diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-12-12-05-30-12.gh-issue-100188.sGCSMR.rst b/Misc/NEWS.d/next/Core and Builtins/2022-12-12-05-30-12.gh-issue-100188.sGCSMR.rst
new file mode 100644
index 00000000000000..ec62fbd582fb00
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-12-12-05-30-12.gh-issue-100188.sGCSMR.rst	
@@ -0,0 +1,3 @@
+The ``BINARY_SUBSCR_LIST_INT`` and ``BINARY_SUBSCR_TUPLE_INT``
+instructions are no longer used for negative integers because
+those instructions always miss when encountering negative integers.
diff --git a/Python/specialize.c b/Python/specialize.c
index a1666ccc91594b..c6c50271647891 100644
--- a/Python/specialize.c
+++ b/Python/specialize.c
@@ -1302,8 +1302,12 @@ _Py_Specialize_BinarySubscr(
     PyTypeObject *container_type = Py_TYPE(container);
     if (container_type == &PyList_Type) {
         if (PyLong_CheckExact(sub)) {
-            _py_set_opcode(instr, BINARY_SUBSCR_LIST_INT);
-            goto success;
+            if (Py_SIZE(sub) == 0 || Py_SIZE(sub) == 1) {
+                _py_set_opcode(instr, BINARY_SUBSCR_LIST_INT);
+                goto success;
+            }
+            SPECIALIZATION_FAIL(BINARY_SUBSCR, SPEC_FAIL_OUT_OF_RANGE);
+            goto fail;
         }
         SPECIALIZATION_FAIL(BINARY_SUBSCR,
             PySlice_Check(sub) ? SPEC_FAIL_SUBSCR_LIST_SLICE : SPEC_FAIL_OTHER);
@@ -1311,8 +1315,12 @@ _Py_Specialize_BinarySubscr(
     }
     if (container_type == &PyTuple_Type) {
         if (PyLong_CheckExact(sub)) {
-            _py_set_opcode(instr, BINARY_SUBSCR_TUPLE_INT);
-            goto success;
+            if (Py_SIZE(sub) == 0 || Py_SIZE(sub) == 1) {
+                _py_set_opcode(instr, BINARY_SUBSCR_TUPLE_INT);
+                goto success;
+            }
+            SPECIALIZATION_FAIL(BINARY_SUBSCR, SPEC_FAIL_OUT_OF_RANGE);
+            goto fail;
         }
         SPECIALIZATION_FAIL(BINARY_SUBSCR,
             PySlice_Check(sub) ? SPEC_FAIL_SUBSCR_TUPLE_SLICE : SPEC_FAIL_OTHER);