diff --git a/Lib/ntpath.py b/Lib/ntpath.py
index ecfc7d48dbb192..c48fc1d5fa4db0 100644
--- a/Lib/ntpath.py
+++ b/Lib/ntpath.py
@@ -85,16 +85,16 @@ def isabs(s):
         sep = b'\\'
         altsep = b'/'
         colon_sep = b':\\'
-        double_sep = b'\\\\'
     else:
         sep = '\\'
         altsep = '/'
         colon_sep = ':\\'
-        double_sep = '\\\\'
     s = s[:3].replace(altsep, sep)
     # Absolute: UNC, device, and paths with a drive and root.
-    return s.startswith(colon_sep, 1) or s.startswith(double_sep)
-
+    if s.startswith(sep):
+        return s.startswith(sep, 1)
+    else:
+        return s.startswith(colon_sep, 1)
 
 # Join two (or more) paths.
 def join(path, *paths):
diff --git a/Lib/test/test_ntpath.py b/Lib/test/test_ntpath.py
index c816f99e7e9f1b..029410774fc78d 100644
--- a/Lib/test/test_ntpath.py
+++ b/Lib/test/test_ntpath.py
@@ -234,11 +234,12 @@ def test_isabs(self):
         tester('ntpath.isabs("c:/foo/bar")', 1)
         tester('ntpath.isabs("\\\\conky\\mountpoint\\")', 1)
 
-        # gh-44626: paths with only a drive or root are not absolute.
+        # gh-44626 & gh-117352: paths with only a drive or root are not absolute.
         tester('ntpath.isabs("\\foo\\bar")', 0)
         tester('ntpath.isabs("/foo/bar")', 0)
         tester('ntpath.isabs("c:foo\\bar")', 0)
         tester('ntpath.isabs("c:foo/bar")', 0)
+        tester('ntpath.isabs("/:/foo/bar")', 0)
 
         # gh-96290: normal UNC paths and device paths without trailing backslashes
         tester('ntpath.isabs("\\\\conky\\mountpoint")', 1)
diff --git a/Misc/NEWS.d/next/Core and Builtins/2024-03-29-07-34-39.gh-issue-117352.-34fR4.rst b/Misc/NEWS.d/next/Core and Builtins/2024-03-29-07-34-39.gh-issue-117352.-34fR4.rst
new file mode 100644
index 00000000000000..c84e3257da8b1e
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2024-03-29-07-34-39.gh-issue-117352.-34fR4.rst	
@@ -0,0 +1 @@
+Handle ``/:/`` for :func:`ntpath.isabs`.