diff --git a/src/prebid.js b/src/prebid.js
index 7f2d8798e2a..cad3f65fe13 100644
--- a/src/prebid.js
+++ b/src/prebid.js
@@ -138,10 +138,29 @@ function validateVideoMediaType(adUnit) {
 }
 
 function validateNativeMediaType(adUnit) {
+  function err(msg) {
+    logError(`Error in adUnit "${adUnit.code}": ${msg}. Removing native request from ad unit`, adUnit);
+    delete validatedAdUnit.mediaTypes.native;
+    return validatedAdUnit;
+  }
+  function checkDeprecated(onDeprecated) {
+    for (const key of ['sendTargetingKeys', 'types']) {
+      if (native.hasOwnProperty(key)) {
+        const res = onDeprecated(key);
+        if (res) return res;
+      }
+    }
+  }
   const validatedAdUnit = deepClone(adUnit);
   const native = validatedAdUnit.mediaTypes.native;
   // if native assets are specified in OpenRTB format, remove legacy assets and print a warn.
   if (native.ortb) {
+    if (native.ortb.assets?.some(asset => !isNumber(asset.id) || asset.id < 0 || asset.id % 1 !== 0)) {
+      return err('native asset ID must be a nonnegative integer');
+    }
+    if (checkDeprecated(key => err(`ORTB native requests cannot specify "${key}"`))) {
+      return validatedAdUnit;
+    }
     const legacyNativeKeys = Object.keys(NATIVE_KEYS).filter(key => NATIVE_KEYS[key].includes('hb_native_'));
     const nativeKeys = Object.keys(native);
     const intersection = nativeKeys.filter(nativeKey => legacyNativeKeys.includes(nativeKey));
@@ -149,6 +168,8 @@ function validateNativeMediaType(adUnit) {
       logError(`when using native OpenRTB format, you cannot use legacy native properties. Deleting ${intersection} keys from request.`);
       intersection.forEach(legacyKey => delete validatedAdUnit.mediaTypes.native[legacyKey]);
     }
+  } else {
+    checkDeprecated(key => `mediaTypes.native.${key} is deprecated, consider using native ORTB instead`, adUnit);
   }
   if (native.image && native.image.sizes && !Array.isArray(native.image.sizes)) {
     logError('Please use an array of sizes for native.image.sizes field.  Removing invalid mediaTypes.native.image.sizes property from request.');
diff --git a/test/spec/unit/pbjs_api_spec.js b/test/spec/unit/pbjs_api_spec.js
index deb80873cfa..5e833dc81b6 100644
--- a/test/spec/unit/pbjs_api_spec.js
+++ b/test/spec/unit/pbjs_api_spec.js
@@ -1,33 +1,32 @@
 import {
+  createBidReceived,
   getAdServerTargeting,
+  getAdUnits,
   getBidRequests,
   getBidResponses,
   getBidResponsesFromAPI,
   getTargetingKeys,
-  getTargetingKeysBidLandscape,
-  getAdUnits,
-  createBidReceived
+  getTargetingKeysBidLandscape
 } from 'test/fixtures/fixtures.js';
-import { auctionManager, newAuctionManager } from 'src/auctionManager.js';
-import { targeting, newTargeting, filters } from 'src/targeting.js';
-import { config as configObj } from 'src/config.js';
+import {auctionManager, newAuctionManager} from 'src/auctionManager.js';
+import {filters, newTargeting, targeting} from 'src/targeting.js';
+import {config as configObj} from 'src/config.js';
 import * as ajaxLib from 'src/ajax.js';
 import * as auctionModule from 'src/auction.js';
-import { registerBidder } from 'src/adapters/bidderFactory.js';
-import {resizeRemoteCreative} from 'src/secureCreatives.js';
+import {resetAuctionState} from 'src/auction.js';
+import {registerBidder} from 'src/adapters/bidderFactory.js';
 import {find} from 'src/polyfill.js';
 import * as pbjsModule from 'src/prebid.js';
+import $$PREBID_GLOBAL$$ from 'src/prebid.js';
 import {hook} from '../../../src/hook.js';
 import {reset as resetDebugging} from '../../../src/debugging.js';
-import $$PREBID_GLOBAL$$ from 'src/prebid.js';
-import {resetAuctionState} from 'src/auction.js';
 import {stubAuctionIndex} from '../../helpers/indexStub.js';
 import {createBid} from '../../../src/bidfactory.js';
 import {enrichFPD} from '../../../src/fpd/enrichment.js';
 import {mockFpdEnrichments} from '../../helpers/fpd.js';
 import {generateUUID} from '../../../src/utils.js';
 import {getCreativeRenderer} from '../../../src/creativeRenderers.js';
-import { BID_STATUS, EVENTS, GRANULARITY_OPTIONS, TARGETING_KEYS } from 'src/constants.js';
+import {BID_STATUS, EVENTS, GRANULARITY_OPTIONS, TARGETING_KEYS} from 'src/constants.js';
 
 var assert = require('chai').assert;
 var expect = require('chai').expect;
@@ -2475,6 +2474,52 @@ describe('Unit: Prebid Module', function () {
             }
           });
 
+          if (FEATURES.NATIVE) {
+            Object.entries({
+              missing: {},
+              negative: {id: -1},
+              'not an integer': {id: 1.23},
+              NaN: {id: 'garbage'}
+            }).forEach(([t, props]) => {
+              it(`should reject native ortb when asset ID is ${t}`, () => {
+                const adUnit = {
+                  code: 'au',
+                  mediaTypes: {
+                    native: {
+                      ortb: {
+                        assets: [props]
+                      }
+                    }
+                  },
+                  bids: [{bidder: 'appnexus'}]
+                };
+                $$PREBID_GLOBAL$$.requestBids({
+                  adUnits: [adUnit]
+                });
+                expect(auctionArgs.adUnits[0].bids.length).to.equal(0);
+              });
+            });
+
+            ['sendTargetingKeys', 'types'].forEach(key => {
+              it(`should reject native that includes both ortb and ${key}`, () => {
+                const adUnit = {
+                  code: 'au',
+                  mediaTypes: {
+                    native: {
+                      ortb: {},
+                      [key]: {}
+                    }
+                  },
+                  bids: [{bidder: 'appnexus'}]
+                };
+                $$PREBID_GLOBAL$$.requestBids({
+                  adUnits: [adUnit]
+                });
+                expect(auctionArgs.adUnits[0].bids.length).to.equal(0);
+              })
+            });
+          }
+
           it('should throw error message and remove adUnit if adUnit.bids is not defined correctly', function () {
             const adUnits = [{
               code: 'ad-unit-1',