diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 750aa1ed87bca1..28d77ab11c98a9 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -500,6 +500,7 @@ jobs:
       options: ./configure --config-cache --disable-gil --with-thread-sanitizer --with-pydebug
       suppressions_path: Tools/tsan/suppressions_free_threading.txt
       tsan_logs_artifact_name: tsan-logs-free-threading
+      os-matrix: '["ubuntu-22.04", "macos-14"]'
 
   # CIFuzz job based on https://google.github.io/oss-fuzz/getting-started/continuous-integration/
   cifuzz:
diff --git a/.github/workflows/reusable-tsan.yml b/.github/workflows/reusable-tsan.yml
index b6d5d8fa1c7157..5ff0a9d0e23045 100644
--- a/.github/workflows/reusable-tsan.yml
+++ b/.github/workflows/reusable-tsan.yml
@@ -15,12 +15,19 @@ on:
         description: 'Name of the TSAN logs artifact. Must be unique for each job.'
         required: true
         type: string
+      os-matrix:
+        required: false
+        type: string
+        default: '["ubuntu-22.04"]'
 
 jobs:
   build_tsan_reusable:
-    name: 'Thread sanitizer'
-    runs-on: ubuntu-22.04
+    name: 'Thread sanitizer (${{ matrix.os }})'
+    runs-on: ${{ matrix.os }}
     timeout-minutes: 60
+    strategy:
+      matrix:
+        os: ${{fromJson(inputs.os-matrix)}}
     steps:
     - uses: actions/checkout@v4
     - name: Runner image version
@@ -31,6 +38,7 @@ jobs:
         path: config.cache
         key: ${{ github.job }}-${{ runner.os }}-${{ env.IMAGE_VERSION }}-${{ inputs.config_hash }}
     - name: Install Dependencies
+      if: ${{ startsWith(matrix.os, 'ubuntu') }}
       run: |
         sudo ./.github/workflows/posix-deps-apt.sh
         # Install clang-18
@@ -64,6 +72,10 @@ jobs:
       run: make pythoninfo
     - name: Tests
       run: ./python -m test --tsan -j4
+      if: ${{ startsWith(matrix.os, 'ubuntu') }}
+    - name: Tests
+      run: ./python.exe -m test --tsan -j4
+      if: ${{ startsWith(matrix.os, 'macos') }}
     - name: Display TSAN logs
       if: always()
       run: find ${GITHUB_WORKSPACE} -name 'tsan_log.*' | xargs head -n 1000
diff --git a/Lib/test/test_capi/test_mem.py b/Lib/test/test_capi/test_mem.py
index 6ab7b685c2e18b..0c2963cf6fa8c6 100644
--- a/Lib/test/test_capi/test_mem.py
+++ b/Lib/test/test_capi/test_mem.py
@@ -1,8 +1,8 @@
 import re
+import sys
 import textwrap
 import unittest
 
-
 from test import support
 from test.support import import_helper, requires_subprocess
 from test.support.script_helper import assert_python_failure, assert_python_ok
@@ -75,12 +75,20 @@ def check_malloc_without_gil(self, code):
     def test_pymem_malloc_without_gil(self):
         # Debug hooks must raise an error if PyMem_Malloc() is called
         # without holding the GIL
+        if support.check_sanitizer(thread=True) and sys.platform == 'darwin':
+            # See: gh-120696
+            raise unittest.SkipTest("this test will hang on macOS with TSAN")
+
         code = 'import _testcapi; _testcapi.pymem_malloc_without_gil()'
         self.check_malloc_without_gil(code)
 
     def test_pyobject_malloc_without_gil(self):
         # Debug hooks must raise an error if PyObject_Malloc() is called
         # without holding the GIL
+        if support.check_sanitizer(thread=True) and sys.platform == 'darwin':
+            # See: gh-120696
+            raise unittest.SkipTest("this test will hang on macOS with TSAN")
+
         code = 'import _testcapi; _testcapi.pyobject_malloc_without_gil()'
         self.check_malloc_without_gil(code)