERON:0000307 ! blastula intersection_of: RO:0002387 UBERON:0000926 ! has potential to develop into mesoderm relationship: part_of UBERON:0000307 ! blastula -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002387 UBERON:0000926 ! has potential to develop into mesoderm [Term] @@ -103912,7 +103672,7 @@ is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0002570 UBERON:0001650 ! conduit for hypoglossal nerve relationship: part_of UBERON:0001676 ! occipital bone -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002570 UBERON:0001650 ! conduit for hypoglossal nerve [Term] @@ -104029,7 +103789,7 @@ is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: site_of GO:0009790 ! embryo development relationship: part_of UBERON:0000474 ! female reproductive system -relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa +relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa relationship: site_of GO:0009790 ! embryo development [Term] @@ -104907,7 +104667,7 @@ is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004710 ! skeleton of pectoral appendage relationship: part_of UBERON:0004710 ! pectoral appendage -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002576 UBERON:0004710 ! skeleton of pectoral appendage [Term] @@ -105144,7 +104904,7 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: bounding_layer_of UBERON:0000468 ! multicellular organism intersection_of: RO:0002202 UBERON:0007383 ! develops from enveloping layer of ectoderm relationship: bounding_layer_of UBERON:0000468 ! multicellular organism -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa relationship: RO:0002202 UBERON:0007383 ! develops from enveloping layer of ectoderm [Term] @@ -105191,7 +104951,7 @@ is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0004710 ! pectoral appendage relationship: part_of UBERON:0007272 ! pectoral appendage skeleton -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0007414 @@ -105531,7 +105291,7 @@ intersection_of: filtered_through UBERON:0001982 ! capillary intersection_of: RO:0000086 PATO:0001548 ! has quality quality of a liquid intersection_of: RO:0002494 UBERON:0001969 ! transformation of blood plasma relationship: filtered_through UBERON:0001982 ! capillary -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002494 UBERON:0001969 ! transformation of blood plasma [Term] @@ -105621,7 +105381,7 @@ is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0010719 ! has skeleton girdle skeleton relationship: part_of UBERON:0010707 ! appendage girdle complex -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002551 UBERON:0010719 ! has skeleton girdle skeleton [Term] @@ -105796,7 +105556,7 @@ is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: part_of UBERON:0007823 ! appendage girdle region relationship: part_of UBERON:0007823 ! appendage girdle region -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002176 UBERON:0007828 ! connects girdle bone/zone [Term] @@ -105950,7 +105710,7 @@ xref: NCIT:C34248 is_a: UBERON:0034921 ! multi organ part structure relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0009145 ! pharyngeal region of foregut -relationship: RO:0002160 NCBITaxon:7711 ! only in taxon Chordata +relationship: RO:0002162 NCBITaxon:7711 ! in taxon Chordata [Term] id: UBERON:0008816 @@ -106963,7 +106723,7 @@ is_a: UBERON:0007688 ! anlage relationship: BSPO:0000096 UBERON:0004140 ! primary heart field relationship: BSPO:0000098 UBERON:0004140 ! primary heart field relationship: part_of UBERON:0003081 ! lateral plate mesoderm -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0009891 @@ -107360,7 +107120,7 @@ namespace: uberon xref: EHDAA2:0004512 is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0004571 ! systemic arterial system -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0010192 @@ -107789,7 +107549,7 @@ xref: XAO:0003075 xref: ZFA:0000737 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: part_of UBERON:0011137 ! axial skeletal system -relationship: RO:0002160 NCBITaxon:89593 ! only in taxon Craniata +relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata [Term] id: UBERON:0010329 @@ -107989,7 +107749,7 @@ xref: VSAO:0000037 xref: Wikipedia:Endoskeleton xref: XAO:0004026 is_a: UBERON:0010912 ! subdivision of skeleton -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 UBERON:0010522 ! composed primarily of replacement element [Term] @@ -108015,7 +107775,7 @@ synonym: "desmoskeleton" RELATED [VSAO:curator] xref: VSAO:0000035 xref: XAO:0004025 is_a: UBERON:0010912 ! subdivision of skeleton -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0010371 @@ -108188,7 +107948,7 @@ xref: VSAO:0000214 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002328 GO:0040011 ! functionally related to locomotion property_value: terms:contributor https://orcid.org/0000-0001-9114-8737 creation_date: 2012-04-23T10:46:51Z @@ -108704,7 +108464,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0001708 ! has skeleton jaw skeleton relationship: part_of UBERON:0000165 ! mouth -relationship: RO:0002160 NCBITaxon:7776 ! only in taxon Gnathostomata +relationship: RO:0002162 NCBITaxon:7776 ! in taxon Gnathostomata relationship: RO:0002551 UBERON:0001708 ! has skeleton jaw skeleton [Term] @@ -109175,7 +108935,7 @@ synonym: "schizocoelom" NARROW [] xref: EHDAA2:0004731 xref: Wikipedia:Coelom is_a: UBERON:0000481 ! multi-tissue structure -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0012054 @@ -109287,7 +109047,7 @@ xref: FMA:293103 xref: SCTID:89066004 is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0000033 ! head -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata [Term] id: UBERON:0012320 @@ -109367,7 +109127,7 @@ intersection_of: UBERON:0004923 ! organ component layer intersection_of: adjacent_to UBERON:0000042 ! serous membrane intersection_of: RO:0002473 UBERON:0006815 ! composed primarily of areolar connective tissue relationship: adjacent_to UBERON:0000042 ! serous membrane -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002473 UBERON:0006815 ! composed primarily of areolar connective tissue [Term] @@ -109708,7 +109468,7 @@ namespace: uberon def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [https://orcid.org/0000-0002-6601-2165] subset: non_informative is_a: UBERON:0000475 ! organism subdivision -relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 ! in taxon Eumetazoa [Term] id: UBERON:0013702 @@ -110333,7 +110093,7 @@ intersection_of: RO:0002219 UBERON:0011899 ! surrounded by epimysium intersection_of: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue relationship: part_of UBERON:0018254 ! skeletal musculature relationship: RO:0002103 CL:0000100 ! synapsed by motor neuron -relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata +relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata relationship: RO:0002202 UBERON:0003082 ! develops from myotome relationship: RO:0002219 UBERON:0011899 ! surrounded by epimysium relationship: RO:0002473 UBERON:0001134 ! composed primarily of skeletal muscle tissue @@ -110492,7 +110252,7 @@ is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: BSPO:0000126 UBERON:0000465 ! material anatomical entity relationship: BSPO:0000126 UBERON:0000465 ! material anatomical entity -relationship: RO:0002160 NCBITaxon:33213 ! only in taxon Bilateria +relationship: RO:0002162 NCBITaxon:33213 ! in taxon Bilateria [Term] id: UBERON:0015228 @@ -111437,7 +111197,7 @@ is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000033 ! head relationship: extends_fibers_into UBERON:0000955 ! brain -relationship: RO:0002160 NCBITaxon:89593 ! only in taxon Craniata +relationship: RO:0002162 NCBITaxon:89593 ! in taxon Craniata [Term] id: UBERON:0034717 diff --git a/pato-full.owl b/pato-full.owl index bd66c3c..538ff04 100644 --- a/pato-full.owl +++ b/pato-full.owl @@ -21,14 +21,14 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + An ontology of phenotypic qualities (properties, attributes or characteristics). PATO - the Phenotype And Trait Ontology quality 1.2 - 2024-09-04 + 2024-11-11 @@ -216,6 +216,14 @@ + + + + + + + + @@ -6170,145 +6178,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. - CHEBI:13302 - CHEBI:21123 - CHEBI:33698 - CHEBI:4291 - KEGG:C00039 - Deoxyribonucleic acid - chebi_ontology - (Deoxyribonucleotide)m - (Deoxyribonucleotide)n - (Deoxyribonucleotide)n+m - DNA - DNAn - DNAn+1 - DNS - Desoxyribonukleinsaeure - deoxyribonucleic acids - desoxyribose nucleic acid - thymus nucleic acid - CHEBI:16991 - - deoxyribonucleic acid - - - - - Deoxyribonucleic acid - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)m - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n+m - KEGG_COMPOUND - - - - - DNA - IUPAC - - - - - DNA - KEGG_COMPOUND - - - - - DNA - UniProt - - - - - DNAn - KEGG_COMPOUND - - - - - DNAn+1 - KEGG_COMPOUND - - - - - DNS - ChEBI - - - - - Desoxyribonukleinsaeure - ChEBI - - - - - deoxyribonucleic acids - ChEBI - - - - - desoxyribose nucleic acid - ChemIDplus - - - - - thymus nucleic acid - ChEBI - - - - @@ -12252,60 +12121,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - chebi_ontology - canonical deoxyribonucleoside residues - common 2'-deoxyribonucleoside residue - common 2'-deoxyribonucleoside residues - dN - dNuc - standard deoxyribonucleoside residues - CHEBI:33793 - - canonical deoxyribonucleoside residue - - - - - canonical deoxyribonucleoside residues - ChEBI - - - - - common 2'-deoxyribonucleoside residue - CBN - - - - - common 2'-deoxyribonucleoside residues - CBN - - - - - dN - CBN - - - - - dNuc - CBN - - - - - standard deoxyribonucleoside residues - ChEBI - - - - @@ -15123,25 +14938,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - chebi_ontology - canonical deoxyribonucleotide residues - CHEBI:50298 - - canonical deoxyribonucleotide residue - - - - - canonical deoxyribonucleotide residues - ChEBI - - - - @@ -18220,7 +18016,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18408,6 +18204,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -18466,7 +18263,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - @@ -18475,7 +18271,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18652,6 +18448,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -18671,7 +18468,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18706,6 +18503,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -19366,7 +19164,8 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + + @@ -19391,7 +19190,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -19507,12 +19306,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - - An endothelial cell that lines the vasculature. @@ -19549,11 +19342,35 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + + + + + + + + + + + + + + + + + + Any epithelial cell that is part of some squamous epithelium. CALOHA:TS-1249 squamous epithelial cell + + + + Any epithelial cell that is part of some squamous epithelium. + FBC:Autogenerated + @@ -19563,19 +19380,33 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + + + + + + + A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. FMA:66773 mesotheliocyte + Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. mesothelial cell - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. GOC:tfm ISBN:0721662544 + PMID:26106328 + + + + + Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. + PMID:26106328 @@ -19594,7 +19425,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -19970,6 +19801,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20062,10 +19894,9 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - + @@ -20089,6 +19920,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual BTO:0002606 CALOHA:TS-0415 FMA:54536 + https://cellxgene.cziscience.com/cellguide/CL_0000125 neuroglial cell neuroglia @@ -20412,6 +20244,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20518,6 +20351,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20566,6 +20400,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual BTO:0003865 FMA:62930 MESH:D019858 + https://cellxgene.cziscience.com/cellguide/CL_0000164 enteroendocrine cell @@ -20782,6 +20617,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -20823,7 +20659,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -20914,7 +20750,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21016,19 +20852,20 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + - + - A cell specialized to detect and transduce light. + A cell specialized in detecting light stimuli that are involved in visual perception. BTO:0001060 CALOHA:TS-0868 FMA:86740 @@ -21038,7 +20875,7 @@ The modern definition of neurosecretion has evolved to include the release of an - A cell specialized to detect and transduce light. + A cell specialized in detecting light stimuli that are involved in visual perception. MESH:D010786 @@ -21188,6 +21025,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21212,6 +21050,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21238,6 +21077,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21309,6 +21149,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21376,6 +21217,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21384,11 +21226,8 @@ The modern definition of neurosecretion has evolved to include the release of an A cell with more than one nucleus. - AEO:0000203 - WBbt:0008074 - syncitium - syncytial cell - syncytium + multinucleated cells + polynuclear cells multinucleate cell @@ -21396,6 +21235,19 @@ The modern definition of neurosecretion has evolved to include the release of an A cell with more than one nucleus. FB:ma + Wikipedia:Multinucleate + + + + + multinucleated cells + Wikipedia:Multinucleate + + + + + polynuclear cells + Wikipedia:Multinucleate @@ -21486,7 +21338,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21495,11 +21347,11 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Eukaryota. + Any cell that in taxon some Eukaryota. MESH:D005057 eukaryotic cell @@ -21507,7 +21359,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Any cell that only exists in Eukaryota. + Any cell that in taxon some Eukaryota. FBC:Autogenerated @@ -21521,7 +21373,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21530,17 +21382,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Eumycetozoa. + Any cell that in taxon some Eumycetozoa. Eumycetozoan cell - Any cell that only exists in Eumycetozoa. + Any cell that in taxon some Eumycetozoa. FBC:Autogenerated @@ -21560,6 +21412,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21811,6 +21664,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21852,6 +21706,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21892,7 +21747,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21935,7 +21790,7 @@ The modern definition of neurosecretion has evolved to include the release of an GOC:tfm MESH:D014327 PMID:37630754 - doi:10.1007/978-3-030-84725-8 + doi:10.1007/978-3-030-84725-8 @@ -22112,7 +21967,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22123,7 +21978,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22637,7 +22492,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22646,17 +22501,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Fungi. + Any cell that in taxon some Fungi. fungal cell - Any cell that only exists in Fungi. + Any cell that in taxon some Fungi. FBC:Autogenerated @@ -22676,8 +22531,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22938,6 +22793,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23081,6 +22937,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23164,6 +23021,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23641,6 +23499,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23806,6 +23665,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -24178,6 +24038,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + https://cellxgene.cziscience.com/cellguide/CL_0000666 window cell fenestrated endothelial cell @@ -24284,6 +24145,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -24403,6 +24265,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell that stores and secretes pancreatic polypeptide hormone. FMA:62938 FMA:83409 + https://cellxgene.cziscience.com/cellguide/CL_0000696 type F enteroendocrine cell PP cell @@ -24570,7 +24433,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -24737,6 +24600,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25063,7 +24927,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + @@ -25381,7 +25247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -25741,6 +25607,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25853,6 +25720,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25898,6 +25766,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25949,6 +25818,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2010-09-10T10:48:54Z FMA:62939 + https://cellxgene.cziscience.com/cellguide/CL_0002067 type A enteroendocrine cell @@ -26871,7 +26741,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -26910,7 +26780,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -27177,56 +27047,89 @@ The modern definition of neurosecretion has evolved to include the release of an - + - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development. 2010-09-24T01:13:01Z - myotubule - single cell sarcomere + myofiber + myofibril myotube - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development. GOC:dos GOC:tfm ISBN:0323052908 PMID:22274696 + + + + myofiber + FBbt:00005812 + + + + + myofibril + FBbt:00005812 + - + + + + + + - A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. + + + + + + + A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage. 2010-09-24T02:06:10Z Schwann cell precursor cell + Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. Schwann cell precursor - A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. + A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage. GOC:tfm + PMID:15580626 + PMID:30971890 + PMID:35815410 + + + + + Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. + PMID:35815410 @@ -27366,7 +27269,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D000073637 - This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). oligodendrocyte precursor cell @@ -27394,14 +27296,6 @@ The modern definition of neurosecretion has evolved to include the release of an PMID:24133281 - - - - This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). - ISBN:9780702028991 - PMID:10704434 - PMID:2182078 - @@ -27419,7 +27313,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -27616,6 +27510,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2011-02-28T03:48:11Z FMA:62104 KUPO:0001099 + https://cellxgene.cziscience.com/cellguide/CL_0002543 endothelial cell of vein venous endothelial cell @@ -27631,25 +27526,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - - 2011-02-28T04:20:39Z - See CL:0002619. - embryonic blood vessel endothelial progenitor cell - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - GOC:tfm - - - - @@ -27856,6 +27732,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesenchymal stem cell of adipose tissue. 2011-03-01T09:57:17Z + https://cellxgene.cziscience.com/cellguide/CL_0002570 mesenchymal stem cell of adipose mesenchymal stem cell of adipose tissue @@ -27885,6 +27762,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO:0001220 CALOHA:TS-0898 MESH:D012583 + https://cellxgene.cziscience.com/cellguide/CL_0002573 neurolemmocyte @@ -27939,6 +27817,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel endothelial cell that is part of the retina. 2011-03-06T03:28:27Z + https://cellxgene.cziscience.com/cellguide/CL_0002585 @@ -28690,6 +28569,68 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface. + multi-ciliated cell + multiciliated cell + https://cellxgene.cziscience.com/cellguide/CL_0005012 + multiciliated epithelial cell + + While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility + multi-ciliated epithelial cell + + + + + A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface. + CL:CVS + PMID:28400610 + PMID:30422572 + PMID:38032388 + + + + + While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility + PMID:22118931 + PMID:23959957 + PMID:25729351 + PMID:26378583 + + + + @@ -29036,6 +28977,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -29810,6 +29752,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. + https://cellxgene.cziscience.com/cellguide/CL_0011012 neural crest cell @@ -29924,6 +29867,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -30418,6 +30362,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + https://cellxgene.cziscience.com/cellguide/CL_1000223 pulmonary neuroendocrine cell @@ -30446,22 +30391,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + + - - - - - - - Any ciliated cell that is part of some lung. + An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface. lung ciliated cell @@ -30469,8 +30410,8 @@ The modern definition of neurosecretion has evolved to include the release of an - Any ciliated cell that is part of some lung. - FBC:Autogenerated + An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface. + PMID:27864314 @@ -30490,6 +30431,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -31110,6 +31052,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO:0004758 FMA:67761 KUPO:0001095 + https://cellxgene.cziscience.com/cellguide/CL_1000413 arterial endothelial cell @@ -31506,6 +31449,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelial cell that is part of the pleura. FMA:86737 + https://cellxgene.cziscience.com/cellguide/CL_1000491 pleural mesothelial cell mesothelial cell of pleura @@ -31582,6 +31526,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelial cell that is part of the visceral pleura. FMA:86739 + https://cellxgene.cziscience.com/cellguide/CL_1000493 mesothelial cell of visceral pleura @@ -31819,7 +31764,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Endothelial cells forming the walls of the capillaries within the cerebral cortex. + A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex. CALOHA:TS-2372 cerebral cortex endothelial cells endothelial cells of cerebral cortex @@ -31829,7 +31774,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Endothelial cells forming the walls of the capillaries within the cerebral cortex. + A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex. NPX:PDR @@ -32194,7 +32139,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -33923,6 +33868,54 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm. + + 2024-08-15T10:38:46Z + syncytium + syncytial cell + + + + + A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm. + PMID:20851884 + Wikipedia:Syncytium + + + + + syncytium + WBbt:0008074 + + + + @@ -34444,8 +34437,7 @@ The modern definition of neurosecretion has evolved to include the release of an - - + @@ -46511,7 +46503,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -46551,7 +46542,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -46779,53 +46769,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - GO:0055132 - DNA metabolism - cellular DNA metabolism - biological_process - GO:0006259 - - - - - - - - - - DNA metabolic process - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - ISBN:0198506732 - - - - @@ -46840,7 +46783,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -47038,7 +46981,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -48963,7 +48905,6 @@ The modern definition of neurosecretion has evolved to include the release of an - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stress @@ -50517,12 +50458,90 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. GO:0009552 biological_process @@ -52280,6 +52299,18 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + The directed movement of organelles or molecules along microtubules in neuron projections. Wikipedia:Axoplasmic_transport axon cargo transport @@ -52608,44 +52639,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006870 - sulphate transport - biological_process - GO:0008272 - sulfate transport - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - @@ -53528,7 +53521,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -53569,7 +53561,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -53641,7 +53632,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -53684,8 +53676,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -54508,7 +54500,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -54548,7 +54541,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -54556,7 +54548,6 @@ The modern definition of neurosecretion has evolved to include the release of an The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). - UM-BBD_enzymeID:e0711 alkaloid anabolism alkaloid biosynthesis alkaloid formation @@ -55677,44 +55668,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - response to organic nitrogen - biological_process - GO:0010243 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to organonitrogen compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - PMID:9869419 - - - - @@ -61294,7 +61247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -63080,50 +63033,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - DNA-protein complex transport - biological_process - GO:0015869 - protein-DNA complex transport - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - DNA-protein complex transport - GOC:mah - - - - @@ -64120,12 +64029,90 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. stem cell renewal biological_process @@ -64642,7 +64629,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -79022,49 +79008,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a protein-DNA complex into its constituent components. - DNA-protein complex disassembly - biological_process - GO:0032986 - protein-DNA complex disassembly - - - - - The disaggregation of a protein-DNA complex into its constituent components. - GOC:mah - - - - - DNA-protein complex disassembly - GOC:mah - - - - @@ -79173,39 +79116,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - A macromolecular complex containing both protein and DNA molecules. - DNA-protein complex - cellular_component - GO:0032993 - - Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. - protein-DNA complex - - - - - A macromolecular complex containing both protein and DNA molecules. - GOC:mah - - - - - DNA-protein complex - GOC:mah - - - - @@ -86044,7 +85954,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -86088,8 +85999,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -87806,6 +87717,7 @@ The modern definition of neurosecretion has evolved to include the release of an membrane-enclosed organelle cellular_component GO:0043227 + membrane-bounded organelle @@ -87827,6 +87739,7 @@ The modern definition of neurosecretion has evolved to include the release of an cellular_component biological condensate GO:0043228 + non-membrane-bounded organelle @@ -87864,6 +87777,7 @@ The modern definition of neurosecretion has evolved to include the release of an Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. cellular_component GO:0043229 + intracellular organelle @@ -88429,7 +88343,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -88719,7 +88633,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -89869,6 +89783,7 @@ The modern definition of neurosecretion has evolved to include the release of an cellular component biogenesis at cellular level biological_process GO:0044085 + cellular component biogenesis @@ -95425,8 +95340,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -96404,8 +96319,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -105716,7 +105631,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -106123,41 +106037,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051027 - DNA transport - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - @@ -106391,129 +106270,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - regulation of DNA metabolism - biological_process - GO:0051052 - - regulation of DNA metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - down regulation of DNA metabolic process - down-regulation of DNA metabolic process - downregulation of DNA metabolic process - negative regulation of DNA metabolism - inhibition of DNA metabolic process - biological_process - GO:0051053 - negative regulation of DNA metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - positive regulation of DNA metabolism - up regulation of DNA metabolic process - up-regulation of DNA metabolic process - upregulation of DNA metabolic process - activation of DNA metabolic process - stimulation of DNA metabolic process - biological_process - GO:0051054 - positive regulation of DNA metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - @@ -125040,49 +124796,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - DNA-protein complex assembly - biological_process - GO:0065004 - protein-DNA complex assembly - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - GOC:jl - - - - - DNA-protein complex assembly - GOC:mah - - - - @@ -127515,7 +127228,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2010-03-08T03:56:28Z biological_process GO:0071705 - + nitrogen compound transport @@ -127763,58 +127476,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - mah - 2010-09-08T10:03:26Z - DNA-protein complex subunit organization - protein-DNA complex