diff --git a/Lib/test/test_struct.py b/Lib/test/test_struct.py
index 94873ff6124d02..8f14ed30588810 100644
--- a/Lib/test/test_struct.py
+++ b/Lib/test/test_struct.py
@@ -1,10 +1,12 @@
 from collections import abc
 import array
+import gc
 import math
 import operator
 import unittest
 import struct
 import sys
+import weakref
 
 from test import support
 from test.support import import_helper
@@ -672,6 +674,21 @@ def __del__(self):
         self.assertIn(b"Exception ignored in:", stderr)
         self.assertIn(b"C.__del__", stderr)
 
+    def test__struct_reference_cycle_cleaned_up(self):
+        # Regression test for python/cpython#94207.
+
+        # When we create a new struct module, trigger use of its cache,
+        # and then delete it ...
+        _struct_module = import_helper.import_fresh_module("_struct")
+        module_ref = weakref.ref(_struct_module)
+        _struct_module.calcsize("b")
+        del _struct_module
+
+        # Then the module should have been garbage collected.
+        gc.collect()
+        self.assertIsNone(
+            module_ref(), "_struct module was not garbage collected")
+
     def test_issue35714(self):
         # Embedded null characters should not be allowed in format strings.
         for s in '\0', '2\0i', b'\0':
diff --git a/Misc/NEWS.d/next/Library/2022-06-24-19-23-59.gh-issue-94207.VhS1eS.rst b/Misc/NEWS.d/next/Library/2022-06-24-19-23-59.gh-issue-94207.VhS1eS.rst
new file mode 100644
index 00000000000000..3d38524ac0e83c
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-06-24-19-23-59.gh-issue-94207.VhS1eS.rst
@@ -0,0 +1,2 @@
+Made :class:`_struct.Struct` GC-tracked in order to fix a reference leak in
+the :mod:`_struct` module.
diff --git a/Modules/_struct.c b/Modules/_struct.c
index 4daf9529d882c5..20307ad15be814 100644
--- a/Modules/_struct.c
+++ b/Modules/_struct.c
@@ -1496,10 +1496,26 @@ Struct___init___impl(PyStructObject *self, PyObject *format)
     return ret;
 }
 
+static int
+s_clear(PyStructObject *s)
+{
+    Py_CLEAR(s->s_format);
+    return 0;
+}
+
+static int
+s_traverse(PyStructObject *s, visitproc visit, void *arg)
+{
+    Py_VISIT(Py_TYPE(s));
+    Py_VISIT(s->s_format);
+    return 0;
+}
+
 static void
 s_dealloc(PyStructObject *s)
 {
     PyTypeObject *tp = Py_TYPE(s);
+    PyObject_GC_UnTrack(s);
     if (s->weakreflist != NULL)
         PyObject_ClearWeakRefs((PyObject *)s);
     if (s->s_codes != NULL) {
@@ -2078,13 +2094,15 @@ static PyType_Slot PyStructType_slots[] = {
     {Py_tp_getattro, PyObject_GenericGetAttr},
     {Py_tp_setattro, PyObject_GenericSetAttr},
     {Py_tp_doc, (void*)s__doc__},
+    {Py_tp_traverse, s_traverse},
+    {Py_tp_clear, s_clear},
     {Py_tp_methods, s_methods},
     {Py_tp_members, s_members},
     {Py_tp_getset, s_getsetlist},
     {Py_tp_init, Struct___init__},
     {Py_tp_alloc, PyType_GenericAlloc},
     {Py_tp_new, s_new},
-    {Py_tp_free, PyObject_Del},
+    {Py_tp_free, PyObject_GC_Del},
     {0, 0},
 };
 
@@ -2092,7 +2110,7 @@ static PyType_Spec PyStructType_spec = {
     "_struct.Struct",
     sizeof(PyStructObject),
     0,
-    Py_TPFLAGS_DEFAULT | Py_TPFLAGS_BASETYPE,
+    Py_TPFLAGS_DEFAULT | Py_TPFLAGS_HAVE_GC | Py_TPFLAGS_BASETYPE,
     PyStructType_slots
 };