diff --git a/CHANGES.md b/CHANGES.md
index 34a27e796..8ba91aec6 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -1,5 +1,14 @@
 # Release Notes
 
+## 2.13.1
+
+This release fixes the `--scie` option to support building a Pex PEX
+scie with something like `pex pex -c pex --venv --scie eager -o pex`.
+Previously, due to the output filename of `pex` colliding with fixed
+internal scie lift manifest file names, this would fail.
+
+* Handle all output file names when building scies. (#2484)
+
 ## 2.13.0
 
 This release improves error message detail when there are failures in
diff --git a/pex/scie/science.py b/pex/scie/science.py
index 509358941..054dda891 100644
--- a/pex/scie/science.py
+++ b/pex/scie/science.py
@@ -70,11 +70,40 @@ def _science_binary_url(suffix=""):
 SCIE_JUMP_VERSION = "1.1.1"
 
 
+@attr.s(frozen=True)
+class Filename(object):
+    name = attr.ib()  # type: str
+
+    @property
+    def placeholder(self):
+        # type: () -> str
+        return "{{{name}}}".format(name=self.name)
+
+
+@attr.s(frozen=True)
+class Filenames(object):
+    @classmethod
+    def avoid_collisions_with(cls, scie_name):
+        # type: (str) -> Filenames
+        return cls(
+            pex=Filename("_pex" if scie_name == "pex" else "pex"),
+            configure_binding=Filename(
+                "_configure-binding.py"
+                if scie_name == "configure-binding.py"
+                else "configure-binding.py"
+            ),
+        )
+
+    pex = attr.ib()  # type: Filename
+    configure_binding = attr.ib()  # type: Filename
+
+
 def create_manifests(
     configuration,  # type: ScieConfiguration
     name,  # type: str
     pex_info,  # type: PexInfo
     layout,  # type: Layout.Value
+    filenames,  # type: Filenames
 ):
     # type: (...) -> Iterator[Manifest]
 
@@ -84,7 +113,7 @@ def create_manifests(
         # interpreter executing the venv PEX.
         installed_pex_dir = ""
     elif layout is Layout.LOOSE:
-        installed_pex_dir = "{pex}"
+        installed_pex_dir = filenames.pex.placeholder
     else:
         production_assert(pex_info.pex_hash is not None)
         pex_hash = cast(str, pex_info.pex_hash)
@@ -102,7 +131,7 @@ def create_manifests(
             "argv1": "{scie.env.PEX_BOOTSTRAP_URLS={scie.lift}}",
         },
         "scie_jump": {"version": SCIE_JUMP_VERSION},
-        "files": [{"name": "configure-binding.py"}, {"name": "pex"}],
+        "files": [{"name": filenames.configure_binding.name}, {"name": filenames.pex.name}],
         "commands": [
             {
                 "env": {"default": env_default},
@@ -126,7 +155,7 @@ def create_manifests(
                 },
                 "name": "configure",
                 "exe": "#{cpython:python}",
-                "args": ["{pex}", "{configure-binding.py}"],
+                "args": [filenames.pex.placeholder, filenames.configure_binding.placeholder],
             }
         ],
     }  # type: Dict[str, Any]
@@ -290,9 +319,10 @@ def build(
     pex_info = PexInfo.from_pex(pex_file)
     layout = Layout.identify(pex_file)
     use_platform_suffix = len(configuration.targets) > 1
+    filenames = Filenames.avoid_collisions_with(name)
 
     errors = OrderedDict()  # type: OrderedDict[Manifest, str]
-    for manifest in create_manifests(configuration, name, pex_info, layout):
+    for manifest in create_manifests(configuration, name, pex_info, layout, filenames):
         args = [science, "--cache-dir", _science_dir(env, "cache")]
         if env.PEX_VERBOSE:
             args.append("-{verbosity}".format(verbosity="v" * env.PEX_VERBOSE))
@@ -301,12 +331,13 @@ def build(
             [
                 "lift",
                 "--file",
-                "pex={pex_file}".format(pex_file=pex_file),
+                "{name}={pex_file}".format(name=filenames.pex.name, pex_file=pex_file),
                 "--file",
-                "configure-binding.py={configure_binding}".format(
+                "{name}={configure_binding}".format(
+                    name=filenames.configure_binding.name,
                     configure_binding=os.path.join(
                         os.path.dirname(__file__), "configure-binding.py"
-                    )
+                    ),
                 ),
                 "build",
                 "--dest-dir",
diff --git a/pex/version.py b/pex/version.py
index e149d3235..597ed68a3 100644
--- a/pex/version.py
+++ b/pex/version.py
@@ -1,4 +1,4 @@
 # Copyright 2015 Pex project contributors.
 # Licensed under the Apache License, Version 2.0 (see LICENSE).
 
-__version__ = "2.13.0"
+__version__ = "2.13.1"
diff --git a/tests/integration/scie/test_pex_scie.py b/tests/integration/scie/test_pex_scie.py
index 34b95ec23..0c9641fec 100644
--- a/tests/integration/scie/test_pex_scie.py
+++ b/tests/integration/scie/test_pex_scie.py
@@ -19,6 +19,7 @@
 from pex.scie import SciePlatform, ScieStyle
 from pex.targets import LocalInterpreter
 from pex.typing import TYPE_CHECKING
+from pex.version import __version__
 from testing import IS_PYPY, PY_VER, make_env, run_pex_command
 
 if TYPE_CHECKING:
@@ -369,3 +370,32 @@ def make_20240415_3_10_14_url(platform):
         stderr.decode("utf-8"),
         flags=re.DOTALL | re.MULTILINE,
     ), stderr.decode("utf-8")
+
+
+@skip_if_pypy
+def test_pex_pex_scie(
+    tmpdir,  # type: Any
+    pex_project_dir,  # type: Any
+):
+    # type: (...) -> None
+
+    pex = os.path.join(str(tmpdir), "pex")
+    run_pex_command(
+        args=[
+            pex_project_dir,
+            "-c",
+            "pex",
+            "--scie",
+            "lazy",
+            "--scie-python-version",
+            "3.12",
+            "-o",
+            pex,
+        ]
+    ).assert_success()
+    assert (
+        __version__
+        == subprocess.check_output(args=[pex, "-V"], env=make_env(PATH=None))
+        .decode("utf-8")
+        .strip()
+    )