subunit organisation - protein-DNA complex subunit organization - biological_process - GO:0071824 - protein-DNA complex organization - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - GOC:mah - - - - - DNA-protein complex subunit organization - GOC:mah - - - - - protein-DNA complex subunit organisation - GOC:mah - - - - @@ -127928,7 +127589,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -128112,72 +127773,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The biosynthetic process resulting in the formation of DNA. - mah - 2010-09-15T02:14:33Z - DNA anabolism - DNA biosynthesis - DNA formation - DNA synthesis - biological_process - GO:0071897 - DNA biosynthetic process - - - - - The biosynthetic process resulting in the formation of DNA. - GOC:mah - - - - - DNA anabolism - GOC:mah - - - - - DNA biosynthesis - GOC:mah - - - - - DNA formation - GOC:mah - - - - - DNA synthesis - GOC:mah - - - - @@ -136463,7 +136058,7 @@ The modern definition of neurosecretion has evolved to include the release of an The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. biological_process GO:0099531 - + presynaptic process involved in chemical synaptic transmission @@ -144577,7 +144172,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -144621,8 +144217,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -146980,121 +146576,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organonitrogen compound. - pr - 2012-11-04T15:17:52Z - organonitrogen compound metabolism - biological_process - GO:1901564 - - organonitrogen compound metabolic process - - - - - The chemical reactions and pathways involving organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - pr - 2012-11-04T15:18:00Z - organonitrogen compound anabolism - organonitrogen compound biosynthesis - organonitrogen compound formation - organonitrogen compound synthesis - biological_process - GO:1901566 - - organonitrogen compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound anabolism - GOC:TermGenie - - - - - organonitrogen compound biosynthesis - GOC:TermGenie - - - - - organonitrogen compound formation - GOC:TermGenie - - - - - organonitrogen compound synthesis - GOC:TermGenie - - - - @@ -152564,11 +152045,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + + + + + + + The directed movement of sulfate across a membrane. dph 2013-08-14T14:46:04Z + sulphate transport biological_process GO:1902358 sulfate transmembrane transport @@ -158740,6 +158228,48 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + tb + 2014-08-05T19:21:21Z + multiciliate cell differentiation + biological_process + GO:1903251 + multi-ciliated epithelial cell differentiation + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + GOC:TermGenie + GOC:sp + GO_REF:0000086 + PMID:22231168 + PMID:24934224 + + + + @@ -164079,6 +163609,16 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + @@ -164089,12 +163629,32 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + @@ -164105,12 +163665,40 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in an epithelial cell. sl 2015-03-06T22:27:17Z @@ -168009,7 +167597,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -188770,139 +188358,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:15Z - regulation of DNA anabolism - regulation of DNA biosynthesis - regulation of DNA formation - regulation of DNA synthesis - biological_process - GO:2000278 - regulation of DNA biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - regulation of DNA anabolism - GOC:obol - - - - - regulation of DNA biosynthesis - GOC:obol - - - - - regulation of DNA formation - GOC:obol - - - - - regulation of DNA synthesis - GOC:obol - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:20Z - negative regulation of DNA anabolism - negative regulation of DNA biosynthesis - negative regulation of DNA formation - negative regulation of DNA synthesis - biological_process - GO:2000279 - negative regulation of DNA biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - negative regulation of DNA anabolism - GOC:obol - - - - - negative regulation of DNA biosynthesis - GOC:obol - - - - - negative regulation of DNA formation - GOC:obol - - - - - negative regulation of DNA synthesis - GOC:obol - - - - @@ -190317,73 +189772,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - yaf - 2011-04-04T10:01:20Z - positive regulation of DNA anabolism - positive regulation of DNA biosynthesis - positive regulation of DNA formation - positive regulation of DNA synthesis - biological_process - GO:2000573 - positive regulation of DNA biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - positive regulation of DNA anabolism - GOC:obol - - - - - positive regulation of DNA biosynthesis - GOC:obol - - - - - positive regulation of DNA formation - GOC:obol - - - - - positive regulation of DNA synthesis - GOC:obol - - - - @@ -249171,6 +248559,12 @@ Classes for population already exist in IDO ('organism population', I + + + + + + @@ -250401,7 +249795,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -250814,7 +250208,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251106,7 +250500,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251197,7 +250591,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251422,7 +250816,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251567,7 +250961,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -252333,7 +251727,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253320,7 +252714,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253417,7 +252811,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253459,7 +252853,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253834,7 +253228,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253947,7 +253341,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253964,7 +253358,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254064,7 +253458,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254584,7 +253978,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254956,7 +254350,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255036,7 +254430,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255207,7 +254601,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255939,7 +255333,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257209,7 +256603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257642,7 +257036,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257792,7 +257186,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258060,7 +257454,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258158,7 +257552,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258322,7 +257716,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258406,7 +257800,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259382,7 +258776,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259549,7 +258943,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259829,7 +259223,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260125,7 +259519,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260348,7 +259742,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260566,7 +259960,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260635,7 +260029,6 @@ Classes for population already exist in IDO ('organism population', I UBERON:0001016 - @@ -260681,7 +260074,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -261027,7 +260420,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -261182,7 +260575,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -262387,7 +261780,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -262887,7 +262280,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -264600,7 +263993,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -265550,7 +264943,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -266987,7 +266380,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -267435,7 +266828,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -267809,7 +267202,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -271718,7 +271111,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -272794,7 +272187,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273038,7 +272431,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273210,7 +272603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273455,7 +272848,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -274705,7 +274098,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276191,7 +275584,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276248,7 +275641,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276760,7 +276153,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -277927,7 +277320,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278014,7 +277407,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278090,7 +277483,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278213,7 +277606,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -279891,7 +279284,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -279974,7 +279367,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280042,7 +279435,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280638,7 +280031,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280895,7 +280288,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -281564,7 +280957,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282020,7 +281413,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282155,7 +281548,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282211,7 +281604,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282279,7 +281672,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282547,7 +281940,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -283779,7 +283172,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284106,7 +283499,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284353,7 +283746,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284572,7 +283965,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284798,7 +284191,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284861,7 +284254,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -285753,7 +285146,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -294763,7 +294156,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -296644,7 +296037,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -298020,7 +297413,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -298505,7 +297898,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -299142,7 +298535,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -304414,7 +303807,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -305158,7 +304551,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -305387,7 +304780,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -307641,7 +307034,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -308109,7 +307502,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -308890,7 +308283,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -311212,7 +310605,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -313375,7 +312768,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -314915,7 +314308,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -315631,7 +315024,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -315693,7 +315086,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316239,7 +315632,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316484,7 +315877,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316626,7 +316019,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316690,7 +316083,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316976,7 +316369,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -317347,7 +316740,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320027,7 +319420,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320769,7 +320162,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320928,7 +320321,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -321957,7 +321350,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -322230,7 +321623,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -322754,7 +322147,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -323255,7 +322648,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -326415,7 +325808,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -327681,7 +327074,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -328932,7 +328325,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -329535,7 +328928,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -329609,7 +329002,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -330119,7 +329512,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -331764,7 +331157,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333210,7 +332603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333543,7 +332936,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333784,7 +333177,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -334932,7 +334325,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -336868,7 +336261,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -337408,7 +336801,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -340331,7 +339724,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -344717,14 +344110,14 @@ Classes for population already exist in IDO ('organism population', I - + - + - + diff --git a/pato-simple.json b/pato-simple.json index 66cc687..eceae75 100644 --- a/pato-simple.json +++ b/pato-simple.json @@ -22,9 +22,9 @@ "val" : "1.2" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-09-04" + "val" : "2024-11-11" } ], - "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-09-04/pato-simple.json" + "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-11-11/pato-simple.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/PATO_0000000", diff --git a/pato-simple.obo b/pato-simple.obo index ea28bee..43b6b09 100644 --- a/pato-simple.obo +++ b/pato-simple.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: pato/releases/2024-09-04/pato-simple.owl +data-version: pato/releases/2024-11-11/pato-simple.owl subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" @@ -23,7 +23,7 @@ ontology: pato/pato-simple property_value: dc:description "An ontology of phenotypic qualities (properties, attributes or characteristics)." xsd:string property_value: dc:title "PATO - the Phenotype And Trait Ontology" xsd:string property_value: has_ontology_root_term PATO:0000001 -property_value: owl:versionInfo "2024-09-04" xsd:string +property_value: owl:versionInfo "2024-11-11" xsd:string property_value: terms:license https://creativecommons.org/licenses/by/3.0/ [Term] diff --git a/pato-simple.owl b/pato-simple.owl index c6881a3..270bdbb 100644 --- a/pato-simple.owl +++ b/pato-simple.owl @@ -13,14 +13,14 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + An ontology of phenotypic qualities (properties, attributes or characteristics). PATO - the Phenotype And Trait Ontology quality 1.2 - 2024-09-04 + 2024-11-11 diff --git a/pato.json b/pato.json index 2e575bd..ad1aecb 100644 --- a/pato.json +++ b/pato.json @@ -22,9 +22,9 @@ "val" : "1.2" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-09-04" + "val" : "2024-11-11" } ], - "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-09-04/pato.json" + "version" : "http://purl.obolibrary.org/obo/pato/releases/2024-11-11/pato.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", @@ -1147,92 +1147,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "lbl" : "deoxyribonucleic acid", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." - }, - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "Deoxyribonucleic acid", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)m", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)n", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "(Deoxyribonucleotide)n+m", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "IUPAC" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNA", - "xrefs" : [ "UniProt" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNAn", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNAn+1", - "xrefs" : [ "KEGG_COMPOUND" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "DNS", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "Desoxyribonukleinsaeure", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "deoxyribonucleic acids", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "desoxyribose nucleic acid", - "xrefs" : [ "ChemIDplus" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "thymus nucleic acid", - "xrefs" : [ "ChEBI" ] - } ], - "xrefs" : [ { - "val" : "KEGG:C00039" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:13302" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:21123" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:33698" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "CHEBI:4291" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_17087", "lbl" : "ketone", @@ -5626,42 +5540,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_33793", - "lbl" : "canonical deoxyribonucleoside residue", - "type" : "CLASS", - "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasRelatedSynonym", - "val" : "canonical deoxyribonucleoside residues", - "xrefs" : [ "ChEBI" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "common 2'-deoxyribonucleoside residue", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "common 2'-deoxyribonucleoside residues", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "dN", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "dNuc", - "xrefs" : [ "CBN" ] - }, { - "pred" : "hasRelatedSynonym", - "val" : "standard deoxyribonucleoside residues", - "xrefs" : [ "ChEBI" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_33822", "lbl" : "organic hydroxy compound", @@ -7972,22 +7850,6 @@ "val" : "chebi_ontology" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CHEBI_50298", - "lbl" : "canonical deoxyribonucleotide residue", - "type" : "CLASS", - "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/chebi#3_STAR" ], - "synonyms" : [ { - "pred" : "hasRelatedSynonym", - "val" : "canonical deoxyribonucleotide residues", - "xrefs" : [ "ChEBI" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "chebi_ontology" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_50299", "lbl" : "canonical ribonucleotide residue", @@ -11122,6 +10984,10 @@ "lbl" : "squamous epithelial cell", "type" : "CLASS", "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of some squamous epithelium.", + "xrefs" : [ "FBC:Autogenerated" ] + }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], "xrefs" : [ { "val" : "CALOHA:TS-1249" @@ -11133,9 +10999,10 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.", - "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + "val" : "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "PMID:26106328" ] }, + "comments" : [ "Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasExactSynonym", @@ -11406,6 +11273,8 @@ "val" : "CALOHA:TS-0415" }, { "val" : "FMA:54536" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000125" } ] } }, { @@ -11698,6 +11567,8 @@ "val" : "FMA:62930" }, { "val" : "MESH:D019858" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000164" } ] } }, { @@ -11916,7 +11787,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A cell specialized to detect and transduce light.", + "val" : "A cell specialized in detecting light stimuli that are involved in visual perception.", "xrefs" : [ "MESH:D010786" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -12116,22 +11987,16 @@ "meta" : { "definition" : { "val" : "A cell with more than one nucleus.", - "xrefs" : [ "FB:ma" ] + "xrefs" : [ "FB:ma", "Wikipedia:Multinucleate" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", - "val" : "syncitium" + "val" : "multinucleated cells", + "xrefs" : [ "Wikipedia:Multinucleate" ] }, { "pred" : "hasExactSynonym", - "val" : "syncytial cell" - }, { - "pred" : "hasExactSynonym", - "val" : "syncytium" - } ], - "xrefs" : [ { - "val" : "AEO:0000203" - }, { - "val" : "WBbt:0008074" + "val" : "polynuclear cells", + "xrefs" : [ "Wikipedia:Multinucleate" ] } ] } }, { @@ -12165,7 +12030,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Eukaryota.", + "val" : "Any cell that in taxon some Eukaryota.", "xrefs" : [ "FBC:Autogenerated" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -12179,7 +12044,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Eumycetozoa.", + "val" : "Any cell that in taxon some Eumycetozoa.", "xrefs" : [ "FBC:Autogenerated" ] } } @@ -12362,7 +12227,7 @@ "meta" : { "definition" : { "val" : "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.", - "xrefs" : [ "GOC:tfm", "MESH:D014327", "PMID:37630754" ] + "xrefs" : [ "GOC:tfm", "MESH:D014327", "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", @@ -12695,7 +12560,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any cell that only exists in Fungi.", + "val" : "Any cell that in taxon some Fungi.", "xrefs" : [ "FBC:Autogenerated" ] } } @@ -13254,6 +13119,9 @@ "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "window cell" + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000666" } ] } }, { @@ -13361,6 +13229,8 @@ "val" : "FMA:62938" }, { "val" : "FMA:83409" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0000696" } ] } }, { @@ -13927,6 +13797,8 @@ }, "xrefs" : [ { "val" : "FMA:62939" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002067" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -14753,15 +14625,17 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.", + "val" : "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development.", "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ] }, "synonyms" : [ { "pred" : "hasExactSynonym", - "val" : "myotubule" + "val" : "myofiber", + "xrefs" : [ "FBbt:00005812" ] }, { "pred" : "hasExactSynonym", - "val" : "single cell sarcomere" + "val" : "myofibril", + "xrefs" : [ "FBbt:00005812" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -14777,9 +14651,10 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19.", - "xrefs" : [ "GOC:tfm" ] + "val" : "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage.", + "xrefs" : [ "GOC:tfm", "PMID:15580626", "PMID:30971890", "PMID:35815410" ] }, + "comments" : [ "Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], "synonyms" : [ { "pred" : "hasExactSynonym", @@ -14864,7 +14739,6 @@ "val" : "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.", "xrefs" : [ "GOC:tfm", "PMID:10704434", "PMID:11756508", "PMID:20142420", "PMID:2182078", "PMID:24133281", "PMID:9826671" ] }, - "comments" : [ "This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991)." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { "pred" : "hasBroadSynonym", @@ -15021,6 +14895,8 @@ "val" : "FMA:62104" }, { "val" : "KUPO:0001099" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002543" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -15030,24 +14906,6 @@ "val" : "2011-02-28T03:48:11Z" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0002546", - "lbl" : "embryonic blood vessel endothelial progenitor cell", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "An endothelial progenitor cell that participates in angiogenesis during development.", - "xrefs" : [ "GOC:tfm" ] - }, - "comments" : [ "See CL:0002619." ], - "basicPropertyValues" : [ { - "pred" : "http://purl.org/dc/terms/contributor", - "val" : "https://orcid.org/0000-0003-1980-3228" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2011-02-28T04:20:39Z" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002547", "lbl" : "fibroblast of the aortic adventitia", @@ -15159,6 +15017,9 @@ "pred" : "hasExactSynonym", "val" : "mesenchymal stem cell of adipose" } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002570" + } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" @@ -15189,6 +15050,8 @@ "val" : "CALOHA:TS-0898" }, { "val" : "MESH:D012583" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002573" } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", @@ -15208,6 +15071,9 @@ "xrefs" : [ "GOC:tfm" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0002585" + } ], "basicPropertyValues" : [ { "pred" : "http://purl.org/dc/terms/contributor", "val" : "https://orcid.org/0000-0003-1980-3228" @@ -15627,6 +15493,31 @@ }, "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0005012", + "lbl" : "multi-ciliated epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.", + "xrefs" : [ "CL:CVS", "PMID:28400610", "PMID:30422572", "PMID:38032388" ] + }, + "comments" : [ "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility" ], + "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], + "synonyms" : [ { + "pred" : "hasBroadSynonym", + "val" : "multi-ciliated cell" + }, { + "pred" : "hasBroadSynonym", + "val" : "multiciliated cell" + }, { + "pred" : "hasExactSynonym", + "val" : "multiciliated epithelial cell" + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0005012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005024", "lbl" : "somatomotor neuron", @@ -16130,7 +16021,10 @@ "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.", "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ] + "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_0011012" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011019", @@ -16412,6 +16306,9 @@ "pred" : "hasExactSynonym", "val" : "pulmonary neuroendocrine cell", "xrefs" : [ "PMID:33355253" ] + } ], + "xrefs" : [ { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000223" } ] } }, { @@ -16420,8 +16317,8 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Any ciliated cell that is part of some lung.", - "xrefs" : [ "FBC:Autogenerated" ] + "val" : "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.", + "xrefs" : [ "PMID:27864314" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ] } @@ -16713,6 +16610,8 @@ "val" : "FMA:67761" }, { "val" : "KUPO:0001095" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000413" } ] } }, { @@ -16885,6 +16784,8 @@ } ], "xrefs" : [ { "val" : "FMA:86737" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000491" } ] } }, { @@ -16912,6 +16813,8 @@ "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "xrefs" : [ { "val" : "FMA:86739" + }, { + "val" : "https://cellxgene.cziscience.com/cellguide/CL_1000493" } ] } }, { @@ -17012,7 +16915,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "Endothelial cells forming the walls of the capillaries within the cerebral cortex.", + "val" : "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.", "xrefs" : [ "NPX:PDR" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ], @@ -18006,6 +17909,28 @@ "val" : "2024-07-19T09:14:23Z" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4052002", + "lbl" : "syncytial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm.", + "xrefs" : [ "PMID:20851884", "Wikipedia:Syncytium" ] + }, + "synonyms" : [ { + "pred" : "hasExactSynonym", + "val" : "syncytium", + "xrefs" : [ "WBbt:0008074" ] + } ], + "basicPropertyValues" : [ { + "pred" : "http://purl.org/dc/terms/contributor", + "val" : "https://orcid.org/0009-0000-8480-9277" + }, { + "pred" : "http://purl.org/dc/terms/date", + "val" : "2024-08-15T10:38:46Z" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000011", "lbl" : "vacuole inheritance", @@ -24661,31 +24586,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0006259", - "lbl" : "DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.", - "xrefs" : [ "ISBN:0198506732" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA metabolism" - }, { - "pred" : "hasExactSynonym", - "val" : "cellular DNA metabolism" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "GO:0055132" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006325", "lbl" : "chromatin organization", @@ -25873,7 +25773,6 @@ "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", "xrefs" : [ "GOC:mah" ] }, - "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", @@ -28012,27 +27911,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0008272", - "lbl" : "sulfate transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:krc" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "sulphate transport" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", - "val" : "GO:0006870" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008283", "lbl" : "cell population proliferation", @@ -29215,9 +29093,6 @@ "pred" : "hasExactSynonym", "val" : "alkaloid synthesis" } ], - "xrefs" : [ { - "val" : "UM-BBD_enzymeID:e0711" - } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" @@ -29844,26 +29719,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0010243", - "lbl" : "response to organonitrogen compound", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", - "xrefs" : [ "PMID:9869419" ] - }, - "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "response to organic nitrogen" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010256", "lbl" : "endomembrane system organization", @@ -33114,25 +32969,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0015869", - "lbl" : "protein-DNA complex transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex transport", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015870", "lbl" : "acetylcholine transport", @@ -41083,25 +40919,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0032986", - "lbl" : "protein-DNA complex disassembly", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The disaggregation of a protein-DNA complex into its constituent components.