diff --git a/ddl/db_test.go b/ddl/db_test.go
index 6177151cdd434..8b11eeaead13e 100644
--- a/ddl/db_test.go
+++ b/ddl/db_test.go
@@ -3331,6 +3331,38 @@ func (s *testDBSuite4) TestAlterShardRowIDBits(c *C) {
 	c.Assert(err.Error(), Equals, "[autoid:1467]Failed to read auto-increment value from storage engine")
 }
 
+func (s *testDBSuite2) TestSkipSchemaChecker(c *C) {
+	s.tk = testkit.NewTestKit(c, s.store)
+	tk := s.tk
+	tk.MustExec("use test")
+	tk.MustExec("drop table if exists t1")
+	defer tk.MustExec("drop table if exists t1")
+	tk.MustExec("create table t1 (a int)")
+	tk2 := testkit.NewTestKit(c, s.store)
+	tk2.MustExec("use test")
+
+	// Test skip schema checker for ActionSetTiFlashReplica.
+	tk.MustExec("begin")
+	tk.MustExec("insert into t1 set a=1;")
+	tk2.MustExec("alter table t1 set tiflash replica 2 location labels 'a','b';")
+	tk.MustExec("commit")
+
+	// Test skip schema checker for ActionUpdateTiFlashReplicaStatus.
+	tk.MustExec("begin")
+	tk.MustExec("insert into t1 set a=1;")
+	tb := testGetTableByName(c, s.tk.Se, "test", "t1")
+	err := domain.GetDomain(s.tk.Se).DDL().UpdateTableReplicaInfo(s.tk.Se, tb.Meta().ID, true)
+	c.Assert(err, IsNil)
+	tk.MustExec("commit")
+
+	// Test can't skip schema checker.
+	tk.MustExec("begin")
+	tk.MustExec("insert into t1 set a=1;")
+	tk2.MustExec("alter table t1 add column b int;")
+	_, err = tk.Exec("commit")
+	c.Assert(terror.ErrorEqual(domain.ErrInfoSchemaChanged, err), IsTrue)
+}
+
 func (s *testDBSuite2) TestLockTables(c *C) {
 	s.tk = testkit.NewTestKit(c, s.store)
 	tk := s.tk
diff --git a/domain/domain.go b/domain/domain.go
index 696a5bd22f5d3..07bcbfe1b6fdb 100644
--- a/domain/domain.go
+++ b/domain/domain.go
@@ -254,12 +254,23 @@ func (do *Domain) tryLoadSchemaDiffs(m *meta.Meta, usedVersion, newVersion int64
 		if err != nil {
 			return false, nil, err
 		}
+		if canSkipSchemaCheckerDDL(diff.Type) {
+			continue
+		}
 		tblIDs = append(tblIDs, ids...)
 	}
 	builder.Build()
 	return true, tblIDs, nil
 }
 
+func canSkipSchemaCheckerDDL(tp model.ActionType) bool {
+	switch tp {
+	case model.ActionUpdateTiFlashReplicaStatus, model.ActionSetTiFlashReplica:
+		return true
+	}
+	return false
+}
+
 // InfoSchema gets information schema from domain.
 func (do *Domain) InfoSchema() infoschema.InfoSchema {
 	return do.infoHandle.Get()
diff --git a/store/mockstore/mocktikv/cluster.go b/store/mockstore/mocktikv/cluster.go
index 672e88f14bb28..f941e749145f0 100644
--- a/store/mockstore/mocktikv/cluster.go
+++ b/store/mockstore/mocktikv/cluster.go
@@ -371,13 +371,15 @@ func (c *Cluster) Split(regionID, newRegionID uint64, key []byte, peerIDs []uint
 }
 
 // SplitRaw splits a Region at the key (not encoded) and creates new Region.
-func (c *Cluster) SplitRaw(regionID, newRegionID uint64, rawKey []byte, peerIDs []uint64, leaderPeerID uint64) *Region {
+func (c *Cluster) SplitRaw(regionID, newRegionID uint64, rawKey []byte, peerIDs []uint64, leaderPeerID uint64) *metapb.Region {
 	c.Lock()
 	defer c.Unlock()
 
 	newRegion := c.regions[regionID].split(newRegionID, rawKey, peerIDs, leaderPeerID)
 	c.regions[newRegionID] = newRegion
-	return newRegion
+	// The mocktikv should return a deep copy of meta info to avoid data race
+	meta := proto.Clone(newRegion.Meta)
+	return meta.(*metapb.Region)
 }
 
 // Merge merges 2 regions, their key ranges should be adjacent.
diff --git a/store/mockstore/mocktikv/rpc.go b/store/mockstore/mocktikv/rpc.go
index 32dff89fd0427..09e3c6b8d057f 100755
--- a/store/mockstore/mocktikv/rpc.go
+++ b/store/mockstore/mocktikv/rpc.go
@@ -624,9 +624,7 @@ func (h *rpcHandler) handleSplitRegion(req *kvrpcpb.SplitRegionRequest) *kvrpcpb
 		}
 		newRegionID, newPeerIDs := h.cluster.AllocID(), h.cluster.AllocIDs(len(region.Peers))
 		newRegion := h.cluster.SplitRaw(region.GetId(), newRegionID, k, newPeerIDs, newPeerIDs[0])
-		// The mocktikv should return a deep copy of meta info to avoid data race
-		metaCloned := proto.Clone(newRegion.Meta)
-		resp.Regions = append(resp.Regions, metaCloned.(*metapb.Region))
+		resp.Regions = append(resp.Regions, newRegion)
 	}
 	return resp
 }