diff --git a/Lib/typing.py b/Lib/typing.py
index 972b8ba24b27e8..7ff546fbb6492e 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -280,8 +280,6 @@ def _remove_dups_flatten(parameters):
     for p in parameters:
         if isinstance(p, (_UnionGenericAlias, types.UnionType)):
             params.extend(p.__args__)
-        elif isinstance(p, tuple) and len(p) > 0 and p[0] is Union:
-            params.extend(p[1:])
         else:
             params.append(p)
 
diff --git a/Misc/NEWS.d/next/Library/2022-01-22-13-17-35.bpo-46470.MnNhgU.rst b/Misc/NEWS.d/next/Library/2022-01-22-13-17-35.bpo-46470.MnNhgU.rst
new file mode 100644
index 00000000000000..45b9cea3cd56ad
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-01-22-13-17-35.bpo-46470.MnNhgU.rst
@@ -0,0 +1 @@
+Remove unused branch from ``typing._remove_dups_flatten``