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex disassembly", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032988", "lbl" : "protein-RNA complex disassembly", @@ -41184,27 +41001,6 @@ "val" : "cellular_component" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0032993", - "lbl" : "protein-DNA complex", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "A macromolecular complex containing both protein and DNA molecules.", - "xrefs" : [ "GOC:mah" ] - }, - "comments" : [ "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here." ], - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "cellular_component" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033002", "lbl" : "muscle cell proliferation", @@ -45923,6 +45719,7 @@ "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", "xrefs" : [ "GOC:go_curators" ] }, + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "membrane-enclosed organelle" @@ -45944,7 +45741,7 @@ "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.", "xrefs" : [ "GOC:go_curators" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_mouse" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_mouse" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "non-membrane-enclosed organelle" @@ -45969,7 +45766,7 @@ "val" : "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", "xrefs" : [ "GOC:go_curators" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "cellular_component" @@ -47040,7 +46837,7 @@ "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.", "xrefs" : [ "GOC:jl", "GOC:mah" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "cellular component biogenesis at cellular level" @@ -56542,20 +56339,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051027", - "lbl" : "DNA transport", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", - "xrefs" : [ "GOC:ai" ] - }, - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051046", "lbl" : "regulation of secretion", @@ -56699,88 +56482,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051052", - "lbl" : "regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA metabolism" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051053", - "lbl" : "negative regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "down regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "down-regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "downregulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA metabolism" - }, { - "pred" : "hasNarrowSynonym", - "val" : "inhibition of DNA metabolic process" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0051054", - "lbl" : "positive regulation of DNA metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.", - "xrefs" : [ "GOC:ai" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA metabolism" - }, { - "pred" : "hasExactSynonym", - "val" : "up regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "up-regulation of DNA metabolic process" - }, { - "pred" : "hasExactSynonym", - "val" : "upregulation of DNA metabolic process" - }, { - "pred" : "hasNarrowSynonym", - "val" : "activation of DNA metabolic process" - }, { - "pred" : "hasNarrowSynonym", - "val" : "stimulation of DNA metabolic process" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051055", "lbl" : "negative regulation of lipid biosynthetic process", @@ -66449,25 +66150,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0065004", - "lbl" : "protein-DNA complex assembly", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.", - "xrefs" : [ "GOC:jl" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex assembly", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065007", "lbl" : "biological regulation", @@ -67725,7 +67407,7 @@ "val" : "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", "xrefs" : [ "GOC:mah" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "mah" @@ -67866,38 +67548,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0071824", - "lbl" : "protein-DNA complex organization", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA-protein complex subunit organization", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "protein-DNA complex subunit organisation", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "protein-DNA complex subunit organization" - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "mah" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-09-08T10:03:26Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071826", "lbl" : "protein-RNA complex organization", @@ -68076,43 +67726,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0071897", - "lbl" : "DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The biosynthetic process resulting in the formation of DNA.", - "xrefs" : [ "GOC:mah" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "DNA anabolism", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA biosynthesis", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA formation", - "xrefs" : [ "GOC:mah" ] - }, { - "pred" : "hasExactSynonym", - "val" : "DNA synthesis", - "xrefs" : [ "GOC:mah" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "mah" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-09-15T02:14:33Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071944", "lbl" : "cell periphery", @@ -72461,7 +72074,7 @@ "val" : "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.", "xrefs" : [ "GOC:dos" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_synapse" ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate", "http://purl.obolibrary.org/obo/go#goslim_synapse" ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" @@ -78186,70 +77799,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1901564", - "lbl" : "organonitrogen compound metabolic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The chemical reactions and pathways involving organonitrogen compound.", - "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound metabolism", - "xrefs" : [ "GOC:TermGenie" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "pr" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2012-11-04T15:17:52Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1901566", - "lbl" : "organonitrogen compound biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "The chemical reactions and pathways resulting in the formation of organonitrogen compound.", - "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] - }, - "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound anabolism", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound biosynthesis", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound formation", - "xrefs" : [ "GOC:TermGenie" ] - }, { - "pred" : "hasExactSynonym", - "val" : "organonitrogen compound synthesis", - "xrefs" : [ "GOC:TermGenie" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "pr" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2012-11-04T15:18:00Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901588", "lbl" : "dendritic microtubule", @@ -81249,6 +80798,10 @@ "val" : "The directed movement of sulfate across a membrane.", "xrefs" : [ "GOC:TermGenie", "GOC:dph", "PMID:9055073" ] }, + "synonyms" : [ { + "pred" : "hasExactSynonym", + "val" : "sulphate transport" + } ], "basicPropertyValues" : [ { "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", "val" : "dph" @@ -84693,6 +84246,30 @@ "val" : "biological_process" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903251", + "lbl" : "multi-ciliated epithelial cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:sp", "GO_REF:0000086", "PMID:22231168", "PMID:24934224" ] + }, + "synonyms" : [ { + "pred" : "hasBroadSynonym", + "val" : "multiciliate cell differentiation" + } ], + "basicPropertyValues" : [ { + "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", + "val" : "tb" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", + "val" : "2014-08-05T19:21:21Z" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", + "val" : "biological_process" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903292", "lbl" : "protein localization to Golgi membrane", @@ -101159,80 +100736,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000278", - "lbl" : "regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that modulates the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-12-08T04:48:15Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000279", - "lbl" : "negative regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "negative regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2010-12-08T04:48:20Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000282", "lbl" : "regulation of cellular amino acid biosynthetic process", @@ -102010,43 +101513,6 @@ "val" : "biological_process" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000573", - "lbl" : "positive regulation of DNA biosynthetic process", - "type" : "CLASS", - "meta" : { - "definition" : { - "val" : "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.", - "xrefs" : [ "GOC:obol" ] - }, - "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA anabolism", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA biosynthesis", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA formation", - "xrefs" : [ "GOC:obol" ] - }, { - "pred" : "hasExactSynonym", - "val" : "positive regulation of DNA synthesis", - "xrefs" : [ "GOC:obol" ] - } ], - "basicPropertyValues" : [ { - "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by", - "val" : "yaf" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date", - "val" : "2011-04-04T10:01:20Z" - }, { - "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", - "val" : "biological_process" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000647", "lbl" : "negative regulation of stem cell proliferation", @@ -154411,6 +153877,9 @@ "val" : "protein" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/PR_000050567", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PR_000064867", "lbl" : "protein-containing molecular entity", @@ -162854,7 +162323,7 @@ "val" : "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].", "xrefs" : [ "BIRNLEX:844", "ISBN:0-14-051288-8", "ISBN:3110148986", "NLM:nervous+system", "WB:rynl", "Wikipedia:Nervous_system", "ZFIN:curator" ] }, - "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#cumbo", "http://purl.obolibrary.org/obo/uberon/core#efo_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas", "http://purl.obolibrary.org/obo/uberon/core#pheno_slim", "http://purl.obolibrary.org/obo/uberon/core#uberon_slim", "http://purl.obolibrary.org/obo/uberon/core#vertebrate_core" ], + "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#cumbo", "http://purl.obolibrary.org/obo/uberon/core#efo_slim", "http://purl.obolibrary.org/obo/uberon/core#pheno_slim", "http://purl.obolibrary.org/obo/uberon/core#uberon_slim", "http://purl.obolibrary.org/obo/uberon/core#vertebrate_core" ], "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "neurological system", @@ -218774,6 +218243,10 @@ "id" : "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" }, { "id" : "http://purl.obolibrary.org/obo/go#goslim_agr", "type" : "PROPERTY", @@ -219488,30 +218961,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_16765", "pred" : "http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of", "obj" : "http://purl.obolibrary.org/obo/CHEBI_57887" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000004" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33696" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33793" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_50298" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/RO_0000087", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_75771" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_16991", - "pred" : "http://purl.obolibrary.org/obo/RO_0000087", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_77746" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_17087", "pred" : "is_a", @@ -220696,10 +220145,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_33792", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33791" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_33793", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_33791" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_33822", "pred" : "is_a", @@ -221312,10 +220757,6 @@ "sub" : "http://purl.obolibrary.org/obo/CHEBI_50297", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CHEBI_50319" - }, { - "sub" : "http://purl.obolibrary.org/obo/CHEBI_50298", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_50297" }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_50299", "pred" : "is_a", @@ -221878,7 +221319,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000000", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000005", @@ -221916,6 +221357,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000014", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000039" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000021", "pred" : "is_a", @@ -221940,17 +221385,13 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000023", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000021" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000023", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000023", "pred" : "http://purl.obolibrary.org/obo/RO_0000056", "obj" : "http://purl.obolibrary.org/obo/GO_0007143" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000023", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000024", @@ -222012,6 +221453,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000030", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000055" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000030", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000030", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -222026,8 +221471,12 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000031", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000034", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000034", "pred" : "is_a", @@ -222227,7 +221676,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000064", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000064", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -222235,7 +221688,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000066", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000066", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222264,10 +221717,6 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000071", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004638" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000071", - "pred" : "http://purl.obolibrary.org/obo/RO_0002202", - "obj" : "http://purl.obolibrary.org/obo/CL_0002546" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000075", "pred" : "is_a", @@ -222276,6 +221725,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000076", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006914" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000077", "pred" : "is_a", @@ -222288,10 +221741,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000077", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002078" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001136" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000080", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000080", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222392,6 +221849,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000115", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000213" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000115", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000115", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -222430,11 +221891,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000095" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000123", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000255" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0000123", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000123", @@ -222544,6 +222001,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000152", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000152", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222572,6 +222033,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000163", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000163", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222640,6 +222105,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000187", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000183" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000187", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000187", "pred" : "is_a", @@ -222651,7 +222120,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000188", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000188", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222671,7 +222140,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000197", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000197", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -222707,11 +222176,15 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000210", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000006" + "obj" : "http://purl.obolibrary.org/obo/CL_0000101" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000210", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008028" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000210", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", - "obj" : "http://purl.obolibrary.org/obo/GO_0050962" + "obj" : "http://purl.obolibrary.org/obo/GO_0050908" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000211", "pred" : "is_a", @@ -222764,6 +222237,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000219", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0048870" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000221", "pred" : "is_a", @@ -222772,6 +222249,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000221", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000222", "pred" : "is_a", @@ -222780,6 +222261,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000222", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000223", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000223", "pred" : "is_a", @@ -222796,6 +222281,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000225", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001405" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000226", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000226", "pred" : "is_a", @@ -222812,6 +222301,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000227", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001406" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000228", "pred" : "is_a", @@ -222854,7 +222347,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000000" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000255", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000257", @@ -222862,8 +222355,12 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000257", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_142796" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000287", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000287", "pred" : "is_a", @@ -222948,6 +222445,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000347", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000347", "pred" : "is_a", @@ -222964,6 +222465,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000348", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000348", "pred" : "is_a", @@ -222979,7 +222484,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000349", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000349", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -223046,7 +222551,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0010017" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000365", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000393", @@ -223182,16 +222687,16 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000521", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + "obj" : "http://purl.obolibrary.org/obo/CL_0000351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000351" + "obj" : "http://purl.obolibrary.org/obo/CL_4052002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000525", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -223248,6 +222753,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000547", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002242" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000547", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000547", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223316,6 +222825,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000549", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000765" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000549", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000549", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223332,6 +222845,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000550", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000765" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000550", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000550", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", @@ -223448,6 +222965,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000558", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000764" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000558", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000558", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -223524,6 +223045,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000566", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0011026" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000566", "pred" : "http://purl.obolibrary.org/obo/RO_0002104", @@ -223660,6 +223185,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000680", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000055" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000680", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", @@ -223758,7 +223287,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002405" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000738", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000738", @@ -223800,6 +223329,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000763", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000763", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000763", "pred" : "is_a", @@ -223892,10 +223425,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000837", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000837", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000837", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -224011,7 +223552,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001035", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001035", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224096,6 +223637,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0001066", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000038" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0001066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/PR_000050567" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0001066", "pred" : "http://purl.obolibrary.org/obo/CL_4030046", @@ -224152,6 +223697,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002031", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002031", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002031", "pred" : "is_a", @@ -224168,6 +223717,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002032", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002032", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002032", "pred" : "is_a", @@ -224415,7 +223968,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002319", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002319", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224423,7 +223976,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002320", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002320", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224475,11 +224028,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + "obj" : "http://purl.obolibrary.org/obo/CL_0000737" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000737" + "obj" : "http://purl.obolibrary.org/obo/CL_4052002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002372", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", @@ -224487,15 +224040,19 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000030" + "obj" : "http://purl.obolibrary.org/obo/CL_0011026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0011026" + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001402" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002375", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000333" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002375", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/CL_0002573" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002377", "pred" : "is_a", @@ -224535,7 +224092,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002494", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002494", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -224584,10 +224141,6 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002543", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" - }, { - "sub" : "http://purl.obolibrary.org/obo/CL_0002546", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000222" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002547", "pred" : "is_a", @@ -224848,6 +224401,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0005000", "pred" : "http://purl.obolibrary.org/obo/RO_0002100", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0031514" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005012", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0010007" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0005024", "pred" : "is_a", @@ -224940,6 +224509,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0008019", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000219" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008019", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0008019", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -225192,6 +224765,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0011026", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011026", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0011026", "pred" : "is_a", @@ -225351,15 +224928,23 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000271", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_4030034" + "obj" : "http://purl.obolibrary.org/obo/CL_0000067" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000271", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", - "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000082" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4030034" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000272", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000151" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000272", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -225763,7 +225348,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000020", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + "obj" : "http://purl.obolibrary.org/obo/CL_0000255" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000020", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -226200,6 +225785,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4047005", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002354" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000228" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4052002", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0000768" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000011", "pred" : "is_a", @@ -226339,11 +225936,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000785", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000004" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0000785", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" + "obj" : "http://purl.obolibrary.org/obo/GO_0110165" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000785", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -229464,10 +229057,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006022", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901135" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006022", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006022", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -229484,10 +229073,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006023", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901137" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006023", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006023", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -229548,18 +229133,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006139", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006259", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0090304" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006259", - "pred" : "http://purl.obolibrary.org/obo/RO_0004007", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" + "obj" : "http://purl.obolibrary.org/obo/GO_0016043" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", @@ -229592,10 +229169,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006412", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0019538" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0006412", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006412", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", @@ -230992,6 +230565,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008088", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0043005" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008089", "pred" : "is_a", @@ -231048,18 +230625,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008219", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0009987" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0015698" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0072348" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0008272", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008283", "pred" : "is_a", @@ -231276,10 +230841,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901137" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009101", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231288,10 +230849,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009112", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0055086" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009112", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009112", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231311,7 +230868,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009308", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009308", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009308", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231319,11 +230880,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009308" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0009308" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231523,7 +231084,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009820", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009820", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -231536,10 +231101,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009821", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044550" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0009821", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009821", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -231824,14 +231385,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010171", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0010243", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901698" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0010243", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010256", "pred" : "is_a", @@ -233415,7 +232968,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014075", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014075", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", @@ -233900,22 +233453,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015851", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18282" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0006886" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0015931" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0031503" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0015869", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015870", "pred" : "is_a", @@ -234288,10 +233825,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044238" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0019538", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -238064,18 +237597,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032984", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032984" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032986", - "pred" : "http://purl.obolibrary.org/obo/RO_0002590", - "obj" : "http://purl.obolibrary.org/obo/GO_0032993" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032988", "pred" : "is_a", @@ -238100,14 +237621,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032991", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/PR_000000001" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032993", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0032993", - "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033002", "pred" : "is_a", @@ -239851,7 +239364,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042430", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -239859,11 +239376,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0042430" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0042430" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -240427,7 +239944,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043279", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043279", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", @@ -240499,7 +240016,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "is_a", @@ -242307,11 +241824,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009112" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_0009112" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046112", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -242607,11 +242124,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_0017085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0017085" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046681", "pred" : "is_a", @@ -245308,10 +244825,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050907", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0007606" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0050908", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009584" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050908", "pred" : "is_a", @@ -245416,14 +244929,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050975", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050954" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051027", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0050657" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051027", - "pred" : "http://purl.obolibrary.org/obo/RO_0004009", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051046", "pred" : "is_a", @@ -245488,50 +244993,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051051", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0006810" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0019219" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0060255" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051052", - "pred" : "http://purl.obolibrary.org/obo/RO_0002211", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010605" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0045934" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051053", - "pred" : "http://purl.obolibrary.org/obo/RO_0002212", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010604" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0045935" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0051054", - "pred" : "http://purl.obolibrary.org/obo/RO_0002213", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051055", "pred" : "is_a", @@ -250500,18 +249961,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0065003", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0065004", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0065003" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0065004", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0071824" - 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}, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0006259" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0141187" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_0071897", - "pred" : "http://purl.obolibrary.org/obo/RO_0004008", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0071944", "pred" : "is_a", @@ -254923,7 +254352,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" + "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901160", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", @@ -254931,11 +254364,11 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901160" + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901566" + "obj" : "http://purl.obolibrary.org/obo/GO_1901160" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", @@ -255340,30 +254773,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901552", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0001885" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/BFO_0000003" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0008152" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901564", - "pred" : "http://purl.obolibrary.org/obo/RO_0004007", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0009058" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_1901564" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_1901566", - "pred" : "http://purl.obolibrary.org/obo/RO_0004008", - "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901588", "pred" : "is_a", @@ -256103,11 +255512,15 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902358", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0008272" + "obj" : "http://purl.obolibrary.org/obo/GO_0072348" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902358", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0098661" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902358", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16189" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902414", "pred" : "is_a", @@ -256788,6 +256201,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903226", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002065" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0005012" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903292", "pred" : "is_a", @@ -258059,7 +257480,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904587", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010243" + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904587", "pred" : "is_a", @@ -260728,34 +260149,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000271", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0044346" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010556" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051052" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000278", - "pred" : "http://purl.obolibrary.org/obo/RO_0002211", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010558" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051053" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_2000278" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000279", - "pred" : "http://purl.obolibrary.org/obo/RO_0002212", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000282", "pred" : "is_a", @@ -261088,22 +260481,6 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000543", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007369" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0010557" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0051054" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_2000278" - }, { - "sub" : "http://purl.obolibrary.org/obo/GO_2000573", - "pred" : "http://purl.obolibrary.org/obo/RO_0002213", - "obj" : "http://purl.obolibrary.org/obo/GO_0071897" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000647", "pred" : "is_a", @@ -271686,7 +271063,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", @@ -271770,7 +271147,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0015165" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6656" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", @@ -271838,7 +271215,7 @@ "obj" : "http://purl.obolibrary.org/obo/PATO_0002236" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000023", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000023", @@ -271862,7 +271239,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000026", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000030", @@ -271898,7 +271275,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007811" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000033", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000042", @@ -271934,7 +271311,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000327" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000043", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000043", @@ -272142,7 +271519,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000075", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000075", @@ -272414,7 +271791,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0007369" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000109", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000110", @@ -272438,7 +271815,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0001841" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000110", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000111", @@ -272458,7 +271835,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0048513" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000111", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000114", @@ -272554,7 +271931,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011215" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000125", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000125", @@ -272578,7 +271955,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000153", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000154", @@ -272586,7 +271963,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000154", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000158", @@ -272614,7 +271991,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", @@ -272722,7 +272099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000179", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000203", @@ -272814,7 +272191,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000344", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", @@ -272822,7 +272199,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000353", @@ -272858,7 +272235,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000088" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000358", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32525" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000358", @@ -272954,7 +272331,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000383", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000383", @@ -273174,7 +272551,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005769" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000483", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000483", @@ -273246,7 +272623,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002417" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000916", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000922", @@ -273266,7 +272643,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010316" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000923", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000924", @@ -273318,7 +272695,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035804" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000930", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", @@ -273334,7 +272711,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", @@ -273390,7 +272767,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004151" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000948", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000948", @@ -273410,7 +272787,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0015204" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000949", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000949", @@ -273690,7 +273067,7 @@ "obj" : "http://purl.obolibrary.org/obo/PATO_0001748" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000977", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32524" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000977", @@ -273726,7 +273103,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000988", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000988", @@ -273786,7 +273163,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003134" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000992", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000992", @@ -273818,7 +273195,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001004", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001004", @@ -273866,7 +273243,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", @@ -273918,7 +273295,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000540" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001016", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001016", @@ -273950,7 +273327,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001017", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001017", @@ -274006,7 +273383,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001033", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001033", @@ -274058,7 +273435,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001042", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001042", @@ -274302,7 +273679,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001884" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", @@ -274378,7 +273755,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001137", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", @@ -274646,7 +274023,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004765" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001474", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001474", @@ -274894,7 +274271,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001555", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001555", @@ -275238,7 +274615,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001572" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001650", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001650", @@ -275342,7 +274719,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_117570" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", @@ -275446,7 +274823,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", @@ -276414,7 +275791,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000956" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001950", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001950", @@ -276606,7 +275983,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0012275" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", @@ -276674,7 +276051,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002019", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002019", @@ -276698,7 +276075,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", @@ -276774,7 +276151,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000170" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002048", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002048", @@ -277086,7 +276463,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000026" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002091", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002091", @@ -277354,7 +276731,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002193", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002199", @@ -277382,7 +276759,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002199", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002200", @@ -277482,7 +276859,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000982" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002217", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002217", @@ -277714,7 +277091,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002328", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002328", @@ -277746,7 +277123,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007503" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002329", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002329", @@ -277758,7 +277135,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002330", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002330", @@ -277802,7 +277179,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002342", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002342", @@ -278202,7 +277579,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000479" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002384", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", @@ -278218,7 +277595,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001015" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002385", @@ -278242,7 +277619,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", @@ -278426,7 +277803,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000010" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", @@ -278478,7 +277855,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000138" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002418", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002418", @@ -278590,7 +277967,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002481", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002506", @@ -278694,7 +278071,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002530", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002530", @@ -278722,7 +278099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002536", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6656" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", @@ -278746,7 +278123,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0008816" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002539", @@ -278762,7 +278139,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002546", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002553", @@ -278810,7 +278187,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005844" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002726", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002726", @@ -279090,7 +278467,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003068", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003068", @@ -279198,7 +278575,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0016879" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003075", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003075", @@ -279302,7 +278679,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003081", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003081", @@ -279378,7 +278755,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007530" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", @@ -279426,7 +278803,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000479" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", @@ -279446,7 +278823,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010364" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003113", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003114", @@ -279542,7 +278919,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003278" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003129", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003133", @@ -280822,7 +280199,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0035642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003716", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003716", @@ -281134,7 +280511,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", @@ -281414,7 +280791,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0014950" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004040", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004040", @@ -281570,7 +280947,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004117", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004117", @@ -281754,7 +281131,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002350" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004146", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32523" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004148", @@ -282786,7 +282163,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004708", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004708", @@ -282978,7 +282355,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0002418" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", @@ -283038,7 +282415,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004770", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004770", @@ -283358,7 +282735,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0003068" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004880", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004883", @@ -283462,7 +282839,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000060" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004923", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004924", @@ -283638,7 +283015,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000187" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005090", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005092", @@ -284122,7 +283499,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005434", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005456", @@ -284642,7 +284019,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0005587" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005769", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005769", @@ -285038,7 +284415,7 @@ "obj" : "http://purl.obolibrary.org/obo/GO_0043209" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006135", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006136", @@ -285246,7 +284623,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0005423" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", @@ -285266,7 +284643,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011997" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", @@ -285390,7 +284767,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006562", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006563", @@ -285442,7 +284819,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", @@ -285474,7 +284851,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006601", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006601", @@ -285490,7 +284867,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000307" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", @@ -285562,7 +284939,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0001676" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006682", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006682", @@ -285662,7 +285039,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", @@ -286226,7 +285603,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004710" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007272", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007272", @@ -286418,7 +285795,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", @@ -286470,7 +285847,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007272" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007390", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007414", @@ -286706,7 +286083,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007779", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007779", @@ -286774,7 +286151,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010707" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", @@ -286894,7 +286271,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0007823" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", @@ -287002,7 +286379,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0009145" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008814", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008816", @@ -287818,7 +287195,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004140" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009889", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009891", @@ -288178,7 +287555,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004571" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010191", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010192", @@ -288598,7 +287975,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0011137" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010323", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010329", @@ -288794,7 +288171,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010362", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010362", @@ -288810,7 +288187,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010364", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010371", @@ -288958,7 +288335,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000468" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", @@ -289362,7 +288739,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", @@ -289754,7 +289131,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011997", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012054", @@ -289834,7 +289211,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012314", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012320", @@ -289882,7 +289259,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0004923" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", @@ -290174,7 +289551,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013701", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013702", @@ -290586,7 +289963,7 @@ "obj" : "http://purl.obolibrary.org/obo/CL_0000100" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014892", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014892", @@ -290722,7 +290099,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000465" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015212", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015228", @@ -291450,7 +290827,7 @@ "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034713", - "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034713", @@ -293755,6 +293132,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000076", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006914" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000080", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -293920,7 +293304,7 @@ "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ], "restrictions" : [ { "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0050962" + "fillerId" : "http://purl.obolibrary.org/obo/GO_0050908" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000219", @@ -293980,14 +293364,14 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000255", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000257", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_142796" } ] }, { @@ -294060,7 +293444,7 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000365", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0010017" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" } ] }, { @@ -294150,7 +293534,7 @@ "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000521", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002160", + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002162", "fillerId" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" } ] }, { @@ -295193,6 +294577,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002240" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005012", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031514" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010007" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005024", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000100" ], @@ -295504,10 +294898,10 @@ } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000271", - "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000064" ], + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000067" ], "restrictions" : [ { "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", - "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000115" } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000272", @@ -296123,6 +295517,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002354" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4052002", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001908" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0000768" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000011", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048308" ], @@ -297870,13 +297274,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006259", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006325", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -298592,13 +297989,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008272", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16189" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008284", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -298945,13 +298335,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000468" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010243", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010256", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -300183,13 +299566,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18282" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015869", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015870", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -302437,13 +301813,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032986", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032988", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], @@ -306440,13 +305809,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051027", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051046", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -306489,27 +305851,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006810" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051052", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051053", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051054", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0006259" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051055", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -309372,13 +308713,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065004", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065010", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043227" ], @@ -309753,13 +309087,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071824", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -309795,13 +309122,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000738" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071897", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071971", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -312630,20 +311950,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0001885" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901564", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901566", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", - "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901588", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005874" ], @@ -313538,6 +312844,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0005012" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903292", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -315893,20 +315206,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044346" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000278", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000279", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000282", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -316117,13 +315416,6 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007369" } ] - }, { - "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000573", - "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], - "restrictions" : [ { - "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", - "fillerId" : "http://purl.obolibrary.org/obo/GO_0071897" - } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000647", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -326885,6 +326177,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007610", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", diff --git a/pato.obo b/pato.obo index 2da3316..7e82100 100644 --- a/pato.obo +++ b/pato.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: releases/2024-09-04/pato.obo +data-version: releases/2024-11-11/pato.obo subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" @@ -23,7 +23,7 @@ ontology: pato property_value: dc:description "An ontology of phenotypic qualities (properties, attributes or characteristics)." xsd:string property_value: dc:title "PATO - the Phenotype And Trait Ontology" xsd:string property_value: has_ontology_root_term PATO:0000001 -property_value: owl:versionInfo "2024-09-04" xsd:string +property_value: owl:versionInfo "2024-11-11" xsd:string property_value: terms:license https://creativecommons.org/licenses/by/3.0/ [Term] diff --git a/pato.owl b/pato.owl index 087c90d..54f5071 100644 --- a/pato.owl +++ b/pato.owl @@ -21,14 +21,14 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + An ontology of phenotypic qualities (properties, attributes or characteristics). PATO - the Phenotype And Trait Ontology quality 1.2 - 2024-09-04 + 2024-11-11 @@ -216,6 +216,14 @@ + + + + + + + + @@ -6170,145 +6178,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. - CHEBI:13302 - CHEBI:21123 - CHEBI:33698 - CHEBI:4291 - KEGG:C00039 - Deoxyribonucleic acid - chebi_ontology - (Deoxyribonucleotide)m - (Deoxyribonucleotide)n - (Deoxyribonucleotide)n+m - DNA - DNAn - DNAn+1 - DNS - Desoxyribonukleinsaeure - deoxyribonucleic acids - desoxyribose nucleic acid - thymus nucleic acid - CHEBI:16991 - - deoxyribonucleic acid - - - - - Deoxyribonucleic acid - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)m - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n - KEGG_COMPOUND - - - - - (Deoxyribonucleotide)n+m - KEGG_COMPOUND - - - - - DNA - IUPAC - - - - - DNA - KEGG_COMPOUND - - - - - DNA - UniProt - - - - - DNAn - KEGG_COMPOUND - - - - - DNAn+1 - KEGG_COMPOUND - - - - - DNS - ChEBI - - - - - Desoxyribonukleinsaeure - ChEBI - - - - - deoxyribonucleic acids - ChEBI - - - - - desoxyribose nucleic acid - ChemIDplus - - - - - thymus nucleic acid - ChEBI - - - - @@ -12252,60 +12121,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - chebi_ontology - canonical deoxyribonucleoside residues - common 2'-deoxyribonucleoside residue - common 2'-deoxyribonucleoside residues - dN - dNuc - standard deoxyribonucleoside residues - CHEBI:33793 - - canonical deoxyribonucleoside residue - - - - - canonical deoxyribonucleoside residues - ChEBI - - - - - common 2'-deoxyribonucleoside residue - CBN - - - - - common 2'-deoxyribonucleoside residues - CBN - - - - - dN - CBN - - - - - dNuc - CBN - - - - - standard deoxyribonucleoside residues - ChEBI - - - - @@ -15123,25 +14938,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - chebi_ontology - canonical deoxyribonucleotide residues - CHEBI:50298 - - canonical deoxyribonucleotide residue - - - - - canonical deoxyribonucleotide residues - ChEBI - - - - @@ -18220,7 +18016,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18408,6 +18204,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -18466,7 +18263,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - @@ -18475,7 +18271,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18652,6 +18448,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -18671,7 +18468,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -18706,6 +18503,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -19366,7 +19164,8 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + + @@ -19391,7 +19190,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -19507,12 +19306,6 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - - - - - An endothelial cell that lines the vasculature. @@ -19549,11 +19342,35 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + + + + + + + + + + + + + + + + + + Any epithelial cell that is part of some squamous epithelium. CALOHA:TS-1249 squamous epithelial cell + + + + Any epithelial cell that is part of some squamous epithelium. + FBC:Autogenerated + @@ -19563,19 +19380,33 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + + + + + + + A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. FMA:66773 mesotheliocyte + Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. mesothelial cell - A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. GOC:tfm ISBN:0721662544 + PMID:26106328 + + + + + Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. + PMID:26106328 @@ -19594,7 +19425,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - + @@ -19970,6 +19801,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20062,10 +19894,9 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual - - + @@ -20089,6 +19920,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual BTO:0002606 CALOHA:TS-0415 FMA:54536 + https://cellxgene.cziscience.com/cellguide/CL_0000125 neuroglial cell neuroglia @@ -20412,6 +20244,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20518,6 +20351,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual + @@ -20566,6 +20400,7 @@ OBSOLETE. PATO divides qualities between normal (monadic, singly-occurring) qual BTO:0003865 FMA:62930 MESH:D019858 + https://cellxgene.cziscience.com/cellguide/CL_0000164 enteroendocrine cell @@ -20782,6 +20617,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -20823,7 +20659,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -20914,7 +20750,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21016,19 +20852,20 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + - + - A cell specialized to detect and transduce light. + A cell specialized in detecting light stimuli that are involved in visual perception. BTO:0001060 CALOHA:TS-0868 FMA:86740 @@ -21038,7 +20875,7 @@ The modern definition of neurosecretion has evolved to include the release of an - A cell specialized to detect and transduce light. + A cell specialized in detecting light stimuli that are involved in visual perception. MESH:D010786 @@ -21188,6 +21025,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21212,6 +21050,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21238,6 +21077,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21309,6 +21149,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21376,6 +21217,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21384,11 +21226,8 @@ The modern definition of neurosecretion has evolved to include the release of an A cell with more than one nucleus. - AEO:0000203 - WBbt:0008074 - syncitium - syncytial cell - syncytium + multinucleated cells + polynuclear cells multinucleate cell @@ -21396,6 +21235,19 @@ The modern definition of neurosecretion has evolved to include the release of an A cell with more than one nucleus. FB:ma + Wikipedia:Multinucleate + + + + + multinucleated cells + Wikipedia:Multinucleate + + + + + polynuclear cells + Wikipedia:Multinucleate @@ -21486,7 +21338,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21495,11 +21347,11 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Eukaryota. + Any cell that in taxon some Eukaryota. MESH:D005057 eukaryotic cell @@ -21507,7 +21359,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Any cell that only exists in Eukaryota. + Any cell that in taxon some Eukaryota. FBC:Autogenerated @@ -21521,7 +21373,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21530,17 +21382,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Eumycetozoa. + Any cell that in taxon some Eumycetozoa. Eumycetozoan cell - Any cell that only exists in Eumycetozoa. + Any cell that in taxon some Eumycetozoa. FBC:Autogenerated @@ -21560,6 +21412,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21811,6 +21664,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21852,6 +21706,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -21892,7 +21747,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -21935,7 +21790,7 @@ The modern definition of neurosecretion has evolved to include the release of an GOC:tfm MESH:D014327 PMID:37630754 - doi:10.1007/978-3-030-84725-8 + doi:10.1007/978-3-030-84725-8 @@ -22112,7 +21967,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22123,7 +21978,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22637,7 +22492,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22646,17 +22501,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + - Any cell that only exists in Fungi. + Any cell that in taxon some Fungi. fungal cell - Any cell that only exists in Fungi. + Any cell that in taxon some Fungi. FBC:Autogenerated @@ -22676,8 +22531,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -22938,6 +22793,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23081,6 +22937,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23164,6 +23021,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23641,6 +23499,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -23806,6 +23665,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -24178,6 +24038,7 @@ The modern definition of neurosecretion has evolved to include the release of an An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + https://cellxgene.cziscience.com/cellguide/CL_0000666 window cell fenestrated endothelial cell @@ -24284,6 +24145,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -24403,6 +24265,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell that stores and secretes pancreatic polypeptide hormone. FMA:62938 FMA:83409 + https://cellxgene.cziscience.com/cellguide/CL_0000696 type F enteroendocrine cell PP cell @@ -24570,7 +24433,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -24737,6 +24600,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25063,7 +24927,9 @@ The modern definition of neurosecretion has evolved to include the release of an + + @@ -25381,7 +25247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -25741,6 +25607,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25853,6 +25720,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25898,6 +25766,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -25949,6 +25818,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2010-09-10T10:48:54Z FMA:62939 + https://cellxgene.cziscience.com/cellguide/CL_0002067 type A enteroendocrine cell @@ -26871,7 +26741,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -26910,7 +26780,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -27177,56 +27047,89 @@ The modern definition of neurosecretion has evolved to include the release of an - + - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development. 2010-09-24T01:13:01Z - myotubule - single cell sarcomere + myofiber + myofibril myotube - A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development. GOC:dos GOC:tfm ISBN:0323052908 PMID:22274696 + + + + myofiber + FBbt:00005812 + + + + + myofibril + FBbt:00005812 + - + + + + + + - A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. + + + + + + + A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage. 2010-09-24T02:06:10Z Schwann cell precursor cell + Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. Schwann cell precursor - A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. + A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage. GOC:tfm + PMID:15580626 + PMID:30971890 + PMID:35815410 + + + + + Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells. + PMID:35815410 @@ -27366,7 +27269,6 @@ The modern definition of neurosecretion has evolved to include the release of an MESH:D000073637 - This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). oligodendrocyte precursor cell @@ -27394,14 +27296,6 @@ The modern definition of neurosecretion has evolved to include the release of an PMID:24133281 - - - - This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). - ISBN:9780702028991 - PMID:10704434 - PMID:2182078 - @@ -27419,7 +27313,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -27616,6 +27510,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2011-02-28T03:48:11Z FMA:62104 KUPO:0001099 + https://cellxgene.cziscience.com/cellguide/CL_0002543 endothelial cell of vein venous endothelial cell @@ -27631,25 +27526,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - - 2011-02-28T04:20:39Z - See CL:0002619. - embryonic blood vessel endothelial progenitor cell - - - - - An endothelial progenitor cell that participates in angiogenesis during development. - GOC:tfm - - - - @@ -27856,6 +27732,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesenchymal stem cell of adipose tissue. 2011-03-01T09:57:17Z + https://cellxgene.cziscience.com/cellguide/CL_0002570 mesenchymal stem cell of adipose mesenchymal stem cell of adipose tissue @@ -27885,6 +27762,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO:0001220 CALOHA:TS-0898 MESH:D012583 + https://cellxgene.cziscience.com/cellguide/CL_0002573 neurolemmocyte @@ -27939,6 +27817,7 @@ The modern definition of neurosecretion has evolved to include the release of an A blood vessel endothelial cell that is part of the retina. 2011-03-06T03:28:27Z + https://cellxgene.cziscience.com/cellguide/CL_0002585 @@ -28690,6 +28569,68 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface. + multi-ciliated cell + multiciliated cell + https://cellxgene.cziscience.com/cellguide/CL_0005012 + multiciliated epithelial cell + + While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility + multi-ciliated epithelial cell + + + + + A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface. + CL:CVS + PMID:28400610 + PMID:30422572 + PMID:38032388 + + + + + While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility + PMID:22118931 + PMID:23959957 + PMID:25729351 + PMID:26378583 + + + + @@ -29036,6 +28977,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -29810,6 +29752,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. + https://cellxgene.cziscience.com/cellguide/CL_0011012 neural crest cell @@ -29924,6 +29867,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -30418,6 +30362,7 @@ The modern definition of neurosecretion has evolved to include the release of an A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + https://cellxgene.cziscience.com/cellguide/CL_1000223 pulmonary neuroendocrine cell @@ -30446,22 +30391,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + - + + + - - - - - - - Any ciliated cell that is part of some lung. + An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface. lung ciliated cell @@ -30469,8 +30410,8 @@ The modern definition of neurosecretion has evolved to include the release of an - Any ciliated cell that is part of some lung. - FBC:Autogenerated + An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface. + PMID:27864314 @@ -30490,6 +30431,7 @@ The modern definition of neurosecretion has evolved to include the release of an + @@ -31110,6 +31052,7 @@ The modern definition of neurosecretion has evolved to include the release of an BTO:0004758 FMA:67761 KUPO:0001095 + https://cellxgene.cziscience.com/cellguide/CL_1000413 arterial endothelial cell @@ -31506,6 +31449,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelial cell that is part of the pleura. FMA:86737 + https://cellxgene.cziscience.com/cellguide/CL_1000491 pleural mesothelial cell mesothelial cell of pleura @@ -31582,6 +31526,7 @@ The modern definition of neurosecretion has evolved to include the release of an A mesothelial cell that is part of the visceral pleura. FMA:86739 + https://cellxgene.cziscience.com/cellguide/CL_1000493 mesothelial cell of visceral pleura @@ -31819,7 +31764,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Endothelial cells forming the walls of the capillaries within the cerebral cortex. + A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex. CALOHA:TS-2372 cerebral cortex endothelial cells endothelial cells of cerebral cortex @@ -31829,7 +31774,7 @@ The modern definition of neurosecretion has evolved to include the release of an - Endothelial cells forming the walls of the capillaries within the cerebral cortex. + A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex. NPX:PDR @@ -32194,7 +32139,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -33923,6 +33868,54 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm. + + 2024-08-15T10:38:46Z + syncytium + syncytial cell + + + + + A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm. + PMID:20851884 + Wikipedia:Syncytium + + + + + syncytium + WBbt:0008074 + + + + @@ -34444,8 +34437,7 @@ The modern definition of neurosecretion has evolved to include the release of an - - + @@ -46511,7 +46503,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -46551,7 +46542,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -46779,53 +46769,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - GO:0055132 - DNA metabolism - cellular DNA metabolism - biological_process - GO:0006259 - - - - - - - - - - DNA metabolic process - - - - - Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. - ISBN:0198506732 - - - - @@ -46840,7 +46783,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -47038,7 +46981,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -48963,7 +48905,6 @@ The modern definition of neurosecretion has evolved to include the release of an - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stress @@ -50517,12 +50458,90 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. GO:0009552 biological_process @@ -52280,6 +52299,18 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + The directed movement of organelles or molecules along microtubules in neuron projections. Wikipedia:Axoplasmic_transport axon cargo transport @@ -52608,44 +52639,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GO:0006870 - sulphate transport - biological_process - GO:0008272 - sulfate transport - - - - - The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:krc - - - - @@ -53528,7 +53521,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -53569,7 +53561,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -53641,7 +53632,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -53684,8 +53676,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -54508,7 +54500,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -54548,7 +54541,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -54556,7 +54548,6 @@ The modern definition of neurosecretion has evolved to include the release of an The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). - UM-BBD_enzymeID:e0711 alkaloid anabolism alkaloid biosynthesis alkaloid formation @@ -55677,44 +55668,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - response to organic nitrogen - biological_process - GO:0010243 - - Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. - response to organonitrogen compound - - - - - Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. - PMID:9869419 - - - - @@ -61294,7 +61247,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -63080,50 +63033,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - DNA-protein complex transport - biological_process - GO:0015869 - protein-DNA complex transport - - - - - The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - - DNA-protein complex transport - GOC:mah - - - - @@ -64120,12 +64029,90 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. stem cell renewal biological_process @@ -64642,7 +64629,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -75931,6 +75917,16 @@ The modern definition of neurosecretion has evolved to include the release of an GO:0032060 bleb assembly + + + + The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + GOC:mah + GOC:mtg_apoptosis + PMID:12083798 + PMID:16624291 + Wikipedia:Bleb_(cell_biology) + @@ -75955,16 +75951,6 @@ The modern definition of neurosecretion has evolved to include the release of an plasma membrane blebbing GOC:pr - - - - The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. - GOC:mah - GOC:mtg_apoptosis - PMID:12083798 - PMID:16624291 - Wikipedia:Bleb_(cell_biology) - @@ -79022,49 +79008,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The disaggregation of a protein-DNA complex into its constituent components. - DNA-protein complex disassembly - biological_process - GO:0032986 - protein-DNA complex disassembly - - - - - The disaggregation of a protein-DNA complex into its constituent components. - GOC:mah - - - - - DNA-protein complex disassembly - GOC:mah - - - - @@ -79173,39 +79116,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - A macromolecular complex containing both protein and DNA molecules. - DNA-protein complex - cellular_component - GO:0032993 - - Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. - protein-DNA complex - - - - - A macromolecular complex containing both protein and DNA molecules. - GOC:mah - - - - - DNA-protein complex - GOC:mah - - - - @@ -86044,7 +85954,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -86088,8 +85999,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -87806,6 +87717,7 @@ The modern definition of neurosecretion has evolved to include the release of an membrane-enclosed organelle cellular_component GO:0043227 + membrane-bounded organelle @@ -87827,6 +87739,7 @@ The modern definition of neurosecretion has evolved to include the release of an cellular_component biological condensate GO:0043228 + non-membrane-bounded organelle @@ -87864,6 +87777,7 @@ The modern definition of neurosecretion has evolved to include the release of an Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. cellular_component