diff --git a/docs/changelog/1561.bugfix.rst b/docs/changelog/1561.bugfix.rst
new file mode 100644
index 000000000..440dacbf5
--- /dev/null
+++ b/docs/changelog/1561.bugfix.rst
@@ -0,0 +1 @@
+Fix global site package always being added with bundled macOs python framework builds - by :user:`gaborbernat`.
diff --git a/src/virtualenv/create/via_global_ref/builtin/cpython/mac_os.py b/src/virtualenv/create/via_global_ref/builtin/cpython/mac_os.py
index ff2895809..4719f68f1 100644
--- a/src/virtualenv/create/via_global_ref/builtin/cpython/mac_os.py
+++ b/src/virtualenv/create/via_global_ref/builtin/cpython/mac_os.py
@@ -4,6 +4,7 @@
 import os
 import struct
 import subprocess
+from textwrap import dedent
 
 from virtualenv.create.via_global_ref.builtin.cpython.common import CPythonPosix
 from virtualenv.create.via_global_ref.builtin.ref import PathRefToDest
@@ -48,6 +49,27 @@ def _executables(cls, interpreter):
             fixed_host_exe = Path(interpreter.prefix) / "Resources" / "Python.app" / "Contents" / "MacOS" / "Python"
             yield fixed_host_exe, targets
 
+    @property
+    def reload_code(self):
+        result = super(CPython2macOsFramework, self).reload_code
+        result = dedent(
+            """
+        # the bundled site.py always adds the global site package if we're on python framework build, escape this
+        import sysconfig
+
+        config = sysconfig.get_config_vars()
+        before = config["PYTHONFRAMEWORK"]
+        try:
+            config["PYTHONFRAMEWORK"] = ""
+            {}
+        finally:
+            config["PYTHONFRAMEWORK"] = before
+        """.format(
+                result
+            )
+        )
+        return result
+
 
 def fix_mach_o(exe, current, new, max_size):
     """
diff --git a/src/virtualenv/create/via_global_ref/builtin/python2/python2.py b/src/virtualenv/create/via_global_ref/builtin/python2/python2.py
index 1f57aef67..4884f6e8d 100644
--- a/src/virtualenv/create/via_global_ref/builtin/python2/python2.py
+++ b/src/virtualenv/create/via_global_ref/builtin/python2/python2.py
@@ -33,8 +33,15 @@ def create(self):
             custom_site_text = custom_site.read_text()
         expected = json.dumps([os.path.relpath(ensure_text(str(i)), ensure_text(str(site_py))) for i in self.libs])
         custom_site_text = custom_site_text.replace("___EXPECTED_SITE_PACKAGES___", expected)
+        custom_site_text = custom_site_text.replace(
+            "# ___RELOAD_CODE___", os.linesep.join("    {}".format(i) for i in self.reload_code.splitlines()).lstrip()
+        )
         site_py.write_text(custom_site_text)
 
+    @property
+    def reload_code(self):
+        return 'reload(sys.modules["site"])  # noqa # call system site.py to setup import libraries'
+
     @classmethod
     def sources(cls, interpreter):
         for src in super(Python2, cls).sources(interpreter):
diff --git a/src/virtualenv/create/via_global_ref/builtin/python2/site.py b/src/virtualenv/create/via_global_ref/builtin/python2/site.py
index 44654d26e..a2ffa9c4d 100644
--- a/src/virtualenv/create/via_global_ref/builtin/python2/site.py
+++ b/src/virtualenv/create/via_global_ref/builtin/python2/site.py
@@ -39,7 +39,7 @@ def load_host_site():
 
     here = __file__  # the distutils.install patterns will be injected relative to this site.py, save it here
 
-    reload(sys.modules["site"])  # noqa # call system site.py to setup import libraries
+    # ___RELOAD_CODE___
 
     # and then if the distutils site packages are not on the sys.path we add them via add_site_dir; note we must add
     # them by invoking add_site_dir to trigger the processing of pth files