diff --git a/kv/variables.go b/kv/variables.go
index 373421826dacb..ad589b280633a 100644
--- a/kv/variables.go
+++ b/kv/variables.go
@@ -23,18 +23,25 @@ type Variables struct {
 
 	// Hook is used for test to verify the variable take effect.
 	Hook func(name string, vars *Variables)
+
+	// Pointer to SessionVars.Killed
+	// Killed is a flag to indicate that this query is killed.
+	Killed *uint32
 }
 
 // NewVariables create a new Variables instance with default values.
-func NewVariables() *Variables {
+func NewVariables(killed *uint32) *Variables {
 	return &Variables{
 		BackoffLockFast: DefBackoffLockFast,
 		BackOffWeight:   DefBackOffWeight,
+		Killed:          killed,
 	}
 }
 
+var ignoreKill uint32
+
 // DefaultVars is the default variables instance.
-var DefaultVars = NewVariables()
+var DefaultVars = NewVariables(&ignoreKill)
 
 // Default values
 const (
diff --git a/session/session_fail_test.go b/session/session_fail_test.go
index 44fa7be1173a0..abd99447d0fd9 100644
--- a/session/session_fail_test.go
+++ b/session/session_fail_test.go
@@ -15,9 +15,11 @@ package session_test
 
 import (
 	"context"
+	"sync/atomic"
 
 	. "github.com/pingcap/check"
 	"github.com/pingcap/failpoint"
+	"github.com/pingcap/tidb/kv"
 	"github.com/pingcap/tidb/util/testkit"
 )
 
@@ -126,3 +128,21 @@ func (s *testSessionSuite) TestRetryPreparedSleep(c *C) {
 
 	tk.MustQuery("select c1 from t").Check(testkit.Rows("21", "0"))
 }
+
+func (s *testSessionSuite) TestKillFlagInBackoff(c *C) {
+	// This test checks the `killed` flag is passed down to the backoffer through
+	// session.KVVars. It works by setting the `killed = 3` first, then using
+	// failpoint to run backoff() and check the vars.Killed using the Hook() function.
+	tk := testkit.NewTestKitWithInit(c, s.store)
+	tk.MustExec("create table kill_backoff (id int)")
+	var killValue uint32
+	tk.Se.GetSessionVars().KVVars.Hook = func(name string, vars *kv.Variables) {
+		killValue = atomic.LoadUint32(vars.Killed)
+	}
+	c.Assert(failpoint.Enable("github.com/pingcap/tidb/store/tikv/tikvStoreSendReqResult", `return("callBackofferHook")`), IsNil)
+	defer failpoint.Disable("github.com/pingcap/tidb/store/tikv/tikvStoreSendReqResult")
+	// Set kill flag and check its passed to backoffer.
+	tk.Se.GetSessionVars().Killed = 3
+	tk.MustQuery("select * from kill_backoff")
+	c.Assert(killValue, Equals, uint32(3))
+}
diff --git a/sessionctx/variable/session.go b/sessionctx/variable/session.go
index 96286e06626bf..45303102af20a 100644
--- a/sessionctx/variable/session.go
+++ b/sessionctx/variable/session.go
@@ -487,7 +487,6 @@ func NewSessionVars() *SessionVars {
 		PreparedStmtNameToID:        make(map[string]uint32),
 		PreparedParams:              make([]types.Datum, 0, 10),
 		TxnCtx:                      &TransactionContext{},
-		KVVars:                      kv.NewVariables(),
 		RetryInfo:                   &RetryInfo{},
 		ActiveRoles:                 make([]*auth.RoleIdentity, 0, 10),
 		StrictSQLMode:               true,
@@ -513,6 +512,7 @@ func NewSessionVars() *SessionVars {
 		AllowRemoveAutoInc:          DefTiDBAllowRemoveAutoInc,
 		LockWaitTimeout:             DefInnodbLockWaitTimeout * 1000,
 	}
+	vars.KVVars = kv.NewVariables(&vars.Killed)
 	vars.Concurrency = Concurrency{
 		IndexLookupConcurrency:     DefIndexLookupConcurrency,
 		IndexSerialScanConcurrency: DefIndexSerialScanConcurrency,
diff --git a/store/tikv/backoff.go b/store/tikv/backoff.go
index 0d31e814e275d..b890b06e19270 100644
--- a/store/tikv/backoff.go
+++ b/store/tikv/backoff.go
@@ -19,6 +19,7 @@ import (
 	"math"
 	"math/rand"
 	"strings"
+	"sync/atomic"
 	"time"
 
 	"github.com/pingcap/errors"
@@ -322,6 +323,12 @@ func (b *Backoffer) BackoffWithMaxSleep(typ backoffType, maxSleepMs int, err err
 	backoffDuration.Observe(float64(realSleep) / 1000)
 	b.totalSleep += realSleep
 
+	if b.vars != nil && b.vars.Killed != nil {
+		if atomic.CompareAndSwapUint32(b.vars.Killed, 1, 0) {
+			return ErrQueryInterrupted
+		}
+	}
+
 	var startTs interface{}
 	if ts := b.ctx.Value(txnStartKey); ts != nil {
 		startTs = ts
diff --git a/store/tikv/region_request.go b/store/tikv/region_request.go
index 9c50af4e0d2c6..2a5146bc6fd71 100644
--- a/store/tikv/region_request.go
+++ b/store/tikv/region_request.go
@@ -95,6 +95,10 @@ func (s *RegionRequestSender) SendReqCtx(bo *Backoffer, req *tikvrpc.Request, re
 					GC:   &kvrpcpb.GCResponse{RegionError: &errorpb.Error{ServerIsBusy: &errorpb.ServerIsBusy{}}},
 				}, nil, nil)
 			}
+		case "callBackofferHook":
+			if bo.vars != nil && bo.vars.Hook != nil {
+				bo.vars.Hook("callBackofferHook", bo.vars)
+			}
 		}
 	})