GO:0043229 + intracellular organelle @@ -88429,7 +88343,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -88719,7 +88633,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -89869,6 +89783,7 @@ The modern definition of neurosecretion has evolved to include the release of an cellular component biogenesis at cellular level biological_process GO:0044085 + cellular component biogenesis @@ -95425,8 +95340,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -96404,8 +96319,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -105716,7 +105631,6 @@ The modern definition of neurosecretion has evolved to include the release of an - @@ -106123,41 +106037,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - biological_process - GO:0051027 - DNA transport - - - - - The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:ai - - - - @@ -106391,129 +106270,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - regulation of DNA metabolism - biological_process - GO:0051052 - - regulation of DNA metabolic process - - - - - Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - down regulation of DNA metabolic process - down-regulation of DNA metabolic process - downregulation of DNA metabolic process - negative regulation of DNA metabolism - inhibition of DNA metabolic process - biological_process - GO:0051053 - negative regulation of DNA metabolic process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - positive regulation of DNA metabolism - up regulation of DNA metabolic process - up-regulation of DNA metabolic process - upregulation of DNA metabolic process - activation of DNA metabolic process - stimulation of DNA metabolic process - biological_process - GO:0051054 - positive regulation of DNA metabolic process - - - - - Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. - GOC:ai - - - - @@ -125040,49 +124796,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - DNA-protein complex assembly - biological_process - GO:0065004 - protein-DNA complex assembly - - - - - The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. - GOC:jl - - - - - DNA-protein complex assembly - GOC:mah - - - - @@ -127515,7 +127228,7 @@ The modern definition of neurosecretion has evolved to include the release of an 2010-03-08T03:56:28Z biological_process GO:0071705 - + nitrogen compound transport @@ -127763,58 +127476,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - mah - 2010-09-08T10:03:26Z - DNA-protein complex subunit organization - protein-DNA complex subunit organisation - protein-DNA complex subunit organization - biological_process - GO:0071824 - protein-DNA complex organization - - - - - Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. - GOC:mah - - - - - DNA-protein complex subunit organization - GOC:mah - - - - - protein-DNA complex subunit organisation - GOC:mah - - - - @@ -127928,7 +127589,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -128112,72 +127773,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The biosynthetic process resulting in the formation of DNA. - mah - 2010-09-15T02:14:33Z - DNA anabolism - DNA biosynthesis - DNA formation - DNA synthesis - biological_process - GO:0071897 - DNA biosynthetic process - - - - - The biosynthetic process resulting in the formation of DNA. - GOC:mah - - - - - DNA anabolism - GOC:mah - - - - - DNA biosynthesis - GOC:mah - - - - - DNA formation - GOC:mah - - - - - DNA synthesis - GOC:mah - - - - @@ -136463,7 +136058,7 @@ The modern definition of neurosecretion has evolved to include the release of an The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. biological_process GO:0099531 - + presynaptic process involved in chemical synaptic transmission @@ -144577,7 +144172,8 @@ The modern definition of neurosecretion has evolved to include the release of an - + + @@ -144621,8 +144217,8 @@ The modern definition of neurosecretion has evolved to include the release of an + - @@ -146980,121 +146576,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways involving organonitrogen compound. - pr - 2012-11-04T15:17:52Z - organonitrogen compound metabolism - biological_process - GO:1901564 - - organonitrogen compound metabolic process - - - - - The chemical reactions and pathways involving organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound metabolism - GOC:TermGenie - - - - - - - - - - - - - - - - - - - - - - - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - pr - 2012-11-04T15:18:00Z - organonitrogen compound anabolism - organonitrogen compound biosynthesis - organonitrogen compound formation - organonitrogen compound synthesis - biological_process - GO:1901566 - - organonitrogen compound biosynthetic process - - - - - The chemical reactions and pathways resulting in the formation of organonitrogen compound. - GOC:TermGenie - GOC:pr - - - - - organonitrogen compound anabolism - GOC:TermGenie - - - - - organonitrogen compound biosynthesis - GOC:TermGenie - - - - - organonitrogen compound formation - GOC:TermGenie - - - - - organonitrogen compound synthesis - GOC:TermGenie - - - - @@ -152564,11 +152045,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + + + + + + + The directed movement of sulfate across a membrane. dph 2013-08-14T14:46:04Z + sulphate transport biological_process GO:1902358 sulfate transmembrane transport @@ -158740,6 +158228,48 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + tb + 2014-08-05T19:21:21Z + multiciliate cell differentiation + biological_process + GO:1903251 + multi-ciliated epithelial cell differentiation + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + GOC:TermGenie + GOC:sp + GO_REF:0000086 + PMID:22231168 + PMID:24934224 + + + + @@ -164079,6 +163609,16 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + @@ -164089,12 +163629,32 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + @@ -164105,12 +163665,40 @@ The modern definition of neurosecretion has evolved to include the release of an + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in an epithelial cell. sl 2015-03-06T22:27:17Z @@ -168009,7 +167597,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -188770,139 +188358,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:15Z - regulation of DNA anabolism - regulation of DNA biosynthesis - regulation of DNA formation - regulation of DNA synthesis - biological_process - GO:2000278 - regulation of DNA biosynthetic process - - - - - Any process that modulates the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - regulation of DNA anabolism - GOC:obol - - - - - regulation of DNA biosynthesis - GOC:obol - - - - - regulation of DNA formation - GOC:obol - - - - - regulation of DNA synthesis - GOC:obol - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - yaf - 2010-12-08T04:48:20Z - negative regulation of DNA anabolism - negative regulation of DNA biosynthesis - negative regulation of DNA formation - negative regulation of DNA synthesis - biological_process - GO:2000279 - negative regulation of DNA biosynthetic process - - - - - Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - negative regulation of DNA anabolism - GOC:obol - - - - - negative regulation of DNA biosynthesis - GOC:obol - - - - - negative regulation of DNA formation - GOC:obol - - - - - negative regulation of DNA synthesis - GOC:obol - - - - @@ -190317,73 +189772,6 @@ The modern definition of neurosecretion has evolved to include the release of an - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - yaf - 2011-04-04T10:01:20Z - positive regulation of DNA anabolism - positive regulation of DNA biosynthesis - positive regulation of DNA formation - positive regulation of DNA synthesis - biological_process - GO:2000573 - positive regulation of DNA biosynthetic process - - - - - Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. - GOC:obol - - - - - positive regulation of DNA anabolism - GOC:obol - - - - - positive regulation of DNA biosynthesis - GOC:obol - - - - - positive regulation of DNA formation - GOC:obol - - - - - positive regulation of DNA synthesis - GOC:obol - - - - @@ -249171,6 +248559,12 @@ Classes for population already exist in IDO ('organism population', I + + + + + + @@ -250401,7 +249795,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -250814,7 +250208,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251106,7 +250500,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251197,7 +250591,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251422,7 +250816,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -251567,7 +250961,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -252333,7 +251727,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253320,7 +252714,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253417,7 +252811,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253459,7 +252853,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253834,7 +253228,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253947,7 +253341,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -253964,7 +253358,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254064,7 +253458,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254584,7 +253978,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -254956,7 +254350,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255036,7 +254430,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255207,7 +254601,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -255939,7 +255333,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257209,7 +256603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257642,7 +257036,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -257792,7 +257186,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258060,7 +257454,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258158,7 +257552,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258322,7 +257716,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -258406,7 +257800,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259382,7 +258776,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259549,7 +258943,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -259829,7 +259223,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260125,7 +259519,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260348,7 +259742,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260566,7 +259960,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -260635,7 +260029,6 @@ Classes for population already exist in IDO ('organism population', I UBERON:0001016 - @@ -260681,7 +260074,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -261027,7 +260420,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -261182,7 +260575,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -262387,7 +261780,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -262887,7 +262280,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -264600,7 +263993,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -265550,7 +264943,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -266987,7 +266380,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -267435,7 +266828,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -267809,7 +267202,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -271718,7 +271111,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -272794,7 +272187,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273038,7 +272431,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273210,7 +272603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -273455,7 +272848,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -274705,7 +274098,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276191,7 +275584,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276248,7 +275641,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -276760,7 +276153,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -277927,7 +277320,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278014,7 +277407,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278090,7 +277483,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -278213,7 +277606,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -279891,7 +279284,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -279974,7 +279367,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280042,7 +279435,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280638,7 +280031,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -280895,7 +280288,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -281564,7 +280957,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282020,7 +281413,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282155,7 +281548,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282211,7 +281604,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282279,7 +281672,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -282547,7 +281940,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -283779,7 +283172,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284106,7 +283499,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284353,7 +283746,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284572,7 +283965,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284798,7 +284191,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -284861,7 +284254,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -285753,7 +285146,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -294763,7 +294156,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -296644,7 +296037,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -298020,7 +297413,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -298505,7 +297898,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -299142,7 +298535,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -304414,7 +303807,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -305158,7 +304551,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -305387,7 +304780,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -307641,7 +307034,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -308109,7 +307502,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -308890,7 +308283,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -311212,7 +310605,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -313375,7 +312768,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -314915,7 +314308,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -315631,7 +315024,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -315693,7 +315086,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316239,7 +315632,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316484,7 +315877,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316626,7 +316019,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316690,7 +316083,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -316976,7 +316369,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -317347,7 +316740,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320027,7 +319420,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320769,7 +320162,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -320928,7 +320321,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -321957,7 +321350,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -322230,7 +321623,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -322754,7 +322147,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -323255,7 +322648,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -326415,7 +325808,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -327681,7 +327074,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -328932,7 +328325,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -329535,7 +328928,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -329609,7 +329002,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -330119,7 +329512,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -331764,7 +331157,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333210,7 +332603,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333543,7 +332936,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -333784,7 +333177,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -334932,7 +334325,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -336868,7 +336261,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -337408,7 +336801,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -340331,7 +339724,7 @@ Classes for population already exist in IDO ('organism population', I - + @@ -344717,14 +344110,14 @@ Classes for population already exist in IDO ('organism population', I - + - + - + diff --git a/src/ontology/reports/basic-report.tsv b/src/ontology/reports/basic-report.tsv index 2726056..5b2c995 100644 --- a/src/ontology/reports/basic-report.tsv +++ b/src/ontology/reports/basic-report.tsv @@ -27,7 +27,7 @@ "A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity." "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." "Any process that activates or increases the frequency, rate or extent of chromatin organization." - "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." "XAO:0000183 MESH:D012590 EMAPA:19027 AAO:0010354 NCIT:C12784 ZFA:0005563 GAID:911 EV:0100342 VHOG:0001274 FMA:58269 SCTID:181163006 Wikipedia:Sclera MA:0000280 BTO:0001606" + "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." "XAO:0000183 MESH:D012590 EMAPA:19027 AAO:0010354 NCIT:C12784 GAID:911 ZFA:0005563 EV:0100342 VHOG:0001274 FMA:58269 SCTID:181163006 Wikipedia:Sclera MA:0000280 BTO:0001606" "A protogynous quality whereby organisms start out as female and change to hermaphrodite at a later life stage." "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." "Wikipedia:Exocytosis" @@ -74,7 +74,7 @@ "A quality inhering in a bearer by virtue of the bearer's disposition to harmonious coexistence." "A reproductive quality inhering in the young of an animal by virtue of their number." - "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." "EMAPA:16989 AAO:0011101 EHDAA2:0001898 GAID:841 neuronames:1228 FMA:5858 Wikipedia:Spinal_nerve SCTID:361099009 NCIT:C12792 MA:0000233 MESH:D013127 BAMS:spin VHOG:0000824 BTO:0000870 XAO:0003101" + "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." "EMAPA:16989 AAO:0011101 EHDAA2:0001898 GAID:841 neuronames:1228 FMA:5858 Wikipedia:Spinal_nerve SCTID:361099009 NCIT:C12792 MA:0000233 BAMS:spin MESH:D013127 VHOG:0000824 BTO:0000870 XAO:0003101" "A quality of a process that happens during the hours of darkness." "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." "Recurrent and often more or less cyclic alteration." @@ -208,7 +208,7 @@ "A quality inhering in a protein or a molecule by virtue of the bearer's lacking a phosphate (PO4) group." "A flexibility which is relatively high." - "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." "EHDAA2:0001929 Wikipedia:Stomodeum FMA:295846 EMAPA:16263 TGMA:0000135 TAO:0001290 BTO:0004224 NCIT:C34306 ZFA:0001290 XAO:0000269" + "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." "Wikipedia:Stomodeum FMA:295846 EMAPA:16263 TGMA:0000135 TAO:0001290 BTO:0004224 NCIT:C34306 ZFA:0001290 XAO:0000269 EHDAA2:0001929" "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." "A color consisting of brown hue and low brightness." "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." "MA:0001481" @@ -444,7 +444,7 @@ "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." "Cell-cell signaling in which the ligand is carried between cells by an exosome." - "An endothelium that is part of an artery [Automatically generated definition]." "EMAPA:35148 VHOG:0001215 NCIT:C49194 BTO:0004757 AAO:0011013 XAO:0000357 MA:0000707 FMA:62116" + "An endothelium that is part of an artery [Automatically generated definition]." "EMAPA:35148 VHOG:0001215 BTO:0004757 NCIT:C49194 AAO:0011013 XAO:0000357 MA:0000707 FMA:62116" "A susceptibility toward an external stimulus which is higher than normal/average." "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." "A volume quality inhering in a homogeneous substance containing 6.02 x 1023 atoms or molecules by virtue of the amount of 3-dimensional space it occupies." @@ -486,7 +486,6 @@ "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." "EMAPA:18963" "A quality inhering in a population by virtue of the proportion of its members that are ill at a given time." - "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." "SCTID:280300006 FMA:14469 EMAPA:25350 MA:0001107" @@ -506,7 +505,6 @@ "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." - "Any ciliated cell that is part of some lung." "A sound frequency in the range of 20 to 20.000 Hz." @@ -535,7 +533,6 @@ "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." "BTO:0000249 FMA:66782 CALOHA:TS-0138" "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." "FMA:62511 BTO:0003687" - "CALOHA:TS-1249" "A temperature which is relatively high." "Cranial nerve that innervates the muscles of the tongue." "MA:0001094 NCIT:C12732 BTO:0003386 AAO:0010477 MESH:D007002 BIRNLEX:820 FMA:50871 Wikipedia:Hypoglossal_nerve BAMS:12n BAMS:XIIn EMAPA:17269 VHOG:0000693 EHDAA2:0000798 GAID:828 SCTID:362471008 MBA:813 XAO:0004215 BAMS:nXII EHDAA:2859" @@ -593,7 +590,7 @@ "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." "A vein that is part of a respiratory system [Automatically generated definition]." "MA:0001809 MA:0001810" - "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." "FMA:10636 Wikipedia:Costocervical_trunk SCTID:244225009 MA:0001939" + "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." "Wikipedia:Costocervical_trunk SCTID:244225009 MA:0001939 FMA:10636" "Any organic ion with a net negative charge." "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." "A texture quality inhering in a bearer by virtue of the bearer's formed or tending to form flakes or thin, crisp fragments." @@ -678,7 +675,7 @@ "A physical quality inhering in a bearer by virtue of the bearer's capacity to do work." "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." - "The sensory system for the sense of taste." "BILA:0000143 ZFA:0001101 Wikipedia:Gustatory_system TAO:0001101 MIAA:0000275 AAO:0010577 MAT:0000275 neuronames:2889 NLXANAT:090803 EFO:0000830 SCTID:423940004 FMA:7194 MA:0002446 XAO:0003197" + "The sensory system for the sense of taste." "BILA:0000143 ZFA:0001101 Wikipedia:Gustatory_system TAO:0001101 MIAA:0000275 AAO:0010577 MAT:0000275 NLXANAT:090803 EFO:0000830 neuronames:2889 SCTID:423940004 FMA:7194 MA:0002446 XAO:0003197" "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." "An adipocyte that is part of the epicardial fat of right ventricle." "FMA:261297" "A pilosity quality of being covered with short hairs or soft down." @@ -767,6 +764,7 @@ "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." "A tolerance quality inhering in a bearer by virtue of the bearer's increased ability to endure a stimulus." "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." "Wikipedia:Sarcoplasm" + "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm." "A presumptive structure that has the potential to develop into a endocardium." "TAO:0002233 ZFA:0001724" "A structural quality inhering in a bearer by virtue of the bearer's underlying structure not changing over time." @@ -854,7 +852,7 @@ "Having both hydrophilic and hydrophobic (or lipophilic) groups." "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." "Any process in which a cell is transported to, and/or maintained in, a specific location." - "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." "SCTID:181371003 EHDAA2:0000182 galen:BrachiocephalicVein GAID:529 EHDAA:9868 MESH:D016121 Wikipedia:Brachiocephalic_vein NCIT:C32816 FMA:4723" + "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." "SCTID:181371003 EHDAA2:0000182 galen:BrachiocephalicVein EHDAA:9868 GAID:529 MESH:D016121 Wikipedia:Brachiocephalic_vein NCIT:C32816 FMA:4723" "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." "A molecular quality that inheres in a molecular entity by virtue of whether that there is a presence of cycles in the connection of the atoms within the molecular entity." @@ -886,7 +884,7 @@ "The part of the cardiovascular system consisting of all arteries." "SCTID:362030008 VHOG:0000273 EHDAA:396 EMAPA:16371 EHDAA2:0000143 MA:0002719 BTO:0004690 EMAPA:16201" "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." "A bone that is part of a head [Automatically generated definition]." "SCTID:118646007 MA:0000576 EMAPA:35996" - "A mesenchymal stem cell of adipose tissue." + "A mesenchymal stem cell of adipose tissue." "https://cellxgene.cziscience.com/cellguide/CL_0002570" "Any substance which is added to food to preserve or enhance its flavour and/or appearance." "Wikipedia:Food_additive" "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." "A mesothelial cell that is part of the epicardium." @@ -909,7 +907,7 @@ "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." "A quality inhering in a bearer by virtue of the bearer's similarity to the appearance of an inflorescence." - "A cell with more than one nucleus." "AEO:0000203 WBbt:0008074" + "A cell with more than one nucleus." "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." "An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed distomedially, ie, pertaining to an inside aspect, but also farther away from the center of the body." "A cellular quality that exists by virtue of the disposition of the cell to adhere to other cells and molecules, through the emergent action of the molecular parts of the cell surface." @@ -917,6 +915,7 @@ "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." "FMA:264898 MA:0000530" "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." + "Any epithelial cell that is part of some squamous epithelium." "CALOHA:TS-1249" "The joining of two lipid bilayers to form a single organelle membrane." "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." "A structural quality inhering in a bearer by virtue of the bearer's disposition to be reduced to smaller pieces with little effort." @@ -964,7 +963,7 @@ "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." "A blood that is part of a capillary." "NCIT:C32212 FMA:263901" - "Structure derived from foregut that becomes a lung[GO]." "NCIT:C34282 EHDAA2:0004089 SCTID:361427007 NCIT:C34260 Wikipedia:Respiratory_bud BTO:0001643" + "Structure derived from foregut that becomes a lung[GO]." "BTO:0001643 NCIT:C34282 EHDAA2:0004089 SCTID:361427007 NCIT:C34260 Wikipedia:Respiratory_bud" "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." "VHOG:0000369 MA:0000074 XAO:0003191 EMAPA:17315 Wikipedia:Left_atrium EHDAA2:0000275 AAO:0010247 FMA:7097 BTO:0001702 galen:LeftAtrium NCIT:C12869 SCTID:244387002" "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." "EMAPA:35428 EFO:0003909 MA:0000094 FMA:9476 EV:0100025 EHDAA2:0004185 VHOG:0001271 TAO:0005063 ZFA:0005063 SCTID:281489000 MESH:D006329" @@ -977,13 +976,12 @@ "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." "SCTID:362637005 EHDAA:7995 FMA:59398 MESH:D008334 Wikipedia:Lower_jaw EFO:0003660 VHOG:0000453 EMAPA:17906 EHDAA2:0001018 ncithesaurus:Lower_Jaw AAO:0000272" "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." "XAO:0000048 EHDAA2:0004419 neuronames:1366 MESH:D009432 AAO:0010578 SCTID:361462002 GAID:1310 ZFA:0000045 FMA:86666 MAT:0000066 CALOHA:TS-0676 NCIT:C34222 BTO:0001764 MIAA:0000066 EMAPA:32737 VHOG:0000057 Wikipedia:Neural_crest" - "Any cell that only exists in Fungi." "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." "Any muscle that is part of the cervical (neck) region." "GAID:149 MA:0000587 MESH:D009334 NCIT:C33163 FMA:9617" "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." "Wikipedia:Transmembrane_protein Wikipedia:Biological_membrane" - "A blood vessel endothelial cell that is part of an arterial endothelium." "KUPO:0001095 BTO:0004758 FMA:67761" + "A blood vessel endothelial cell that is part of an arterial endothelium." "https://cellxgene.cziscience.com/cellguide/CL_1000413 KUPO:0001095 BTO:0004758 FMA:67761" "A neuron that releases serotonin as a neurotransmitter." "WBbt:0006837 MESH:D059326" "A cellular motility which is lower relative to the normal or average." "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." "KEGG:C00701" @@ -1007,7 +1005,7 @@ "A positional quality inhering in a bearer by virtue the bearer's being changed in position." "A structural quality inhering in a bearer by virtue of the bearer's exhibiting excessive discharge of blood from the blood vessels." "A physical quality which is equal to the energy transferred by a force to a moving object." - "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." "FMA:54536 BTO:0002606 CALOHA:TS-0415" + "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." "FMA:54536 BTO:0002606 CALOHA:TS-0415 https://cellxgene.cziscience.com/cellguide/CL_0000125" "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." "A perimeter which is relatively low." "The joining of 2 or more lipid bilayer membranes that surround the nucleus." @@ -1157,7 +1155,7 @@ "An efficiency quality inhering in a bearer by virtue of the bearer's having efficiency." "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." "A sonic hedgehog protein that is encoded in the genome of mouse." "UniProtKB:Q62226" - "Any