diff --git a/beacon-chain/node/config.go b/beacon-chain/node/config.go
index 3139a9fe4d2a..9435c4321bd7 100644
--- a/beacon-chain/node/config.go
+++ b/beacon-chain/node/config.go
@@ -52,7 +52,7 @@ func configureSlotsPerArchivedPoint(cliCtx *cli.Context) {
 	}
 }
 
-func configureProofOfWork(cliCtx *cli.Context) {
+func configureEth1Config(cliCtx *cli.Context) {
 	if cliCtx.IsSet(flags.ChainID.Name) {
 		c := params.BeaconConfig()
 		c.DepositChainID = cliCtx.Uint64(flags.ChainID.Name)
@@ -82,3 +82,16 @@ func configureNetwork(cliCtx *cli.Context) {
 		params.OverrideBeaconNetworkConfig(networkCfg)
 	}
 }
+
+func configureInteropConfig(cliCtx *cli.Context) {
+	genStateIsSet := cliCtx.IsSet(flags.InteropGenesisStateFlag.Name)
+	genTimeIsSet := cliCtx.IsSet(flags.InteropGenesisTimeFlag.Name)
+	numValsIsSet := cliCtx.IsSet(flags.InteropNumValidatorsFlag.Name)
+	votesIsSet := cliCtx.IsSet(flags.InteropMockEth1DataVotesFlag.Name)
+
+	if genStateIsSet || genTimeIsSet || numValsIsSet || votesIsSet {
+		bCfg := params.BeaconConfig()
+		bCfg.ConfigName = "interop"
+		params.OverrideBeaconConfig(bCfg)
+	}
+}
diff --git a/beacon-chain/node/config_test.go b/beacon-chain/node/config_test.go
index d8b555ae1339..779621dcd659 100644
--- a/beacon-chain/node/config_test.go
+++ b/beacon-chain/node/config_test.go
@@ -63,7 +63,7 @@ func TestConfigureProofOfWork(t *testing.T) {
 	require.NoError(t, set.Set(flags.DepositContractFlag.Name, "deposit"))
 	cliCtx := cli.NewContext(&app, set, nil)
 
-	configureProofOfWork(cliCtx)
+	configureEth1Config(cliCtx)
 
 	assert.Equal(t, uint64(100), params.BeaconConfig().DepositChainID)
 	assert.Equal(t, uint64(200), params.BeaconConfig().DepositNetworkID)
@@ -88,3 +88,74 @@ func TestConfigureNetwork(t *testing.T) {
 	assert.DeepEqual(t, []string{"node1", "node2"}, params.BeaconNetworkConfig().BootstrapNodes)
 	assert.Equal(t, uint64(100), params.BeaconNetworkConfig().ContractDeploymentBlock)
 }
+
+func TestConfigureInterop(t *testing.T) {
+	params.SetupTestConfigCleanup(t)
+
+	tests := []struct {
+		name       string
+		flagSetter func() *cli.Context
+		configName string
+	}{
+		{
+			"nothing set",
+			func() *cli.Context {
+				app := cli.App{}
+				set := flag.NewFlagSet("test", 0)
+				return cli.NewContext(&app, set, nil)
+			},
+			"mainnet",
+		},
+		{
+			"mock votes set",
+			func() *cli.Context {
+				app := cli.App{}
+				set := flag.NewFlagSet("test", 0)
+				set.Bool(flags.InteropMockEth1DataVotesFlag.Name, false, "")
+				assert.NoError(t, set.Set(flags.InteropMockEth1DataVotesFlag.Name, "true"))
+				return cli.NewContext(&app, set, nil)
+			},
+			"interop",
+		},
+		{
+			"validators set",
+			func() *cli.Context {
+				app := cli.App{}
+				set := flag.NewFlagSet("test", 0)
+				set.Uint64(flags.InteropNumValidatorsFlag.Name, 0, "")
+				assert.NoError(t, set.Set(flags.InteropNumValidatorsFlag.Name, "20"))
+				return cli.NewContext(&app, set, nil)
+			},
+			"interop",
+		},
+		{
+			"genesis time set",
+			func() *cli.Context {
+				app := cli.App{}
+				set := flag.NewFlagSet("test", 0)
+				set.Uint64(flags.InteropGenesisTimeFlag.Name, 0, "")
+				assert.NoError(t, set.Set(flags.InteropGenesisTimeFlag.Name, "200"))
+				return cli.NewContext(&app, set, nil)
+			},
+			"interop",
+		},
+		{
+			"genesis state set",
+			func() *cli.Context {
+				app := cli.App{}
+				set := flag.NewFlagSet("test", 0)
+				set.String(flags.InteropGenesisStateFlag.Name, "", "")
+				assert.NoError(t, set.Set(flags.InteropGenesisStateFlag.Name, "/path/"))
+				return cli.NewContext(&app, set, nil)
+			},
+			"interop",
+		},
+	}
+
+	for _, tt := range tests {
+		t.Run(tt.name, func(t *testing.T) {
+			configureInteropConfig(tt.flagSetter())
+			assert.DeepEqual(t, tt.configName, params.BeaconConfig().ConfigName)
+		})
+	}
+}
diff --git a/beacon-chain/node/node.go b/beacon-chain/node/node.go
index e7eaddb76602..aac14fa049c1 100644
--- a/beacon-chain/node/node.go
+++ b/beacon-chain/node/node.go
@@ -89,8 +89,9 @@ func New(cliCtx *cli.Context) (*BeaconNode, error) {
 	configureChainConfig(cliCtx)
 	configureHistoricalSlasher(cliCtx)
 	configureSlotsPerArchivedPoint(cliCtx)
-	configureProofOfWork(cliCtx)
+	configureEth1Config(cliCtx)
 	configureNetwork(cliCtx)
+	configureInteropConfig(cliCtx)
 
 	registry := shared.NewServiceRegistry()