diff --git a/charts/kube-prometheus-stack/Chart.yaml b/charts/kube-prometheus-stack/Chart.yaml
index a1bf2ab6d95e..83dab760fce0 100644
--- a/charts/kube-prometheus-stack/Chart.yaml
+++ b/charts/kube-prometheus-stack/Chart.yaml
@@ -23,7 +23,7 @@ name: kube-prometheus-stack
 sources:
   - https://github.com/prometheus-community/helm-charts
   - https://github.com/prometheus-operator/kube-prometheus
-version: 65.5.0
+version: 65.5.1
 appVersion: v0.77.2
 kubeVersion: ">=1.19.0-0"
 home: https://github.com/prometheus-operator/kube-prometheus
diff --git a/charts/kube-prometheus-stack/values.yaml b/charts/kube-prometheus-stack/values.yaml
index ebed5f2babfa..c99b70cddbca 100644
--- a/charts/kube-prometheus-stack/values.yaml
+++ b/charts/kube-prometheus-stack/values.yaml
@@ -807,7 +807,7 @@ alertmanager:
     ## The value "hard" means that the scheduler is *required* to not schedule two replica pods onto the same node.
     ## The value "" will disable pod anti-affinity so that no anti-affinity rules will be configured.
     ##
-    podAntiAffinity: ""
+    podAntiAffinity: "soft"
 
     ## If anti-affinity is enabled sets the topologyKey to use for anti-affinity.
     ## This can be changed to, for example, failure-domain.beta.kubernetes.io/zone
@@ -3783,7 +3783,7 @@ prometheus:
     ## The default value "soft" means that the scheduler should *prefer* to not schedule two replica pods onto the same node but no guarantee is provided.
     ## The value "hard" means that the scheduler is *required* to not schedule two replica pods onto the same node.
     ## The value "" will disable pod anti-affinity so that no anti-affinity rules will be configured.
-    podAntiAffinity: ""
+    podAntiAffinity: "soft"
 
     ## If anti-affinity is enabled sets the topologyKey to use for anti-affinity.
     ## This can be changed to, for example, failure-domain.beta.kubernetes.io/zone
@@ -4693,7 +4693,7 @@ thanosRuler:
     ## The value "hard" means that the scheduler is *required* to not schedule two replica pods onto the same node.
     ## The value "" will disable pod anti-affinity so that no anti-affinity rules will be configured.
     ##
-    podAntiAffinity: ""
+    podAntiAffinity: "soft"
 
     ## If anti-affinity is enabled sets the topologyKey to use for anti-affinity.
     ## This can be changed to, for example, failure-domain.beta.kubernetes.io/zone