of the smallest blood vessels connecting arterioles with venules." "CALOHA:TS-2006 EV:0100035 EMAPA:35198 MA:0000065 BTO:0002045 FMA:63194 NCIT:C12685 MESH:D002196 AAO:0010252 XAO:0000116 EFO:0001906 Wikipedia:Capillary VHOG:0001253 NLXANAT:090902 TAO:0005250 ZFA:0005250" + "Any of the smallest blood vessels connecting arterioles with venules." "CALOHA:TS-2006 EV:0100035 EMAPA:35198 MA:0000065 BTO:0002045 NCIT:C12685 FMA:63194 MESH:D002196 AAO:0010252 XAO:0000116 EFO:0001906 Wikipedia:Capillary VHOG:0001253 NLXANAT:090902 TAO:0005250 ZFA:0005250" "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." "FMA:63182 MESH:D001160 MA:0000063 ZFA:0005255 VHOG:0001763 TAO:0002138 Wikipedia:Arteriole NCIT:C12672 EMAPA:35146 SCTID:337724002 BTO:0001997 AAO:0010253" @@ -1295,7 +1293,7 @@ "Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture." "EMAPA:35263 Wikipedia:Suture_(joint) FMA:7493 SCTID:244509003 GAID:211 MESH:D003393 MA:0001475" "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." - "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." "FMA:83040 NCIT:C33918 SCTID:256965005 BTO:0001335 EHDAA:129 EMAPA:16068 EHDAA:91 Wikipedia:Syncytiotrophoblast" + "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." "Wikipedia:Syncytiotrophoblast FMA:83040 NCIT:C33918 SCTID:256965005 BTO:0001335 EHDAA:129 EMAPA:16068 EHDAA:91" "A cell that secretes glycosaminoglycans." @@ -1353,7 +1351,6 @@ "An endo-epithelial cell of the respiratory tract." "BTO:0004533" "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." - "The biosynthetic process resulting in the formation of DNA." "Any membrane that is part of a pigment granule." "A quality that is equal to the potential energy per unit charge associated with a static (time-invariant) electric field, also called the electrostatic potential." "An action potential that occurs in an atrioventricular node cardiac muscle cell." @@ -1487,7 +1484,6 @@ "Any process that activates or increases the rate of neuroblast proliferation." - "The disaggregation of a protein-DNA complex into its constituent components." "Arteries that supply the spinal cord." "NCIT:C33587 MA:0002043 ZFA:0000682 SCTID:244228006 EHDAA2:0001890 Wikipedia:Spinal_artery EMAPA:18241 TAO:0000682 EHDAA:4355" "Portion of embryonic tissue determined by fate mapping to become a structure." "ZFA:0001116 AAO:0000479 TAO:0001116" "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." "XAO:0000090 EMAPA:16062 CALOHA:TS-0273 GAID:1305 EHDAA2:0000436 Wikipedia:Endoderm MESH:D004707 EV:0100005 MAT:0000175 VHOG:0000154 BILA:0000038 ZFA:0000017 BTO:0000800 MIAA:0000175 TAO:0000017 FMA:69071 SCTID:362855003 AAO:0000139 EFO:0002545 NCIT:C12706" @@ -1549,7 +1545,7 @@ "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." "A spatial quality inhering in a bearer by virtue of the bearer's being located at a right angle relative to another entity." - "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." "VHOG:0001768 EHDAA2_RETIRED:0004658 ZFA:0001681 TAO:0002197 HBA:4006 neuronames:2869 EHDAA2:0003136 NCIT:C32695 Wikipedia:Gray_matter AEO:0001012 MA:0001112 FMA:67242" + "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." "VHOG:0001768 EHDAA2_RETIRED:0004658 TAO:0002197 ZFA:0001681 HBA:4006 neuronames:2869 EHDAA2:0003136 NCIT:C32695 Wikipedia:Gray_matter AEO:0001012 MA:0001112 FMA:67242" "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." @@ -1657,7 +1653,7 @@ "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." "NCIT:C13040 SCTID:25087005 BIRNLEX:1157" "Any process that modulates the frequency, rate or extent of muscle adaptation." - "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." "MESH:D007107 NCIT:C12735 FMA:9825 SCTID:362590003 AAO:0011003 VHOG:0001247 Wikipedia:Immune_system MA:0002711 BILA:0000104 XAO:0003152 ZFA:0001159 GAID:328 BTO:0005810 TAO:0001159" + "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." "MESH:D007107 NCIT:C12735 FMA:9825 SCTID:362590003 AAO:0011003 VHOG:0001247 Wikipedia:Immune_system MA:0002711 BILA:0000104 ZFA:0001159 XAO:0003152 GAID:328 BTO:0005810 TAO:0001159" "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." "Wikipedia:Acidity_regulator" @@ -1751,7 +1747,6 @@ "The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals." "Wikipedia:Spinal_accessory_nucleus MA:0001033 neuronames:2003 FMA:83965" "A structural quality inhering in a bearer by virtue of the bearer's being strongly articulated with another entity." "A fatigability which is relatively normal or average" - "A macromolecular complex containing both protein and DNA molecules." "Serous membrane layer that is adjacent to and lines an organ." "FMA:15860" "A physical quality that inheres in propagating wave (light or sound) virtue of the bearer's change in direction when passing from one medium to another." "A position which is relatively normal or average" @@ -1822,7 +1817,6 @@ "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." "Wikipedia:Embryogenesis" "Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands." "MA:0002469 FMA:5894 EHDAA2:0001400 NCIT:C52557 EMAPA:32813 Wikipedia:Parasympathetic_ganglion NLXANAT:100303 BTO:0001256 SCTID:279284004" "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." - "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." "A color consisting of blue hue and high brightness." "A density quality which lacks pattern." "A quality inhering in a process by virtue of that process having a population or part of a population, where population is defined as a collection of individuals from the same taxonomic class distinguished by one or more characteristics, as participants." @@ -1928,7 +1922,7 @@ "A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location." "An anatomical boundary that corresponds to some physical discontinuity." "CARO:0001004" - "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." "SCTID:362864008 NCIT:C34236 FMA:293357 TAO:0000050 EMAPA:16540 XAO:0000228 ZFA:0000050 Wikipedia:Optic_vesicles AAO:0011039 VHOG:0000165 EHDAA2:0001320" + "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." "SCTID:362864008 NCIT:C34236 FMA:293357 TAO:0000050 EMAPA:16540 XAO:0000228 Wikipedia:Optic_vesicles ZFA:0000050 AAO:0011039 VHOG:0000165 EHDAA2:0001320" "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." "BIRNLEX:965 DHBA:10655 Wikipedia:Metencephalon MESH:D020540 EHDAA2:0001149 NCIT:C32741 GAID:594 EMAPA:17071 CALOHA:TS-2029 MA:0000197 EHDAA:5498 BTO:0000673 FMA:62003 VHOG:0000741 HBA:4833 BAMS:Met" "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." @@ -2016,7 +2010,6 @@ "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." "Wikipedia:Immune_system" "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." - "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." "KEGG:C00039" "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." "A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a polar diameter longer than its equatorial diameter." "Image:http://upload.wikimedia.org/wikipedia/commons/8/88/ProlateSpheroid.png" "A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s)." @@ -2029,7 +2022,7 @@ "A gland that is part of a epidermis." "FMA:59153" "A peramorphic growth quality which is due to a delayed offset." "The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous." "FMA:52737 EHDAA:6035 NCIT:C12797 VHOG:0000800 SCTID:181795004 Wikipedia:Temporal_bone EMAPA:17682 MA:0001476 MESH:D013701 GAID:232" - "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." "BTO:0001220 CALOHA:TS-0898 MESH:D012583" + "A glial cell that myelinates or ensheathes axons in the peripheral nervous system." "BTO:0001220 CALOHA:TS-0898 https://cellxgene.cziscience.com/cellguide/CL_0002573 MESH:D012583" "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." @@ -2106,13 +2099,13 @@ "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." "A quality inhering in a bearer by virtue of the bearer's exhibiting a phenotypic difference between males and females of the same species." "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." - "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "A sleep quality defined by the mathematic properties of the relative time frames of the sleep cycle." "A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish." "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." "PDBeChem:ACH DrugBank:DB03128 KEGG:C01996 Wikipedia:Acetylcholine LINCS:LSM-5888" + "Any cell that in taxon some Eukaryota." "MESH:D005057" "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." "A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." "nifext:2 ILX:0101312 ilxtr:BipolarPhenotype" "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." @@ -2169,7 +2162,6 @@ "Any process that modulates the frequency, rate or extent of a signaling process." "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." - "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "The inferior labial vein is the vein receiving blood from the lower lip." "SCTID:422955002 MA:0002253 FMA:52541 Wikipedia:Inferior_labial_vein" "A somite that is part of a trunk." "AAO:0010385 EMAPA:16184 XAO:0000314 EHDAA2:0003438" "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." @@ -2202,6 +2194,7 @@ "A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part." "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." + "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface." "https://cellxgene.cziscience.com/cellguide/CL_0005012" "A distance which is relatively normal or average." "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." @@ -2265,7 +2258,6 @@ "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." "NCIT:C13301 CALOHA:TS-0620 VHOG:0000170 EHDAA2:0003145 EV:0100007 ZFA:0000393 AAO:0010427 AEO:0000145 BTO:0001393 XAO:0003046 TAO:0000393 Wikipedia:Mesenchyme" "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." - "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." "A paedomorphic growth quality which is due to a delayed onset." "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." @@ -2535,7 +2527,7 @@ "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." "NIF_Subcellular:sao1145756102" "A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting an increased number of cells, typically associated with an increase in size." - "An organ that functions as a secretory or excretory organ." "EHDAA:2161 MA:0003038 WikipediaCategory:Glands Wikipedia:Gland galen:Gland SCTID:134358001 MIAA:0000021 MAT:0000021 FMA:7146 EFO:0000797 AAO:0000212 NCIT:C13319 EHDAA2:0003096 FMA:86294 AEO:0000096 BTO:0000522 EMAPA:18425 HAO:0000375" + "An organ that functions as a secretory or excretory organ." "EHDAA:2161 MA:0003038 WikipediaCategory:Glands Wikipedia:Gland galen:Gland SCTID:134358001 FMA:7146 MAT:0000021 MIAA:0000021 EFO:0000797 AAO:0000212 NCIT:C13319 EHDAA2:0003096 FMA:86294 AEO:0000096 BTO:0000522 EMAPA:18425 HAO:0000375" "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." "Muscle that is part of the respiratory system." "A bone that is part of a craniocervical region." "MA:0000569" @@ -2758,7 +2750,6 @@ "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." "Any compound that has a nucleobase as a part." - "Endothelial cells forming the walls of the capillaries within the cerebral cortex." "CALOHA:TS-2372" "An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed dorsolaterally." "The movement of substances between cells." "A quality inhering in a bearer by virtue of the bearer's being flattened along dorso-ventral axis." @@ -2891,7 +2882,7 @@ "A size quality inhering in a bearer by virtue of the bearer's being abnormally small." - "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." "ZFA:0000008 GAID:571 BIRNLEX:796 MBA:8 EHDAA:2641 BAMS:Br EHDAA:6485 XAO:0000010 galen:Brain MIAA:0000098 EMAPA:16894 FMA:50801 ABA:Brain BILA:0000135 EHDAA2:0000183 EFO:0000302 MAT:0000098 DHBA:10155 BAMS:Brain TAO:0000008 AAO:0010478 HBA:4005 EV:0100164 NCIT:C12439 MA:0000168 MESH:D001921 SCTID:258335003 Wikipedia:Brain BTO:0000142 PBA:3999 VHOG:0000157 MBA:997 CALOHA:TS-0095" + "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." "ZFA:0000008 GAID:571 BIRNLEX:796 MBA:8 EHDAA:2641 EHDAA:6485 BAMS:Br XAO:0000010 galen:Brain MIAA:0000098 EMAPA:16894 FMA:50801 ABA:Brain BILA:0000135 EHDAA2:0000183 EFO:0000302 MAT:0000098 DHBA:10155 BAMS:Brain TAO:0000008 AAO:0010478 HBA:4005 EV:0100164 NCIT:C12439 MA:0000168 MESH:D001921 SCTID:258335003 Wikipedia:Brain BTO:0000142 PBA:3999 VHOG:0000157 MBA:997 CALOHA:TS-0095" "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." "MA:0002409" "The sensory system for the sense of touch and pain." "NLXANAT:090818 neuronames:2887 Wikipedia:Somatosensory_system" "An orientation quality inhering in a bearer by virtue of the bearer having a position that is directed medially." @@ -2933,7 +2924,7 @@ "A quality inhering in a bearer by virtue of the whether the bearer's disposition to react to a stimulus or an agent." "The nonstriated, involuntary muscle tissue located in the wall of the aorta." "NCIT:C49191 BTO:0001685 EFO:0002775 MA:0000702 EMAPA:35135 CALOHA:TS-0048" "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." - "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." "BTO:0001799 VHOG:0001133 Wikipedia:Pulmonary_vein EHDAA:2629 NCIT:C12776 GAID:543 EMAPA:18645 CALOHA:TS-0840 AAO:0010521 SCTID:430160002 EHDAA2:0001579 MESH:D011667 XAO:0000394 galen:PulmonaryVein FMA:66643 MA:0002206" + "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." "BTO:0001799 VHOG:0001133 Wikipedia:Pulmonary_vein EHDAA:2629 NCIT:C12776 GAID:543 EMAPA:18645 CALOHA:TS-0840 AAO:0010521 SCTID:430160002 MESH:D011667 EHDAA2:0001579 XAO:0000394 galen:PulmonaryVein FMA:66643 MA:0002206" "The process in which the anatomical structures of a dendrite are generated and organized." "A ciliated epithelial cell of the esophagus." "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." @@ -2950,7 +2941,7 @@ "A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height." "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." "VHOG:0000107 AAO:0011017 EFO:0003647 Wikipedia:Chordamesoderm TAO:0001204 XAO:0000205 ZFA:0001204" "The cytoplasm of an ovum." - "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." "BTO:0000416 FMA:9639 CARO:0000066 MESH:D004848 Wikipedia:Epithelium ZFA:0001486 SCTID:31610004 EHDAA2:0003066 MA:0003060 CALOHA:TS-0288 VHOG:0000387 XAO:0003045 HAO:0000066 AAO:0010055 AEO:0000066 NCIT:C12710 GAID:402 AAO:0000144 TAO:0001486 BILA:0000066 EMAPA:32738" + "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." "BTO:0000416 FMA:9639 CARO:0000066 MESH:D004848 Wikipedia:Epithelium SCTID:31610004 EHDAA2:0003066 ZFA:0001486 MA:0003060 CALOHA:TS-0288 VHOG:0000387 XAO:0003045 HAO:0000066 AAO:0010055 AEO:0000066 NCIT:C12710 GAID:402 AAO:0000144 TAO:0001486 BILA:0000066 EMAPA:32738" "A quality inhering in a bearer by virtue of the bearer's exhibiting complete growth, differentiation, or development." "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." "A duct that is part of a digestive system [Automatically generated definition]." "ZFA:0005162 TAO:0005162" @@ -2979,7 +2970,6 @@ "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." "Musculature system of the pharyngeal and head regions." "MA:0000571 ZFA:0000328 TAO:0000328" "A triangular shape quality inhering in a bearer by virtue of the bearer's being nearly, but not perfectly, triangular." - "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." "A myocardium that is part of a left ventricle of a heart." "SCTID:362021000 FMA:9558 MA:0002983" "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." @@ -3098,14 +3088,14 @@ "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." - "A cell that stores and secretes pancreatic polypeptide hormone." "FMA:83409 FMA:62938" + "A cell that stores and secretes pancreatic polypeptide hormone." "FMA:83409 FMA:62938 https://cellxgene.cziscience.com/cellguide/CL_0000696" "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." "A spatial pattern inhering in a bearer by virtue of the bearer's being located near a surface." "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." "A zone of skin that is part of a neck [Automatically generated definition]." "FMA:23022 FMA:23021 SCTID:361705004 MA:0000590 NCIT:C52756" "A hole in the diaphragm through which the esophagus passes." "FMA:58289" "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." - "Lung which consists of the left upper lobe and left lower lobe.[FMA]." "EHDAA:4947 Wikipedia:Left_lung NCIT:C32967 SCTID:361982005 VHOG:0000618 FMA:7310 EHDAA2:0000943 EMAPA:17653 MA:0000425" + "Lung which consists of the left upper lobe and left lower lobe.[FMA]." "Wikipedia:Left_lung NCIT:C32967 SCTID:361982005 VHOG:0000618 FMA:7310 EHDAA2:0000943 EMAPA:17653 MA:0000425 EHDAA:4947" @@ -3187,7 +3177,7 @@ "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." "EMAPA:35887 GAID:554 EHDAA2:0004143 NCIT:C34317 MA:0000103 SCTID:308828009 FMA:70301 Wikipedia:Truncus_arteriosus_(embryology) MESH:D014338" "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." "FMA:5889 AEO:0001001 EMAPA:18221 CALOHA:TS-2340 MESH:D005725 NCIT:C12720 MA:0000220 Wikipedia:Autonomic_ganglion" "An acinus that is part of a exocrine gland." - "One of the two elevated edges of the neural groove[GO,MP]." "neuronames:1364 EHDAA2:0001249 FMA:295618 XAO:0004087 NCIT:C34223 SCTID:361461009 Wikipedia:Neural_fold" + "One of the two elevated edges of the neural groove[GO,MP]." "EHDAA2:0001249 FMA:295618 XAO:0004087 NCIT:C34223 SCTID:361461009 Wikipedia:Neural_fold neuronames:1364" "Mesenchyme that is part of a extraembryonic membrane." "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." "A sleep pattern quality inhering in a bearer by virtue of the bearer's inability to sleep." @@ -3249,9 +3239,9 @@ "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." "The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project." "NCIT:C33738 SCTID:368724008 FMA:63589" - "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." "An action potential that occurs in a cardiac muscle cell." "PMID:30257078 PMID:23020233 GC_ID:1" + "Any cell that in taxon some Fungi." "Any oligodendrocyte that is part of a spinal cord." "A neural crest that has_potential_to_developmentally_contribute_to a diencephalon." "ZFA:0000811 TAO:0000811 EFO:0003573 VHOG:0000798 EMAPA:16518 EHDAA2:0000603" "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." @@ -3305,7 +3295,7 @@ "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." "A growth quality of occurrent in which the growth of an organism, structure or group of organisms does not occur." - "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." "VHOG:0000191 Wikipedia:Somite EHDAA2:0003436 TAO:0000155 MIAA:0000068 FMA:85522 GAID:1306 EHDAA:366 ZFA:0000155 EMAPA:31169 EHDAA:699 AAO:0010569 AEO:0001015 BTO:0001558 MAT:0000068 NCIT:C34302 MESH:D019170 XAO:0000058" + "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." "VHOG:0000191 EHDAA2:0003436 Wikipedia:Somite TAO:0000155 MIAA:0000068 FMA:85522 GAID:1306 EHDAA:366 ZFA:0000155 EMAPA:31169 EHDAA:699 AAO:0010569 AEO:0001015 BTO:0001558 MAT:0000068 NCIT:C34302 MESH:D019170 XAO:0000058" "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." "An anatomical surface that is part of a tongue." "FMA:54647 SCTID:314870004" @@ -3421,7 +3411,7 @@ "A cylindrical shape that is hollow." "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "A quality of a single process inhering in a bearer by virtue of the bearer's once or in or a few unpredictable instances." - "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." "galen:Back GAID:30 NCIT:C13062 MESH:D001415 EFO:0001405 CALOHA:TS-2223 Wikipedia:Dorsum_(anatomy) SCTID:123961009 FMA:14181 BTO:0001713" + "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." "GAID:30 galen:Back NCIT:C13062 MESH:D001415 EFO:0001405 CALOHA:TS-2223 Wikipedia:Dorsum_(anatomy) SCTID:123961009 FMA:14181 BTO:0001713" "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." "MA:0001578" "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." "Wikipedia:Sexual_reproduction" "A portion of connective tissue that is part of a back [Automatically generated definition]." "MA:0000495" @@ -3468,7 +3458,7 @@ "Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX)." "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." - "A life cycle stage that starts with fertilization and ends with the fully formed embryo." "HsapDv:0000002 WBls:0000092 OGES:000022 OGES:000000 WBls:0000102 WBls:0000003 SCTID:296280003 FBdv:00005289 XAO:1000012 EV:0300001 FMA:72652 BilaDO:0000002 MmusDv:0000002" + "A life cycle stage that starts with fertilization and ends with the fully formed embryo." "HsapDv:0000002 WBls:0000092 OGES:000022 OGES:000000 WBls:0000102 WBls:0000003 SCTID:296280003 FBdv:00005289 XAO:1000012 MmusDv:0000002 EV:0300001 FMA:72652 BilaDO:0000002" "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." @@ -3502,7 +3492,6 @@ "A distribution which is relatively high." "The directed movement of sulfate across a membrane." "The orderly movement of a vascular associated smooth muscle cell from one site to another." - "A glioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." "A blood that is part of a artery." "FMA:83066" "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." "Any process that activates or increases the frequency, rate or extent of response to acetate." @@ -3709,7 +3698,7 @@ "Any process that activates or increases the frequency, rate or extent of gonad development." "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." - "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." "Wikipedia:Choroid VHOG:0001568 GAID:913 MA:0000263 ZFA:0005229 EMAPA:19077 BTO:0001829 SCTID:181172003 EV:0100347 NCIT:C12344 TAO:0005229 MESH:D002829 CALOHA:TS-2054 FMA:58298" + "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." "Wikipedia:Choroid VHOG:0001568 GAID:913 MA:0000263 ZFA:0005229 EMAPA:19077 BTO:0001829 SCTID:181172003 EV:0100347 NCIT:C12344 TAO:0005229 CALOHA:TS-2054 FMA:58298 MESH:D002829" "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." "FMA:82482 galen:Wall" "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." "Any regulation of signal transduction that takes place in the extracellular region." @@ -3774,7 +3763,7 @@ "MIAA:0000204 MAT:0000204" "A physical quality inhering in a bearer by virtue of the bearer's disposition to deform by heating." - "Serous membrane which is divided into parietal and visceral serous pericardium." "EMAPA:19030 SCTID:243954002 MA:0002739 FMA:9582 Wikipedia:Serous_pericardium" + "Serous membrane which is divided into parietal and visceral serous pericardium." "Wikipedia:Serous_pericardium EMAPA:19030 SCTID:243954002 MA:0002739 FMA:9582" "Any process that modulates the frequency, rate or extent of exosomal secretion." "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." "VHOG:0000767 EMAPA:16054 EHDAA2:0000472" @@ -3803,7 +3792,6 @@ "One of the veins draining a meninix." "SCTID:84842006 FMA:50839" "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." - "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." "FMA:66773" "A texture that is uniformly covered in short, oblong, or trench-like depressions." "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." @@ -3828,7 +3816,6 @@ "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." "A ventral horn of spinal cord that is part of a cervical spinal cord." "BIRNLEX:1680 SCTID:174363005" "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." - "Any cell that only exists in Eumycetozoa." "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." @@ -3979,7 +3966,7 @@ "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." "FMA:58102 SCTID:361318005 Wikipedia:Fibrous_tunic_of_eyeball" "A reproductive quality inhering in an organism or population by virtue of the bearer's potential reproductive capacity ad measured by the number of gametes." - "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." "galen:Muscle VHOG:0001245 SCTID:71616004 ZFA:0005145 GAID:131 MA:0000015 EV:0100146 XAO:0000172 FMA:5022 TAO:0005145" + "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." "galen:Muscle VHOG:0001245 SCTID:71616004 ZFA:0005145 MA:0000015 GAID:131 EV:0100146 XAO:0000172 FMA:5022 TAO:0005145" "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." "CALOHA:TS-2057 MA:0002411 NCIT:C12957 Wikipedia:Exocrine_gland FMA:85539 WikipediaCategory:Exocrine_system EHDAA2:0002225 EMAPA:35329" "A sensitivity toward an external stimulus which is relatively normal or average" "A neural nucleus that is part of the spinal cord." "FMA:77011" @@ -4018,7 +4005,7 @@ "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." "BTO:0001164 CALOHA:TS-0610 MESH:D055016 FMA:84235" "A mesothelium that is part of a diaphragm [Automatically generated definition]." "EMAPA:18429" "A lamina propria that is part of a respiratory system [Automatically generated definition]." "MA:0001821" - "An endothelial cell that is part of the vein." "KUPO:0001099 FMA:62104" + "An endothelial cell that is part of the vein." "https://cellxgene.cziscience.com/cellguide/CL_0002543 KUPO:0001099 FMA:62104" "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." @@ -4329,7 +4316,7 @@ "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." "MIAA:0000061 BTO:0003360 CALOHA:TS-2119 EFO:0001406 MAT:0000061" - "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." "UM-BBD_enzymeID:e0711" + "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." "A monadic quality of continuant inhering in a bearer by virtue of the bearer's being intricate and compounded." "A variability quality inhering in the bearer by virtue of the bearer having a variable number or count of an entity." "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." @@ -4362,7 +4349,7 @@ "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." "A fluorescence which is relatively normal or average." "A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement." - "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." "SCTID:361412007 EHDAA2:0000189 FMA:313607 Wikipedia:Buccopharyngeal_membrane EHDAA:536 EMAPA:16259 VHOG:0000380" + "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." "SCTID:361412007 EHDAA2:0000189 FMA:313607 Wikipedia:Buccopharyngeal_membrane EHDAA:536 VHOG:0000380 EMAPA:16259" "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." "Any signal release from a synapse." @@ -4386,10 +4373,10 @@ "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." "EFO:0002597 BTO:0000394 MA:0000701 NCIT:C49190 CALOHA:TS-0047 EMAPA:35134" "An optical quality inhering in a bearer by virtue of the bearer's having focus." "The directed movement of substances into, out of or within a vacuole." - "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." "EHDAA:936 BIRNLEX:1169 SCTID:181143004 BTO:0004688 EMAPA:16198 VHOG:0000275 XAO:0000179 ZFA:0000107 MA:0000261 AAO:0010340 TAO:0000107 NCIT:C12401 EHDAA2:0000484 FMA:54448" + "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." "EHDAA:936 BIRNLEX:1169 SCTID:181143004 BTO:0004688 EMAPA:16198 VHOG:0000275 ZFA:0000107 XAO:0000179 MA:0000261 AAO:0010340 TAO:0000107 NCIT:C12401 EHDAA2:0000484 FMA:54448" "Smooth muscle found within, and composing the majority of the wall of blood vessels." "ZFA:0005321 Wikipedia:Vascular_smooth_muscle BTO:0001431 MA:0000710 TAO:0005321 EMAPA:35177 CALOHA:TS-1107 NCIT:C33853 MESH:D009131" "A rate which is relatively high." - "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." + "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." "https://cellxgene.cziscience.com/cellguide/CL_0011012" "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." @@ -4518,7 +4505,7 @@ "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." - "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." "VHOG:0000167 EMAPA:16674 BTO:0005351 EHDAA:2912 TAO:0001202 EHDAA2:0001303 SCTID:308789007 ZFA:0001202 NCIT:C34233" + "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." "VHOG:0000167 EMAPA:16674 EHDAA:2912 BTO:0005351 TAO:0001202 EHDAA2:0001303 SCTID:308789007 ZFA:0001202 NCIT:C34233" "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." @@ -4672,7 +4659,7 @@ "A role played by the molecular entity or part thereof within a chemical context." "Any process that modulates the frequency, rate or extent of cardiac muscle growth." "A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity." - "An enteroendocrine cell that produces glucagon." "FMA:62939" + "An enteroendocrine cell that produces glucagon." "FMA:62939 https://cellxgene.cziscience.com/cellguide/CL_0002067" "A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus." "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." "Wikipedia:Interventricular_septum FMA:7133 galen:InterventricularSeptum VHOG:0000386 NCIT:C32874 EHDAA:2603 SCTID:362019005 EMAPA:17333 EFO:0001956 MA:0000085 BTO:0002483" @@ -4722,7 +4709,7 @@ "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." "Anatomical structure that performs a specific function or group of functions [WP]." "WBbt:0003760 SCTID:272625005 MA:0003001 CARO:0020004 EFO:0000634 ENVO:01000162 EMAPA:35949 BIRNLEX:4 NCIT:C13018 Wikipedia:Organ_(anatomy) FMA:67498" - "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." "TAO:0001574 