diff --git a/docs/api-reference/index.rst b/docs/api-reference/index.rst
index b4de420ece7e..b98f5d285e3c 100644
--- a/docs/api-reference/index.rst
+++ b/docs/api-reference/index.rst
@@ -4,6 +4,61 @@ API Reference
 Warehouse has several API endpoints. See :doc:`../application` for the
 parts of Warehouse that generate them.
 
+.. contents:: :local:
+
+API Policies
+------------
+
+Please be aware of the following PyPI API Policies:
+
+Caching
+~~~~~~~
+
+All API requests are cached. Requests to the JSON, RSS or Legacy APIs are
+cached by our CDN provider. You can determine if you've hit the cache based on
+the ``X-Cache`` and ``X-Cache-Hits`` headers in the response.
+
+Requests to the JSON, RSS and Legacy APIs also provide an ``ETag`` header. If
+you're making a lot of repeated requests, please ensure your API consumer will
+respect this header to determine whether to actually repeat a request or not.
+
+The XML-RPC API does not have the ability to indicate cached responses.
+
+Rate Limiting
+~~~~~~~~~~~~~
+
+Due to the heavy caching and CDN use, there is currently no rate limiting of
+PyPI APIs at the edge. The XML-RPC API may be rate limited if usage is causing
+degradation of service.
+
+In addition, PyPI reserves the right to temporarily or permanently prohibit a
+consumer based on irresponsible activity.
+
+If you plan to make a lot of requests to a PyPI API, please adhere to
+the following suggestions:
+
+* Set your consumer's ``User-Agent`` header to uniquely identify your requests.
+  Adding your contact information to this value would be helpful as well.
+* Try not to make a lot of requests (thousands) in a short amount of time
+  (minutes). Generally PyPI can handle it, but it's preferred to make requests
+  in serial over a longer amount of time if possible.
+* If your consumer is actually an organization or service that will be
+  downloading a lot of packages from PyPI, consider `using your own index
+  mirror or cache
+  <https://packaging.python.org/guides/index-mirrors-and-caches/>`_.
+
+API Preference
+~~~~~~~~~~~~~~
+
+For periodically checking for new packages or updates to existing packages,
+please use our RSS feeds.
+
+No new integrations should use the XML-RPC APIs as they are planned for
+deprecation. Existing consumers should migrate to JSON/RSS/Legacy APIs.
+
+Available APIs
+--------------
+
 .. toctree::
     :maxdepth: 2
 
diff --git a/docs/api-reference/xml-rpc.rst b/docs/api-reference/xml-rpc.rst
index 81fe1ba39737..a7576e5c1dd0 100644
--- a/docs/api-reference/xml-rpc.rst
+++ b/docs/api-reference/xml-rpc.rst
@@ -2,6 +2,11 @@
 PyPI's XML-RPC methods
 ======================
 
+.. note::
+   The XML-RPC API will be deprecated in the future. Use of this API is not
+   recommended, and existing consumers of the API should migrate to the RSS
+   and/or JSON APIs instead.
+
 Example usage::
 
   >>> import xmlrpclib