neuronames:2054 MA:0000219 VHOG:0000396 AAO:0000033 CALOHA:TS-2001 BIRNLEX:1123 SCTID:362481007 MESH:D001341 EHDAA2:0000158 BTO:0002507 EHDAA:3767 EHDA:10095 ZFA:0001574 Wikipedia:Autonomic_nervous_system FMA:65553 EMAPA:16984 NCIT:C12673 GAID:706" + "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." "TAO:0001574 neuronames:2054 MA:0000219 VHOG:0000396 AAO:0000033 SCTID:362481007 CALOHA:TS-2001 BIRNLEX:1123 MESH:D001341 EHDAA2:0000158 BTO:0002507 EHDAA:3767 EHDA:10095 ZFA:0001574 Wikipedia:Autonomic_nervous_system FMA:65553 EMAPA:16984 NCIT:C12673 GAID:706" "A cell morphology that inheres in neurons which possess three or more neurites, usually a single axon and many dendrites and dendritic branches." "NLX:378 ILX:0107196" "Any process that activates or increases the frequency, rate or extent of bone development." "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." @@ -4753,9 +4740,8 @@ "A cell that is specialised to accumulate a particular substance(s)." "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." "A size quality which is relatively normal or average" - "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." - "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." "VSAO:0000214 FMA:7182" + "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." "FMA:7182 VSAO:0000214" "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." "MIAA:0000369 EFO:0001650 AAO:0010466 MAT:0000369 XAO:0000305" "Any animal metabolite produced during a metabolic reaction in mammals." @@ -4849,6 +4835,7 @@ "A necessity quality (continuant) inhering in a bearer by virtue of the bearer's being essential or indispensable." "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." + "Mesenchyme that has the potential to develop into a dermis." "EHDAA2:0000598" "The space within an epithelial sphere." "AEO:0000079" @@ -4940,7 +4927,7 @@ "A structural quality inhering in a bearer by virtue of the bearer's lack elastic tension that facilitate response to stimuli." "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." - "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." "OGES:000004 FBdv:00005317 BilaDO:0000008 XAO:1000005 EFO:0001296 HsapDv:0000010 WBls:0000010 BILS:0000109 OGES:000019 MmusDv:0000013 ZFS:0000047" + "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." "OGES:000004 FBdv:00005317 BilaDO:0000008 XAO:1000005 EFO:0001296 HsapDv:0000010 BILS:0000109 WBls:0000010 OGES:000019 MmusDv:0000013 ZFS:0000047" "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." "A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface." "A variability of size which is relatively low." @@ -4956,7 +4943,6 @@ "A molecular entity that minimally consists of a protein." "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." - "The chemical reactions and pathways involving organonitrogen compound." "A variability quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation of color." "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." @@ -5112,7 +5098,7 @@ "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." "FMA:86166 SCTID:20795001 MAT:0000284 MA:0000151 Wikipedia:Skin EV:0100152 MESH:D012867 EHDAA:6530 GAID:933 VHOG:0000860 MIAA:0000284" "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." - "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." "Wikipedia:Thoracid_diaphragm MAT:0000502 EMAPA:17701 EV:0100376 BTO:0000341 EHDAA2:0003495 VHOG:0000713 FMA:13295 MA:0001904 SCTID:181614006 CALOHA:TS-0198 EFO:0000937 GAID:158 MESH:D003964 NCIT:C12702" + "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." "Wikipedia:Thoracid_diaphragm MAT:0000502 EMAPA:17701 EV:0100376 BTO:0000341 EHDAA2:0003495 VHOG:0000713 FMA:13295 MA:0001904 SCTID:181614006 CALOHA:TS-0198 MESH:D003964 EFO:0000937 GAID:158 NCIT:C12702" "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." "KEGG:C01450 Wikipedia:Ketone" @@ -5150,7 +5136,6 @@ "A concentration quality inhering in compound by virtue of the bearer's tendency to act as a hydron donor." "Any process that modulates the frequency, rate or extent of stem cell differentiation." "The process in which the anatomical structures of muscle are generated and organized." - "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "A surface feature shape quality inhering in a bearer by virtue of the bearer's having deeply undulating edges forming lobes." "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." @@ -5273,6 +5258,7 @@ "A nerve that is part of an abdomen [Automatically generated definition]." "MA:0000521" "A leukocyte that lacks granules." "FMA:62855" + "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage." "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." "A permeability which is relatively low." "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." "FMA:13087 NCIT:C34027 SCTID:119203005" @@ -5303,7 +5289,7 @@ "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." "A shape quality inhering in a bearer by virtue of the bearer being divided into four parts." - "Subdivision of skeleton which includes upper and lower jaw skeletons." "GAID:214 TAO:0001227 galen:Jaw EMAPA:35455 MA:0001905 BTO:0001749 SCTID:181811001 Wikipedia:Jaw MESH:D007568 FMA:54396 ZFA:0001227 NCIT:C48821 AAO:0000988" + "Subdivision of skeleton which includes upper and lower jaw skeletons." "GAID:214 TAO:0001227 galen:Jaw EMAPA:35455 MA:0001905 SCTID:181811001 BTO:0001749 Wikipedia:Jaw MESH:D007568 FMA:54396 ZFA:0001227 AAO:0000988 NCIT:C48821" "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." "MA:0000529" "An endothelium that is part of the cardiovascular system." "NCIT:C13053 MA:0000717 XAO:0000356 VHOG:0001217 MESH:D004730 ZFA:0001639 TAO:0002171 EMAPA:35201 BTO:0001853 GAID:519" @@ -5329,7 +5315,7 @@ "Luminal space of the right ventricle of the heart." "FMA:9291 EMAPA:26047" "The controlled release of acid by a cell or a tissue." "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." - "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." "galen:ConnectiveTissue GAID:100 EFO:0000952 TAO:0001641 XAO:0001017 MIAA:0000301 BTO:0000421 AAO:0000098 NCIT:C12374 CALOHA:TS-2009 MAT:0000301 VSAO:0000017 ZFA:0001632 FMA:9640 SCTID:361919005 MA:0000011 MESH:D003238 EMAPA:35251" + "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." "galen:ConnectiveTissue GAID:100 EFO:0000952 TAO:0001641 XAO:0001017 MIAA:0000301 BTO:0000421 AAO:0000098 NCIT:C12374 CALOHA:TS-2009 MAT:0000301 VSAO:0000017 ZFA:0001632 SCTID:361919005 FMA:9640 MA:0000011 MESH:D003238 EMAPA:35251" "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." "A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change." "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." "BTO:0000725 CALOHA:TS-0448" @@ -5463,7 +5449,7 @@ "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." "The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodeling in response to postsynaptic signaling." - "A mesothelial cell that is part of the pleura." "FMA:86737" + "A mesothelial cell that is part of the pleura." "https://cellxgene.cziscience.com/cellguide/CL_1000491 FMA:86737" "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." "The process in which a female gonad is generated and organized." "A quality inhering in a bearer by virtue of the bearer's lacking or not exhibiting variation of shape." @@ -5510,7 +5496,7 @@ "An attachment quality inhering in a flower by virtue of the bearer's lacking a stalk, as in flowers or leaves that grow directly from the stem." "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." "An 1-D extent quality which is equal to the length of the closed curve of a circle." - "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." "ZFA:0001498 TAO:0001498 AAO:0010066 HAO:0000070 EHDAA2:0003070 AEO:0000070 Wikipedia:Simple_squamous_epithelium BTO:0002073 CARO:0000070 BILA:0000070 FMA:45565 NCIT:C13178 XAO:0004010" + "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." "ZFA:0001498 TAO:0001498 AAO:0010066 HAO:0000070 EHDAA2:0003070 AEO:0000070 Wikipedia:Simple_squamous_epithelium CARO:0000070 BTO:0002073 BILA:0000070 FMA:45565 NCIT:C13178 XAO:0004010" "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." "A quality that describes the power of an atom to attract electrons to itself ." "A quality inhering in a bearer by virtue of the bearer's disposition to being capable of indefinite growth or division." @@ -5626,7 +5612,6 @@ "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." "EMAPA:36438 EHDAA2:0004162" "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." - "The chemical reactions and pathways resulting in the formation of organonitrogen compound." "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." "Any apoptotic process in an epithelial cell." "A blood vessel that is part of a brain [Automatically generated definition]." "EMAPA:35182 MA:0002769" @@ -5717,7 +5702,6 @@ "Any process that modulates the frequency, rate or extent of neuroinflammatory response." "A region of the stomach that is lined with glandular epithelium." "EMAPA:17623 NCIT:C77661 MA:0001613 SCTID:27633001" "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." "EFO:0000966 ZFA:0001115 MA:0000004 galen:Trunk BTO:0001493 BILA:0000116 NCIT:C33816 CALOHA:TS-1071 XAO:0000054 SCTID:262225004 AAO:0010339 MIAA:0000296 Wikipedia:Torso XAO:0003025 EMAPA:31857 FMA:7181 TAO:0001115 MAT:0000296" - "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." @@ -5841,6 +5825,7 @@ "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." "FMA:62983 Wikipedia:Myelin NIF_Subcellular:sao593830697" "A variability which is relatively high." + "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface." "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." @@ -5926,7 +5911,8 @@ "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." "EMAPA:36460 SCTID:304066000 Wikipedia:Great_vessels" "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." - "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." "galen:Artery Wikipedia:Artery MAT:0000034 EV:0100026 TAO:0000005 MA:0000064 ZFA:0000005 XAO:0000114 GAID:468 BTO:0000573 NCIT:C12372 EHDAA2:0003253 EMAPA:35147 FMA:50720 EFO:0000814 AAO:0010211 AEO:0000208 CALOHA:TS-0054 MIAA:0000034 SCTID:362877004 MESH:D001158 VHOG:0001251" + "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." "galen:Artery Wikipedia:Artery MAT:0000034 EV:0100026 TAO:0000005 MA:0000064 ZFA:0000005 XAO:0000114 NCIT:C12372 GAID:468 BTO:0000573 EHDAA2:0003253 EMAPA:35147 FMA:50720 EFO:0000814 AAO:0010211 AEO:0000208 CALOHA:TS-0054 MIAA:0000034 SCTID:362877004 MESH:D001158 VHOG:0001251" + "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex." "CALOHA:TS-2372" "EHDAA2:0001267 EMAPA:17585" "A quality inhering in a bearer by virtue of the bearer's having a knob or knoblike protuberance." "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." @@ -6136,7 +6122,7 @@ "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." "A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities." - "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." "MIAA:0000035 EMAPA:18601 EFO:0000265 SCTID:181298001 AAO:0010213 CALOHA:TS-0046 EV:0100027 XAO:0003010 FMA:3734 MESH:D001011 galen:Aorta VHOG:0001523 Wikipedia:Aorta MAT:0000035 NCIT:C12669 GAID:469 BTO:0000135 MA:0000062" + "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." "MIAA:0000035 EMAPA:18601 EFO:0000265 SCTID:181298001 AAO:0010213 CALOHA:TS-0046 EV:0100027 XAO:0003010 MESH:D001011 FMA:3734 galen:Aorta VHOG:0001523 Wikipedia:Aorta MAT:0000035 NCIT:C12669 GAID:469 BTO:0000135 MA:0000062" "A physical quality inhering in a catalyst by virtue of the amount of the catalyst's action." "An endoderm that is part of a buccopharyngeal membrane." "EHDAA2:0000191 EMAPA:16261" @@ -6164,7 +6150,7 @@ "Any process that modulates the frequency, rate or extent of lipid localization." "An embryo at the neurula stage." "NCIT:C34229 BILA:0000061 BTO:0001766" - "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]." "MBA:403 FMA:61817 SCTID:278251007 MA:0000133 VHOG:0001639 CALOHA:TS-2007 BIRNLEX:1042 EFO:0002521 DMBA:15739 Wikipedia:Cerebral_hemisphere AAO:0010480 BAMS:HEM NCIT:C12351 galen:CerebralHemisphere EMAPA:16653 BTO:0000231" + "One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA]." "FMA:61817 SCTID:278251007 MA:0000133 VHOG:0001639 CALOHA:TS-2007 BIRNLEX:1042 EFO:0002521 DMBA:15739 Wikipedia:Cerebral_hemisphere AAO:0010480 BAMS:HEM NCIT:C12351 galen:CerebralHemisphere EMAPA:16653 BTO:0000231 MBA:403" "A fibroblast of the aortic adventitia." "Salts and esters of sulfuric acid" @@ -6187,7 +6173,7 @@ "A positional quality inhering in a bearer by virtue of the bearer's having mistakenly taken course, way, or passage; ill-routed." "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." "A fibroblast that is part of lung." "CALOHA:TS-0575 BTO:0000764" - "A mesothelial cell that is part of the visceral pleura." "FMA:86739" + "A mesothelial cell that is part of the visceral pleura." "https://cellxgene.cziscience.com/cellguide/CL_1000493 FMA:86739" "A myocardium that is part of a outflow tract [Automatically generated definition]." "EHDAA2:0001358 VHOG:0000603 MA:0000489 EMAPA:35623" "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." "The soft tissue that fills the cavities of bones." "EFO:0000868 Wikipedia:Bone_marrow MA:0000134 GAID:1287 MAT:0000084 AAO:0011007 galen:BoneMarrow VHOG:0001218 NCIT:C12431 EMAPA:32760 EV:0100046 FMA:9608 BTO:0000829 SCTID:421320006 XAO:0000123 MIAA:0000084 CALOHA:TS-0087 MESH:D001853 BTO:0000141" @@ -6299,7 +6285,7 @@ "A structure quality inhering in a bearer by virtue of the bearer's body containing one cyst - a formation of a sac-like closed membranous structure not associated with neoplasia." "An ester of an alcohol and sulfuric acid." "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." "SCTID:278196006 EV:0100162 FMA:7157 BIRNLEX:844 WBbt:0005735 neuronames:3236 GAID:466 VHOG:0000402 MA:0000016 AAO:0000324 EFO:0000802 MAT:0000026 EMAPA:16469 XAO:0000177 EHDAA2:0001246 EHDAA:826 ZFA:0000396 BTO:0001484 CALOHA:TS-1313 MIAA:0000026 TAO:0000396 Wikipedia:Nervous_system MESH:D009420 NCIT:C12755 BILA:0000079" - "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." "SCTID:181367001 AAO:0010212 TAO:0000082 MA:0000067 MAT:0000037 ZFA:0000082 FMA:50723 XAO:0000115 VHOG:0001743 CALOHA:TS-1108 EHDAA2:0003254 MESH:D014680 EV:0100031 EFO:0000816 MIAA:0000037 AEO:0000209 EMAPA:35906 Wikipedia:Vein BTO:0000234 NCIT:C12814 GAID:492 galen:Vein" + "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." "AAO:0010212 TAO:0000082 MA:0000067 MAT:0000037 ZFA:0000082 FMA:50723 XAO:0000115 VHOG:0001743 CALOHA:TS-1108 EHDAA2:0003254 MESH:D014680 EV:0100031 EFO:0000816 MIAA:0000037 AEO:0000209 EMAPA:35906 Wikipedia:Vein BTO:0000234 NCIT:C12814 GAID:492 galen:Vein SCTID:181367001" "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." "A positional which is relatively low." "A dendrite quality inhering in a neuron by virtue of the bearer's dendrite having a terminal tuft." "SAO:754373097 ILX:0112065" @@ -6428,7 +6414,6 @@ "A structure quality inhering in a bearer by virtue of the bearer's disposition to admit the passage of gas or liquid through pores or interstices." "A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity." "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." "Wikipedia:Physical_property" - "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." "A skeletal joint that is part of a appendage girdle region." "MA:0001505" "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." @@ -6538,7 +6523,7 @@ "The abdominal segment of the torso." "Wikipedia:Lumbar FMA:259211 EMAPA:35104 MA:0000021 SCTID:362875007" "On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP]." "Wikipedia:Carotid_canal FMA:55805 EMAPA:18707" "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." - "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." "MESH:D019858 FMA:62930 BTO:0003865" + "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." "https://cellxgene.cziscience.com/cellguide/CL_0000164 MESH:D019858 FMA:62930 BTO:0003865" "EMAPA:32754 EHDAA2:0004621 FMA:293087" "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." "A mucosa that is part of a lower lip [Automatically generated definition]." "NCIT:C12225 SCTID:362089001 FMA:59833" @@ -6555,7 +6540,6 @@ "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." "OBO_REL:lacks_part" "A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions." "A quality of being covered with short, dense, matted hairs." - "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." "A polar solvent that is capable of acting as a hydron (proton) donor." "Mesenchyme surrounding the developing optic cup which develops into the sclera." @@ -6660,7 +6644,7 @@ "Any process that modulates the frequency, rate or extent of steroid hormone secretion." "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." - "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." + "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." "https://cellxgene.cziscience.com/cellguide/CL_0000666" "A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build." "A process in which a protein is transported to, or maintained in, the cell cortex." "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." @@ -6766,7 +6750,6 @@ "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." - "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." "An multicellular anatomical structure that has subparts of multiple organs as a part." "CARO:0020001" "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." "An action potential which is relatively high." @@ -6811,6 +6794,7 @@ "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." "A myocardial endocrine cell that is part of the atrium." "FMA:83389" + "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." "The disaggregation of an organelle into its constituent components." "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." @@ -7239,7 +7223,7 @@ "MA:0003220 EMAPA:32904" "An avidity which is relatively normal or average." "Any process that activates or increases the frequency, rate or extent of presynapse assembly." - "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." "EHDAA:408 MESH:D002343 VHOG:0000267 EFO:0001952 BTO:0004697 TAO:0005081 Wikipedia:Internal_carotid_artery AAO:0011054 NCIT:C32836 EHDAA2:0000873 FMA:3947 GAID:481 AAO:0010219 MA:0001930 SCTID:362045001 EMAPA:16328 ZFA:0005081 XAO:0000366 EHDAA:6389" + "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." "EHDAA:408 MESH:D002343 VHOG:0000267 EFO:0001952 BTO:0004697 TAO:0005081 Wikipedia:Internal_carotid_artery AAO:0011054 NCIT:C32836 EHDAA2:0000873 FMA:3947 GAID:481 AAO:0010219 ZFA:0005081 SCTID:362045001 MA:0001930 EMAPA:16328 XAO:0000366 EHDAA:6389" "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." "SCTID:272631008 MA:0000522" "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." @@ -7273,6 +7257,7 @@ "The expansion of a leukocyte population by cell division." "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." "Wikipedia:Hydrolase" + "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development." "Bone that forms as a replacement of another structural tissue." "ZFA:0001628 TAO:0001637 AAO:0010768" @@ -7442,7 +7427,7 @@ "A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage." "MA:0003037 AAO:0000225 http://palaeos.com/vertebrates/bones/gill_arches/images/ReptileHyoids.gif SCTID:410035009 AAO:0000682" "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." "Wikipedia:Basement_membrane" "Any process that modulates the frequency, rate or extent of oogenesis." - "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." "MIAA:0000141 TAO:0000035 ZFA:0000035 NCIT:C12743 VHOG:0000169 MA:0000275 EHDAA:9057 BTO:0000723 EV:0100343 MAT:0000141 EMAPA:17838 FMA:58241 RETIRED_EHDAA2:0000975 XAO:0000008 Wikipedia:Lens_(anatomy) MESH:D007908 CALOHA:TS-0545 SCTID:181169005 AAO:0010348" + "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." "MIAA:0000141 TAO:0000035 NCIT:C12743 ZFA:0000035 VHOG:0000169 EHDAA:9057 MA:0000275 BTO:0000723 EV:0100343 MAT:0000141 EMAPA:17838 FMA:58241 RETIRED_EHDAA2:0000975 XAO:0000008 Wikipedia:Lens_(anatomy) MESH:D007908 CALOHA:TS-0545 SCTID:181169005 AAO:0010348" "The groups of nerve cell bodies associated with the twelve cranial nerves." "MAT:0000200 TAO:0000013 EFO:0000902 VHOG:0000076 MA:0000213 MIAA:0000200 EMAPA:16659 SCTID:244448001 BIRNLEX:2597 BTO:0000106 ZFA:0000013 MA:0000214 Wikipedia:Cranial_nerve_ganglion XAO:0000027 FMA:54502" "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." "MA:0000688 EMAPA:35494" @@ -7483,7 +7468,7 @@ "A process in which a protein is transported to, or maintained in, a location within a presynapse." "Any process that modulates the frequency, rate or extent of mitosis." "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." - "A tunica adventitia that is part of a artery." "EV:0100030 EMAPA:36295 FMA:14274 SCTID:113261001" + "A tunica adventitia that is part of a artery." "EV:0100030 FMA:14274 EMAPA:36295 SCTID:113261001" "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." "MA:0002904 FMA:74419 BTO:0005553 SCTID:362031007 EMAPA:35137" @@ -7544,7 +7529,6 @@ "Any process that modulates the frequency, rate or extent of angiogenesis." "A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size." "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum." "FMA:83930 ZFA:0000597 TAO:0000597 BIRNLEX:1075 HBA:9230 HBA:9219" - "A cell specialized to detect and transduce light." "CALOHA:TS-0868 FMA:86740 BTO:0001060" "Dermis-derived entity that is made of skeletal tissue." "A fluid flow which is relatively normal or average." @@ -7606,7 +7590,6 @@ "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." - "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." "An alkaloid containing an indole skeleton." "KEGG:C06073 Wikipedia:Indole_alkaloid" "An early neural cell developing from the early ependymal cell of the neural tube." "FMA:70564" "A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions." @@ -7710,7 +7693,6 @@ "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." - "An endothelial progenitor cell that participates in angiogenesis during development." "A malformed quality inhering in a bearer by virtue of the bearer's all-encompassing, grotesque morphological defects." "Any process that activates or increases the frequency, rate or extent of exocytosis." @@ -7929,7 +7911,7 @@ "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." "Any process that activates or increases the rate or extent of cell proliferation." "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." - "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." "MESH:D014602 SCTID:280648000 NCIT:C12811 EMAPA:35901 FMA:58103 CALOHA:TS-2228 Wikipedia:Uvea MA:0002480 GAID:912" + "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." "MESH:D014602 SCTID:280648000 EMAPA:35901 NCIT:C12811 FMA:58103 CALOHA:TS-2228 Wikipedia:Uvea MA:0002480 GAID:912" "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." "Having the consistency of water." @@ -8155,7 +8137,6 @@ "An epithelial sheet bent on a linear axis." "An epithelium that is part of a lens vesicle." "VHOG:0000532 EMAPA:17165 EHDAA2:0000987" "A shape quality inhering in a bearer by virtue of it being a quadrilateral polygon in which all four angles are right angles." "Image:http://upload.wikimedia.org/wikipedia/en/e/ee/Shaperec.svg" - "Any cell that only exists in Eukaryota." "MESH:D005057" "A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width." "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." "NIF_Subcellular:sao414196390" "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." "BTO:0004576 FMA:14072 CALOHA:TS-2159" @@ -8209,7 +8190,7 @@ "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." - "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." "CARO:0000032 galen:BodyPart Wikipedia:Body_part HAO:0000032 MIAA:0000293 XAO:0003013 BIRNLEX:7 EHDAA2:0003032 FMA:7153 NCIT:C32221 ZFA:0001308 VHOG:0001758 EFO:0000808 AAO:0010053 MA:0002433 BILA:0000032 CALOHA:TS-2084 TAO:0001308 EMAPA:36031 AEO:0000032 TGMA:0001840 MESH:D001829 MAT:0000293" + "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." "CARO:0000032 galen:BodyPart Wikipedia:Body_part MIAA:0000293 HAO:0000032 XAO:0003013 BIRNLEX:7 EHDAA2:0003032 FMA:7153 NCIT:C32221 ZFA:0001308 VHOG:0001758 EFO:0000808 AAO:0010053 MA:0002433 BILA:0000032 CALOHA:TS-2084 TAO:0001308 EMAPA:36031 AEO:0000032 TGMA:0001840 MESH:D001829 MAT:0000293" "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." "A flexibility which is relatively low." "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." @@ -8219,7 +8200,7 @@ "A permeability which is relatively normal or average." "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." "Wikipedia:Intraflagellar_transport" - "Membrane organ that surrounds the brain and the spinal cord." "NLXANAT:090204 MA:0001113 BTO:0000144 ZFA:0001355 NCIT:C12348 MAT:0000113 Wikipedia:Meninx TAO:0001355 EMAPA:32660 EFO:0000867 GAID:687 FMA:9589 CALOHA:TS-1177 VHOG:0001295 MESH:D008578" + "Membrane organ that surrounds the brain and the spinal cord." "NLXANAT:090204 MA:0001113 BTO:0000144 ZFA:0001355 NCIT:C12348 MAT:0000113 Wikipedia:Meninx TAO:0001355 EMAPA:32660 EFO:0000867 GAID:687 FMA:9589 VHOG:0001295 CALOHA:TS-1177 MESH:D008578" "Hadron is a subatomic particle which experiences the strong force." "An angular shape quality inhering in a bearer by virtue of the bearer's having a single angle in its length giving the bearer the form of an inverted letter V." @@ -8251,10 +8232,11 @@ "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." "A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging." - "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." "MA:0002437 AAO:0000306 NCIT:C12435 SCTID:91727004 EHDAA2:0003122 AEO:0000122 FMA:9641 Wikipedia:Muscle_tissue EMAPA:32715 galen:MuscleTissue CALOHA:TS-0642 MESH:D009132" + "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." "MA:0002437 AAO:0000306 NCIT:C12435 SCTID:91727004 EHDAA2:0003122 AEO:0000122 FMA:9641 galen:MuscleTissue Wikipedia:Muscle_tissue EMAPA:32715 CALOHA:TS-0642 MESH:D009132" "A behavioral quality inhering in a bearer by virtue of the bearer's being deficient in alertness or activity." "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." + "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement." "FMA:66773" "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." "The part of the venous system that drains the general body tissues[Kardong]." "FMA:45626 Wikipedia:Systemic_venous_system" "A coating quality which is sticky or clammy." @@ -8304,7 +8286,7 @@ "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." - "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." + "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." "https://cellxgene.cziscience.com/cellguide/CL_1000223" "The process in which carboxylic acid is transported across a membrane." "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." @@ -8341,6 +8323,7 @@ "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." + "A cell specialized in detecting light stimuli that are involved in visual perception." "CALOHA:TS-0868 FMA:86740 BTO:0001060" "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." "Any molecular entity that contains carbon." "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." @@ -8361,7 +8344,6 @@ "Affecting all regions without specificity of distribution." "A blood vessel that is part of a limb/fin." "TAO:0005299 ZFA:0005299" "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." - "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." "FMA:71287 EMAPA:18171" @@ -8413,7 +8395,7 @@ "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." "VHOG:0001529 FMA:70335 CALOHA:TS-0650 BTO:0000222" "The proliferation of cells in the inner cell mass." "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." - "A blood vessel endothelial cell that is part of the retina." + "A blood vessel endothelial cell that is part of the retina." "https://cellxgene.cziscience.com/cellguide/CL_0002585" "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." "A sound amplitude which is relatively low." "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." "MA:0001936 FMA:10664 SCTID:244224008 Wikipedia:Transverse_cervical_artery" @@ -8457,6 +8439,7 @@ "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." "MA:0000555" "A bud is a protrusion that forms from an epithelial sheet by localized folding." "BTO:0001639" "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." + "Any cell that in taxon some Eumycetozoa." "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." "A physical quality inhering in a bearer by virtue of that bearer being shielded from visible light." "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." @@ -8542,7 +8525,6 @@ "The orderly movement of a cell that will reside in the hindbrain." "Having a fringe or border of hairlike or fingerlike projections." "A fertility quality of inhering in a male by virtue of the bearer's disposition to initiate, sustain, or support reproduction." - "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds."